This document outlines general principles of antimicrobial therapy. It discusses establishing a clinical diagnosis and microbiological diagnosis before initiating empirical therapy. It also covers determining the appropriate antimicrobial agent based on the likely pathogens, infection site, and host factors. Monitoring the patient's response and making adjustments based on culture results is also discussed.
General Principles of Antimicrobial Selection - 2018Arwa M. Amin
Module: Pharmacology and Therapeutics III, (Therapeutics part)
Coordinator: Dr. Arwa M. Amin Mostafa
Academic Level: Undergraduate, B.Pharmacy
School: Dubai Pharmacy College
Year of first presented in Class: 2018
This presentation is for Educational purpose. It has no commercial value associated with it
General Principles of Antimicrobial Selection - 2018Arwa M. Amin
Module: Pharmacology and Therapeutics III, (Therapeutics part)
Coordinator: Dr. Arwa M. Amin Mostafa
Academic Level: Undergraduate, B.Pharmacy
School: Dubai Pharmacy College
Year of first presented in Class: 2018
This presentation is for Educational purpose. It has no commercial value associated with it
abscess advanced trauma life support anterio advanced trauma life support antibiotics apically repositioned flap dental diseases dr dr shabeel drshabeel’s face eye trauma lidocaine anodontia management medical medicine misuse and abuse orthodontics teeth braces pharmacy pn preparation dental students for community based ed presentations s abscess abscess tooth active orthodonti shabeel shabeel"s shabeel’s shabeelpn trends of antimicrobial usage in dental practice View all
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Guidelines For Antibiotic Use by doctor SaleemMuhammad Saleem
Antibiotic guidelines in surgery,
especially antibiotic prophylaxis.
Prophylactic antibiotics in general surgery, cardiothoracic, vascular, orthopedic,neurosurgery,
Classification of wounds.
Guidelines of prophylactic antibiotics
By doctor Saleem
https://www.saleemplasticsurgeon.com/
WHO CME ANTIBIOTIC STEWARDSHIP ITALY
• Articulate the principles of antimicrobial use in surgical
prophylaxis
• Describe how key institution-specific protocols can improve
the use of antimicrobials for surgical prophylaxis
• Appreciate the importance of pre-operative dosing and limiting
prophylactic antimicrobials to the duration of the surgical
procedure
Antibiotics are most common therapeutic agents used in hospitals across world, however, microbial world is becoming resistant day by day, posing special challenges to clinicians specially working in ICU set ups. There are multiple ways to curb this menace, if approached together in antibiotic stewardship way, can bring about wonders and retain therapeutic potentials of these drugs.
abscess advanced trauma life support anterio advanced trauma life support antibiotics apically repositioned flap dental diseases dr dr shabeel drshabeel’s face eye trauma lidocaine anodontia management medical medicine misuse and abuse orthodontics teeth braces pharmacy pn preparation dental students for community based ed presentations s abscess abscess tooth active orthodonti shabeel shabeel"s shabeel’s shabeelpn trends of antimicrobial usage in dental practice View all
’s abscess abscess advanced trauma life support anterio abscess tooth active orthodontics adolescent advanced trauma life support aesthetic dentistry airway management alignment of teeth amalgam anesthesia in dentistry anesthetics in dentistry anterior open bite antibiotic resistanace antibiotics antibiotics and leukopenia aphthous ulcers apically repositioned flap apicoectomy appliances arch dental arch form orthodontics braces arch length orthodontics braces arch wire orthodontist braces ayurvedha baby teeth bloger boil books braces braces teeth cancer canker sore pain cavity preparation children community based learning congenitally missing teeth cosmetic dentistry csf leaks dental dental anesthetics dental restorations dental teeth dento alveolar fractures disease
Guidelines For Antibiotic Use by doctor SaleemMuhammad Saleem
Antibiotic guidelines in surgery,
especially antibiotic prophylaxis.
Prophylactic antibiotics in general surgery, cardiothoracic, vascular, orthopedic,neurosurgery,
Classification of wounds.
Guidelines of prophylactic antibiotics
By doctor Saleem
https://www.saleemplasticsurgeon.com/
WHO CME ANTIBIOTIC STEWARDSHIP ITALY
• Articulate the principles of antimicrobial use in surgical
prophylaxis
• Describe how key institution-specific protocols can improve
the use of antimicrobials for surgical prophylaxis
• Appreciate the importance of pre-operative dosing and limiting
prophylactic antimicrobials to the duration of the surgical
procedure
Antibiotics are most common therapeutic agents used in hospitals across world, however, microbial world is becoming resistant day by day, posing special challenges to clinicians specially working in ICU set ups. There are multiple ways to curb this menace, if approached together in antibiotic stewardship way, can bring about wonders and retain therapeutic potentials of these drugs.
CDC Key Prevention Strategies for Antimicrobial Resistance Prevent Infection Step 1: Vaccinate Fact:
Influenza and pneumococcal vaccination of at-risk hospital patients and influenza vaccination of healthcare personnel will prevent infections.
Step 2: Get the catheters out Fact:
Catheters and other invasive devices are the # 1 exogenous cause of hospital-onset infections.
Diagnose & Treat Infection Effectively Step 3: Target the pathogen
Fact:
Appropriate antimicrobial therapy saves lives.
Step 4: Access the experts Fact:
Infectious diseases expert input improves the outcome of serious infections.
•
Use Antimicrobials Wisely
Step 5: Practice antimicrobial control Fact:
Programs to improve antimicrobial use are effective. (Antimicrobial Stewardship)
•
Step 6: Use local data
Fact:
The prevalence of resistance can vary by locality, patient population, hospital unit, and length of stay.
•
•
Step 7: Treat infection, not contamination Fact:
A major cause of antimicrobial overuse is “treatment” of contaminated cultures.
Step 8: Treat infection, not colonization Fact:
Step 9: Know when to say “no” to vancomycin Fact:
Vancomycin overuse promotes emergence, selection,and spread of resistant pathogens.
•
Step 10: Stop antimicrobial treatment Fact:
Failure to stop unnecessary antimicrobial treatment contributes to overuse and resistance.
Prevent Transmission
Step 11: Isolate the pathogen Fact:
Patient-to-patient spread of pathogens can be prevented.
•
Step 12: Break the chain of infection Fact:
Healthcare personnel can spread antimicrobial-resistant pathogens from patient to patient
Antimicrobial stewardship; is an activity that includes appropriate selection, dosing, route, and duration of antimicrobial therapy…..
Why is Antimicrobial Stewardship Important?
200-300 million antibiotics are prescribed annually….45% for outpatient use
25-40% of hospitalized patients receive antibiotics
10-70% are unnecessary or suboptimal
5% of hospitalized patients who receive antibiotics experience an Adverse reaction.
Health insurance companies will no longer reimburse for hospital acquired conditions deemed preventable.
Why is an antibiotic policy necessary?
To improve patient care by considered use of antibiotics for prophylaxis and therapy.
To rationalize the use of antibiotics.
To prevent or retard the emergence of resistant strains.
To improve education of junior doctors by providing guidelines for appropriate therapy
What are the clinical uses of antibiotics :
1. Therapeutic use:-
It is administration of an antimicrobial agent where substantial microbial infection has occurred.
2. Prophylactic Use:-
It is the use of antimicrobial agent before any infection has occurred to prevent a subsequent infection.
The Antimicrobial Stewardship Program (ASP) should be administered by multidisciplinary team (AST) composed of:
an infectious diseases (ID)physician
a clinical pharmacist with ID training,
a clinical microbiologist,
an IC professional,
Antibioti
Rational use of antibiotics by M. Jagadeesh, Creative Educational Society's C...Dr. Jagadeesh Mangamoori
Rational use of antibiotics is extremely important as injudicious use can adversely affect the patient, cause emergence of antibiotic resistance and increase the cost of health care.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. The specific questions include the
following:
1. Is an antimicrobial agent indicated on the basis of
clinical findings?
2. Have appropriate clinical specimens been obtained to
establish a microbiologic diagnosis?
3. What are the likely etiologic agents for the patient's
illness?
4. What measures should be taken to protect individuals
exposed to the index case to prevent secondary
cases, and what measures should be implemented to
prevent further exposure?
5. Is there clinical evidence (eg, from clinical trials) that
antimicrobial therapy will confer clinical benefit for the
patient?
3. Once a specific cause is identified, the
following further questions should be
considered:
1. If a specific microbial pathogen is identified, can a
narrower-spectrum agent be substituted for the initial
empirical drug?
2. Is one agent or a combination of agents necessary?
3. What is the optimal dose, route of administration,
and duration of therapy?
4. What specific tests (eg, susceptibility testing) should
be undertaken to identify patients who will not
respond to treatment?
5. What adjunctive measures can be undertaken to
eradicate the infection?
4. Empirical Antimicrobial Therapy
• Antimicrobial agents are frequently used
before the pathogen responsible for a
particular illness or the susceptibility to a
particular antimicrobial agent is known. This
use of antimicrobial agents is called empirical
(or presumptive) therapy and is based upon
experience with a particular clinical entity.
5. Approach to Empirical Therapy
• Formulate a Clinical Diagnosis of Microbial Infection.
Using all available data, the clinician should conclude
that there is anatomic evidence of infection (eg,
pneumonia, cellulitis, sinusitis).
• Obtain Specimens for Laboratory Examination
• Examination of stained specimens by microscopy or
simple examination of an uncentrifuged sample of
urine for white blood cells and bacteria may provide
important etiologic clues in a very short time.
• Formulate a Microbiologic Diagnosis.
6. Approach to Empirical Therapy
• Determine the Necessity for Empirical Therapy
• Institute Treatment
Selection of empirical therapy may be based
upon the microbiologic diagnosis or a clinical
diagnosis without available microbiologic clues. If
no microbiologic information is available, the
antimicrobial spectrum of the agent or agents
chosen must necessarily be broader, taking into
account the most likely pathogens responsible for
the patient's illness.
7. Choice of Antimicrobial Agent
• Selection from among several drugs depends
upon host factors which include the following:
(1) concomitant disease states (eg, AIDS, severe chronic
liver disease);
(2) prior adverse drug effects;
(3) impaired elimination or detoxification of the drug (this
may be genetically predetermined but more frequently
is associated with impaired renal or hepatic function
due to underlying disease);
(4)age of the patient;
(5) pregnancy status.
8. Choice of Antimicrobial Agent
• Pharmacologic factors include
(1) the kinetics of absorption, distribution,
and elimination;
(2) the ability of the drug to be delivered to
the site of infection;
(3) the potential toxicity of an agent;
(4) pharmacokinetic or pharmacodynamic
interactions with other drugs.
20. Antimicrobial Therapy of Infections
with Known Etiology
• Interpretation of Culture Results
The lack of a confirmatory microbiologic diagnosis may be due to
the following:
(1) Sample error, eg, obtaining cultures after antimicrobial agents
have been administered.
(2) Noncultivable or slow-growing organisms, (Histoplasma
capsulatum, bartonella species), where cultures are often
discarded before sufficient growth has occurred for detection.
(3) Requesting bacterial cultures when infection is due to other
organisms.
(4) Not recognizing the need for special media or isolation
techniques.
21. Guiding to Antimicrobial Therapy of
Established Infections
• Susceptibility Testing
Tests measure the concentration of drug
required to inhibit growth of the organism
(minimal inhibitory concentration [MIC]) or to
kill the organism (minimal bactericidal
concentration [MBC]).
• Specialized Assay Methods
1. Beta-Lactamase Assay
2. Synergy Studies
22. Monitoring Therapeutic Response:
Duration of Therapy
•The duration of therapy required for cure depends on
the pathogen, the site of infection, and host factors
(immunocompromised patients generally require longer
courses of treatment).
• In many situations, duration of therapy is determined
empirically. For serious infections, continuing therapy for
7–10 days after the patient has become afebrile is a good
rule of thumb.
• For recurrent infections (eg, sinusitis, urinary tract
infections), longer courses of antimicrobial therapy are
frequently necessary for eradication.
24. Bacteriostatic Versus Bactericidal
Activity
• For agents that are primarily bacteriostatic,
inhibitory drug concentrations are much lower
than bactericidal drug concentrations.
• Bactericidal agents are required for treatment
of acute infections (endocarditis and other
endovascular infections, meningitis, and
infections in neutropenic cancer patients).
• Bacteriostatic agents are preferable in chronic
reccurent infections.
25. Pharmacokinetic Considerations
• Route of Administration
The intravenous route is preferred in the following
situations:
(1) for critically ill patients;
(2) for patients with bacterial meningitis or
endocarditis;
(3) for patients with nausea, vomiting,
gastrectomy, or diseases that may impair oral
absorption;
(4) when giving antimicrobials that are poorly
absorbed following oral administration.
26. Pharmacokinetic Considerations
• Drug Concentrations in Body Fluids.
Most antimicrobial agents are well distributed
to most body tissues and fluids. Penetration
into the cerebrospinal fluid is an exception.
27. Conditions That Alter Antimicrobial
Pharmacokinetics
• Impairment of renal or hepatic function may
result in decreased elimination.
• The pharmacokinetics of antimicrobials are
also altered in the elderly, in neonates, and in
pregnancy.
29. Monitoring Serum Concentrations of
Antimicrobial Agents
• To justify routine serum concentration
monitoring, it should be established
(1) that a direct relationship exists between drug
concentrations and efficacy or toxicity;
(2) that substantial interpatient variability exists in
serum concentrations on standard doses;
(3) that a small difference exists between
therapeutic and toxic serum concentrations;
(4) that the clinical efficacy or toxicity of the drug is
delayed or difficult to measure;
(5) that an accurate assay is available.
30. Management of Antimicrobial Drug
Toxicity
• Allergic reactions
• Cross reactivity
• Adverse reactions to antimicrobials occur with
increased frequency in several groups,
including neonates, geriatric patients, renal
failure patients, and AIDS patients.
• Polypharmacy
31. Rationale for Combination
Antimicrobial Therapy
• Antimicrobial combinations should be selected for
one or more of the following reasons:
(1) To provide broad-spectrum empirical therapy in
seriously ill patients.
(2) To treat polymicrobial infections such as intra-
abdominal abscesses.
(3) To decrease the emergence of resistant strains.
(4) To decrease dose-related toxicity by using reduced
doses of one or more components of the drug regimen.
(5) To obtain enhanced inhibition or killing.