Endometrial hyperplasia - irregular proliferation of the endometrial glands with an increase in the gland to stroma ratio when compared with proliferative endometrium
Endometrial Ca - most common gynaecological maglinancy in the western country, endometrial hyperplasia as the precursor
Incidence of endometrial hyperplasia 3 folds higher than endometrial Ca
Fourth most common cancer in women in Peninsular Malaysia
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
Endometrial hyperplasia - irregular proliferation of the endometrial glands with an increase in the gland to stroma ratio when compared with proliferative endometrium
Endometrial Ca - most common gynaecological maglinancy in the western country, endometrial hyperplasia as the precursor
Incidence of endometrial hyperplasia 3 folds higher than endometrial Ca
Fourth most common cancer in women in Peninsular Malaysia
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
In this playlist you can watch everything about Scrotal swellings. I have discussed introduction, hydrocele, torsion testis, epididymal cyst, varicocele and testicular tumors. If you watch all these videos together you will become cofident in dealing with the problem of Scrotal Swellings.
Disclaimer: A lot from this slides were taken also from https://www.slideshare.net/babysurgeon/scrotal-swellings-1 (Dr Selvaraj Balasubramani)
This covers only :
ANATOMY
CAUSES
TORSION OF TESTIS
EPIDIDYMO-ORCHITIS
HYDROCELE
EPIDIDYMAL CYST
VARICOCELE
Testicular tumors are rare.
1 – 2 % of all malignant tumors.
Most common malignancy in men in the 15 to 35 year age group.
Benign lesions represent a greater percentage of cases in children than in adults.
Most curable solid neoplasm
ACUTE CHOLECYSTITIS- RUQ ABDOMINAL PAIN
#surgicaleducator #ruqabdominalpain #acutecholecystitis #usmle #babysurgeon #surgicaltutor
• Dear Viewers,
• Greetings from “Surgical Educator”
• Today I have uploaded a video on Acute Cholecystitis
• It is one of the common surgical problems you see in surgical wards.
• I have discussed the various causes for RUQ pain, etiology, pathology, clinical features, investigations, complications and treatment of Acute Cholecystitis.
• I have also included a mind map, a diagnostic and a treatment algorithm for Acute Appendicitis.
• I hope the video will be very useful and you will enjoy it.
• You can watch all my surgical teaching videos in the following links:
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
In this playlist you can watch everything about Scrotal swellings. I have discussed introduction, hydrocele, torsion testis, epididymal cyst, varicocele and testicular tumors. If you watch all these videos together you will become cofident in dealing with the problem of Scrotal Swellings.
Disclaimer: A lot from this slides were taken also from https://www.slideshare.net/babysurgeon/scrotal-swellings-1 (Dr Selvaraj Balasubramani)
This covers only :
ANATOMY
CAUSES
TORSION OF TESTIS
EPIDIDYMO-ORCHITIS
HYDROCELE
EPIDIDYMAL CYST
VARICOCELE
Testicular tumors are rare.
1 – 2 % of all malignant tumors.
Most common malignancy in men in the 15 to 35 year age group.
Benign lesions represent a greater percentage of cases in children than in adults.
Most curable solid neoplasm
ACUTE CHOLECYSTITIS- RUQ ABDOMINAL PAIN
#surgicaleducator #ruqabdominalpain #acutecholecystitis #usmle #babysurgeon #surgicaltutor
• Dear Viewers,
• Greetings from “Surgical Educator”
• Today I have uploaded a video on Acute Cholecystitis
• It is one of the common surgical problems you see in surgical wards.
• I have discussed the various causes for RUQ pain, etiology, pathology, clinical features, investigations, complications and treatment of Acute Cholecystitis.
• I have also included a mind map, a diagnostic and a treatment algorithm for Acute Appendicitis.
• I hope the video will be very useful and you will enjoy it.
• You can watch all my surgical teaching videos in the following links:
• surgicaleducator.blogspot.com youtube.com/c/surgicaleducator
• Thank you for watching the video.
COMMON Pediatrics' SURGICAL EMERGENCIES
Presented By: Dr. Raheel Ahmed
FCPS – Pediatrics Medicine
Children hospital, Chandka Medical College, Larkana
Topics we will be discussing today are:
Tracheoesophageal Fistula.
Duodenal Atresia.
Meckel’s Diverticulum.
Hirschprung’s Disease.
Appendicitis.
Biliary Atresia.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Appendicitis: Surgical Perspective
INTRODUCTION
Appendicitis is one of the most common surgical conditions in the pediatric patient.
History of the Procedure: Many early reports exist of inflammation in and around the
appendix, but Reginald Fitz, in 1886, first provided an accurate description of the
disease process. He clearly described the clinical history, physical findings, and
pathology and also was the first to advocate appendectomy as the cure.
Although Thomas Morton is credited with the first successful appendectomy in the
United States in 1887, one of the first surgeons to correctly diagnose acute appendicitis,
perform an appendectomy, have the patient recover, and report his experience was
Senn in 1889. This was also the year that McBurney described the clinical findings of
acute appendicitis, including the point of maximal tenderness, which bears his name.
Problem: Appendicitis may be a significant source of morbidity.
Frequency: Individuals have approximately a 7% risk of developing appendicitis during
their lifetime. Appendicitis is much more common in developed countries. Although the
reason for this discrepancy is unknown, potential risk factors include a diet low in fiber
and high in sugar, family history, and infection.
The peak incidence of appendicitis is in children aged 10-12 years; thereafter, the
incidence continues to decline, although appendicitis occurs in adulthood and into old
age. The lowest incidence of appendicitis is in infancy.
Pathophysiology: Appendicitis is most often due to luminal obstruction followed by
presumed bacterial invasion. In children, obstruction is usually due to lymphoid
hyperplasia of the submucosal follicles. The cause of this hyperplasia is controversial,
but dehydration and a viral infection have been proposed. Another common cause of
obstruction of the appendix is a fecalith. Other rare causes include foreign bodies,
parasitic infections, and inflammatory strictures.
Luminal obstruction and mucus production result in increased intraluminal pressure.
Bacteria trapped within the appendiceal lumen begin to multiply, and the appendix
becomes distended. Venous congestion and edema follow next, and by 12 hours after
onset, the inflammatory process may become transmural. Peritoneal irritation then
develops. If the obstruction is left untreated, arterial blood flow to the appendix is
compromised, and this leads to tissue ischemia. Full thickness necrosis of the
appendiceal wall leads to perforation with the release of fecal and suppurative contents
into the peritoneal cavity. Depending on the duration of the disease process, either a
localized walled-off abscess occurs, or if the pathologic process has advanced rapidly,
the perforation is free in the peritoneal cavity and generalized peritonitis occurs.
Clinical:
2. Acute appendicitis
A history of periumbilical pain followed by anorexia or nausea is typical, followed by the
development of localized right lower quadrant pain. Unfortunately, fewer than half of the
children present with this classic combination of signs and symptoms. The length of the
illness is usually less than 24-36 hours.
All patients with appendicitis have abdominal pain and many have anorexia; absence of
both of these findings should place the diagnosis of appendicitis in question. The child
who states that riding in a vehicle was painful when the vehicle hit the bumps in the road
on the way to the hospital may have peritoneal irritation.
Atypical pain is common and occurs in 40-45% of patients. This includes children who
initially have localized pain and those with no visceral symptoms.
Physical examination helps to distinguish appendicitis from other abdominal diseases.
Examination of the child requires skill, patience, and warm hands. Initial and continued
observation of the child is of critical importance. An ill-appearing quiet child who is lying
very still in bed, perhaps with his or her legs flexed, is much more concerning than a
child who is laughing, playing, and walking around the room. The examination should be
thorough and start with areas other than the abdomen. Because lower lobe pneumonias
can cause abdominal findings, a history of such should be elicited and a thorough chest
examination performed.
Begin examination of the abdomen by asking the child to point with one finger to the site
of maximal pain. Palpate the abdomen at a site distant to this, with the most tender area
examined last. A particularly anxious child may be palpated with a stethoscope.
Distracting questions concerning school and family members may be helpful to relieve
anxiety during the examination. Observing the child's facial expressions during this
questioning and palpating is critical.
During the abdominal examination, try to avoid eliciting rebound tenderness. This is a
painful practice and certainly destroys any trust that has been garnered during the
examination. Other methods can be used to establish that the patient has peritoneal
irritation. Asking the patient to jump up and down or to bounce his or her pelvis off the
bed while in the supine position may elicit pain in the presence of peritoneal irritation.
Alternatively, other acceptable maneuvers are tapping the patient's soles and shaking
the stretcher.
The digital rectal examination can be helpful in establishing the correct diagnosis,
especially in sexually active teenage females. The child should be told that the
examination is uncomfortable but should not cause sharp pain. The rectal examination is
particularly important in the child with a pelvic appendix in whom the findings on the
abdominal examination for appendicitis may be equivocal and indicative of peritoneal
irritation. During the examination, one may elicit pain during palpation of the right side of
the pelvis or one may feel a pelvic mass, which is more important when perforated
appendicitis is suspected.
Perforated appendicitis
A thorough history and physical examination is again paramount for a correct diagnosis.
3. Certain features of a child's presentation may suggest a perforated appendix. A child
younger than 6 years with symptoms for more than 48 hours is much more likely to have
a perforated appendix. The child may have generalized abdominal pain and may have a
temperature higher than 38°C. Examination of the abdomen may reveal generalized
peritonitis or a tender right lower quadrant mass. Younger children are much more likely
to present with diffuse abdominal pain and peritonitis, perhaps because their omentum is
not well developed and cannot contain the perforation.
INDICATIONS
Appendectomy is indicated once the diagnosis of appendicitis or perforated appendicitis
has been made. An exception would be a well-localized appendiceal perforation in a
child who is clinically well. This presentation allows initial nonoperative treatment with
definitive treatment months later with an interval appendectomy .
RELEVANT ANATOMY AND CONTRAINDICATIONS
Relevant Anatomy: The vermiform appendix is located in the right lower quadrant,
arises from the cecum, and is generally 5-10 cm in length. The appendix is lined by
typical colonic epithelium. The submucosa contains lymphoid follicles, which are very
few at birth. This number gradually increases to a peak of about 200 follicles in persons
aged 10-20 years. In persons older than 30 years, less than one half that number is
present, and the number continues to decrease throughout adulthood.
The relation of the base of the appendix to the cecum is constant, but the tip may be
found in a variety of locations. Note that the anatomic position of the appendix
determines the symptoms and the site of tenderness when the appendix becomes
inflamed.
Contraindications: Almost no contraindications exist to the surgical treatment of
appendicitis. However, note that certain patients with unrecognized perforated
appendicitis may present in a state florid septic shock. In these patients, and even in
those not so ill, one must ensure that the patient is adequately fluid resuscitated and is
administered appropriate broad-spectrum antibiotics prior to proceeding to the operating
room.