The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
herpes simplex virus is a double stranded DNA virus causing many symptoms all over the body. it affects globally all over the world .
neonatal hsv attacks even the baby and made them to a fatal conditions.
Immunity
Definitions
Components of Immune system
Types
Innate immunity and Mechanism
Adaptive immunity and Mechanism
2. Antigen
Origin of Antigen
Immunogen
3. Antibody- Immunoglobulin
- Structure
- Classification
- Function of each antibody
herpes simplex virus is a double stranded DNA virus causing many symptoms all over the body. it affects globally all over the world .
neonatal hsv attacks even the baby and made them to a fatal conditions.
Immunity
Definitions
Components of Immune system
Types
Innate immunity and Mechanism
Adaptive immunity and Mechanism
2. Antigen
Origin of Antigen
Immunogen
3. Antibody- Immunoglobulin
- Structure
- Classification
- Function of each antibody
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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BACTERIAL INFECTCTIONS OF ORAL CAVITY i /certified fixed orthodontic courses ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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Dentists play an important role in the diagnosis and management of desquamative gingivitis. The importance of being able to recognise and properly diagnose this condition is accentuated by the fact that a serious and life threatening disease may initially manifest as desquamative gingivitis.
Granulomatous diseases of the head & neckMammootty Ik
covers all the important granulomatous diseases of head and neck region with a brief and to-the-point description of pathogenesis, clinical features , differential diagnosis and management of each disorder
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. A B AC T E R I A L I N F E C T I O N I S T H E I N VA S I O N O F
B O DY T I S S U E S B Y D I S E A S E - C AU S I N G B AC T E R I A ,
T H E I R M U LT I P L I C AT I O N A N D T H E R E AC T I O N O F
B O DY T I S S U E S TO T H E S E M I C RO O RG A N I S M S A N D
T H E TOX I N S T H AT T H E Y P RO D U C E .
Bacterial Infection
3. Leprosy
Also called as Hansen’s Disease.
Caused by Mycobacterium leprea.
Affects skin, peripheral nerves, upper respiratory tract,
eyes, testes, bones and joints.
It is unique in exhibiting dopa oxidase activity.
Staining smears taken from skin and nasal mucosa with ZN
method demonstrate the presence of the bacilli.
4. Tuberculoid Type Lepramatous Type
Lesions are characterised by
single or multiple macular,
erythematous eruptions.
Peripheral nerves are involved
with loss of sensation
accompanied by loss of
sweating of affected skin.
These develop early
erythematous macules or
papules that lead to progressive
thickening of skin and
characteristic nodules.
Facial nerve paralysis occurs
due to facial nerve involvement.
Types
6. Pathogenesis
Host’s defenses are crucial in determining patient’s
response to disease.
Tuberculoid type of leprosy is characterized by
strong CMI, positive lepromin test, granuloma
formation, paucity of bacilli.
Lepromatous type of leprosy is characterized by
suppressed CMI, negative lepromin test, no
granuloma formation and multiple bacilli.
7. Diagnosis and Treatment
Tests for humoral responses are monoclonal antibodies,
ELISA, PCR, etc.
In children sweat function test is used.
MDT is used which includes rifampicin, dapsone and
clofazimine is used for treatment.
Tuberculoid type rifampicin + dapsone for 6 months.
Lepramatous type rifampicin + dapsone + clofazimine
8. Tularemia
Also called Rabbit Fever.
It is highly communicable and transmitted from
infected mammals to humans.
It occurs more frequently in adults.
9. Clinical Features
Based on site of infection, tularemia has 6 clinical
symptoms:
a). Ulceroglandular(most common)
b). Glandular
c). Oropharyngal
d). Pneumonic
e). Oculoglandular
f). typhoidal
10. Treatment
Disease responds to antibiotic therapy.
Streptomycin is the drug of choice.
Also responds well to adequate doses of gentamicin
and tetracycline.
11. Botryomycosis
It is a chronic granulomatous infection.
A number of common bacteria such as
staphylococcus, streptococcus, Escherichia,
pseudomonas and probably many others may serve
as etiologic agents of the disease.
13. Treatment
This condition may be caused by a variety of
different micro organisms of low virulence.
Therefore, pathogenesis may be related more to a
modified host resistance or tissue hypersensitivity
than to a specific micro organisms.
Treatment is non specific, however surgical
invention aids in cure.
14. Actinomycosis
It is a chronic, granulomatous, suppurative and fibrosing disease
caused by anaerobic or microphilic gram positive, non acid fast,
branched filamentous bacteria.
They are a normal flora of oral cavity, colon and vagina.
It is characterized by formation of abscesses that tend to drain by
formation of sinus tracts.
They are classified according to the location of lesions as-
-cervicofacial
-abdominal
-pulmonary forms
It appears to be an endogenous infection and not communicable.
16. Treatment and Prognosis
Long standing fibrosis cases are treated by draining the
abcsess, excising the sinus tract with high doses of
antibiotics.
Surgical drainage of abcsesses and excision of sinus tract is
necessary to accelerate healing.
17. Syphilis
It is a veneral i.e. sexually transmitted disease caused
by spirocheates, treponema pallidum.
It is transmitted by following routes:
Coitus
Transfusion of infected blood
Mother to foetal transmission
18. Acquired syphilis Congenital syphilis
Mainly contracted as a
veneral disease.
It may also be acquired by
dentists while working on
infected patients in a
contagious state.
Its divided into 3 types
based on their appearance
and type of lesions:
a).Primary
b).Secondary
c). Tertiary
It is only transmitted
from infected mother to
foetus only.
It is a very rare disease.
Morphological features
are :
a). Saddle nose
b). Bony lesions,
mucocutaneous lesions
c). High palatal arch
d). Mulberry molar
Types
19. Demonstration of
treponemas Serological test
Dark ground microscopy
Direct flourescent
antibody staining for
T.pallidum.
Treponemas in tissue by:
a). Silver impregnation
method
b). Immunoflourescent
staining
Non treponemal test
Treponemal test
Diagnosis
VDR
L
RPR
TPI TPH
A
21. Prophylaxis
Early syphilis: Benzathine benzyl penicillin 24 lac
units i.m. in a single dose after sensitivity test.
Late syphilis: Benzathine benzyl penicillin 24
lacs units i.m. once weekly for 3 weeks.
22. Hutchinson's Triad
Hypoplasia of incisor and molar teeth.
8th nerve deafness and interstitial keratitis.
75% of congenital syphilis patients suffer from one
or more components of Hutchinson's triads.
23. Gonorrhoea
It is a veneral disease affecting the male and female
genitourinary tract.
It is caused by gram negative diplococci Neisseria
gonorrhoea.
The bacterium is a strict parasite and dies rapidly
outside the host in 1 to 2 hr in exudates and in 3 to
4 days in culture.
24. Oral Manifestations
Extra genital infection of the oral cavity occurs as a result of
oral-genital contact or inoculation through infected hands.
Lips may develop acute painful ulceration, gingiva may
become erythematous with or without necrosis.
Tongue may present red, dry ulcerations or become glazed
or swollen with painful erosions.
Gonococcal pharyngitis and tonsilitis are also well
recognized.
25. Diagnosis and Treatment
Diagnosis is established by bacteriological
examination of smear or culture.
Organism is sensitive to large doses of penicillin or
doxycycline.
26. Tuberculosis
It is an infectious, granulomatous disease caused by
mycobacterium tuberculosis.
Primarily affects lungs but also affected are intestines,
bones, joints, meninges, lymph glands, skin and other
tissues.
The bacterium is a facultative intracellular parasite.
It causes pulmonary or generalized infection in
immunocompromised patients.
27. Pathogenesis
Bacilli-host interaction: droplet nuclei inhaled by patient
Most bacilli are exhaled by ciliary reaction and 10% enters the alveoli
Initial stage is asymptomatic but 2 – 4 weeks after infection, specific
immunity develops and accumulation of a large number of activated
macrophages at the site of primary lesion.(granulomatus or
tubercles are formed).
Lesion consists of epithelioid cells, langerhans cells, plasma cells and
fibroblasts
Central part of the lesion contains caseous necrosis (dry cheesy,
granular and yellow in appearance).
Ranne complex necrotic material may undergo calcification(in lung
parenchyma or hilar lymph nodes.
Sometimes necrotic material may liquefy, discharging in the lungs leading
to cavity formation.
29. Oral Manifestations
Most commonly affected site is tongue. Others are
palate, lips, buccal mucosa, gingiva and frenula.
Usual presentation is irregular superficial or deep
painful ulcers which tend to increase in size slowly.
It may also involve the bone of the maxilla and
mandible.
Microorganisms may enter the pulp chamber and
root canal of the tooth with an open cavity.
30. Treatment
Isoniazid (NPH) combined with rifampicin for 9
months
INH and rifampicin and pyrazinamide for 2
months followed by INH and rifampicin for 4
months.
Other drugs used are streptomycin and
ethambutol.
31. Cat-Scratch Disease
It is a condition caused by Bartonella lenselae a
gram negative bacillus demonstrable with silver
stain.
It occurs at any age most commonly in children and
young adults by a traumatic break in the skin by
scratch or by household bite of cat, dog or monkeys.
33. Treatment and Prognosis
Prognosis is good since the disease is self limiting
and regresses within a period of weeks or months.
Incision and drainage of involved node may be
necessary.
Antibiotic therapy is ineffective
34. Scarlet Fever
It is a highly contagious, systemic infection.
It occurs predominantly in children.
It is caused by β-heamolytic streptococci, streptococcus
pyogens which produces a pyrogenic exotoxin
These organisms produce clear heamolysis around colonies
on blood agar plates.
Scarlet fever may reflect a hypersensitivity reaction
requiring prior exposure to the toxin.
36. Oral Manifestation
Chief manifestations are termed as ‘Stomatitis scarlatina’.
Small, red macules may appear in the hard and soft palate and uvula which are
called Forchheimer spots.
Palate and throat is often fiery red.
Tonsils and faucial pillars are usually swollen and sometimes covered with a grayish
exudate.
In early course of the disease, tongue exhibits a white coating and the fungiform
pappila are edematous and hyperemic. This phenomenon has been described
clinically as ‘strawberry tongue’.
Later, the tongue coating is lost and appears red and glistening and smooth except
the pappliae this is called as ‘raspberry tongue’.
37. Diptheria
It is an acute, life threatening infection and
communicable disease of skin and mucous membrane.
Caused by toxemic strains of corneybacterium diptheria.
Characterized by local inflammation and formation of a
graying adherent psuedomembrane which bleeds on
removal.
Also referred as ‘The strangling angel of children’.
38. Clinical Features
Signs and symptoms arise 1 to 5 days after exposure.
Swelling of neck (Bull neck).
Onset is gradual.
Manifestations are fever, sore throat, weakness,
headache, change of voice.
39. Of patients Of tonsils
Diptheria cases:
Pseudomembrane present
Diptheria carriers:
Pseudomembrane absent
On the basis of location of
pseudomembrane:
a). Pharyngeal
b). Laryngeal
c). Tracheal
d). Tonsillar
e). Nasal
f). Conjunctival
g). Cutaneous
h). Genital
Classification
40. Oral Manifestations
Formation of ‘Diptheric Membrane’.
In oral cavity, appears as non specific ulcers.
Soft palate is temporarily paralysed.
Patients have peculiar nasal twang.
If infection spreads unchanged in repiratory tract:
a). Larynx becomes edematous, covered by pseudomembrane.
b). Husky voice
c). Suffocation if airways is not cleared.
41. Meliodosis
Specific infection in man and animals.
Caused by burkholderia pseudomallei.
It is endemic in certain areas of far east including
Burma, India, Indo-china, malaysia and thialand.
42. Diagnosis and Treatment
Diagnosed by culturing the organism from clinical and
throat sample.
Treatment involves:
Incision and drainage accompanied by massive antibiotic
therapy.
Tetracycline alone or in combination with chloremphenicol
is drug of choice.
43. Acute Chronic
Fever
Diarrhoea
Acute pulmonary
infection
Death as a result of
septicemia
In those patients who
have survived acute type.
It is of granulomatous
type, characterized by
multiple, small, non
specific abscesses.
Clinical Features
44. Tetanus
Tetanus is an acute infection of the nervous system
characterized by intense activity of motor neurons and
resulting in severe muscle spasms.
It is caused by exotoxin of the anaerobic gram positive
bacillus clostridium tetani.
Most commonly occurs in non immunized, partially
immunized or even fully immunized people.
In infants were umbilical cord is cut with unsterile
instrument or in children with otorrhea.
After acute trauma.
45. Pathogenesis
Suitable anaerobic conditions favour the spores of
clostridium to enter the wounds and germinate.
These produce tetanospasmin(potent neurotoxin)
It binds to the peripheral motor nerve terminals and enters
the axons cell body in the brain stem and spinal cord in
a retrograde direction.
Toxins migrate to the synapse where they block the
receptors of glycine and GABA which increases the resting
state of locomotor neurons thereby producin rigidity.
46. Generalized Tetanus Local Tetanus
Lock jaw due to the spasm of
masseter is the first symptom.
Dysphagia, stiffness or pain in
the neck, shoulder or back
muscles occurs concurrently.
Laryngeal spasm leading to
asphyxia.
Spasm of muscle near the
wound is uncommon.
Cephalic tetanus characterized
by spasm of muscle and facial
palsy is rare.
Acute oral infection, trauma,
TMJ dysfunction and even
hysteria may be manifested.
Types
47. Prophylaxis
Wound debriment and booster doses of tetanus
toxoid.
For unimmunized indivisuals, anti-tetanus
serum(ATS) 1500 units or TIG 250 units should be
given.
48. Rhinoscleroma
It is a chronic, slowly progressive, localized infectious,
granulomatous disease caused by bacillus klebsiella
rhinoscleromatus which is a gram negative, non motile
bacillus.
Mode of infection is through nasal exudates.
Granulomatous lesions are chiefly found in upper
respiratory tract involving nose, lacrymal glands, orbit, skin
and paranasal sinuses.
Oral lesions impair taste, anesthesia of the soft palate and
enlargement of the uvula and upper lip are described.
50. Noma
It means a rapidly spreading mutilating, gangrenous
stomatitis that occurs usually in debilitated or
nutritionally deficient persons.
Occurs chiefly in undernourished persons.
The condition is usually seen around the gingiva and
progressed to destruction of the mouth and the lower
lip.
52. Treatment
The prognosis is considerably better if antibiotics are
administered before the patient reaches the final
stage.
Immediate treatment of any existing
malnourishment further improves the probability of
saving the patient.