This document outlines the pharmacology content for the cardiovascular, hematological, respiratory, and autonomic nervous systems. It includes sections on drugs for hypertension, angina, arrhythmias, hyperlipidemia, shock, hematinics, coagulation, antiplatelets, fibrinolytics, diuretics, antihistamines, H2 antagonists, prostaglandins, asthma, cough and respiratory stimulants. For each drug class, it describes the mechanism of action, uses, adverse effects, dosing, and pharmacokinetics of common representative drugs. The document provides a comprehensive overview of pharmacology topics related to these body systems.
I upload a series of knowledge for pharmaceutical professional such as students and other specialized field. Presentation for "LEARN & EARN KNOWLEDGE" based.
Disease induced by/ due to the activity of a physician or therapy. For example, an iatrogenic illness is an illness that is caused by a medication or physician.
What are iatrogenic effects?
Medical error and negligence. Iatrogenic conditions do not necessarily result from medical errors, such as mistakes made in surgery, or the prescription or dispensing of the wrong therapy, such as a drug. In fact, intrinsic and sometimes adverse effects of a medical treatment are iatrogenic.
What is social Iatrogenesis?
Medicalisation is associated with a social process that Illich termed 'iatrogenesis'. This concept refers to the detrimental consequences of medical interventions (clinical iatrogenesis), such as adverse drug reactions and hospital acquired infections.
I upload a series of knowledge for pharmaceutical professional such as students and other specialized field. Presentation for "LEARN & EARN KNOWLEDGE" based.
Disease induced by/ due to the activity of a physician or therapy. For example, an iatrogenic illness is an illness that is caused by a medication or physician.
What are iatrogenic effects?
Medical error and negligence. Iatrogenic conditions do not necessarily result from medical errors, such as mistakes made in surgery, or the prescription or dispensing of the wrong therapy, such as a drug. In fact, intrinsic and sometimes adverse effects of a medical treatment are iatrogenic.
What is social Iatrogenesis?
Medicalisation is associated with a social process that Illich termed 'iatrogenesis'. This concept refers to the detrimental consequences of medical interventions (clinical iatrogenesis), such as adverse drug reactions and hospital acquired infections.
Pharmacology is define study of interaction between drug and biological system.
Pharmacokinetics define as study of absorption distribution metabolism and excretion of drug.
Pharmacodynamic is defined as study of mechanism of action of drug side effect.
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Histamine is a biogenic amine present in many animal and plant tissues that function as neurotransmitters and are also found in non-neural tissues, have complex physiologic and pathologic effects through multiple receptor subtypes, and are often released locally.
It is also present in venoms and stinging secretions. It is synthesized by decarboxylation of the amino acid, histidine. Histamine is mainly present in storage granules of mast cells in tissues like skin, lungs, liver, gastric mucosa, placenta, etc. It is one of the mediators involved in inflammatory and hypersensitivity reactions.
Pharmacology is define study of interaction between drug and biological system.
Pharmacokinetics define as study of absorption distribution metabolism and excretion of drug.
Pharmacodynamic is defined as study of mechanism of action of drug side effect.
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Histamine is a biogenic amine present in many animal and plant tissues that function as neurotransmitters and are also found in non-neural tissues, have complex physiologic and pathologic effects through multiple receptor subtypes, and are often released locally.
It is also present in venoms and stinging secretions. It is synthesized by decarboxylation of the amino acid, histidine. Histamine is mainly present in storage granules of mast cells in tissues like skin, lungs, liver, gastric mucosa, placenta, etc. It is one of the mediators involved in inflammatory and hypersensitivity reactions.
The Six Classifications of Drugs of Abuse (Grade 9 (Mapeh) Health Lesson)Jewel Jem
The Six Classifications of Drugs of Abuse
> Gateway Drugs
> Depressants
> Stimulants
> Narcotics
> Hallucinogens
> Inhalants
Along with meanings, types and pictures
The good and bad effects of each classifications of the drugs of abuse
Pharmacology KDT problem based questionsAbhinav Kumar
Taken from KD Tripathi textbook of Pharmacology 7th Edition. Use for quick review. Screenshots taken from pdf version of the book.
Abhinav Kumar, KMC Mangalore
140201306
clinical pharmacology,clinical,injections,pharmacological,what is pharmacology,lethal injection drugs,pharmacology definition,Plus review of anatomy of the ANS
General introduction about hypertension and structure activity relationship of Different types of antihypertensive drugs, and related questions that were asked in exams.
detailed SAR and mode of action of ACE inhibitors
This slide talks about the different pharmacological properties of Antihypertensive Drugs. The classification and examples of these drugs are also given in detail.
Precise pharmacology directly delivers content to the point and it's simplified version of pharmacology notes relevant to medical students . Classification of drug,mode of action of a drug ,clinical indication(use) ,drug formulation ,dosages as per indication, side effects and contraindicationsas it's clearly presented.
This presentation contains a brief classification of medication on the basis of sources, dosage form, law, affect on body systems, and therapeutic effects. Students of pharmacy, nursing sciences, and medical can benefit from it, for any complain or error, please contact me freely.
Scope: This subject is intended to impart the fundamental knowledge on various aspects
(classification, mechanism of action, therapeutic effects, clinical uses, side effects and
contraindications) of drugs acting on different systems of body and in addition,emphasis
on the basic concepts of bioassay. Objectives: Upon completion of this course the student should be able to
1. Understand the mechanism of drug action and its relevance in the treatment of
different diseases
2. Demonstrate isolation of different organs/tissues from the laboratory animals by
simulated experiments
3. Demonstrate the various receptor actions using isolated tissue preparation
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Pharmacology microsyllabus
1. Phr Sangita Shakya MMIHS
Pharmacology - II
Theory
1. Pharmacology of Cardiovascular System:
a) Digitalis and cardiac glycosides.
• Definition of cardiac glycosides
• Classification
• General information about CHF
• Mechanism of action, ADR, drug interaction, pharmacokinetics, pharmacological
action, Uses of digoxin
b) Antihypertensive drugs :
• Definition of hypertension
• Types of hypertension
• Pathophysiology
• Classification of antihypertensive agents
Explain Mechanism of action, ADR, Dose, Pharmacokinetics,CI, Uses of each group of
antihypertensive drugs including :
o ACE Inhibitors: Captopril, Enalapril
o Angiotensin ( AT1) Antagonist : Losartan, valsartan
o Β adrenergic Blockers: propanolol, atenolol, metorpolol
o Calcium channel blockers: Nifedipine, amlodipine, verapamil, diltiazem
o Diuretics :
Physiology of urine formation [ site of drug action]
Thiazides: hydrochlorothiazide
High ceiling : furosemide,
Potassium sparing diuretics: amiloride, spironolactone
Central sympatholytics : clonidine, methyldopa
α-adrenergic blockers: prazocin, phenoxybenzamine, phentolamine
o Vasodilators :
Arteriolar : hydralazine, Minoxidil
Arterial & venous: sodium Nitroprusside
c). Antianginal and Vasodilator drugs, including calcium channel beta lockers and beta
adrenergic antagonists
• Define angina
• Pathophysiology , Types of angina
• Classification of antiangina agents based on types of angina
Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of each group
of antianginal drugs including :
1
2. Phr Sangita Shakya MMIHS
o Organic nitrates
Short acting : Glyceryl trinitrate ( GTN)
Long acting: Isosorbide dinitrate
o Beta Blockers : propanolol, metoprolol, atenolol
o Calcium Channel Blockers:
Phenylalkylamine: verapamil
Benzothiazepine : Diltiazem
Dihydropyridines : nifedipine, felodipine, nicardipine, amlodipine
o potassium channels openers: Nicorandil
d) Antiarrhythmic drugs
• Define arrhythmias
• Pathophysiology , Types of arrhythmias
• Classification of antiarrhythmic agents
Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of each group of
antiarrhythmics drugs including :
It can be classified as Class I, II, III & VI
or
o Membrane stabilizing agents : quinidine, procanamide,, lidocaine
o Antiadrenergic agents: propanolol, esmolol,
o Agents widening AP: amiodarone,
o Calcium channels blockers: verapamil, diltiazem
o For PSVT: adenosine, digitalis
o For A-V blocks : Isoprenaline
e) Antihyperlipedernic drugs
• Definition of hyperlipedemia
• Pathophysiology of hyperlipedemia : Triglycerides, cholesterol
• Antihyperlipidemic Drugs
Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of each group of
antianginal drugs including :
• Atorvastatin
• Clofibrate
• Colestipol
• Gemfibrozil
• Lovastatin
• Simvastatin
f) Drugs used in the therapy of shock.
• Definition of shock
• Types of shock
• Explain about ABC therapy
2
3. Phr Sangita Shakya MMIHS
•
Name of Drug based on type of shock
2. Drugs Acting on the Hemopoietic System:
a) Hermatinics : Definition, Enlist Oral Iron compound
Ferrous sulphate---, its absorption, distribution ,excretion & uses , dose & adr
Enlist parenteral iron preparation--- its composition, application, dose
b) Hemostatic agents : Definition, Formation of clot, Difference between venous &
arterial thrombosis, Mechanism of coagulation, Intrinsic & Extrinsic pathway
c) Vitamin K and Coagulants: Definition of coagulants, Classification of Vitamine K,
MOA, Uses, precaution
d) Anticoagulants: Definition , Classification ( oral & parenteral),
o Heparin : Introduction, MOA, ADR, Precaution, Monitoring parameters of aPTT,
Dosage regimen, PK, Uses
o Mode of action and dose of Antidotes like protamine sulfate .
o Difference between Heparin & Low Molecular Weight Heparins (e.g.
enoxaparin, dalteparin)
o Coumarin Derivatves e.g. Warfarin: Introduction, MOA, ADR, Precaution,
Monitoring parameters of INR , Dosage regimen, PK, Antidotes for warfarin
overdose, Drug interaction, factors affecting activity of warfarin.
e) Anti-platelet drugs: Introduction, Platelets activation, Antiplatelets classification,
Write MOA, ADR, Precaution, Dosage regimen, PK, Uses of aspirin & clopidogrel
f) Fibrinolytic: Introduction, Enlist the fibrinolytics
Write MOA, ADR, Dosage regimen, PK, Uses of Streptokinase, tPA
Antifibrinolytics : Introduction, Enlist the antifibrinolytics , Write the application, adr &
dose of Tranexaemic acid
3. Drugs acting on urinary system:
a) Fluid and electrolyte balance b) Diuretics
• Explain about body fluid compartment
• Function of electrolyte & electrolytic distribution
• Regulation of water loss & Dehydration
4. Autocoids: Definition & Classification of autocoids
a) Histamine : Introduction, location, synthesis, function of histamine depending on
Receptor types, pharmacological action, uses, preparation.
b) Antihistamine : H1Antagonist- Classification, pharmacological action, Uses & adverse
effects Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of
following drugs:
• First generation drugs :
o Potent and sedative : Diphenhydramine,Promethazine
o Potent but less sedative : Chlorpheniramine, Cyclizine
o Moderately sedative: Pheniramine
3
4. Phr Sangita Shakya MMIHS
o Less potent and less sedative: Mepyramine
o Second generation drugs:
•
Non –Sedating Anti allergic: Terfenadine , cetrizine, loratadine, Fexofenadine
• Antivertigo : Cinnarizine,
c) H2 Antagonist: Classification, pharmacological action, Uses & adverse effects
Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of following
drugs:
• Cemitidine, Ranitidine, famotidine
d) 5-HT and their antagonists : Definition, pharmacological action, function, Synthesis,
classification, Uses of serotonin, cyproheptadine
e) Prostaglandins, thromboxanes and leukotrienes Pentagastrin, Cholecystokinin,
Angiotensin, Bradykinin and Substance ; Introduction, pharmacological action ,
Synthesis, function or clinical uses
5. Drugs Acting on the Respiratory System:
a) Anti-asthmatic drugs including bronchodilators.
a. Definition of Asthma
b. Classification of antiasthmatic drugs.
c. Explain Mechanism of action, ADR, Dose, Pharmacokinetics, CI, Uses of
each group of antiasthmatic drugs including
i. Bronchodialtors: Salbutamol, Salmeterol, formoterol, Ipratropium
bromide, theophylline, aminophylline,
ii. Corticosteroids: prednisolone, beclomethasone, fluticasone
iii. Mast cell stabilizers: sodium cromoglycate, Nedocromil
iv. LT antagonist: Montelukast, Zileuton
b) Anti-tussives and expectorants.
• Definition & Etiology of cough
• Classification of Expectorant & antitussives :
[Mention MOA, ADR, , Pharmacokinetics, Doses, Uses &
precaution of following drugs from each group]
i. Mucokinetcis Direct acting: sodium and potassium citrate or
acetate, potassium iodide, Guaiphenesin.
ii. Reflexly acting: Ammonium chloride or Carbonate, Potassium
iodide.
iii. Mucolytics: Bromhexine, Acetylcysteine, Carbocisteine.
• Antitussive ( Cough centre suppressants)
a) Opoids: Codeine, Pholcodine, Morphine
b) Non-opoids : Noscapine, Dextromethorphan
c) Antihistamine: Chlorpeniramine, Diphenhydramine,
Promethazine
c) Respiratory stimulants. : Definition , Classification of respiratory stimulant, Explain
MOA, Pharmacokinetics, ADR, Uses of doxapram.
4