1. Calcium homeostasis is regulated by parathyroid hormone (PTH), calcitonin, and vitamin D. PTH increases calcium absorption in the gut and kidneys while decreasing urinary calcium excretion. Calcitonin decreases calcium levels by inhibiting bone resorption. Vitamin D facilitates intestinal calcium absorption.
2. The normal plasma ionized calcium level is 2.12-2.65 mmol/L. Calcitonin and the kidneys play major roles in calcium homeostasis. Absorption of calcium from the gut is regulated by PTH and vitamin D.
3. A patient lacking PTH after parathyroid damage would have low calcium and phosphate levels, increased muscle excitability (
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta).PTH half-life is approximately 4 minutes. It has a molecular mass of 9.4 kDa.
Calcium metabolism disorders
1. CALCIUM METABOLISM DISORDERS
2. OVERVIEW: Calcium definition and requirement . Calcium metabolism regulators : VD , PTH and calcitonin. Functions of calcium. Calcium metabolic bone diseases. Calcium metabolism disorders. CASE !!
3. WHAT IS CALCIUM? Calcium is a mineral that is essential to bone health, cardiovascular health, muscle maintenance, circulatory health, and blood clotting. Calcium also acts as an enzyme activator. While calcium is found in milk and dairy products, it is also available from other food sources, such as green leafy vegetables, seafood (eating salmon with the bones provides an even greater dose), almonds, blackstrap molasses, broccoli, enriched soy and rice milk products, figs, soybeans and tofu.
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta).PTH half-life is approximately 4 minutes. It has a molecular mass of 9.4 kDa.
Calcium metabolism disorders
1. CALCIUM METABOLISM DISORDERS
2. OVERVIEW: Calcium definition and requirement . Calcium metabolism regulators : VD , PTH and calcitonin. Functions of calcium. Calcium metabolic bone diseases. Calcium metabolism disorders. CASE !!
3. WHAT IS CALCIUM? Calcium is a mineral that is essential to bone health, cardiovascular health, muscle maintenance, circulatory health, and blood clotting. Calcium also acts as an enzyme activator. While calcium is found in milk and dairy products, it is also available from other food sources, such as green leafy vegetables, seafood (eating salmon with the bones provides an even greater dose), almonds, blackstrap molasses, broccoli, enriched soy and rice milk products, figs, soybeans and tofu.
This presentation deals with the physiological aspect of Calcium and phosphate metabolism, it's relationship with the various types of rickets and possible remedies
CALCIUM METABOLISM:
VITAMIN D-PARATHYROID-CALCITONIN ROLE
(Rickets,Osteoporosis,Renal Osteodystrophy)
Prevention Dr.Sandeep C Agrawal Agrasen Hospital Gondia India
Metabolic Bone Diseases:phosphorus,magnesium and other minerals ,Calcium and vitamin D rich diets,Sunlight exposure,vitamin D synthesis,Osteoporosis prevention and diet
This presentation deals with the physiological aspect of Calcium and phosphate metabolism, it's relationship with the various types of rickets and possible remedies
CALCIUM METABOLISM:
VITAMIN D-PARATHYROID-CALCITONIN ROLE
(Rickets,Osteoporosis,Renal Osteodystrophy)
Prevention Dr.Sandeep C Agrawal Agrasen Hospital Gondia India
Metabolic Bone Diseases:phosphorus,magnesium and other minerals ,Calcium and vitamin D rich diets,Sunlight exposure,vitamin D synthesis,Osteoporosis prevention and diet
The 4 Most Important PowerPoint RULES for Successful PresentationsNed Potter
There are a million and one tips and tricks for using PowerPoint effectively, but what REALLY matters most? This presentation takes the 4 most important changes you can make to your presentations and explains simply how to go about them.
The focus is on use of images, making one point per slide, not using bullet points, and keeping things simple. Each of the rules is backed up by actual research, into multimedia learning principles, conducted at the University of California.
There's also several useful sites linked to, including 5 fantastic image resources, and a great place to download fonts.
See the associated blogpost for this slidedeck at http://www.ned-potter.com/blog/the-4-most-important-powerpoint-rules-for-successful-presentations.
If you're interested in more presentation tips, have a look at the other presentations on this Slideshare account, or head over to www.ned-potter.com/blog, where I've also written extensively about Prezi.
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Presentation Skills is one of the most important skills for impressing others. There are three key steps involved in making an effective presentation:
1. Planning
2. Preparation
3. Delivery
All these can be successfully done through proper preparation and practice. Even the best public speakers adopt these vital steps.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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22. Four principal actions of vitamin
D
4. Acts directly on
the parathyroid
glands to decrease
preproPTH
mRNA
1. Increase
Bone resorption
2. Increase GI Ca2+ absorption
through Ca2+ channel and
pump upregulation
3. Ca 2+ reabsorption via
increased TRPV5 expression
in the proximal tubules
28. PTHinhibits phosphate reabsorption by
degradation of Na+-Pi Co-transporters
in the renal epithelium’s apical membrane
When ECF phosphate
levels are low
Na+-Pi Co-
transporters retain
phosphate
29. Increasedplasma phosphate
1. Lowers plasma levels of free Ca 2+ to
stimulates PTH secretion
2. Inhibit the formation of 1,25-
dihydroxycholecalciferol
35. When plasma Ca2+ raised
1. Ca2+ is sensed by a GPCRlinked to PLC.
PLC liberates DAG and IP3
2. DAGactivates PKC
3. PKC inhibits PTH release
4. IP3 starts Ca2+ release from the ER
5. A rise in intracellular free Ca2+
also inhibits PTH secretion
36.
37. PKC and Ca2+ effects
together cause plasma Ca2+ to fall
through PTH
Reduced reabsorption
from the renal tubule
and decreased bone
resorption
52. ACTIONS of Calcitonin
1. lowers Ca2+ and PO4
-3 levels
2. Inhibit bone resorption
3. inhibits the activity of osteoclasts
4. Increases Ca2+ excretion in the urine
54. Glucocorticoids
Lower plasma Ca2+ levels
by inhibiting osteoclast
formation and activity
but long term they
cause osteoporosis by
decreasing bone
formation and
increasing bone
resorption
55. Decrease bone formation by
inhibiting protein synthesis in osteoblasts
Glucocorticoids
Decrease the absorption of Ca2+ and PO4
3–
from the intestine
Increase the renal excretion
of Ca2+ and PO4
3–
56. Growth hormone
Increases Ca2+ excretion in the urine, but it
Increases intestinal absorption of Ca2+ (Greater)
Net positive calcium balance
Insulin-like growth factor I (IGF-I) generated by
the action of growth hormone stimulates
protein synthesis in bone
60. 1. With regards to calcium metabolism
a. It is the ionised calcium concentration which
influences the physiological effects
b. The normal value of ionised calcium is 2.12
2.65mmol/l
c. Calcitonin plays a major role in calcium
homeostasis in humans
d. Absorption of Ca2+ from the GI tract is regulated
by parathyroid hormone
e. 98-99% of filtered calcium is reabsorbed in the
kidney
62. 2. Total plasma calcium:
a) increases with phosphate
b) increases with a rise in albumin,
c) changes its degree of ionisation with pH
changes
d) is decreased in osteoporosis
e) is affected by vitamin D
63. 3. A patient with parathyroid deficiency 10 days after inadvertent
damage to the parathyroid glands during thyroid surgery would
probably have
A. low plasma phosphate and Ca2+ levels and tetany.
B. low plasma phosphate and Ca2+ levels and tetanus.
C. a low plasma Ca2+ level, increased muscular excitability, and spasm of
the muscles of the upper extremity (Trousseau sign).
D. high plasma phosphate and Ca2+ levels and bone demineralization.
E. increased muscular excitability, a high plasma Ca2+ level, and bone
demineralization.
64. 6. Which of the following is not involved in
regulating plasma Ca 2+ levels?
A. Kidneys
B. Skin
C. Liver
D. Lungs
E. Intestine
65. 5. In an experiment, a rat is infused with a small volume of a
calcium chloride solution, or sodium chloride as a control.
Compared to the control condition, which of the following
would result from the calcium load?
A. Bone demineralization
B. Increased formation of 1,25-dihydroxycholecalciferol
C. Decreased secretion of calcitonin
D. Decreased blood coagulability
E. Increased formation of 24,25-dihydroxycholecalciferol
66. 7. 1,25-Dihydroxycholecalciferol affects
intestinal Ca2+ absorption through a
mechanism that
A. includes alterations in the activity of genes
B. activates adenylyl cyclase
C. decreases cell turnover
D. changes gastric acid secretion
E. involves degradation of apical calcium
channels
67. 8. Which of the following would you expect to
find in a patient whose diet has been low in
calcium for 2 months?
A. Increased formation of 24,25
dihydroxycholecalciferol
B. Decreased amounts of calcium-binding
protein in intestinal epithelial cells
C. Increased parathyroid hormone secretion
D. A high plasma calcitonin concentration
E. Increased plasma phosphate