The study investigates the impact of integrated soil fertility management (ISFM) on soybean profitability in Northern Ghana using a split-plot design with two varieties and five ISFM methods. Results indicate that ISFM significantly affects both grain and fodder yields, with farmers favoring a combination of triple superphosphate, fertizol, and boostxtra for higher profitability. The findings are aimed at leveraging scaling-up activities in the Africa Rising Phase 2 program to enhance soybean productivity and support smallholder farmers in the region.