- The infant presented with bleeding from the umbilical stump at 27 days of age. Coagulation studies showed prolonged PT and PTT with low coagulation factors II, VII, IX and X. She was diagnosed with vitamin K deficiency bleeding disorder (VKDBD), also known as hemorrhagic disease of the newborn (HDN). VKDBD is a potentially life-threatening condition caused by low vitamin K levels in newborns. She was treated with fresh frozen plasma, vitamin K, and transfusions which normalized her coagulation studies.
Haemorrhagic and Haemolytic of Newborn DiseasesNaqib Bajuri
actually for haemorrhagic newborn diseases, mainly focus of vit K def...the other is for revision n more commonly occur in child n adults....for haemolytic newborn disease, mainly focus on Rh disease n ABO incompatibility.....the other when childhoods
Haemorrhagic and Haemolytic of Newborn DiseasesNaqib Bajuri
actually for haemorrhagic newborn diseases, mainly focus of vit K def...the other is for revision n more commonly occur in child n adults....for haemolytic newborn disease, mainly focus on Rh disease n ABO incompatibility.....the other when childhoods
Definition of sepsis and septic shock.
The new definition of sepsis 2016 conference.
SIRS, SOFA, QSOFA
Most common pathogen causing sepsis.
Pathogenesis and pathophysiology of sepsis
Biomarkers for detection of sepsis and septic shock
Preseason, sCD14 Subtype marker
Comparison of Procalcitonin and CRP with presepsin.
Mechanism of presepsin detection.
Management of sepsis.
Food hygiene - سلامة الأغذية
تعريف سلامة الأغذية.
أهمية سلامة الأغذية.
العناصر الأساسية لسلامة الأغذية.
أضرار إعادة تسخين الطعام.
الأمراض المنقولة بسبب الغذاء.
الأسباب الرئيسية للأمراض المنقولة بواسطة الغذاء.
العوامل المؤثرة على نمو البكتريا في الأغذية.
أعراض الأمراض الشائعة والمنقولة عن طريق الأطعمة.
فساد الأغذية.
العلامات الدالة على فساد الأغذية.
العوامل التي تسهم في ظهور التسمم الغدائي.
احتياطات الصحة العامة الواجب اتباعها.
العسل ؛ الغذاء الأغنى، الأشهى، والمقاوم للفساد.
حقيقة أم خرافة؟
الإسبوع العالمي للتوعية بالمضادات الحيوية - World antibiotic awareness weekAhmed Al-Abadlah
World antibiotic awareness week - 2016
الإسبوع العالمي للتوعية بالمضادات الحيوية
Gaza - Palestine.
Arabic, Antibiotic, World antibiotic awareness week, الاسبوع العالمي للتوعية ، المضادات الحيوية , د. عبد الرؤوف المناعمة, مشروع الميكروبات الإلكتروني - فلسطين
التوعية العالمية للمضادات
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. • Baby A was a term female infant born via uncomplicated vaginal delivery.
• Maternal serologies were unremarkable.
• she did not receive any prophylaxis or vaccine after delivery.
• She was discharged to home and was reported to have an uneventful
course until, at 27 days of age, she developed severe bleeding from her
umbilical stump.
• The parents used direct pressure but were unable to stop the bleeding.
• At this time, her parents called her primary care physician and were
directed to take her to the emergency department.
3. • She presented at the emergency department with profuse bleeding
from the umbilical stump.
• Parents denied history of bruising, fever, respiratory distress, feeding
intolerance, or changes in voiding, stooling, or activity.
• Parents denied family history of hemophilia or coagulopathy.
• On admission, her complete blood cell count with differential was
unremarkable with hemoglobin of 14.1 g/dL.
4. • Coagulation studies showed prolonged prothrombin time (PT) and
partial thromboplastin time (PTT) without evidence of disseminated
intravascular coagulation (Table 1).
• Blood cultures were obtained and she was started on ampicillin
and cefotaxime.
• With concerns for coagulopathy and her persistent bleeding, and
after 2 unsuccessful attempts to stop the bleeding from her umbilical
stump by cauterization, she was transferred to a medical center with
a hematology service.
7. • During a review of systems with hematology, the parents stated a
history of small nose bleeds occurring over the past 24 hours and
noted that she also appeared paler in color at that time.
• On examination, her pressure dressing to her umbilicus was
saturated with blood.
• She was hemodynamically stable and breathing comfortably on room
air with normal oxygen saturations.
8. • Laboratory values at her admission showed a hemoglobin of
10.7 g/dL, prolonged PT and PTT (Table 1),and low coagulation
factors II, VII, IX, and X (Table 2).
• She was transfused with 10 mL/kg fresh-frozen plasma (FFP) and
given 5-mg vitamin K by mouth.
9.
10. • About 2 hours after arrival at the emergency department, she
developed compensated hemorrhagic shock with an elevated heart
rate of 160 to 170 beats per minute, normal blood pressures, well
perfused extremities, and capillary refill at 3 seconds.
• She was noted to have oxygen saturations of 93% on room air and
was placed on a nasal cannula to maintain adequate oxygen
saturations.
• A normal saline bolus of 10 mL/kg was given and 10 mL/kg
packed red blood cells was ordered.
11. • She was transferred to the neonatal intensive care unit (NICU) for
further management at which time she received the packed red blood
cell transfusion.
• Shortly after being admitted to the NICU, her hemorrhaging subsided.
• Coagulation studies were obtained at approximately 4 hours after FFP
administration and were normalized (Table 2).
12.
13. Summary
• PT >100 sec
• PTT >200 sec
• INR 16
• Fibrinogen 250 mg/dL
• Factor II assay <10 (Low) – Normal range 27%-64%
• Factor VII assay <10 (Low) – Normal range 28%-78%
• Factor IX assay <1 (Low) – Normal range 15%-50%
• Factor X assay <10 (Low) – Normal range 21%-65%
• Factor V, VIII, XI, XII – within normal range.
15. • Hemorrhagic Disease of the Newborn (HDN), now known Vitamin K
Deficiency Bleeding Disorder (VKDBD).
• Hemorrhagic disease of the newborn is a rare bleeding problem that
can occur after birth.
• It’s a potentially life-threatening condition.
• Vitamin K plays a key role in blood clotting. Because vitamin K is not
efficiently passed on from mother to baby in utero, most babies are
born with low stores of this vitamin in their system.
16. • Forms of vitamin K:
– Vitamin K1 (phylloquinon) – plant origin
– Vitamin K2 (menaquinon) – normally produced by bacteria in the
large intestine
• K1 a K2 are used differently in the body
• K1 – used mainly for blood clothing
• K2 – important in non-coagulation actions - as in metabolism and
bone mineralization, in cell growth, metabolism of blood vessel
walls cells.
17. Types of VKDB
VKDB is categorized according to the timing of first symptoms:
- early onset occurs within 24 hours of birth
- classic onset occurs within two to seven days
-late onset occurs within two weeks to six months
Newborns routinely receive vitamin K injection (0.5 -1 mg vitamin
K) or 2 mg orally.
19. Vitamin K Dependent Proteins
• factor II (prothrombin)
• factor VII
• factor IX
• factor X (Stuart factor)
• protein C & protein S
• Protein Z
20. • New born babies are predisposed to develop vitamin K deficiency:
– Minimal transplacental passage of vitamin K
– Limited hepatic storage of vitamin k in newborn
– Low concentration of vitamin k in breast milk
– Absence of the bacterial intestinal flora normally responsible for the
synthesis of vitamin K
22. Investigation
• Coagulation profile: (PT), (aPTT), fibrinogen levels, and a platelet
count.
– A prolonged PT is usually the first laboratory test result to be
abnormal in vitamin K deficiency bleeding.
• Factor assay.
• CBC
• Stool for occult blood
- Others
23. Management
▪ Intramuscular administration of 1 mg of vitamin K at the time of birth
- not effective in the prophylaxis of haemorrhagic disease of the newborn,
particularly in premature infants.
▪ The disease may be effectively treated with a slow intravenous
infusion of 1-5 mg of vitamin K1.
▪ Serious bleeding, particularly in premature infants or those with liver
disease, may require a transfusion of fresh frozen plasma or whole
blood.
▪ specific factor replacement.