ATP (adenosine triphosphate) production declines with age due to mitochondrial dysfunction. Mitochondria are the primary producers of cellular energy in the form of ATP through oxidative phosphorylation. As we age, mitochondrial DNA mutations accumulate, impairing ATP production. This summary discusses strategies to increase ATP levels topically and through supplementation to enhance mitochondrial function and combat signs of aging. These include vitamins B1-B6, biotin, B12, folic acid, magnesium, alpha lipoic acid, carnitine, NADH, coenzyme Q10, creatine, and LED or microcurrent therapy. Maintaining optimal mitochondrial and ATP levels may help slow the visible signs of skin aging.