The document summarizes key information about HIV/AIDS, including:
1) HIV is a lentivirus that causes AIDS by progressively destroying the immune system, allowing other infections to thrive. Once infected, the body cannot rid itself of HIV.
2) Scientists believe HIV originated from chimpanzees in West Africa and was transmitted to humans through contact with their blood.
3) HIV is classified as a retrovirus and exists as two types, HIV-1 and HIV-2. HIV-1 is more widespread and virulent.
4) There is no cure for HIV, but treatment with antiretroviral drugs can control the virus and prevent transmission.
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
Introduction
Disease
Important Properties
Transmission & Epidemiology
Risk factor of reactivation
Pathogenesis
Clinical Findings
Laboratory Diagnosis
Approaches to the diagnosis of latent infections
Treatment
Prevention
The PPT is mainly all about Mycobacterium Tuberculosis. Agents causing the disease Tuberculosis, pathogenesis, laboratory diagnosis, treatment and prophylaxis. It was made for both BSc and MSc students.
Introduction
Disease
Important Properties
Transmission & Epidemiology
Risk factor of reactivation
Pathogenesis
Clinical Findings
Laboratory Diagnosis
Approaches to the diagnosis of latent infections
Treatment
Prevention
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
Adenoviridae is a group of medium sized, non-enveloped, double stranded DNA viruses that replicate and produce disease in the eye and in the respiratory, gastrointestinal and urinary tracts;
It Contains Pathogenesis of viral diseases like AIDS, Hepatitis, Influenza and Rabies.
It contains detail pathogenesis with various verified sources.
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A detailed description of HIV covering virology, morphology, pathogenesis, clinical stages and manifestations, laboratory diagnosis, and diagnostic strategy, and therapeutic options and prevention.
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. KURSK STATE MEDICAL UNIVERSITY
DEPARTMENT OF MICROBIOLOGY
HIV- Human
Immunodeficiency
Virus
Student:Guilherme L. Paschoalini
Group: 29 – 2nd year
KURSK - 2014
2. HIV
The human immunodeficiency virus is a lentivirus that causes
the acquired immunodeficiency syndrome (AIDS), a condition
in humans in which progressive failure of the immune
system allows opportunistic infections and cancers to prosper
Unlike some other viruses, the human body cannot get rid of
HIV. That means that once you have HIV, you have it for life.
Scientists identified a type of chimpanzee in West Africa as
the source of HIV infection in humans. They believe that the
chimpanzee version of the immunodeficiency virus (called
simian immunodeficiency virus, or SIV) most likely was
transmitted to humans and mutated into HIV when humans
hunted these chimpanzees for meat and came into contact
with their infected blood. HIV was first described in USA in
1981 amongst homosexuals, haitians and heroine addicts.
3. CLASSIFICATION
Family: Retroviridae
Subfamily:Orthoretrovirinae
Genus:Lentivirus
Species: HIV 1 / HIV 2
HIV 1- Isolated in America, Europe & central Africa
HIV 2- In West Africa – Less virulent and not spread as
widely and rapidly as HIV 1
4. MORPHOLOGY
It is roughly spherical - diameter of about 120 nm
Composed of two copies of positive single stranded RNA
(Held together by protein P7) enclosed by a
conical capsid composed of viral protein P24
Very high genetic variability
The RNA genome consists of 9 genes - Three of these
genes: gag, pol, and env, contain information needed to
make the structural proteins for new virus particles.
Inside of capsid are three enzymes required for HIV
replication: reverse transcriptase, integrase and protease.
A matrix composed of the viral protein P17 surrounds the
capsid ensuring the integrity of the virion particle
The matrix is surrounded by phospholipids – 2 layers –
Embedded by 70 copies of a complex HIV protein
(glycoprotein) – Spikes: 2 units – Gp41 and Gp120
5.
6.
7. RESISTANCE
HIV doesn't survive well outside the body
It is inactivated within 10 minutes at temperature 50ºC and
within seconds in temperature100ºC; by treatment with
alcohol 50%, 35% isopropanol, 0.5% formaldehyde, 0-3%
hydrogen peroxide
May survive up to 7 days in dry blood
Virus is inactivated under extreme changes of pH in acidic
and alkaline medium.
8. CULTIVATION
Culture of HIV is difficult
Is not done frequently because of the risk involved
The virus is cell associated - Patient’s peripheral blood
mononuclear cells (CD4, T-cells, macrophages) are co-
cultivated with those of uninfected human blood in the
presence of PHA and interleukins 2
Cytolysis and syncitia formation
The fluid of culture is tested to demonstrate the reverse
transcriptase activity
9. FACTORS OF VIRULENCE
Enzymes:
Revere transcriptase - enzyme used to generate complementary DNA
(cDNA) from an RNA template
Protease - cleaves newly synthesized polyproteins at the appropriate
places to create the mature protein components of an infectious
HIV virion. Without effective HIV protease, HIV virions remain
uninfectious.
Ribonuclease - catalyzes the cleavage of RNA
Integrase - main function is to insert the viral DNA into the host
chromosomal DNA
Inner core capsid protein – Forms the capsid
Nucleic acid-binding proteins
Glycoproteins
Gp120 – Constains conserved highly regions that binds to CD4
proteins of host cells – Attachment in host cells
Gp41 – Analogous to the fusion – Penetration in host cells
10. EPIDEMIOLOGY
TRANSMISSION – HIV is transmitted through blood,
semen, vaginal fluid and from infected mother to her
child
I. Sexual contact – HIV is predominantly a sexual
transmitted disease
II. Contaminated needles
III. Organ transplacentation
IV. Blood or blood products
• It is not spread by air or water, vector, saliva, tears, or
sweat, casual contact like shaking hands or sharing dishes,
closed-mouth or “social” kissing
• HIV risk factors and routes of transmission apply to
everyone equally, some people are at higher risk because of
where they live and who their sex partners are.
11. Approximately 35.3 million people are living with HIV
globally.
Sub-Saharan Africa is the region most affected - This means
that about 5% of the adult population in this area is infected
A reconstruction of its genetic history shows that the HIV
pandemic almost certainly originated in Kinshasa, the capital
of the Democratic Republic of the Congo, around 1920.
30 million deaths till now
12.
13.
14. PATHOGENESIS
Receptor for virus is CD4 receptor. Therefore virus may infect
any cells having CD4 receptors on the surface.
The specific binding site to the virus is enveloped
glycoprotein (Gp120).
Infection is transmitted when virus enters the blood or tissues
of a person and comes into contact with suitable host cells,
principally CD4 lymphocytes.
Double stranded DNA transcript to the viral DNA and
integrated into genome of infected cells causing latent
infection. From time to time lytic infection is initiated
releasing progeny virions which infect other cells.
Long and variable incubation period of HIV infection is
because of the latency.
The primary pathogenic mechanism is damaged to T-
lymphocytes (CD4). CD4 cells decrease in numbers and the
ratio of CD4 over CD8 is reversed.
15. Infected CD4 cells do not appear to release normal
amount of interleukins, interferons and other
lymphokines. Therefore, immune state of a person
decreases
Though the major damage is to cellular immunity,
humoral mechanism is affected.
Patients are unable to respond to new antigens. An
important feature to HIV infection is the polyclonal
activation of B-lymphocytes.
This leads to hyper-γ-globulinaemia. All classes of
immunoglobulins are involved but level of Ig G and Ig A
particularly rose. In infants and children Ig M is
elevated. Hyper-γ-globulinaemia is more of hindrance
than help because it is composed of mainly useless Ig.
Monocyte, macrophage function also affected. As a
result chemotaxis and antigen presentation and
intracellular killing by these cells are diminished. NK
cells are also affected by HIV leading to state of innate
immunity.
16. CLINICAL MANIFESTATION
HIV infection damages respiratory system, pneumonia,
bronchitis, pleuritis may take place
CNS may be affected: meningitis, dementia etc.
GIT: enteritis, decrease body mass, diarrhea.
Malignancies: Carposious sarcoma, other tumors
HIV infection has 4 stages:
1. Incubation period (2-4weeks)
2. Stages of primary manifestation (years)
3. Stage of secondary manifestation
4. Terminal stage (AIDS)
17. LABORATORY DIAGNOSIS
Include test for immunodeficiency detection as well as
specific test for HIV
Immunological test - Total count of leukocyte and
lymphocyte (detect leucopenia), CD4 cells must be counted
and the ratio between CD4 and CD8 cells is detected,
counting of platelets and rising level of Ig G and Ig A
ELISA TEST
PCR
In order to prove presence of HIV, antibodies are
detected:
1. HIV-1: antibodies to gp41, gp120, gp160, p24
2. HIV-2: antibodies to gp36, gp105, gp140
18. PREVENTION
Determination of people of risk group
Identification of source of infection and
control
Health education – Sex should be practised by
avoiding exchange of body fluid (condoms are
utilized), using sterile needles and syringes
19. TREATMENT
Drugs of choice are inhibitors of reverse
transcriptase activity:
1. Nucleoside drag (inhibition of HIV-revertase ):
2. Retrovir (ZDV, AZT);
3. Videx (DDI);
4. Nivid (DDC);
5. Zerit (D4T);
6. Epivir (3TC)
Nonnucleoside drug:
1. Viramune;
2. Resariptor
Inhibitor of HIV-protease:
1. Crizivan