Calcium homeostasis is tightly regulated by the interaction of the parathyroid hormone (PTH), calcitonin, vitamin D, bone, kidney, and intestine. PTH increases blood calcium levels by promoting bone resorption and calcium reabsorption in the kidney. Vitamin D assists by increasing intestinal calcium absorption. Hypocalcemia stimulates PTH release, while hypercalcemia inhibits PTH. Disorders occur if calcium levels become too high or low.
Describe the regulation of PTH
Describe the effect of PTH on bone
What is Osteocytic Osteolysis
Explain the mechanism of bone resorption by PTH- RANKL/OPGL
Describe the role of Osteoprotegerin (OPG)
Describe the actions of PTH on kidney and intestine
Describe Hyperparathyroidism and Hypoparathyroidism
Describe the effect of Calcitonin on calcium homeostasis
Describe Osteoporosis & Osteopetrosis
<PARATHYROID HORMONES (The Calcium Regulating Gland)> first recognized in 1850 by Richard Owen.
<INTRODUCTION>Parathyroid glands are small glands of the endocrine system which are located in the neck behind the thyroid.><Called parathyroid due to proximity to the thyroid gland.><Yellowish brown, small ovoid bodies about 6 mm long, 3mm wide and 2mm thick.><Human being have 4 tiny parathyroid glands.><Each weighting around 30-50mg, but may weight as much as 70 mg, and in diameter is 3-4 or till 8 millimeters>
<Each parathyroid gland is made up of chief cells and oxyphil cells.><Chief cells more numerous, smaller, with a slightly eosinophilic cytoplasm.><secrete Parathyroid hormone (PTH). Also known as parathormone or parathyrin.>
<PARATHORMONE>Protein in nature (84 amino acids)><Molecular weight= 9,500.>< Half- life = 10 minutes><Normal plasma level of PTH = 1.5 to 5.5 ng/dL>
<SYNTHESIS OF AND SECRETION OF PARATHORMONE>PTH is encoded by a gene in chromosome 11><After translation, it become pre-pro-parathyroid hormone (pre-pro-PTH) contains 115 amino acids><In endoplasmic reticulum 29 amino acids removed, so it called pro-parathyroid hormone (pro-PTH) contains 89 amino acids><In the Golgi, removed more amino acids by peptidase to become mature hormone (PTH).><It is stored in secretory vesicles within the cells, and released when required>
<METABOLISM OF PTH>Half-life= 4 minute><60- 70 % of PTH is degraded by kupffer cells of liver, by means of proteolysis><Degradation of about 20-30% PTH occurs in kidneys and to a lesser extent in other organs>
<Half life – 4 min. How does PTH produce its effect on biological system?>
<REGULATION OF PARATHORMONE SECRETION>Regulators of secretion of PTH include calcium, vit D and phosphorus.>
<MECHANISM OF SECRETION OF PARATHORMONE> <CALCIUM-SENSING RECEPTORS (CaSR)><CaSR is a plasma membrane or a cell surface receptor, structured as G protein-coupled that is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland and the cells lining the kidney tubule. (Hendy & et al., 2000)><PTH RECEPTORS>PTHR1 is physiologically more important than others two.><PTHR = 60-80 kDa membrane glycoprotein.>
<ACTION OF PTH>Important role in maintaining blood calcium level.>< Also controls blood phosphate level>
<DISORDERS OF PARATHORMONE.><increased pth secretion leads to an increase in serum levels by increasing bone resorption and enhancing renal calcium reabsorption. >
<3 TYPES>Primary hyperparathyroidism, Secondary hyperparathyroidism, Tertiary hyperparathyroidism.><The most common cause of hypercalcaemia is primary hyperparathyroidism>
Physiology of Parathyroid glands
Outline :
- Location of Parathyroid glands.
- Who discovered the glands.
- Some info. about it.
- Parathyroid hormone.
- Histology of the gland.
- PTH biosynthesis.
- The calcium-sensing receptors (CaSR)
- Why Calcium is so Important?
- Calcitonin
- vitamin D
-Metabolic bone diseases (Hypercalcaemia and hypocalcaemia)
Describe the regulation of PTH
Describe the effect of PTH on bone
What is Osteocytic Osteolysis
Explain the mechanism of bone resorption by PTH- RANKL/OPGL
Describe the role of Osteoprotegerin (OPG)
Describe the actions of PTH on kidney and intestine
Describe Hyperparathyroidism and Hypoparathyroidism
Describe the effect of Calcitonin on calcium homeostasis
Describe Osteoporosis & Osteopetrosis
<PARATHYROID HORMONES (The Calcium Regulating Gland)> first recognized in 1850 by Richard Owen.
<INTRODUCTION>Parathyroid glands are small glands of the endocrine system which are located in the neck behind the thyroid.><Called parathyroid due to proximity to the thyroid gland.><Yellowish brown, small ovoid bodies about 6 mm long, 3mm wide and 2mm thick.><Human being have 4 tiny parathyroid glands.><Each weighting around 30-50mg, but may weight as much as 70 mg, and in diameter is 3-4 or till 8 millimeters>
<Each parathyroid gland is made up of chief cells and oxyphil cells.><Chief cells more numerous, smaller, with a slightly eosinophilic cytoplasm.><secrete Parathyroid hormone (PTH). Also known as parathormone or parathyrin.>
<PARATHORMONE>Protein in nature (84 amino acids)><Molecular weight= 9,500.>< Half- life = 10 minutes><Normal plasma level of PTH = 1.5 to 5.5 ng/dL>
<SYNTHESIS OF AND SECRETION OF PARATHORMONE>PTH is encoded by a gene in chromosome 11><After translation, it become pre-pro-parathyroid hormone (pre-pro-PTH) contains 115 amino acids><In endoplasmic reticulum 29 amino acids removed, so it called pro-parathyroid hormone (pro-PTH) contains 89 amino acids><In the Golgi, removed more amino acids by peptidase to become mature hormone (PTH).><It is stored in secretory vesicles within the cells, and released when required>
<METABOLISM OF PTH>Half-life= 4 minute><60- 70 % of PTH is degraded by kupffer cells of liver, by means of proteolysis><Degradation of about 20-30% PTH occurs in kidneys and to a lesser extent in other organs>
<Half life – 4 min. How does PTH produce its effect on biological system?>
<REGULATION OF PARATHORMONE SECRETION>Regulators of secretion of PTH include calcium, vit D and phosphorus.>
<MECHANISM OF SECRETION OF PARATHORMONE> <CALCIUM-SENSING RECEPTORS (CaSR)><CaSR is a plasma membrane or a cell surface receptor, structured as G protein-coupled that is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland and the cells lining the kidney tubule. (Hendy & et al., 2000)><PTH RECEPTORS>PTHR1 is physiologically more important than others two.><PTHR = 60-80 kDa membrane glycoprotein.>
<ACTION OF PTH>Important role in maintaining blood calcium level.>< Also controls blood phosphate level>
<DISORDERS OF PARATHORMONE.><increased pth secretion leads to an increase in serum levels by increasing bone resorption and enhancing renal calcium reabsorption. >
<3 TYPES>Primary hyperparathyroidism, Secondary hyperparathyroidism, Tertiary hyperparathyroidism.><The most common cause of hypercalcaemia is primary hyperparathyroidism>
Physiology of Parathyroid glands
Outline :
- Location of Parathyroid glands.
- Who discovered the glands.
- Some info. about it.
- Parathyroid hormone.
- Histology of the gland.
- PTH biosynthesis.
- The calcium-sensing receptors (CaSR)
- Why Calcium is so Important?
- Calcitonin
- vitamin D
-Metabolic bone diseases (Hypercalcaemia and hypocalcaemia)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
3. Introduction
Total plasma [Ca++] = 2.5mmol/L
Range is 2.1 to 2.6 mmol/L
Very tightly controlled
Body
content
Bone intracellular extracellular
Calcium 1300 gm 99% 1% 0.1%
7. Functions of Calcium
1. Nerve and muscle functions
- Decreased extracellular calcium – increase excitability of
excitable cells and lowers the threshold potential – less
inward current is required to depolarize the threshold
potential – less inward current is required to fire AP
- Hence causing tingling and numbness (sensory) and
spontaneous muscle twitches (motor neurons and
muscles)
9. Functions of Calcium
3. Preserving bone density
- construction, formation and maintenance of bone and
teeth. This function helps reduce the occurrence of
osteoporosis
10. Functions of Calcium
4. Neurotransmitter release
- Directly proportional to the calcium level
- Arrival of action potential to axonal terminal
opening of voltage gated calcium channels
calcium influx into the terminal transmitter vesicle fuse
with the release sites exocytosis-release of transmitters
into the cleft
11. Functions of Calcium
5. Calcium assists in maintaining all cells and connective
tissues in the body and regulating mitotic transition and
cell division.
6. Essential component in the production of enzyme and
hormones that regulate digestion, energy, and fat
metabolism.
12. Calcium Homeostasis
Blood calcium is tightly regulated by:
1) Principle organ systems:
Intestine
Bone
Kidney
2) Hormones:
Parathyroid hormone (PTH)
Vitamin D
Calcitonin
14. Parathyroid Hormone (PTH)
There are 4 parathyroids glands, located on the dorsal side of the
thyroid
The blood supply to the parathyroid glands is from the thyroid arteries.
17. Parathyroid Hormone (PTH)
Mechanism
Increase in extracellular calcium concentration Ca2+
binds to the receptor and activates phospholipase C
increased levels of IP04/Ca2+ which inhibits PTH
secretion.
When extracellular Ca2+ is decreased, there is decreased
Ca2+ binding to the receptor, which stimulates PTH
secretion.
18. Parathyroid Hormone (PTH)
Actions of PTH on bone, kidney and small intestine
Direct vs indirect
1) Actions on bone
- PTH receptors on osteoblasts – initial bone formation
(direct action)
- Later on – bone resorption (indirect action) via cytokines
from osteoblast
- Overall effect : promote bone resorption and increase
calcium concentration
19. Parathyroid Hormone (PTH)
a) Inhibits PO4 reabsorption (inhibits Na-PO4 cotransport
in PCT) – phosphaturia – less complexed Ca-PO4 –
increase plasma calcium
b) Stimulates calcium reabsorption (on DCT)
Phosphaturia + Ca2+ reabsorption = increase in Ca2+
concentration
20. Parathyroid Hormone (PTH)
3. Actions on small intestine (indirect)
- Stimulates Ca2+ reabsorption via activation of vitamin D.
- PTH stimulates renal 1 alpha hydroxylase converts 25-
hydroxycholecalciferol to 1,25 dihydroxycholecalciferol
stimulates intestinal Ca2+ absorption
24. Vitamin D
Common diseases related to vitamin D
1) Rickets - insufficient amounts of calcium and
phosphate to mineralize the growing bones growth
failure and skeletal deformities
2) Osteomalacia – new bone fails to mineralize bending
and softening of weight bearing bones
25. Calcitonin
a straight-chain peptide with 32 amino acids.
synthesized and secreted by the parafollicular cells of the thyroid
gland.
major stimulus for calcitonin secretion is increased plasma Ca2+
concentration
The major action of calcitonin is to inhibit osteoclastic bone
resorption, which decreases the plasma Ca2+ concentration.
calcitonin does not participate in the minute-to-minute regulation of
the plasma Ca2+ concentration in humans.
a physiologic role for calcitonin in humans is uncertain because
neither thyroidectomy (with decreased calcitonin levels) nor thyroid
tumors (with increased calcitonin levels) cause a derangement of
Ca2+ metabolism, as would be expected if calcitonin had important
regulatory functions.
27. Calcium handling in the nephron
- 67% of the filtered load is reabsorbed @ PCT
- Ca2+ reabsorption is tightly coupled to Na+ reabsorption in
the proximal tubule
28. Calcium handling in the nephron
- @ ALH , 25% of the filtered load of Ca2+ is reabsorbed
- The mechanism of coupling in the thick ascending limb depends on the
lumen-positive potential difference, which is generated by the Na+-K+-2Cl-
cotransporter.
- Loop diuretics such as furosemide inhibit Ca2+ reabsorption to the same
extent that they inhibit Na+ reabsorption.
29. Calcium handling in the nephron
@ DT 8% of the filtered load of Ca2
the site of regulation of Ca2+ reabsorption.
the distal tubule is the only nephron segment in which Ca2+ reabsorption is not
coupled directly to Na+ reabsorption.
it has its own regulatory hormone, PTH.
Thiazide diuretics increase Ca2+ reabsorption, while the other classes of diuretics
decrease it.
30. Hypocalcaemia
Symptoms and signs
"CATS go numb"- Convulsions, Arrythmias, Tetany and
numbness/parasthesias in hands, feet, around mouth and
lips.
Trousseau sign of latent tetany (eliciting carpal spasm by
inflating the blood pressure cuff and maintaining the cuff
pressure above systolic)
Chvostek's sign (tapping of the inferior portion of the
zygoma will produce facial spasms
32. Hypercalcemia
"Stones, Bones, Groans, Thrones and Psychiatric Overtones“
-Stones (renal or biliary)
-Bones (bone pain)
-Groans (abdominal pain, nausea and vomiting)
-Thrones (sit on throne - polyuria)
-Psychiatric overtones (Depression 30-40%, anxiety, cognitive dysfunction,
insomnia, coma)
33. Summary
Calcium is crucial for body physiological function
It must be tightly regulated to maintain physiological
stability, by the interaction between the major organs
(Intestine, kidney, bone) and hormones ( PTH, Calcitonin,
Vitamin D)
34. Summary
A decrease in calcium level – stimulate PTH release –
increase bone reabsorption, increase Ca2+ reabsorption
from kidney (DCT), decrease PO4 reabsorption from
kidney (PCT), and increase calcium uptake from GI
(indirect)
Vitamin D – same action but increase PO4 reabsorption
from kidney
Calcium imbalance must be recognized and treated early
to prevent any catastrophe.