This document discusses cardiac anatomy and positioning of electrophysiology catheters from the perspective of interventional electrophysiologists. It describes the orientation of the heart, components of the cardiac conduction system, relationships between surface ECGs and intracardiac recordings, and catheter placement for electrophysiology studies. Diagrams show views of the heart from different angles and depictions of the positions of the His bundle, coronary sinus, and other catheters.
Our concepts of heart disease are based on the enormous reservoir of physiologic and anatomic knowledge derived from the past 70 years' of experience in the cardiac catheterization laboratory.
As Andre Cournand remarked in his Nobel lecture of December 11, 1956, the cardiac catheter was the key in the lock.
By turning this key, Cournand and his colleagues led us into a new era in the understanding of normal and disordered cardiac function in huma
Our concepts of heart disease are based on the enormous reservoir of physiologic and anatomic knowledge derived from the past 70 years' of experience in the cardiac catheterization laboratory.
As Andre Cournand remarked in his Nobel lecture of December 11, 1956, the cardiac catheter was the key in the lock.
By turning this key, Cournand and his colleagues led us into a new era in the understanding of normal and disordered cardiac function in huma
preop TEE assessment of atrial septal defect is very important for making decision for device closure, properly assessed adequate rims of ASD will reduce risk of device embolization to almost nil.
preop TEE assessment of atrial septal defect is very important for making decision for device closure, properly assessed adequate rims of ASD will reduce risk of device embolization to almost nil.
AV nodal reentrant tachycardia (AVNRT), or atrioventricular nodal reentrant tachycardia, is a type of tachycardia (fast rhythm) of the heart. It is a type of supraventricular tachycardia (SVT), meaning that it originates from a location within the heart above the bundle of His. AV nodal reentrant tachycardia is the most common regular supraventricular tachycardia. It is more common in women than men (approximately 75% of cases occur in females). The main symptom is palpitations. Treatment may be with specific physical maneuvers, medication, or, rarely, synchronized cardioversion. Frequent attacks may require radiofrequency ablation, in which the abnormally conducting tissue in the heart is destroyed.
AVNRT occurs when a reentry circuit forms within or just next to the atrioventricular node. The circuit usually involves two anatomical pathways: the fast pathway and the slow pathway, which are both in the right atrium. The slow pathway (which is usually targeted for ablation) is located inferior and slightly posterior to the AV node, often following the anterior margin of the coronary sinus. The fast pathway is usually located just superior and posterior to the AV node. These pathways are formed from tissue that behaves very much like the AV node, and some authors regard them as part of the AV node.
The fast and slow pathways should not be confused with the accessory pathways that give rise to Wolff-Parkinson-White syndrome (WPW syndrome) or atrioventricular reciprocating tachycardia (AVRT). In AVNRT, the fast and slow pathways are located within the right atrium close to or within the AV node and exhibit electrophysiologic properties similar to AV nodal tissue. Accessory pathways that give rise to WPW syndrome and AVRT are located in the atrioventricular valvular rings. They provide a direct connection between the atria and ventricles, and have electrophysiologic properties similar to ventricular myocardium.
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals travelling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supraventricular tachycardia referred to as an atrioventricular reciprocating tachycardia.The incidence of WPW is between 0.1% and 0.3% in the general population.Sudden cardiac death in people with WPW is rare (incidence of less than 0.6%), and is usually caused by the propagation of an atrial tachydysrhythmia (rapid and abnormal heart rate) to the ventricles by the abnormal accessory pathway.
TGA is a complex congenital heart disease.Understanding the anatomy,physiology,surgery and anaesthetic management is very important for patient's better outcome.This ppt explains all these points in detail.
My presentation regarding criss cross heart ,,,
feel free to download it ,,,u can use it in teaching sets but donot remove my name ,,, this is all ...藍藍藍藍
Aula sobre a Síndrome de Wolff Parkinson-White , ministrada no I Simpósio Catarinense de Arritmia Cardíaca, realizado em Julho de 2017, em Florianópolis - SC.
O evento, promovido pela Clínica Ritmo, clínica especializada no tratamento de Arritmias e Implante de Marcapasso, teve como objetivo abordar todas as formas de arritmias cardíacas e as possibilidades de tratamentos, com temas trazidos a partir de casos reais tratados pelos especialistas da Clínica Ritmo nos últimos cinco anos.
Para saber mais sobre os procedimentos, acesse: http://www.clinicaritmo.com.br/
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
9. V Wave = CS (LBB)V Wave = CS (LBB)
& RVa (RBB)& RVa (RBB)
His potential = HisHis potential = His
A-Wave = HRAA-Wave = HRA
Relationship of the Intracardiac Electrogram to the Activation
Sequence
15. Koch’s Triangle
An imaginary area called Koch’s triangle extends from the tricuspid annulus to the tendon of
Todaro to the CS ostium. Two tracts of atrial fibers within Koch’s triangle form anatomically
distinct conduction pathways to the compact AV node.
• His bundle and compact AV node are at the apex of Koch’s triangle (thus must be avoided
during ablation) and define the anterior aspect of the atrial septum.
•CS ostium is at the base and forms the posterior portion of the atrial septum.
• Tricuspid annulus defines the third face of Koch’s triangle.
• The anterior/superior tract, which lies along the tendon of Tadaro near the compact AV node,
is the fast pathway. The posterior/inferior tract, which lies along the tricuspid valve annulus
near the CS ostium, is the slow pathway of the AV node. The slow pathway is farther away
from the AV node and can usually be safely ablated.
1515
16. Right Atrial Anatomy
The triangle in the picture is called the “Triangle of Koch” and has one face made
up of the tricuspid annulus, another the “Tendon of Todaro” and the last the base
of the CSos. At the tip of the triangle is the AV node. Thus EP doctors have this
in mind when they ablate in the RA in order to avoid ablating the AV node and
causing complete heart block requiring a pacemaker implantation.
Nakagawa et al., Circulation, 1996;94
At the base of the CSos is theAt the base of the CSos is the
Thesbian Valve (ThV). This canThesbian Valve (ThV). This can
be quite large and completelybe quite large and completely
cover the CSos making it verycover the CSos making it very
difficult to insert a CS catheter.difficult to insert a CS catheter.
Some patients also have aSome patients also have a
diverticulum, which is a hugediverticulum, which is a huge
pouch just inside the CSos. Thispouch just inside the CSos. This
too makes advancing the CStoo makes advancing the CS
catheter difficult after accessingcatheter difficult after accessing
the CSos.the CSos.
The heart lies in the mediastinum with its own long axis tilted relative to the long axis of the body. Appreciation of this discrepancy is important in the setting of cross-sectional echocardiography.
Relationship of the intracardiac electrogram to the activation sequence: Intracardiac recordings record only the activation in the small area in the local proximity of the electrode on the catheter that is being used for the recording. This is unlike the 12 lead recordings which represent the entire activation of the heart. Thus the following potentials or waves are recorded: A wave – the A wave represents the atrial activation at the site the catheter is located in right or left atrium. In a standard EP study the HRA catheter is used to record the A wave from the high right atrium near the sinus node. His potential – the His potential is recorded by the His (HBE) catheter which is straddling the tricuspid valve. It represents the activation as it leaves the AV node and rapidly travels past the electrode on the His bundle. V wave – the V wave is recorded usually by the RVA catheter located in the apex of the right ventricle (RV) and the His catheter located on the His with its tip in the (RV) complex is the activation of the right and left ventricles. If an ablation catheter is placed in the RV it too will record a V wave.
所以 , 心臟構造相關位置是很重要的 所以 , 心臟構造相關位置是很重要的 A. Superior Vena Cava B. Right Atrium C. Coronary Sinus D. Inferior Vena Cava E. Pulmonary Veins F. Left Atrium G. Left Ventricle H. Right Ventricle
Intracardiac EGM recordings – Catheter Placement : In the standard electrophysiology study (EPS) procedure, 4 catheters are generally inserted and placed in the high right atrium (HRA), coronary sinus (CS), His region (HIS) and right ventricular apex (RVA). If an ablation procedure is to be performed, one more catheter called the ablation catheter is inserted. Below are the locations where the 4 catheters used in the EPS are placed. High right atrium (HRA): positioned in the right atrial appendage His bundle electrogram (HBE or HIS): positioned with the tip electrodes crossing the tricuspid annulus and a few millimeters on the ventricular side of the tricuspid annulus, and the proximal electrodes on the atrial side of the tricuspid annulus. The best His potential recording is a few millimeters into the ventricular side of the tricuspid annulus. Coronary Sinus (CS): positioned in the coronary sinus between the left atrium and left ventricular and covers anywhere from the left posteroseptal region to the left anterior region depending on how deep it is placed in the CS. Right ventricular apex (RVA): positioned in the right ventricular apex. An alternative location can be the right ventricular outflow tract (RVOT) Characteristic recordings will be made as the wavefront propagates across the recording pairs or unipolar recording electrodes. Those recordings are then compared in terms of relative timing of those various catheters around the heart.
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His catheter specifications: Since the true His is a little higher than a normal Josephson or Cournand catheter reaches, often the His recording may be problematic. The His catheter is often very unstable requiring the doctor to reposition it several times during the procedure. Therefore catheters with multiple electrodes (6-10) with close spacing (2mm) help obtain better recordings. Also using catheters with a longer reach and/or larger curve can help. Curves such as the CRD-2 and IBI His curve are extremely helpful with stability and reach up to the true site of the His potential. Catheters with a longer reach and multiple electrodes tend to give better stability and better His recordings. The His catheter is usually only used for recording, but occasionally can be used for Parahisan pacing. Narrower spacing is desirable to be able to record a sharper His potential. Also by having an octapolar or decapolar catheter, it will have more electrodes back further on the shaft to help record the atrial potential which is often lost more distally. Most Common Curves If fixed curve, CRD-2, CRD, JSN or IBI His Curve, Josephson or Cournand If a big heart, CRD-1 or JSN-1 If steerable, a medium sweep or IBI Medium Usually is only used for recording, but the distal pair of electrodes may be used for Parahisian pacing Most Common Access Femoral access Most Common Electrode Number Quadripolar, but Hexapolar, Octapolar or Decapolar are common Most Common Electrode Spacing Usually 2mm or 5mm, but 10mm (rare) or 2-5-2mm (rare) can also be used
An imaginary area called Koch’s triangle extends from the tricuspid annulus to the tendon of Todaro to the CS ostium. Two tracts of atrial fibers within Koch’s triangle form anatomically distinct conduction pathways to the compact AV node. The His bundle and compact AV node are at the apex of Koch’s triangle, and thus must be avoided during ablation. These structures define the anterior aspect of the atrial septum. The CS ostium is at the base and forms the posterior portion of the atrial septum. The anterior/superior tract, which lies along the tendon of Tadaro near the compact AV node, is the fast pathway. The posterior/inferior tract, which lies along the tricuspid valve annulus near the CS ostium, is the slow pathway of the AV node. Tricuspid annulus defines the third face of Koch’s triangle. The slow pathway is farther away from the AV node and can usually be ablated (isolated without causing complete AV block.
At the base of the CSos is the Thesbian Valve (ThV). This can be quite large and completely cover the CSos making it very difficult to insert a CS catheter. Some patients also have a “Diverticulum”, which is a huge pouch just inside the CSos. This too makes advancing the CS catheter difficult after accessing the CSos. Again as in the previous slide, the “Triangle of Koch” has one face of the triangle made up of the tricuspid annulus, another the “Tendon of Todaro” and the last the base of the CSos. At the tip of the triangle is the AV node. Thus EP doctors have this in mind when they ablate in the RA in order to avoid ablating the AV node and causing complete heart block requiring a pacemaker implantation.
1. Ouyang F, Fotuhi P, Ho SY, Hebe J, Volkmer M, Goya M, Burns M, Antz M, Ernst S, Cappato R, Kuck KH: Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp: electrocardiographic characterization for guiding catheter ablation. J Am Coll Cardiol 2002;39:500-508 2. Ito S, Tada H, Naito S, Kurosaki K, Ueda M, Hoshizaki H, Miyamori I, Oshima S, Taniguchi K, Nogami A: Development and validation of an ECG algorithm for identifying the optimal ablation site for idiopathic ventricular outflow tract tachycardia. J Cardiovasc Electrophysiol 2003;14:1280-1286 3. Yamauchi Y, Aonuma K, Takahashi A, Sekiguchi Y, Hachiya H, Yokoyama Y, Kumagai K, Nogami A, Iesaka Y, Isobe M: Electrocardiographic characteristics of repetitive monomorphic right ventricular tachycardia originating near the His-bundle. J Cardiovasc Electrophysiol 2005;16:1041-1048 4. Ouyang F, Ma J, Ho SY, Bansch D, Schmidt B, Ernst S, Kuck KH, Liu S, Huang H, Chen M, Chun J, Xia Y, Satomi K, Chu H, Zhang S, Antz M: Focal atrial tachycardia originating from the non-coronary aortic sinus: electrophysiological characteristics and catheter ablation. J Am Coll Cardiol 2006;48:122-131
CS catheter specifications: The CS catheter can be placed from the superior or inferior approaches. If placed by the superior approach, a fixed curve catheter is more often used, but if placed from the inferior approach it is almost always a steerable catheter. Since the CS is a long structure, wider spaced pairs with a tight spacing between the pairs is desirable. Thus, 2-8-2mm spacing is the most common. The CS catheter is mainly used for recording, but is often used for pacing as well. Most Common Curves If fixed curve from the superior access, CSL, DAO-1, DAO, CRD or IBI Special Curve If fixed curve from the inferior access, JSN, JSN-1 or IBI Josephson If steerable, an Extra Large Curl or Medium Sweep or IBI Medium or Large Usually is used mainly for recording, but any pair of electrodes may be used for pacing (especially the distal and proximal pairs). Most Common Access Femoral access – mostly steerable Superior – mostly fixed curve, but steerable as well Most Common Electrode Number Decapolar, but Hexapolar and Octapolar are occasionally used Most Common Electrode Spacing Usually 2-8-2mm or 5mm, but 2-5-2mm, 2mm or 2-10-2mm can also be used for more detail
The RVA catheter is placed in the right ventricular apex. Since that area is highly trabeculated the stability is good. Because it is only used as a reference to see the atrial timing and for pacing, the spacing and number of electrodes are not important. Most Common Curves JSN, CRD, CRD-1, DAO or DAO-1, or IBI Josephson, Cournand, Damoto if steerable, a medium sweep or IBI Medium Pace from the distal pair of electrodes and record from the proximal pair Most Common Access Femoral access (on extremely rare occasions a straight curved catheter from the Superior approach is used ) Most Common Electrode Number Quadripolar Most Common Electrode Spacing 5mm, but 10mm and 2-5-2mm can also be used
This slide shows a fluoroscopy image of the pulmonary veins and am MRI image of the same veins. None the close resemblance of the two pictures. The picture on the upper right shows the sheath that was used to inject the contrast dye through.
The CS drains into the base of the RA and is used to insert a catheter to evaluate conduction between the LA and LV. The CS is actually the part from the CSos to the branching of the vein of Marshall. From there on it is called the Great Cardiac Vein. The Vein of Marshall travels next to the left superior and inferior pulmonary veins (PVs), superior vena cava (SVC) travels next to the right superior and inferior PVs, and pulmonary arteries (PAs) (especially the left PA) travel within close proximity to the left and right superior PVs. Thus by placing catheters in those structures, far-field signals can be recorded from the PVs, helping to distinguish whether ectopy occurs from right or left PVs. The posterior vein of the left ventricle is often targeted for placement of a bi-ventricular pacing lead. The RCA courses between the RA and RV, and the conduction between those 2 structures can be evaluated by a mapping wire in the RCA. The middle cardiac vein (MCV) courses between the RV and LV on the inferior aspect of the heart. When the patient has an epicardial pathway located in the posteroseptal region, the pathway can be accessed to ablate through this vessel. However, due to its close proximity to the posterior descending artery, it can be dangerous.