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23. Class I: Sodium Channel
Blockers
• Decrease Na+ movement in phases 0 and 4
• Decreases rate of propagation (conduction)
via tissue with fast potential (Purkinje)
– Ignores those with slow potential (SA/AV)
• Indications: ventricular dysrhythmias
24. Class Ia Agents
• Slow conduction • PDQ:
through ventricles – procainamide
• Decrease (Pronestyl®)
repolarization rate – disopyramide
(Norpace®)
– Widen QRS and QT
intervals – qunidine
• May promote Torsades – (Quinidex®)
des Pointes!
25. Class Ib Agents
• Slow conduction • LTMD:
through ventricles – lidocaine (Xylocaine®)
• Increase rate of – tocainide (Tonocard®)
repolarization – mexiletine (Mexitil®)
• Reduce automaticity – phenytoin (Dilantin®)
– Effective for ectopic
foci
• May have other uses
26. Class Ic Agents
• Slow conduction • flecainide
through ventricles, (Tambocor®)
atria & conduction • propafenone
system (Rythmol®)
• Decrease
repolarization rate
• Decrease contractility
• Rare last chance drug
27. Class II: Beta Blockers
• Beta1 receptors in heart attached to Ca++
channels
– Gradual Ca++ influx responsible for
automaticity
• Beta1 blockade decreases Ca++ influx
– Effects similar to Class IV (Ca++ channel
blockers)
• Limited # approved for tachycardias
35. Blood Pressure = CO X PVR
• Cardiac Output = SV x HR
• PVR = Afterload
36. BP = CO x PVR
cardiac factors circulating volume
heart rate 1. Beta Blockers salt ACEi’s
2. CCB’s
contractility 3. C.A. Adrenergics aldosterone Diuretics
Key:
CCB = calcium channel blockers
CA Adrenergics = central-acting adrenergics
ACEi’s = angiotensin-converting enzyme inhibitors
37. BP = CO x PVR
Hormones Peripheral Sympathetic
1. vasodilators Receptors
2. ACEI’s alpha beta
3. CCB’s 1. alpha blockers 2. beta blockers
Central Nervous System Local Acting
1. CA Adrenergics 1. Peripheral-Acting Adrenergics
40. Peripheral Acting Adrenergics
• reserpine (Serpalan®)
• inhibits the release of NE
• diminishes NE stores
• leads to hypotension
• Prominent side effect of depression
– also diminishes seratonin
41. Adrenergic Side Effects
• Common
– dry mouth, drowsiness, sedation & constipation
– orthostatic hypotension
• Less common
– headache, sleep disturbances, nausea, rash &
palpitations
42. RAAS
ACE Inhibitors Angiotensin I
.
ACE
Angiotensin II
1. potent vasoconstrictor
- increases BP
2. stimulates Aldosterone
- Na+ & H2O
reabsorbtion
43. Renin-Angiotensin
Aldosterone System
• Angiotensin II = vasoconstrictor
• Constricts blood vessels & increases BP
• Increases SVR or afterload
• ACE-I blocks these effects decreasing SVR &
afterload
44. ACE Inhibitors
• Aldosterone secreted from adrenal glands
cause sodium & water reabsorption
• Increase blood volume
• Increase preload
• ACE-I blocks this and decreases preload
51. Diuretic Site of Action
.
Distal
tubule
proximal
tubule
Collecting
duct
loop of Henle
52. Mechanism
• Water follows Na+
• 20-25% of all Na+ is reabsorbed into the blood
stream in the loop of Henle
• 5-10% in distal tubule & 3% in collecting ducts
• If it can not be absorbed it is excreted with the
urine
∀ ⇓ Blood volume = ⇓ preload !
62. Platelet Inhibitors
• Inhibit the aggregation of platelets
• Indicated in progressing MI, TIA/CVA
• Side Effects: uncontrolled bleeding
• No effect on existing thrombi
66. Anticoagulants
• Interrupt clotting cascade at various points
– No effect on platelets
• Heparin & LMW Heparin (Lovenox®)
• warfarin (Coumadin®)
67. Heparin
• Endogenous
– Released from mast cells/basophils
• Binds with antithrombin III
• Antithrombin III binds with and inactivates excess
thrombin to regionalize clotting activity.
– Most thrombin (80-95%) captured in fibrin mesh.
• Antithrombin-heparin complex 1000X as effective
as antithrombin III alone
68. Heparin
• Measured in Units, not milligrams
• Indications:
– MI, PE, DVT, ischemic CVA
• Antidote for heparin OD: protamine.
– MOA: heparin is strongly negatively charged.
Protamine is strongly positively charged.
69. warfarin (Coumadin®)
• Factors II, VII, IX and X all vitamin K
dependent enzymes
• Warfarin competes with vitamin K in the
synthesis of these enzymes.
• Depletes the reserves of clotting factors.
• Delayed onset (~12 hours) due to existing
factors
73. Cholesterol Metabolism
• Cholesterol important component in
membranes and as hormone precursor
• Synthesized in liver
– Hydroxymethylglutaryl coenzyme A reductase
– (HMG CoA reductase) dependant
• Stored in tissues for latter use
• Insoluble in plasma (a type of lipid)
– Must have transport mechanism
74. Lipoproteins
• Lipids are surrounded by protein coat to ‘hide’
hydrophobic fatty core.
• Lipoproteins described by density
– VLDL, LDL, IDL, HDL, VHDL
• LDL contain most cholesterol in body
– Transport cholesterol from liver to tissues for use
(“Bad”)
• HDL move cholesterol back to liver
– “Good” b/c remove cholesterol from circulation
75. Why We Fear Cholesterol
• Risk of CAD linked to LDL levels
• LDLs are deposited under endothelial surface and
oxidized where they:
– Attracts monocytes -> macrophages
– Macrophages engulf oxidized LDL
• Vacuolation into ‘foam cells’
– Foam cells protrude against intimal lining
• Eventually a tough cap is formed
– Vascular diameter & blood flow decreased
76. Why We Fear Cholesterol
• Plaque cap can rupture
• Collagen exposed
• Clotting cascade activated
• Platelet adhesion
• Thrombus formation
• Embolus formation possible
• Occlusion causes ischemia