The document discusses the pancreas and pancreatic exocrine insufficiency (PEI). It notes that the pancreas has both exocrine and endocrine functions, with the exocrine function secreting digestive enzymes through ducts into the small intestine. PEI occurs when there is a decrease or failure of this exocrine secretion, causing symptoms like fatty stools. Causes include chronic pancreatitis, cystic fibrosis, pancreatic cancer, and surgery. Diagnosis involves stool tests and imaging, while treatment is pancreatic enzyme replacement therapy to supplement deficient enzymes.
Pancreatitis - being one of the differentials for acute abdomen which includes Acute & Chronic pancreatitis, their aetiology, pathogenesis, clinical features & possible complications.
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
Pancreatitis - being one of the differentials for acute abdomen which includes Acute & Chronic pancreatitis, their aetiology, pathogenesis, clinical features & possible complications.
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
ENZYMATIC STUDY IN ACUTE AND CHRONIC PANCREATITIS.Sandhya Rani
PANCREATITIS IS A CONDITION IN THIS PANCREASE ATTACKED BY ITS OWN ENZYMES AND GETS INFLAMMED. PARAMETERS STUDIED: COMPARING AMYLASE AND LIPASE NORMALS WITH DISEASED.
The gastrointestinal tract is the tract or passageway of the digestive system that leads from the mouth to the anus.
GI tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus.
The hollow organs that make up the GI tract are mouth, esophagus, stomach, small intestine, large intestine and anus.
The GI tract contains all the major organs of the digestive system, in humans and other animals.
Digestive disorders are among the most common problems in health care.
Approximately 30-40% adults claim to have frequent indigestion.
Indigestion
Peptic ulcer
Carcinoma of the Stomach
Gastric Surgery
Dumping Syndrome
Constipation
Diarrohoea
Steatorrhoea
Lactose Intolerance
Coeliac Disease
Tropical sprue
Irritable Bowel Syndrome
Inflammatory Bowel Diseases
Intestinal Gas and Flatulence
Diverticular Disease
Indigestion also called dyspepsia which means discomfort in the upper digestive tract.
Indigestion can be caused by dietary indulgences-excessive volumes of food or high intake of fat, sugar, caffeine, spices or alcohol or both.
Symptoms : vague abdominal pain
Bloating
Nausea
Regurgitation and belching
If it is prolonged it can lead to gastro-oesophagul reflux, gastritis, peptic ulcer disease, delayed gastric emptying, gall bladder disease or cancer.
It can be treated by eating slowly, chewing thoroughly and not eating or drinking excessively.
Localized erosion of the mucosal lining of those portions of the alimentary tract that come in contact with the gastric juice.
This disintegration of tissues can also result in necrosis.
Ulcers occurs in oesophagus, stomach, jejunum and duodenum but majority of ulcers are found in the duodenum.
All the ulcers have same symptoms and same response to treatment regardless of location.
Mechanism of ulcer formation
Three vital mechanisms are the mucus layer, prostaglandins and probably the urogastrone /epidermal healing factor(URO/EHF).
These mechanisms can protect the stomach against HCL up to twice the maximum concentration which the stomach is capable of secreting.
The mucous layer, viscous gel is ideally suited for its function of protection from chemical and physical hazards of water proofing and lubrication.
The second line of defence are prostaglandins.
Third line of defence that is urogastrone plays important role by inhibiting gastric acid secretion and by stimulation of cell proliferation and regeneration for healing the ulcer.
If mucosal line is broken then underlying layers of the stomach are exposed to the effect of concentrated acid which results in peptic ulcer.
Duodenal Ulcer :
Peptic ulcer that develops in first part of the small intestine.
Hypersecretion of acid
Tissue resistance is normal
Acid hypersecretion is due to increased number of parietal cells and impaired rapid gastric emptying with loss of buffering effect.
Excess production of acid and pepsin is the primary factor.
Gastric Ulcer
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
4. Pancreas - gland which lies behind the stomach
It is about 12-15 cm long and 2.5 cm thick
Divided into three parts: the head, body and tail
Connected to the duodenum usually by two ducts
Storage for digestive enzymes
Dual function gland having both endocrine and exocrine functions
ENDOCRINE
Secretion of a substance (a hormone) from gland into
the blood
EXOCRINE
Refers to the secretion of a substance out through
duct. of a gland
5. ENDOCRINE
• Consists of cells called pancreatic islets
• Islets secrete hormones
eg. insulin, glucagon
EXOCRINE
• Consists of cells called acini
• Acini produce pancreatic juice which
contains digestive enzymes
6. Exocrine pancreas secretes about 2 L pancreatic juice daily
Alkaline pH (7.1-8.2)
It contains water, salts, bicarbonates and digestive enzymes
Functions
Helps to neutralize acidic gastric juice
Pancreatic juice contains enzymes like pancreatic proteases, lipase, and amylase
Pancreatic amylase digests carbohydrates, proteases digest proteins and lipase digest fats
Among these lipase is the most important as fat digestion is primarily done by this
enzyme
Gut 2005;54(Suppl VI):vi1–vi28. doi: 10.1136/gut.2005.065946
7.
8. It is a condition in which there is decrease in or failure of pancreatic exocrine secretion
i.e pancreatic enzymes
Symptoms
Steatorrhea (fatty foul smelling stools) - main symptom
Weight loss
Diarrhea
Abdominal pain
Loss of appetite, nutrient malabsorption
Gut 2005;54(Suppl VI):vi1–vi28. doi: 10.1136/gut.2005.065946
9. CAUSES OF PEI
Genetic disorders
- Cystic fibrosis
Pancreatic disorders
-Chronic pancreatitis
-Duct obstruction due to
stones or cancer
-Surgery of pancreas
Gastrointestinal
surgery
Others
-Diabetes
-HIV
10. Gut 2005;54(Suppl VI):vi1–vi28. doi: 10.1136/gut.2005.065946
Pancreatitis: Inflammation of the pancreas
• Acute Pancreatitis: Acute inflammation of the pancreas, usually accompanied by
abdominal pain and elevations of serum pancreatic enzymes
• Chronic Pancreatitis: Long standing inflammation of the pancreas which leads to slow,
irreversible damage to the pancreas
11. Chronic pancreatitis is a condition affecting nearly 0.04% to 5% of the population
worldwide
In chronic pancreatitis patients, PEI has been seen in 22% to 94% patients
Majority of patients have pancreatitis of unknown origin (60% cases)
Alcohol and smoking is an important risk factor
Other risks include intake of high fat diet, gallstones and repeated attacks of acute
pancreatitis
Cochrane Database of Systematic Reviews 2009, Issue .Journal of Gastroenterology and Hepatology 2004;19 (9) : 998 - 1004
12. Symptoms
Pain, fever ,vomiting
Inability to digest food (weight loss and nutritional deficiencies)
Inability to produce insulin (diabetes)
Diagnosis
Suspected by history of severe abdominal pain, weight loss and steatorrhea, USG and
CT scan
Management
Pancreatic enzymes and pain killers as initial medical therapy for pain relief
Surgical management
Stop alcohol consumption
Journal of Gastroenterology and Hepatology 2004;19 (9) : 998 - 1004 Best Practice & Research Clinical Gastroenterology 2006 ;20(3):507–529
13.
14. Ducts are tubes that carry the pancreatic digestive juices to the main pancreatic duct and
the duodenum
Ductal obstruction can occur due to:
- pancreatic cancer
- gallstones
If the tumour blocks the pancreatic duct the pancreatic enzymes may not be secreted in
the required amount
15. Hereditary disease that mainly affects the exocrine pancreas
Thickened secretions from the pancreas block the pancreatic ducts and movement of the
digestive enzymes into the duodenum
Therapeutics and Clinical Risk Management 2008:4(5) 1079–1084
16. Diabetes :
- PEI may be present in approximately 20% -29%of patients with diabetes mellitus
HIV patients:
-Malabsorption of nutrients and fats which can be improved by pancreatic enzyme
supplements in HIV patients
1.Pancreatology 2003;3:395-402
2.Dtsch Arztebl Int 2009; 106(48): 789–94
3.Aliment Pharmacol Ther. 2001 Oct;15(10):1619-25
17.
18. There are few centers where tests for stool fat, stool enzymes are available
Diagnosis is mainly done based on clinical symptoms , stool tests plus imaging
studies
( USG, CT)
Computed Tomography (CT) Scan
Abdominal Ultrasound (USG): Can detect gallstones
Indian J Gastroenterol 2009:28(6):201–205
19. Stool (faecal) fat test
Measures the amount of fat in the stool
> 7 g fat/d in the stool is diagnostic of steatorrhoea ( normal : less than 7 g/day)
Indian J Gastroenterol 2009 :28(6):201–205
Coefficient of fat absorption (CFA)
• Measures amount of fat absorbed by food
• Higher the CFA the better the fat absorption
Coefficient of nitrogen absorption (CNA)
• To evaluate the absorption of proteins
• Higher the CNA the better the protein
absorption
20. Will have some disease of the pancreas OR GI tract
Symptoms of steatorrhea, weight loss, diarrhea, abdominal pain, loss of appetite and
sometimes diabetes
Investigations:
Fat in stools – high
USG/CT scan showing abnormalities of pancreas
Coefficient of fat absorption- low
Coefficient of nitrogen ( protein) absorption- low
21.
22. Symptomatic relief of steatorrhoea, abdominal pain
Decrease in stool fat excretion
Improved quality of life
Best Practice & Research Clinical Gastroenterology 2006 ;20(3):507–529
23. Identify the cause of disorder and treat it
Administration of pancreatic enzymes
Fat soluble vitamins like vitamin A, D, E, and K are needed
Alcoholism and smoking are known risk factors that need to be avoided
A low-fat diet may be useful ( < 20 g/day)
24.
25. Used to replace deficient pancreatic digestive enzymes in the duodenum
Widely accepted therapy of choice for exocrine pancreatic insufficiency of any cause
Useful in the management of PEI in conditions like cystic fibrosis, chronic pancreatitis,
after pancreatic and gastrointestinal surgery
Pancreas 2003; 26: 1–7.
Pancreatic enzyme replacement therapy (PERT) is supplementation therapy containing
pancreatic enzymes like lipase, amylase and protease
26. Helps prevent weight loss and control symptoms such as fullness and diarrhea
Sometimes used for relief of pain
Aliment Pharmacol Ther 2010; 31, 57–72
Pancreatic enzyme replacement therapy should be prescribed with both meals and
snacks
Patient should be instructed to take additional enzymes if a large or fatty meal is eaten
27.
28. PANSTAL capsules are a type of pancreatic enzyme replacement therapy
It contains a mixture of digestive enzymes
Granules are enteric-coated to protect from gastric acid destruction or inactivation
Each capsule contains
Pancreatin (150 mg) which has three types of pancreatic enzymes
Lipase (10,000 PhEur units)
breaks down fats
Amylase (8,000 PhEur units)
breaks down carbohydrates
Protease (600 PhEur units)
breaks down proteins
29.
30. Safe and well-tolerated treatment
Most common side effects were abdominal pain flatulence ,diarrhea & nausea
Other reported complications of pancreatic enzymes include perioral and perianal
irritation in infants, increased uric acid in urine and allergic reactions
N Engl J Med 1997;336:1283-9 http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020725s003lbl.pdf
31. No drug interactions have been identified
Pregnancy and lactation: Should be generally avoided in pregnancy. It is not known if
PANSTAL is excreted in human milk
Pediatric Use: similar to adult patients
32. PANSTAL Capsules are indicated for patients with pancreatic exocrine insufficiency
associated with:
Chronic pancreatitis is the most frequent and relevant indication for pancreatin
supplementation therapy
After pancreatectomy ,gastrointestinal bypass surgery , pancreatic ductal obstruction
Cystic fibrosis
Gut 2005;54(Suppl VI):vi1–vi28. doi: 10.1136/gut.2005.065946
33. When swallowing of capsules is difficult, capsules can be carefully opened and the
contents added to a small amount of low acidic soft food as apple puree, mashed or
pureed bananas or carrots at room temperature
Soft food should be swallowed immediately without chewing and followed with a glass of
water or juice to ensure swallowing
Doses should be taken during meals or snacks, not before or after
Do not take without food
34. Adults and Children Over 6 Years Old
One to two PANSTAL Capsules per meal or snack
Children Under 6 Years Old
Up to one PANSTAL Capsule per meal or snack
35. For smaller meals and snacks 10,000 units of lipase should be used
In case of treatment failure, dosage should be increased two to three times
Because of potential side effects, doses of more than 75,000 units of lipase per meal are
not recommended
Dosage should be adjusted according to the severity of the disease, control of
steatorrhea and maintenance of good nutritional status
Curr Treat Options Gastroenterol. 2003 Oct;6(5):369-374.
Editor's Notes
> 7 g fat/d in the stool is diagnostic of steatorrhea (with treatment generally initiated in patients with symptomatic steatorrhea > 15 g/d), the levels of fat in the stool often exceed 50 g/d in advanced PEI