Arteriovenous malformations (AVMs) of the brain are abnormal connections between arteries and veins in the brain that bypass the normal circulation. The cause of AVMs is unknown, though they are usually congenital. Symptoms vary depending on the location of the AVM and include brain hemorrhage in over 50% of cases, seizures in 20-25% of cases, and other neurological issues. Diagnosis involves CT, MRI, and cerebral angiogram imaging. Treatment options include surgery for accessible and smaller AVMs, stereotactic radiosurgery for smaller inaccessible ones, and endovascular procedures like using coils for parts of larger AVMs. Outcomes depend on the treatment, with surgery offering up to
Brain arteriovenous malformations (bAVM) are abnormal connections of arteries and veins in the brain, forming a tangled web of vessels instead of a normal capillary network treated with multimodalities including, SRS, embolisation and Microneurosurgery.
This slides updates the management of AVM highlighting the importance of SM grading, Pollock radiation grading etc.
Spinal Tumors: approach and managementAmit Agrawal
The spinal cord consists of
Central canal surrounded by an H-shaped gray matter region containing neurons
Outer myelinated nerve tracts, termed white matter, surround the central gray matter
Central canal is lined with ependymal cells
Astrocytes support gray matter neurons and white matter axons
I am a Neurosurgeon with advanced training in Interventional vascular Neurosurgery(FINR) from Zurich, Switzerland, and FMINS-Fellowship in minimally invasive and Endoscopic Neurosurgery from Germany.
I am presently working in Columbia asia hospitals, Bangalore.
My areas of interest are Vascular Neurosurgery, Stroke specialist, interventional neuroradiology, Endoscopic and minimally invasive Neurosurgery, Endoscopic spine surgery.
Brain arteriovenous malformations (bAVM) are abnormal connections of arteries and veins in the brain, forming a tangled web of vessels instead of a normal capillary network treated with multimodalities including, SRS, embolisation and Microneurosurgery.
This slides updates the management of AVM highlighting the importance of SM grading, Pollock radiation grading etc.
Spinal Tumors: approach and managementAmit Agrawal
The spinal cord consists of
Central canal surrounded by an H-shaped gray matter region containing neurons
Outer myelinated nerve tracts, termed white matter, surround the central gray matter
Central canal is lined with ependymal cells
Astrocytes support gray matter neurons and white matter axons
I am a Neurosurgeon with advanced training in Interventional vascular Neurosurgery(FINR) from Zurich, Switzerland, and FMINS-Fellowship in minimally invasive and Endoscopic Neurosurgery from Germany.
I am presently working in Columbia asia hospitals, Bangalore.
My areas of interest are Vascular Neurosurgery, Stroke specialist, interventional neuroradiology, Endoscopic and minimally invasive Neurosurgery, Endoscopic spine surgery.
you will learn about brain tumor, types of brain tumor, grading of brain tumor, risk factors for brain tumor, diagnosis for brain tumor, treatment for brain tumor, supportive care and rehabilitation for patients with brain tumor.
Carotid artery disease is commonly seen in association with atherosclerosis and complicate the situation. clearcut guidelines with necessary surgical details are provided in presentations.
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
you will learn about brain tumor, types of brain tumor, grading of brain tumor, risk factors for brain tumor, diagnosis for brain tumor, treatment for brain tumor, supportive care and rehabilitation for patients with brain tumor.
Carotid artery disease is commonly seen in association with atherosclerosis and complicate the situation. clearcut guidelines with necessary surgical details are provided in presentations.
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
I am a Neurosurgeon with advanced training in Interventional vascular Neurosurgery(FINR) from Zurich, Switzerland, and FMINS-Fellowship in minimally invasive and Endoscopic Neurosurgery from Germany.
I am presently working in Columbia asia hospitals, Bangalore.
My areas of interest are Vascular Neurosurgery, Stroke specialist, interventional neuroradiology.
Presentation about the hazards and potential complications that could happen in any cardiac or peripheral catheterization procedure and how to avoid them
Presentation during IFNR 2016.
Brief description with available evidence on various coma arousal therapy with an illustrative study for each therapy and recommendation for future.
External validation of prognostic model of tbiDhaval Shukla
Develop and describe prognostic model incorporating clinical and radiological variables for the prediction of mortality in severe traumatic brain injury. Externally validation of CRASH model with the dataset from our neurosurgical intensive care unit.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. Cause of AVM
• Not known
• Usually congenital
• Not hereditary
• Most AVMs do not grow or change in size
– Blood vessels may increase in diameter
– AVMs shrink due to clots in parts of an AVM
– AVMs may enlarge due to redirection of blood flow
4. Epidemiology
• Less than one percent of the general
population
• One in 200–500 people may have an AVM
• More common in males than females
6. Symptoms
• Symptoms may vary with location
• More than 50 % present with brain hemorrhage
• 20% - 25% with seizures
• Localized headache
• 15% may have difficulty with movement, speech
and vision
7. Brain hemorrhage
• Abnormal and “weakened” blood vessels over
time eventually burst from the high pressure
of blood flow from the arteries
• 1–3 % chance per year of bleeding
• Risk of bleeding = 105 – age (in years)
8. Brain hemorrhage
• 10–15% risk of death
• Loss of normal function
– Temporary
– Permanent: 20–30%
• Brain damage depends on
– Amount of blood
– Site of bleed
10. Rebleeding risk
• More during first year after initial bleeding
– 6% to 18%
• Higher in the first year after the second bleed
– 25%
• Higher risk of bleeding in ages 11 – 35 years
11. Diagnosis
• Computed tomography (CT)
– Hemorrhage
• Magnetic resonance imaging (MRI)
– Location and size
14. Diagnosis
• Cerebral angiogram (DSA)
– Required for treatment
– Insertion of a catheter (small tube)
through an artery in leg to
each vessels going to brain
– Injection of contrast material (dye)
– Taking pictures of all blood vessels
of brain
17. Medical Therapy
• Avoid
– Any activities that may excessively elevate blood
pressure
– Blood thinning drugs like warfarin
• Regular checkups with a neurologist
• Antiepileptic drugs
19. Stereotactic radiosurgery
(Gamma Knife)
Indications
• Small
• Difficult to reach by surgery
Mechanism
• Produce direct damage to the vessels
that will cause a scar and allow the AVM
to “clot off”
• Takes 2 years to cure AVM
20. Endovascular treatment
Indications
• Usually for a part of AVM
• Rest of AVM requires treatment either with
surgery or Gamma Knife
• Occasionally for small AVM
Mechanism
• Blocking off abnormal blood vessels to stop blood
flowing to AVM
– Liquid tissue adhesives (glues)
– Coils
– Particles and other materials used
22. Outcome – Surgery
• Small AVMs
– Cure: 94 to 100%
– Morbidity and mortality: <10%
– Bleeding
– Infection
– Paralysis or loss of function (temporary or permanent)
– Convulsions (controllable or uncontrollable)
– Coma (reversible or irreversible)
– Death
– Seizure-free: 81%
• Large AVMs
– Morbidity and mortality: 25%
23. Outcome – Gamma Knife
• Cure: 61% to 87% (after 2 years)
• Morbidity (during 2years): 1 to 36%
• Mortality (during 2years): 0 to 9%
• Seizure-free: 43%
24. Outcome – Endovascular treatment
• Cure: 5 to 40%
• Morbidity rates: 8% -10%
– Same as for surgery
• Mortality rate: 1%
• Seizure-free: 50%
25. Conclusion
• AVMs are difficult to treat and treatment decision should be
individualized
• If AVM has not ruptured (never bled) there is no need of specific
treatment.
• Patient requires only symptomatic treatment
• Whenever possible microsurgery is the best option
• Gamma Knife is an optional treatment for inaccessible AVM
• Endovascular treatment is not effective as stand alone for most
cases
• Medium size AVMs require multimodal treatment
• Very large AVMs should not be treated
Editor's Notes
What is a brain AVM?
Normally, arteries carry blood containing oxygen from the heart to the brain, and veins carry blood with less oxygen away from the brain and back to the heart. When an arteriovenous malformation (AVM) occurs, a tangle of blood vessels in the brain or on its surface bypasses normal brain tissue and directly diverts blood from the arteries to the veins.
Why do brain AVMs occur?
We do not know why AVMs occur. Brain AVMs are usually congenital, meaning someone is born with one. However, they usually are not hereditary. People probably do not inherit an AVM from their parents, and they probably will not pass an AVM on to their children.
Do brain AVMs change or grow? Most AVMs do not grow or significantly change although the vessels involved may dilate. There are some reported cases of AVMs shrinking or enlarging, but this may be due to clots in parts of an AVM causing it to shrink, or to redirect blood in adjacent vessels toward an AVM resulting in enlargement.
How common are brain AVMs?
Brain AVMs occur in less than one percent of the general population. It is estimated that about one in 200–500 people may have an AVM. AVMs are more common in males than females.
Where do brain AVMs occur?
Brain AVMs can occur anywhere within the brain or on the covering of the brain. This includes the four major lobes of the front part of the brain (frontal, parietal, temporal,
2
3
occipital), the back part of the brain (cerebellum), the brainstem, or the ventricles (deep
spaces within the brain that produce the cerebrospinal fluid).
What are the symptoms of a brain AVM? Symptoms may vary with location • More than 50 percent of patients with an AVM present with intracranial hemorrhage. • 20% - 25% of patients with an AVM have seizures, either focal or generalized. • Patients may have localized pain in the head due to increased blood flow around an AVM. • 15% may have difficulty with movement, speech and vision.
What causes brain AVMs to bleed?
A brain AVM contains abnormal and, therefore, “weakened” blood vessels that direct
blood away from normal brain tissue. These abnormal and weak blood vessels dilate
over time and may eventually burst from the high pressure of blood flow from the arteries
causing bleeding into the brain.
What are the chances of a brain AVM bleeding?
There is a 1–3 percent chance per year of a brain AVM bleeding. Over a 15-year period, there is a 25 percent total chance of an AVM bleeding into the brain, causing brain damage and stroke.
Does one bleed increase the chance of a second bleed?
The risk of recurrent intracranial bleeding is slightly elevated for a short period of time after the first bleed. In 2 studies, the risk during the first year after initial bleeding was 6% and then dropped to the baseline rate. In another study, risk of recurrence during the first year was 17.9%. The risk of recurrent bleeding may be even higher in the first year after the second bleed and has been reported to be 25% during that year. Individuals with an AVM are at a slightly higher risk of bleeding between the ages of 11 and 35.
How are AVMs diagnosed?
Most AVMs are detected on either a computed
tomography (CT) brain scan or with a magnetic resonance
imaging (MRI) brain scan. These tests are very good at
detecting brain AVMs. They also provide information
about the location and size of the AVM and whether it
may have bled.
A doctor may also perform a cerebral angiogram. This test
involves inserting a catheter (small tube) through an artery
in the leg and guiding it into each of the vessels in the
neck going to the brain, injecting contrast material (dye)
and taking pictures of all the blood vessels in the brain.
For any type of treatment involving an AVM, an
angiogram may be needed to better identify the type of
AVM.
What different types of treatment are available?
• Medical Therapy. If there are no symptoms or almost none, or if an AVM is in
an area of the brain that cannot be easily treated, conservative medical
management may be indicated. If possible, a person with an AVM should avoid
any activities that may excessively elevate blood pressure, such as heavy lifting or
straining, and they should avoid blood thinners like warfarin. A person with an
AVM should have regular checkups with a neurologist.
Surgery. If an AVM has bled and/or is in an area that can be easily operated
upon, then surgical removal may be recommended. The patient is put to sleep
with anesthesia, a portion of the skull is removed, and the AVM is surgically
removed. When the AVM is completely taken out, the possibility of any further
bleeding should be eliminated.
Stereotactic radiosurgery. An AVM that is not too large, but is in an area that is
difficult to reach by regular surgery, may be treated by performing stereotactic
radiosurgery. In this procedure a cerebral angiogram is done to localize the AVM.
Focused-beam high energy sources are then concentrated on the brain AVM to
produce direct damage to the vessels that will cause a scar and allow the AVM to
“clot off.”
Interventional neuroradiology/endovascular neurosurgery. It may be possible
to treat part or all of the AVM by placing a catheter (small tube) inside the blood
vessels that supply the AVM and blocking off the abnormal blood vessels with a
variety of different materials. These include liquid tissue adhesives (glues), micro-
coils, particles and other materials used to stop blood flowing to the AVM.