The document summarizes characteristics of the immunologic system and immunodeficiency diseases. It describes the components and functions of nonspecific and specific immunity. It discusses the development of T cells and B cells and the five classes of immunoglobulins. It also classifies primary immunodeficiency diseases and describes some common conditions in children like congenital hypogammaglobulinemia.

1. Immunologic system Tianjin general hospital JiangLihong

9. B cell

10. T cell

11. macrophage

12. macrophage

13. macrophage

14. macrophage

15. neutrophil

16. basophil

17. Eosinophil

19. Thymus gland

21. appenditis

28. Components and characters of nonspecific immunity Thin,damaged easily Physical barrier Skin and mucosa 35-70%of that of adult 60%of content for adult Kill bacteria Complement properdin Low gastric acidity,fail to destroy bacteria,low lactic acid from skin Kill bacteria Tissue fluid:gastric juice,lactic acid from skin Penetration,meningitis,intrauterine infection barrier Blood-brain barrier placental barrier Perfect after 34w GA phagocytosis Macrophage Imperfect,infection diffuse easily Filtration Lymph nodes Characters in children Function Components

32. T cell

36. B cell

47. Primary immunodeficincy disease common manifestation

60. HIV infection

71. Thanks