Atrophic rhinitis, also known as ozaena, is a chronic inflammation of the nasal mucosa that results in atrophy, squamous metaplasia, and crust formation. It is characterized by the atrophy of the nasal mucosa and turbinates, scanty viscid secretions, loss of ciliated columnar epithelium, and crust formation. The pathophysiology involves periarteritis and endarteritis of the nasal mucosa, decreasing blood supply and resulting in atrophy of mucous glands, epithelium, and metaplasia of the ciliated columnar epithelium. Treatment involves antibiotics, estrogen therapy, surgical procedures to narrow the nasal cavity and increase lubrication, and sal
Inflammation of the mucosa of sinuses associated with inflammation of the nasal mucosa is called rhinosinusitis (RS).
CLASSIFICATION:
• Acute RS: Symptoms lasting for less than 4 weeks with complete resolution.
• Subacute RS: Duration 4-12 weeks.
• Chronic RS: Duration ~ 12 weeks.
• Recurrent RS: Four or more episodes of RS per year; each lasting for 7-10 days or more with complete resolution in between the episodes.
• Nasal obstruction.
• Nasal discharge/congestion, anterior, or posterior in the form of postnasal drip.
• Facial pain or pressure.
• Alteration in the sense of smell, hyposmia or anosmia.
• Other symptoms include cough, fever, halitosis, fatigue, dental pain, pharyngitis, headache or ear fullness.
Granulomatous diseases of the larynx- ALL DETAILS ABOUT TB, FUNGAL LARYNGITIS, SARCOIDOSIS, SYPHILIS, LEPROSY, Wegner granulomatosis, rhinoscleroma ARE GIVEN
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. • DEFINITION: It is a chronic inflammation of
the nasal mucosa resulting in atrophy ,
squamous metaplasia and crust formation
due to periarterial fibrosis and end arteritis.
• Key-points:
– Atrophy of the nasal mucosa and turbinate.
– Scanty viscid secretion
– Loss of ciliated columnar epithelium
– Crust formation
3. • TYPE:
– Primary
– Secondary: infection or surgery
• Long-standing purulent sinusitis.
• Iatrogenic: Radical turbinectomy,
maxillectomy, post-radiotherapy.
• Tuberculosis, Syphilis, Leprosy,
Rhinoscleroma.
• Deviated nasal septum (atrophy in
wider nasal cavity).
• FORM:
– Rhinitis sicca : mild form
– Severe form : ozaena
• Turbinante atrophy
• Squamous metaplasia
• Degeneration of goblet cells
• Secondary growth of saprophytes
6. ETIOLOGY
PRIMARY : Not known
1. Developmental:
– Congenitally spacious nasal cavity
– Poor pneumatization of maxillary antrum
2. Heredity: 30% cases autosomal inheritance; 67% = Dominant, 33% = Recessive.
3. Endocrinal: estrogen progesterone imbalance, common in female after puberty; Symptoms
aggravated due to estrogen deficiency.
4. Race: white & yellow races >>> negroes
5. Malnutrition: chronic iron deficiency anemia, vitamin A & D deficiency
6. Chronic inflammation
7. Nasal and sinus suppuration: Klebsiella ozaenae (Perez & Abel bacillus), Coccobacillus
foetides ozaena, Bacillus mucosus, Diphtheroids, Haemophilus influenzae, Proteus vulgaris, E.
coli, Staphylocococci & Streptococci.
8. More common: Blood group O and B
9. Immunological factor: Altered cellular immunity and loss of tolerance of nasal tissue may
trigger destructive autoimmune process on nasal mucosa.
10. Reflex sympathetic dystrophy syndrome (RSDS) causes vasodilatation & hyperaemic
decalcification of turbinates followed by vasoconstriction.
11. Surfactant deficiency in nasal secretion: ciliary dysfunction + stasis of nasal secretions.
7. CLINICAL FEATURES
• Age : Onset after puberty, 14-16 years
• Sex: more in females
• Race: Rare in negroes
9. Causes of Anosmia
• Loss of olfactory neural elements
• Thick secretion & crusts over olfactory area
• Degeneration of secretory glands → scanty mucous for dissolving odoriferous
materials
Causes of nasal obstruction
• Blunting of sensory nerve endings
• Crust formation
• Lack of eddy current formation in roomy cavity
10.
11. INVESTIGATIONS
1. Radiology: X ray PNS, CT scan of the PNS
2. Hematology: ESR, Sugar, Estrogen, Progesterone,
Serology; Serum iron, vitamin-A/ D & protein levels-
malnutrition
3. Pathology: Nasal swab- smear or HPE of nasal mucosa.
4. Saccharine test: ed nasal muco-ciliary clearance time.
5. Culture & sensitivity of nasal discharge.
12.
13. There is a metaplasia of columnar or
ciliated epithelium to squamous
epithelium with decrease in the
number of compound alveolar
glands. Histopathologically, there
are 2 types of atrophic rhinitis:
Type I: Characterized by endarteritis
and periarteritis, which may be as a
result of chronic infection. These
patients may benefit by vasodilator
effect of estrogen therapy.
Type II: Characterized by
vasodilation of capillaries which
may become worse by estrogen
therapy.
HISTOPATHOLOGY
14. D/D
1. Syphilis
2. Lupus
3. Leprosy
4. Tuberculosis
5. Rhinoscleroma
6. Sinusitis
D/D for ozaena D/D for dry nose
Atrophic rhinitis Atrophic rhinitis
Purulent sinusitis Rhinitis sicca
Nasal foreign body Radiotherapy
Rhinitis caseosa Sjogren’s syndrome
Malignancy
15. SPECIFIC INVESTIGATIONS TO RULE OUT OTHER D/Ds:
1. Chest X-ray: T.B., bronchiectasis, lung abscess
2. Serology for syphilis: V.D.R.L., T.P.H.A., T.P.I.
3. Sputum for AFB, Mantoux test: T.B.
4. Nasal smear study: Leprosy
5. Complement fixation test & biopsy: Rhinoscleroma
18. ACTION OF PLACENTAL EXTRACT
Progesterone
leads to
hyperplasia
of nasal
mucosa &
glandular
secretion
Estrogen
leads to
vasodilatation
Biogenic
stimulator of
metabolic &
regenerative
process
Intra-
placental
serum boosts
up immunity
Mechanical
narrowing of
nasal
passage
19. SURGICAL TREATMENT
• Aim:
– Decrease size of nasal cavity
– Decrease air entry
– Increase lubrication
1. Narrowing of nasal cavity:
a) At lateral wall:
i. Dermofat graft
ii. Bone cartilage graft
iii. Synthetic teflon paste or acrylic mould
b) At floor: placental graft submucosally
c) Young’s and modified young’s operation
2. Transplantation of parotid duct