Anti-aging

Anti-aging
2017
STUDENT/
OMNIA IBRAHEM ABDEL-REHEM
SUPERVISOR / MAHASEN M. ABDEL-
HADY

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 Anti-aging medicine
Today's healthcare challenges and
tomorrow's opportunity can only be met by
those who search out deeper explanations
of the body processes that generate health
and disease. Life expectancy has increased
due to advances in medical science.
However it has come with little progress
towards quality of life or the length of
disease-free years in the majority of
population.
Most researchers believe that maximum life
span in human is slightly over 110 years.
Beyond that age, the estimates and
speculation enter the realms of science
fiction.

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 GROWTH, DEVELOPMENT AND AGING
Old age is the most unexpected of all things that happens
to man. -
Aging has been a fact of life ever since it was created.
Human beings go through variousphases of life from being
child to youth to being adultwith youth being the best
part of life from health point of view. Good health,strong
muscles, an efficient immune system, a sharp memory and
a healthybrain are characteristic of idealyouth. The
hormones work at their peak capacityduring the youth
years.
Anti-Aging medicine aims to maintainor achieve this
irrespective of chronologicalage i.e. to stay healthyand
biologicallyefficient.
The prestigiousscientific journal, Biogerontology,defines
aging as: “The progressive failing abilityof the body's own
intrinsic and genetic powers to defend, maintainand
repair itself in order to keep working efficiently.”
We are now living in the information age. Medical
knowledge is increasing at an amazing rate-doublingevery
three years. This doublingrate of information is
progressively decreasing. The world is changing and so is
the way we view our healthand well-being as we age.
Many natural aging mechanisms frequently result in actual
diseases. From this we can conclude that fighting an aging

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process may well bring about an improvement of an age
related illness.
All animalsor plants eventuallyshow signs of aging even if
they are in a protected environment. When we look at
Ayurveda which prescribes plantsor their componentsand
extracts to fight against illness, one has to wonder why?
Nature created these plant chemicalsto help them protect
against diseases or aging. Humanshave lateradapted
these chemicals for theirown use to increase their
chances of maintainingtheirhealth.

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 What is anti-aging medicine?
Anti-aging medicine is an evolving branch of medical
science and appliedmedicine. It treats the underlying
causes of aging and aims at alleviatingany age related
ailment. Its goal is to extend the healthy lifespan of
humanshaving youthful characteristics.
Conventional and alternativemedicaldisciplinesare used
in an integrated approach to achieve the best possible
result for the patient. It is a holistic discipline,seeing the
patient as a whole and not as someone having an isolated
disease.
Those physiciansinterested in studying age related
medicine can do so by attendingcourses offered by
variousorganization across the globe with predominant
being The American Academy of Anti-Aging Medicineor
A4M. It is not yet formally accredited by the American
MedicalAssociation. Some scientists and physicianstake
offense at the name Anti-Aging as they think it is
unscientific. They have suggested terms such as Age
Management Medicine,AdvancedPreventive Medicine,
Interventive Bio gerontology. But the underlying principles
remain the same.

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 Causes Of Anti-Aging
 Regular Smoking and drinking
 Lack of exercise
 Sun exposure
 Stress and strain
 Lack of sleep
 Lack of nutrients

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 there are three main biochemical processes involved in
aging. These are oxidation, glycation and methylation.
Other relevant processes are chronic inflammation and
hormonal deregulation.
Oxidation
Free radicals are a group of simple compounds with an
electron missing from their chemical structure. This makes
them unstable. They seek out other chemical structures
from which they can acquire an electron and in the process
make them unstable.
Free radicals in small and controlled quantities are useful in
everyday metabolism. They take part in several normal
reactions within the body including breathing. These free
radicals are mainly produced during oxygen metabolism
within the cells. The problem starts when the production of
these free radicals increases and goes out of control.
Free radical reactions can be divided into three stages:
Initiation, Propagation and Termination. The defense
mechanisms against these are inactivating them within the
cells soon after production, removing them by scavenging
antioxidants and increasing the elimination of material
already damaged by free radicals.
To put it in practice means to prevent exposure to free
radicals from sources such as pollution, bad diet, and
smoking and take antioxidants. The term antioxidant refers
to chain-breaking compound. Broadly antioxidant is any
substance, that when present at low concentrations
compared with those of an oxidizable substrate
significantly delays or inhibits oxidation of that substrate.

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Free radicals damage the cell membrane which is
composed of lipids and proteins. Their interaction results in
the production of the chemical Melondialdehyde which is
very harmful, contributing to another important aging
process called glycation.
Glycation
When glucose molecules and other sugars such as fructose
attach themselves to proteins, it is called glycation. This
results in brownish discoloration of tissues. The binding of
sugar to protein causes cross linking of proteins. Cross
linked proteins cause more damage by reacting with free
radicals and other toxins to create Advanced Glycation
Endproducts (AGEs). These AGEs bind to cells at special
attachment sites called RAGEs (Receptor for AGEs). These
result in the production of several harmful chemicals
damaging tissues.
AGEs are found in most tissues in the body and their
concentration increases from the age of twenty onward.
However nutrient such as carnosine and other Anti-Aging
supplements/drugs can help in breaking this process.
Unfortunately the process of glycation not only affects
proteins, but also interferes with DNA. A cross linked
DNA molecule is of no use at all. There are drugs being
investigated which can actually break this bond between
cross linked proteins which are glycated.

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Methylation
When ‘methyl groups’ are being added to different
constituents of the proteins, DNA and other molecules to
keep them in good, active condition, it is called
methylation. This is necessary for the normal maintenance
of tissues and is usually kept at a healthy levels naturally by
the body. Methylation of certain parts of the DNA causes
permanent switching off of unnecessary genes and saves
the body from abnormal DNA division. This means that
methylation of those particular sections of DNA blocks any
abnormal DNA from being passed onto the future
generations of cells.
Any chronic inflammation process affects methylation
because the immune system, which is heavily involved in
fighting inflammation, gorges itself on methyl groups,
leaving nothing for other tissues of the body.
Low methylation is reflected in the increasing levels of
homocysteine, which is found in chronic inflammatory
processes such as lupus, heart disease and diabetes.
Increased intake of methylators reduces the risk of these
diseases.

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Chronic inflammation
There are scientists who believe that most age related
changes in the body are due to chronic inflammation. When
there is chronic inflammation, the body tissues are eaten
away by toxic chemicals, resulting in dementia, thickening
of the arteries, arthritis, diabetes, hormonal imbalance and
so on. Taking low dose of anti-inflammatory chemicals
such as Aspirin keeps age related inflammation at bay.
However, this is not a widely shared opinion. A diet
containing nutrients i.e. fish (contains anti-inflammatory
oils), fruit and vegetables, particularly berries (which are
packed full of antioxidants and inflammation-fighting
flavonoids) along with supplements like alpha lipoic acid
and co-enzyme Q10 are helpful.

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Hormonal deregulation
There is little doubt about the important role hormones play
in our lives and in aging. The pacemakers of youth, these
precious little chemicals keep us young, healthy and
vibrant. In general, aging results in imbalance of hormones
in the body or one can also ask “Does hormonal imbalance
cause aging?” Hormones such as growth hormone,
melatonin and DHEA need to be replaced or reactivated
during aging to prevent the body from falling apart. It is
also important to make sure that the binding sites of the
hormones need to be in good working order. According to
Dr. Eric Braver man, proponent of pause theory, every
organ in the body ages at a different rate. The classical
example of this is the menopause in females and the
literature is replete with Hormone Replacement Therapy
for the same. It seems prudent to replace the other
hormones in physiological limits. Hormone replacement
therapy is likely to play a very important role in
maintaining health in time to come. It is very important
here to make the distinction between the Synthetic
hormones and the Bio identical hormones which is
discussed later.

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 How to put anti-aging program
together?
Principles
 Enhance health through eating a hormonally correct diet
 Enrich body with optimum doses of proven antioxidants
and nutraceuticals
 Improve physical exercise performance, which includes
aerobic, anaerobic and flexibility training
 Replace hormones to levels to those of 20-30 years old.

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 Diet
The importance of food we eat can be summarized by
what Dr. Barry Sears said and I quote: “The food you
eat is probablythe most powerful drug you will
encounter. But to use this drug correctly, you have to
apply the hormonal rules about the food that haven't
changed in the past 40 million years and are unlikely
to change anytime soon.”
Balancing Insulin and glucagon activity is at the core
of eating a hormonallycorrect diet. The hormonally
correct diet contains 30% protein, 50% carbohydrates
and 20% fat along with vitamins, minerals and
drinking plentyof water which is filtered,
mineralized and magnetized. Eating small meals
every 4-5 hours and eating the proper ratio of
proteins, carbohydratesand fat at each meal or snack
can mean a difference between illness and good
health.
Eating proper food for one's height, weight and body
type and activity level is the foundationfor a better
quality of life and greater longevity.

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Anti-Aging Diet
 Fruits and Vegetables:for young and healthy
skin.
 Whole grains: Good for skin and reduce the risk
of developing diabetes.

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 Omega-3 Fatty acids:
Protect heart and reduce
risk of stroke.
 Dairy Foods: Contains calcium and vitamins for
strong bone.
Beans and lentils: Contains plant based proteins
which is a goodalternative of red meat.

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 Exercise
Dr. Alex Lief
, MD Harvard Medical School has said and I
quote: “Exercise is the closest thing we have
to an anti-aging pill.” Regular physical
activity has been a way of life for virtually
every person who has reached the age of 100
years in sound condition. Exercise is
medicine. If you think that smoking is not
good, the following statement will enlighten.
“Not exercising has the equivalent impact on
your health as smoking one and one half
pack of cigarettes a day.”

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 Anti-Aging Supplements
Coenzyme Q10
Coenzyme Q10 (CoQ10) is an essential component
of healthy mitochondrial function. It is incorporated
into cells' mitochondria throughout the body where it
facilitates and regulates the oxidation of fats and
sugars into energy. Aging humans have been found
to have over 50% less CoQ10 on average compared
to that of young adults. This finding makes CoQ10
one of the most important nutrients for people over 30
to supplement with. About 95% of cellular energy is
produced in the mitochondria. The mitochondria are
the cells "energy powerhouses" and many maladies
have been referred to as "mitochondrial disorders." A
growing body of scientific research links a deficiency
of CoQ10 to age-related mitochondrial disorders.

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Acetyl-L-Carnitine Arginate
The amino acid acetyl-L-carnitine boosts
mitochondrial energy production through its ability to
facilitate fatty acid transport and oxidation in the cell.
Since 1995, Life Extension customers have been
supplementing with acetyl-L-carnitine and deriving the
many benefits this form of carnitine has shown in
published studies. With the discovery of acetyl-L-
carnitine arginate the benefits of acetyl-L-carnitine
can now be greatly augmented. Acetyl-L-Carnitine
Arginate is a patented form of carnitine that stimulates
the growth of neurites in the brain. Studies show that
acetyl-l-carnitine-arginate stimulates the growth of
new neurites by an astounding 19.5% (as much as
Nerve Growth Factor itself). Acetyl-l-carnitine-arginate
acts together with acetyl-l-carnitine to increase neurite
outgrowth.

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Carnosine
Carnosine is a multifunctional dipeptide made up of a
chemical combination of the amino acids beta-alanine and L-
histidine. It is found both in food and in the human body.
Long-lived cells such as nerve cells (neurons) and muscle
cells (myocytes) contain high levels of carnosine. Muscle
levels of carnosine correlate with the maximum life spans of
animals. Carnosine levels decline with age. Muscle levels
decline 63% from age 10 to age 70, which may account for
the normal age-related decline in muscle mass and function.
Since carnosine acts as a pH buffer, it can keep on
protecting muscle cell membranes from oxidation under the
acidic conditions of muscular exertion. Carnosine enables
the heart muscle to contract more efficiently through
enhancement of calcium response in heart myocytes. Aging
causes irreversible damage to the body's proteins. The
underlying mechanism behind this damage is glycation. A
simple definition of glycation is the cross-linking of proteins
and sugars to form non-functioning structures in the body.
The process of glycation can be superficially seen as
unsightly wrinkled skin. Glycation is also an underlying
cause of age-related catastrophes including the neurologic,
vascular, and eye disorders. Carnosine is a unique dipeptide
that interferes with the glycation process.

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 Fish Oil
Studies on omega-3 fatty acids are so impressive that an
agency of the National Institutes of Health published a report
stating that fish oil can help reduce deaths from heart
disease. The FDA itself states supportive but not conclusive
research shows that consumption of EPA and DHA omega-3
fatty acids may actually reduce the risk of coronary heart
disease. There are several mechanisms attributed to fish
oil's beneficial effects. The latest government report cites the
triglyceride-lowering effects of fish oil
on reducing heart and blood vessel
disorders. Another beneficial
mechanism of fish oil is to protect
healthy blood flow in arteries.
Whey Protein
Many people think of whey protein as a
supplement only used by athletes wanting to
increase their muscle mass. But evolving
research suggests the branched-chain amino
acids (BCAAs) leucine, isoleucine, and valine
and other fractions found in whey can mimic the longevity
benefits of calorie restriction. Whey protein can also have a
positive impact on muscle construction and immunity due to
its BCAA profile and naturally occurring lactoferrin and
immunoglobins.

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Green Tea Extract
What makes green tea extract such an important nutrient are
the large volumes of published scientific findings that
validate its multiple biological benefits. The most significant
findings involve studies showing that green tea extract helps
maintain cellular DNA and membrane structural integrity.
Decades of research shows that green tea inhibits the
development of undesirable cell colonies. The active
constituents in green tea are powerful antioxidants called
polyphenols (catechins) and flavonols. Several catechins are
present in green tea and account for the bulk of favorable
research reports. Epigallocatechin gallate (EGCG) is the
most powerful of these catechins. EGCG functions as an
antioxidant that is about 25-100 times more potent than
vitamins C and E. One cup of green tea may provide 10-40
mg of polyphenols and has antioxidant effects that are
greater than a serving of broccoli, spinach, carrots, or
strawberries. Theoretically, the high antioxidant activity of
green tea makes it beneficial for protecting the body from
oxidative damage due to free radicals.

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Lipoic Acid
Lipoic Acid is a highly potent antioxidant that
counteracts reactive free radicals in the mitochondria,
the power plants of cells where energy for all cellular
activities is generated. Some scientists believe that
mitochondrial free radicals play an important role in
human aging, and have theorized that extra amounts
of free-radical inhibiting compounds such as lipoic
acid may be able to help slow aging. Lipoic acid is
also effective in recycling other antioxidants such as
Vitamin E back into their original form after they
detoxify free radicals. There also is evidence that
lipoic acid can reduce glycation damage due to
excess glucose in the blood, which may be involved in
aging. Lipoic acid consists of two different forms
(isomers) that have vastly different properties. The "R"
form is the biologically active component (native to
the body) that is responsible for lipoic acid's
phenomenal antioxidant effect.

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L-Alpha-glycerylphosphorylcholine
(GPC)
L-alpha glycerylphosphoryl-choline (GPC) is a
byproduct of phosphatidylcholine and helps to boost
acetylcholine. It aids in the synthesis of several
brain phospholipids, which increases the availability
of acetylcholine in various brain tissues. The GPC
form of choline has been shown in studies to help
protect against cognitive decline normally seen in
aging.
Pyrroloquinoline Quinone (PQQ)
Until recently, the only options for aging individuals to
promote replenishmentof the declining numbers of
mitochondria (the cell’s “energy powerhouses”)in their
bodies were long-term calorie restriction or exhaustive
physical activity—difficult or impractical for most aging
people.Now there is a viable alternative. PQQ activates
genes that promote the formation of new mitochondria. It
also beneficially interacts with genes directly
involved in mitochondrial health. These same
genes support healthy body weight, normal fat
and sugar metabolism,and youthful cellular
proliferation.

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Resveratrol
Findings from published scientific literature
indicate that resveratrol may be the most
effective compound for maintaining optimal
health and promoting longevity. Resveratrol is
a phytoalexin, a polyphenolic compound which
is produced by Vitis vinifera as a response to
attack by molds. Research funded by Life Extension showed
that a combination of low-dose (20 mg)
resveratrol plus grapeseed extract mimicked
many of the favorable gene expression
changes seen in calorie-restricted animals.
Other studies, however, indicate that higher
doses may be needed to obtain all of
resveratrol’s positive benefits including
promoting healthy insulin sensitivity,
enhanced mitochondrial function, reduced
expression of inflammatory factors, and protection against
the effects of a high-fat diet.
Calorie Restriction
Since the 1930s it has been known that a diet restricted in calories,
but otherwise rich in nutrients, dramatically extends the life span of
experimental animals. Over two thousand studies have confirmed the
effectivenessof calorie restriction (or "undernutrition without
malnutrition, " as Roy Walford calls it) in a wide variety of species.
While the effectivenessof this antiaging regimen is likely far greater
than others currently available, the difficultyof the regimen for most
people is also far greater. Serious life-extensionists should
nevertheless considertrying at least a mild version of the diet.

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 Anti-Aging Hormones
Your hormones are chemical messengers
that are keeping your body functioning.
From regulating metabolism and growth to
controlling immune function and
reproduction, hormones are major players in
all that you do and all that you are –
physically at least.
Most people associate human growth
hormone and DHEA with aging, but
progesterone, testosterone, estrogen and
cortisol play a role in aging as well. If the
delicate balance of any one of these
hormones is destroyed, it can take a serious
toll on your body, mind and spirit – and be
mistaken as classic signs of aging.

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DHEA
DHEA is a precursor hormone produced from
cholesterol by the adrenal glands inside the body.
This hormone plays a crucial role in the formation of
the sex hormones – estrogen and testosterone – as
well as fuels the transformation that occurs as the
body grows and matures.
Around your mid to late twenties, DHEA begins a
gradual decline, which contributes to the aging
process. By the age of 70, you generally have less
than 10 percent of the DHEA you had in your
twenties. Therapy with DHEA can be helpful in
treating auto-immune disorders, obesity, dementia,
osteoporosis and chronic fatigue. In some cases, it
may be more effective to replace testosterone or
estrogen to correct imbalances rather than DHEA ,
due to its role in converting to the sex hormones.

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Progesterone
Progesterone serves multiple functions in the body of
both men and women. It is vital for regulating the
sleep cycle, as well as boosting immunity and brain
function. In women, progesterone is an essential
hormone of the reproductive process. Many women
will experience fluctuations of progesterone
throughout their life cycles. An imbalance of this
hormone can lead to symptoms classically associated
with aging, such as poor sleep, moody swings and
foggy thinking.
Progesterone also serves as a precursor hormone,
converting to estrogen, testosterone or cortisol on the
steroid hormone pathway. Low levels of progesterone
can lead to increased levels of cortisol and low levels
of the sex hormones, which will trigger impaired
immune function and a host of other
issues associated with hormone
imbalance.

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Growth hormone
The hormone HGH (human growth hormone) is
secreted by the pituitary gland and is crucial for
normal development and maintenance of organs and
tissues - especially in children. HGH enhances tissue
growth, increases muscle mass and strengthens bone
density throughout the life cycle.
Hormone therapy with HGH is most commonly used
in the medical industry to treat children with stunted
growth or young people suffering from hormone
deficiencies. In a few cases, HGH may be necessary
for treatment of hormone imbalance in adults, but this
is rare.
When FDA-approved HGH is prescribed,
it is in the form of a powder with a diluting
solution for use as an injection. This is
the only formulation that has been
approved by the FDA. Of the HGH
sprays and pills that are available without
a prescription, few have been proven to
be effective.

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Testosterone
Testosterone is the principle hormone in the group of
hormones known as androgens. Although classically
associated with men, testosterone serves functions in
both men and women.
In men, testosterone deepens the voice during
puberty, stimulates the growth of facial and body hair,
increases sexual drive, and is responsible for sperm
production. In regards to aging, testosterone
contributes to energy, memory, moods, muscle mass
and strength, and sexual stamina and performance.
Women must keep testosterone levels in fine balance,
as it plays an integral role in mood, energy, weight
and sex drive. Without enough testosterone, gaining
and sustaining lean body mass can be difficult. As
testosterone declines with age, it impacts weight
management and sex drive.

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Estrogen
The term estrogen collectively refers to the hormones,
estradiol, estrone and estriol. Each has a different chemical
structure and function. Like testosterone, estrogen plays a
role in the physiology of both men and women. However,
estrogen plays a greater role in the aging process for women
than in men.
The primary role of estrogen in the female body is to
stimulate growth and development of sexual characteristics
and reproduction, induce the changes of the breasts during
adolescence and pregnancy and aid the growth of the
uterine lining during the follicular phase of the menstrual
cycle. Estrogen is responsible for hundreds of functions in
the female body including protecting women from heart
disease and colon cancer. It also regulates
several metabolic processes, including
cholesterol levels and bone growth.
In men, estrogen aids in the facilitation of
many of the physical changes men
experience during puberty, such as chest
and facial hair growth, muscle development
and deepening of the voice. Estrogen also
helps to protect the bones and the brain in men.

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 Melatonin
Is a hormone produced in the brain when we’re
exposed to dim lighting to prepare us for sleep. After
puberty, our melatonin levels decrease, sometimes
making it more difficult to fall asleep as we age
(especially after 40).
Anti-aging claim:
Research done on mice a few years ago revealed that
supplemental melatonin neutralizes oxidative damage
and inflammation to help delay the process of aging.
Some practitioners I know feel that a lack of melatonin
is a big culprit in cancer.

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Pregnenolone
Is known as the "mother hormone" because it is the
precursor of a number of hormones including DHEA,
testosterone and estrogen. Studies have
demonstrated that the neurosteroid Pregnenolone has
a stimulatory effect on memory.
 Pursuing hormone therapy for anti-aging
A specialized physician can help you determine if
hormone therapy will treat or reverse your hormone
imbalance and the symptoms often linked to
advanced aging. Lab testing, followed by a thorough
consultation, will ensure you get the quality treatment
you need to live better and longer.

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Anti-Aging Vitamins
We learn from a young age that the right mix of vitamins
and minerals is a crucial component for total body health,
but as we grow older, they play an ever-increasing role in
helping to fight the signs of aging as well. Vitamin-rich
supplements support the body internally, but do their
benefits translate when they’re applied to the skin through
beauty products? “In general, for healthy skin, vitamins
applied topically is the best route,” explains Omaha, NE,
dermatologist Joel Schlessinger, MD. “But oral vitamins
can’t be discounted as they are an important part of the
equation. But what are the top five best anti-aging
vitamins?

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 Vitamin E, the dry-skin defender
Topically: Vitamin E is a powerful fat-soluble antioxidant
that protects lipids from oxidizing, which helps skin retain
its natural moisturizers. It is incorporated into many creams
and oils that claim to help minimize scars, burns and stretch
marks.
Internally:Due to its lipid solubility (it does not easily
dissolve in water), vitamin E is particularly good at helping
to prevent oxidative damage and protect cell membranes.
“Vitamin E is important, but don’t overdo it as a
supplement,” says New York nutritionist Keri Glassman.
“You are probably getting enough of it in your
multivitamin.”

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 Vitamin A, the wrinkle reducer
Topically: Topical products that contain
retinoids (a synthetic form of vitamin A)
can help treat skin disorders like acne and
psoriasis while reducing brown spots and
wrinkles and smoothing out rough patches
by increasing cell turnover. When applied
to the skin, vitamin A is known to
promote collagen synthesis.
Internally: While vitamin A deficiencies are rare in
developed countries, this fat-soluble vitamin helps cells
function properly and is essential for proper vision and
bone development. Before isotretinoin (Accutane) was
available, oral vitamin A was often prescribed as a
treatment for acne because of its ability to decrease the size
of the sebaceous glands and the amount of oil produced.

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 Vitamin C, the free-radical fighter
Internally: Commonly associated with its
ability to strengthen the immune system and
ward off the common cold, this water-
soluble antioxidant is also needed for tissue growth, collagen
formation and wound healing, as well as the maintenance of
healthy bones, teeth and gums. “If you could get
enough vitamin C orally, it would have additional
beauty benefits,” says Dr. Schultz. “But you can’t get
enough of it for it to work that way. You would literally
need to take a few hundred thousand units of it during
the day, and, at some point, your body just flushes it
out.”
Topically:Perhaps the best free-radical avenger of all the
vitamins, vitamin C smooths rough
patches and helps fade brown spots. It
also stimulates collagen, making it a
popular ingredient in products that target
sun-damaged skin. The problem with
vitamin C is that its potency decreases
significantly when it is exposed to
oxygen, and the ingredient can be too
harsh for a lot of skin types. “You need a
stable form of vitamin C that the skin can
absorb to get the benefits,” explains Dr. Schultz. “I
recommend looking for formulations that incorporate tetra
hexadecyl ascorbate. It’s a good chemical form of vitaminC.”

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 Vitamin K, the dark-circle
diminisher
Internally: Fat-soluble vitamin K plays an
important role in how the kidneys function and
helping to aid in proper bone growth and repair.
It is also the main factor behind why blood clots
when you get a cut. “This vitamin has been
getting a lot of attention recently,” says
Glassman. “There’s more research being done with it now,
but I would be nervous about taking any more than what is
in your multivitamin.”
Topically: Like it does internally, vitamin K can also
control blood clotting when applied on the surface of the
skin. When used as a topical ingredient, it helps diminish
the appearance of spider veins, under-eye circles and
broken capillaries, and is also believed to help with
bruising post-surgery.

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Vitamin B3, the hydration booster
Internally: Also referred to as niacin,
vitamin B3 is necessary for proper protein and
fat metabolization in the body and plays a role
in helping the digestive system function
properly.
Topically:Vitamin B3 helps the skin retain
moisture by boosting the production of fatty acids and
ceramides, the two main factors responsible for protecting
and fortifying the skin barrier. It is also a milder alternative
to exfoliators like glycolic and salicylic acids when used in
skin-care products.

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Some Of Anti-Aging Products
 Clinique Smart Custom-Repair Serum
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive
What it is:
A powerful, multitalented serum that visibly improves
wrinkles, evens skintone, lifts, and brightens for skin that
looks firm, fresh, and youthful-looking.
Solutions for:
- Fine lines and wrinkles
- Dark spots and uneven skintone
- Loss of firmness and elasticity
If you want to know more…
Clinique smart technology plus calming ingredients, like red algae, visibly
transform skin—increasing skin’s capacity for repair. Recommended for all skin
types, ages, and ethnicities, skin is visibly firmer, smoother, more radiant, and
more youthful-looking. Featuring patented technology developed over five years
of research, this serum smooths the way for flawless makeup application.
What it is formulated WITHOUT:
- Parabens
What else you need to know:
This product is allergy tested, non-acnegenic, and free of oil and fragrance.

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 Shiseido Benefiance WrinkleResist24
Day Cream
✔ Normal
✔ Dry
What it is:
An age-defense day cream to improve the look of
existing visible lines while protecting skin from
environmental aggressors like UV rays.
Solutions for:
- Dullness and uneven texture
This hydrating, luxurious day cream from Shiseido’s number one-selling wrinkle
targeting range dramatically lessens the look of visible lines and protects skin
from UV rays, which can lead to premature visible signs of aging. Signature
WrinkleResist24—with chlorella extract, mukurossi extract, and gambir extract—
along with super bio-hyaluronic acid and hydroxyproline help reduce the
appearance of wrinkles.
This product is dermatologist tested.
Research results:
In a consumer survey, tested on 100 women after 4 weeks:
- 94% of women felt the formula moistens skin
- 92% felt the formula makes skin silky
- 88% felt the formula makes skin smooth

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 Dr. Jart+ Premium Beauty Balm SPF 45
✔ Normal
✔ Dry
✔ Sensitive
what it is:
A one-step balm that perfects the appearance of skin
while protecting it from the sun and environmental
factors.
Solutions for:
- Dryness
- Redness
- Dullness/uneven texture
- Acne/blemishes
- Loss of firmness/elasticity
if you want to know more…
A moisturizer, sunscreen, and treatment serum, Premium Beauty Balm SPF 45 is
an all-in-one product that provides advanced brightening properties. Perfect
under makeup, its natural-looking coverage minimizes the appearance of
imperfections and evens the skin tone. Antioxidant bio-peptides and adenosine
Protect skin from harsh environmental factors while restoring firmness and
elasticity. This lightweight formula features mineral sunscreens to provide broad
spectrum sun protection from both UVA and UVB rays. Skin is left looking
smooth, perfect, and natural.
- Sulfates
- Phthalates
Beauty Balms or BB Creams were originally developed as a perfect post-
procedure cream used to treat, hydrate, prime, protect, and camouflage the skin.
Great for all skin types including those with sensitive skin, these versatile five-in-
one formulas are designed to do it all: treat with high levels of active skin care
ingredients; moisturize and smooth dehydrated skin; prime and perfect skin’s
surface; camouflage and color correct the skin tone; and protect skin from the
sun with SPF. They can be used as a last step for their skin care benefits or used
on their own as an instant beautifier.

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 Kate Somerville+ Retinol Firming Eye
Cream
✔ Normal
✔ Oily
✔ Combination
✔ Dry
What it is:
An eye cream that visibly brightens, firms, and hydrates
the eye area for a more youthful appearance without
sensitivity.
Solutions for:
- Dryness
This silky, weightless eye cream improves the appearance of firmness, texture,
and elasticity, and reduces the appearance of lines and wrinkles around the eye
area. It firms the delicate eye area with retinol and bio retinols, natural
ingredients that mimic the effect of retinol but with less sensitivity. Hyaluronic
acid hydrates and helps smooth the appearance of skin. The unique gold
applicator tip feels cool on contact, provides targeted application, and flexes to
massage the product around the eye area. The formula can be used as an
under-eye cream and on the upper brow area.
- Parabens
- Sulfates
- Phthalates
Kate's Retinol tips...
-If you are a first time user, it can take up to eight weeks for your skin to
acclimate to Retinol.
-Pair with my Dermal Quench Liquid Lift + Retinol for best results.
"Retinol has the power to transform your skin—it firms, smooths, and reduces the
appearance of wrinkles. Choose a product that combines traditional retinol with
natural bio retinols for reduced sensitivity."—Kate Somerville, Brand Founder

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 Lancer The Method: Polish
✔ Normal
✔ Dry
What it is:
A powerful antiaging exfoliator.
Solutions for:
- Dryness
- Blackheads and enlarged pores
This daily polish is a skin resurfacing treatment and the first step
in The Lancer Method. Formulated for a two-pronged approach to exfoliation, it
includes pure minerals and pumpkin and pomegranate enzymes to gently and
effectively remove surface debris and dull, dry surface cells. A warming element
and Lavender scent complete this luxurious daily ritual.
- Parabens
- Sulfates
- Phthalates
Using his unrivaled clinical experience, Dr. Lancer worked to develop a line of
technologically advanced, active ingredient-focused products designed to
improve the overall health and appearance of skin, while also giving patients the
sought-after ‘Lancer Glow.’ Backed by first-class dermatology, utmost luxury, and
true efficacy, Lancer Skin care seeks to bring “Believable Beauty” to all skin.
The Lancer Method, the core of Dr. Lancer’s philosophy, is based on a biological
principle universal to all skin: the cellular cycle of renewal. By devising a system
that supports this process through manual exfoliation, Dr. Lancer was able to
create a unique antiaging line that delivers beautiful, glowing results to all skin
types. The three steps of The Lancer Method dramatically improve the
appearance of fine lines, texture, discoloration, and pore size. All of the Lancer
skin care treatments are formulated for optimum efficacy and luminous results.

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 Algenist GENIUS UltimateAnti-Aging
Cream
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive
what it is:
An advanced, antiaging moisturizer that visibly firms,
lifts, combats deep wrinkles, brightens, and nourishes
the face.
Solutions for:
- Dryness
The ultra-nourishing and luxurious GENIUS Ultimate Anti-Aging Cream is
a potent face cream that infuses skin with top-of-the-line biotechnology to
combat advanced signs of aging. The blend of actives features alguronic
acid, plant collagen, and microalgae oil to visibly brighten, hydrate, firm,
lift, improve elasticity, and smooth fine lines and wrinkles for a youthful
glow.
- Parabens
- Sulfates
- Phthalates
what else you need to know:
This product is dermatologist tested and noncomedogenic.

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 SUNDAY RILEY Good Genes All-In-One
Lactic Acid Treatment
✔ Normal
✔ Oily
✔ Combination
✔ Dry
what it is:
A clarifying, line smoothing lactic acid treatment.
Solutions for:
- Dark spots
Good Genes All-In-One Lactic Acid Treatment is formulated with high potency,
purified grade lactic acid that immediately exfoliates dull, pore-clogging dead skin
cells, revealing smoother, fresher, younger-looking skin. Fine lines appear
visually plumped while the skin looks more radiant. With continued use, the
appearance of stubborn hyperpigmentation and the visible signs of aging are
reduced for a healthier-looking complexion. Perfect for all skin types and all ages,
this treatment is enhanced with licorice for brightening, Good Genes clarifies,
smooths, and retexturizes for instant radiance.
- Parabens
- Sulfates
- Phthalates
Backstage at NY Fashion Week, Sunday Riley combines two pumps of Good
Genes and one pump of Ceramic Slip Clay Cleanser for a "flash facial." Leave on
for one to 10 minutes for an immediately radiant, deep detox facial. This product
is cruelty-free.
"As with any AHA, use a sunscreen to prevent sun sensitivity."—Sunday Riley

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 GLAMGLOW DREAMDUO™ Overnight
Transforming Treatment
✔ Normal
✔ Oily
✔ Combination
✔ Dry
What it is:
A moisturizing serum and seal dream team overnight
treatment for visibly plumper, more hydrated skin that lets
you to wake up to a soft, smooth complexion.
Solutions for:
- Dryness
DREAMDUO™ Overnight Transforming Treatment is a two-step overnight
treatment that leaves skin looking and feeling radiant, hydrated, prepped, and
plumped—with an energizing afterglow. DREAMSERUM (pearl) is a melt-in face
serum that infuses antiaging antioxidants into the skin, while supercharged
essential vitamins support an even, flawless complexion. DREAMSEAL (gray) is
a nourishing moisture boost of hyaluronic acid and mozuku green algae that
plumps and recharges skin’s glow.
This set contains:
- 0.68 oz/ 20 mL DREAMSERUM
- 0.68 oz/ 20 mL DREAMSEAL
- Parabens
- Sulfates
- Phthalates

46 | P a g e
 Tatcha The Essence Plumping Skin
Softener
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive
What it is:
A resurfacing softener of 98.7 percent pure antiaging Japanese superfoods that
makes all skin care work better.
Solutions for:
- Dryness
A daily seven-second ritual to reveal your softest, most youthful-looking skin, delivering:
- Antiaging: pure, 98.7 percent hadasei-3, a concentrate of nourishing green tea, rice, and
algae—Japan’s three essential nutrients for skin health and youthful radiance.
- Smoothing and resurfacing: the natural fermentation of these nutrients produces lactic acid,
helping to support natural cell turnover for improved skin texture and a smooth luster.
- Plumping hydration: instantly doubles skin’s natural moisture content, above and beyond the
results from a moisturizer, softening and plumping the look of fine lines and wrinkles.
- Maximizesperformance of all skin care: skin’s channels are flush with lasting hydration,
creating a pathway to deliver treatments that follow more deeply and amplifying their
effectiveness.
- Parabens
- Sulfates
- Phthalates
This product is cruelty-free, non-sensitizing, non-irritating, dermatologist tested, and formulated
without oil.
Geisha embraced and perfected the tradition of beauty waters as the foundation to their beauty
ritual to restore and soften their skin. This secret has been passed down by generations; today,
97 percent of Japanese women use an essence. Tatcha honors this ancient practice in our
modern, powerful evolution.
"Your purchase of a full-sized Tatcha skin care item will send an incredible girl to school for day
through our Beautiful Faces, Beautiful Futures partnership."—Victoria Tsai, Founder

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 Fresh Lotus Youth Preserve Face Cream
with Super 7 Complex
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive
What it is:
A lightweight daily moisturizer proven to prevent visible signs of aging,
provide 24 hours of significant moisture, and boost radiance with Fresh’s
proprietary Super 7 Complex.
Solutions for:
- Dryness
Push the pause button on aging with Lotus Youth Preserve Face Cream with Super 7 Complex.
This lightweight, daily moisturizer for all skin types prevents skin from showing visible signs of
aging, delivers intense 24-hour hydration, and improves elasticity, leaving you with a soft and
supple canvas ready for makeup.
The face cream is formulated with Fresh’s proprietary Super 7 Complex, a blend of seven super-
charged ingredients including antioxidant-rich lotus root extract specifically designed to minimize
and prevent visible signs of aging, defend against wrinkles, deliver intense hydration, and boost
radiance. It is further enriched with maca root extract, noted for enhancing luminosity. Ideal for all
skin types, this lightweight daily moisturizer delivers intense 24-hour hydration.
- Parabens
- Sulfates
- Phthalates
what else you need to know:
"The lotus has been cultivated in eastern Asia for over 3,000 years. The plant is considered
sacred in many cultures, but I especially love the way the Buddhists regard it. They believe that it
is the ultimate symbol of complete purification, as it journeys through muddy waters to rise above
the surface and blossom into a stunning flower. Various parts of the lotus have been used in
traditional herbal medicine for centuries to treat a number of skin diseases, most often
inflammation. After doing clinical tests, we were stunned at this ingredient’s high levels of
polyphenols, the most powerful antioxidants known to defend against wrinkle-causing free
radicals."—Lev Glazman, Fresh Co-founder

48 | P a g e
 What is needed for age prevention ?
 Drink lots of water
 Regular exercise
 Intake of healthy
foods
 Adequate sleep
 Use sunscreens and moisturizers

Anti-aging

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