Anticancer ruthenium(ii) complexes - Anjali Devi J S
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The power point presentation describes development of Ru(II) complexes for cancer treatment. The presentation is prepared based on three review articles published in Chemical Society Reviews on 2017 and 2018: (1)Chem. Soc. Rev., 2017,46,5771 (2)Chem. Soc. Rev., 2017,46,7706 (3)Chem. Soc. Rev., 2018,47, 909-928.
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This document is the third edition of a book on lung cancer edited by Jack A. Roth, James D. Cox, and Waun Ki Hong. It contains chapters written by experts on various topics related to lung cancer, including smoking cessation, lung cancer genetics, detection and diagnosis of preneoplastic lung lesions, surgical and non-surgical treatments, targeted therapies, screening and prevention. The book provides a comprehensive overview of the current state of knowledge across the multidisciplinary field of lung cancer research and clinical management.
Publication HS
This document lists 41 publications authored or co-authored by Himadri Samanta from 1977 to 2007. The publications cover research conducted by Samanta and collaborators on topics including thymineless death in Escherichia coli, radiation response of thymine starved bacteria, interferon action and the enzymology of interferon pathways, expression of hepatitis B virus antigens, characterization of recombinant enzymes expressed in cell lines, analysis of drug-resistant HIV strains, and discovery of new classes of HIV integrase inhibitors.
Wing Lam CV Feb-2016
Wing Lam is a research scientist at Yale University specializing in herbal medicine and cancer pharmacology. He has over 15 years of experience identifying active compounds from herbs to treat diseases like cancer, metabolic disorders, and viral infections. Some of his accomplishments include developing the herbal formulation PHY906 to reduce chemotherapy side effects and enhance cancer treatment, identifying compounds that activate Wnt signaling for tissue regeneration, and developing nucleoside analogs for cancer and viral infections. He has published over 30 papers in peer-reviewed journals and presented at international conferences on topics related to herbal medicine and cancer chemotherapy.
Antioxidants in-human-health-and-diseases
This document provides the front matter, including title page, dedication page, and contents page, for a book titled "Antioxidants in Human Health and Disease". The book is edited by Tapan K. Basu, Norman J. Temple, and Manohar L. Garg and contains 27 chapters contributed by various authors on topics related to antioxidants and their role in human health and disease. The book is published by CABI Publishing and copyrighted in 1999.
Bibliography of Publications by Ravi S
This document lists 37 publications by Ravi S. Harapanhalli, Ph.D., including original peer-reviewed articles, manuscripts pending publication, proceedings from meetings, a U.S. patent application, and book chapters. The publications cover a wide range of topics including synthesis of organic compounds, radiopharmaceutical development and testing, radioprotection studies, and modification of antibodies for tumor targeting.
11JAN17 Lindsay Jordan Resume
Lindsay Jordan has over 15 years of experience in the pharmaceutical industry, specializing in immunology techniques including cell culture, molecular biology, and ELISA development. She has worked at Biothera Pharmaceuticals since 2007 where she developed and validated potency assays, authored SOPs, and supported clinical trials. Prior to this, she held positions at 3M Pharmaceuticals and ViroMED Laboratories, optimizing assays and discovering drug mechanisms of action. Jordan has a Bachelor's degree in Biology and is proficient in laboratory techniques and data analysis software. She has authored multiple publications and presentations on topics including beta-glucan immunology and cancer immunotherapy.
New biochemical markers of risk of Coronary Heart Disease (CHD)
This document discusses the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for predicting cardiovascular disease risk. It notes that traditional risk factors have low sensitivity and specificity. HsCRP is emerging as a stronger predictor of risk than LDL and can help reclassify some patients as higher risk. Larger studies like the JUPITER trial are investigating using hsCRP levels to determine who may benefit from statin therapy independent of LDL levels. While hsCRP shows promise, more research is still needed to understand genetic and other factors that may influence hsCRP levels and risk predictions.
Poster IC Congresso UNIFESP Final
This study aims to evaluate the gene expression profile of FOXE1 mRNA in paired thyroid tumor and non-tumor tissue samples. Preliminary results from the first 10 paired samples show variation in FOXE1 gene expression levels between tumor and non-tumor tissues, with non-tumor tissue appearing to have higher FOXE1 expression compared to tumor tissue. Analysis of more sample pairs is ongoing, and FOXE1 expression levels will be compared to patient clinical data and tumor pathological characteristics. The results so far indicate there may be a profile of FOXE1 expression in thyroid cancer.
Ph.D. Proposal
This document outlines a research proposal on investigating the ethnobotany and ethnomedicine of plants in Goa. The proposal discusses the need to study indigenous medicinal plant knowledge and potential plant-based treatments for diseases like diabetes, viral infections, and cancer. The aims are to study pharmacologically active local wild plants, isolate bioactive compounds, and culture plants with bioactivities. The methodology proposed includes collecting plant samples, preparing extracts using different solvents, and testing extracts for activities like antidiabetic, anti-inflammatory, antioxidant, anticancer, and antiviral effects. Characterization of bioactive compounds using chromatography and spectroscopy is also proposed. A timeline outlines the activities over 5 years including literature review, screening plants,
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...
Presentación del Dr. David Guillespie, investigador contratado por el CIBICAN - Universidad de La Laguna gracias al Proyecto Europeo IMBRAIN, en relación a los resultados alcanzados durante la ejecución del mismo y los planes de futuro. La misma se presentó durante las Jornadas IMBRAIN llevadas a cabo el 13 de Octubre de 2015 en la Sección de Física en la Universidad de La Laguna
Dr. Swami Gyan Prakash
Dear Friend,
Please let you all know that because of mental illness, people of the world are full of sins. Mother Earth has reached bottom, and on the Holocaust. It can be prevented by the supreme consciousness. Therefore, at the present time I am working for super consciousness to operate the mental disorder for ultimate welfare (peace).
Today, there is a great need of holy revolution (peace-revolution). There are three main objectives for the ultimate benefit of the world;
1. Elimination of ground root of mental illnesses.
2. Establishment of Ideal Human Doctrine
3. Cow slaughter ban and protect the earth from the Holocaust.
I, therefore, kindly request you all for holy purpose to complete with the holy spirit (pure mind, super conscience, speech and deed) to come forward and cooperate and find the ultimate benefit of your human life that is Peace.
Thanks & Regards
You own Reverence & Faith
Dr. Swami Gyan Prakash
Souder Trust in Science SLA 2011
Lawrence Souder from Drexel University presented on June 14, 2011 at a panel on "International Year of Chemistry: Perils and Promises of Modern Communication in the Sciences" at the Special Libraries Association meeting. His talk covered Trust in Science and Science by Blogging, using as an example the NASA press release on arsenic in bacteria and subsequent controversy taking place in the blogosphere
Hui Zhang CV 2016
This document is a curriculum vitae for Hui Zhang, a professor at Johns Hopkins University School of Medicine. It lists his current appointments, education history, professional experience, and publications. Specifically, it details that he is currently a professor in the Department of Pathology at JHU and director of the Mass Spectrometry Core Facility. It provides information on his education from Beijing University and University of Pennsylvania. It also lists over 45 publications in peer-reviewed journals related to proteomics and mass spectrometry research.
Rahman cv up-dated-6.19.16
Mohammad Rahman is a senior research associate at Ohio State University studying cancer metastasis. He has a PhD in cancer biology from Shimane Medical University in Japan and has held several postdoctoral research positions. His research focuses on how exosomes secreted by cancer cells drive metastasis by inducing epithelial to mesenchymal transition in other cells. He recently discovered that lung cancer cell exosomes can induce EMT in recipient cells, which may be important for establishing the tumor microenvironment and cancer spread. The goal of his current research proposal is to investigate the mechanisms by which cancer-derived exosomal contents drive metastasis.
Rahman_CV-up-dated_3.21.16
Mohammad Rahman is a senior research associate at Ohio State University studying cancer metastasis. He has a PhD in cancer biology from Shimane Medical University in Japan and has held several postdoctoral research positions. His research focuses on how exosomes secreted by cancer cells drive metastasis by inducing epithelial to mesenchymal transition in other cells. He recently discovered that lung cancer cell exosomes can induce EMT in recipient cells, which may be important for establishing the tumor microenvironment and cancer spread. The goal of his current research proposal is to investigate the mechanisms by which cancer-derived exosomal contents drive metastasis.
北醫藥學院教師研究專長簡介
The laboratory focuses on developing drug delivery systems using biomaterials like hyaluronic acid. A thermosensitive injectable hydrogel was created using nanocomplexes of doxorubicin and hyaluronic acid for local cancer treatment. This hydrogel inhibited cancer cell growth and selectively targeted the lymphatic system due to hyaluronic acid's affinity for the lymphatic system. The lab is also exploring combination therapy delivery systems, such as a thermosensitive hydrogel incorporating doxorubicin and docetaxel-loaded nanoparticles for overcoming drug resistance in tumors.
Monoclonal antibodies
Introduction to the peak and importance of monoclonal antibodies in health and disease as a highly novel immunoregulatory tool.
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New biochemical markers of risk of Coronary Heart Disease (CHD)
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Classical & Quantum Statistics
Different physical situation encountered in nature are described by three types of statistics-Maxwell-Boltzmann Statistics, Bose-Einstein Statistics and Fermi-Dirac Statistics
Phase diagram
The interpretation of phase diagrams have application in petroleum industry, metallurgy, chemical industry, solvent separation and so on. This presentation guid you to understand phase diagrams.
Born–Oppenheimer Approximation.pdf
The Born-Oppenheimer approximation, proposed in 1927 by physicists Max Born and J. Robert Oppenheimer, treats the motions of nuclei and electrons in molecules separately. It approximates that the nuclei in a molecule are stationary relative to the rapidly moving electrons. This allows molecular structure and properties to be determined by first solving the electronic Schrodinger equation at fixed nuclear positions, and then adding the internuclear repulsion energy to obtain the total internal energy of the molecule. As a result of this approximation, molecules have well-defined shapes determined by the equilibrium positions of their nuclei.
Coordination complexes-bonding and magnetism.pdf
This document discusses coordination complexes, their bonding properties, and magnetism. It covers several theories of bonding in coordination complexes including valence bond theory, crystal field theory, and ligand field theory. Valence bond theory describes coordinate covalent bonds formed between metal centers and ligands. Crystal field theory models ligand fields as point charges that split the metal's d orbitals into different energy levels, influencing complex properties. Magnetism arises from both spin and orbital contributions of unpaired electrons. Temperature and external fields can induce spin state changes between high and low spin configurations in some complexes.
1. Random walk.pdf
The presentation on simple mathematics of random walk. This mathematical concept have applications in calculations of Brownian motion and signal processing.
Poisson distribution
This document provides information about the Poisson distribution, a discrete probability distribution that can be used to predict the probability of certain events occurring within a fixed time period or other interval. The key points are:
- The Poisson distribution gives the probability of a given number of discrete events happening in a fixed time interval, where the events are independent and cannot occur simultaneously.
- It is defined by one parameter, lambda (λ), which represents the average number of events occurring per interval. The mean and variance of the distribution are both equal to λ.
- Some examples of phenomena that can be modeled by the Poisson distribution include the number of phone calls received per minute or cars passing on a road per hour.
Probability
Probability is a numerical measure of how likely an event is to occur. It is defined as the number of favorable outcomes divided by the total number of possible outcomes. A random experiment is an action with some defined outcomes that may occur by chance. The sample space is the set of all possible outcomes. Conditional probability is the probability of one event occurring given that another event has occurred.
Normal distribution
A normal (Gaussian) distribution, sometimes called Bell curve, is a distribution that occur naturally (eg: Height of people).
Binomial distribution
This document discusses the binomial distribution, an important discrete probability distribution that describes the number of successes in a fixed number of independent yes/no experiments, such as coin tosses, where the probability of success p is the same for each trial. The key points are:
- The binomial distribution formula is used to calculate the probability of getting x successes in n trials.
- Examples of binomial experiments include calculating the probability of getting a certain number of heads when tossing a coin multiple times.
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Computational Chemistry- An Introduction
Describes introduction to theoretical methods in chemistry, the tools of computational quantum chemistry
Gamma function
The gamma function is a generalization of the factorial function to complex and real number arguments. It is defined as Γ(n) = ∫_0^∞ e^{-x} x^{n-1} dx for n > 0. Some key properties of the gamma function are:
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Lagrange multiplier
This document discusses the Lagrange multiplier method for finding the constrained maximum or minimum of a function subject to an equality constraint. It provides examples of using Lagrange multipliers to find the dimensions of a rectangle with maximum area given a perimeter, and to find the points on a circle closest to and farthest from a given point. The key steps are to set up the Lagrange multiplier equation relating the gradients of the objective function and constraint, solve for the critical points, and evaluate the objective function at these points to find the maximum or minimum.
Stirling's approximation
This document discusses Stirling's approximation, which provides an accurate way to calculate large factorials. It was developed by Scottish mathematician James Stirling. The derivation shows that the natural logarithm of N! can be approximated as NlnN - N. This allows factorials of huge numbers like Avogadro's number to be calculated. The document also provides a more accurate form of Stirling's approximation and uses it to calculate some large factorials with low error rates.
Combinatorics
Combinatorics is a subfield of discrete mathematics that focuses on counting combinations and arrangements of discrete objects. It involves counting the number of ways to put things together into various combinations. Some key rules in combinatorics include the sum rule, which states that the number of ways to accomplish either of two independent tasks is the sum of the number of ways to accomplish each task individually. The product rule states that the number of ways to accomplish two independent tasks is the product of the number of ways to accomplish each task. Generating functions can be used to efficiently represent counting sequences by coding terms as coefficients of a variable in a formal power series. They allow problems involving counting and arrangements to be solved using operations with formal power series.
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Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
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When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
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Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
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at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
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measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
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the last few Gyr, consistent with the body of work surrounding the VRM.
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原版纸张【微信：741003700 】【(uvic毕业证书)维多利亚大学毕业证】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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2:同时对留学生所学专业登记给予评定
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6:个人职称评审加20分
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Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
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among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
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The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
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Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
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photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
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be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
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Applied Science: Thermodynamics, Laws & Methodology.pdf
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The debris of the ‘last major merger’ is dynamically young
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aziz sancar nobel prize winner: from mardin to nobel
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Cytokines and their role in immune regulation.pptx
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Anticancer ruthenium(ii) complexes - Anjali Devi J S
- 1. Anticancer Ruthenium(II) complexes Anjali Devi J S Research Scholar Department of Chemistry University of Kerala
- 4. Cancer Treatment and Awareness in Kerala Jishnu Raghavan Born: 23 April 1979 Died: 25 March 2016 (aged 36)
- 5. Most of the FDA approved anticancer drugs are organic molecules Anticancer drugs 5-Fluorouracil Doxorubicin
- 6. November 16, 1926 - August 8, 2009 Barnett Rosenberg In 1969 B. Rosenberg showed in vivo inhibition of sarcoma and leukemia by platinum compounds and claimed the platinum compounds as a new class of potent antitumor agents Metallodrugs for cancer Cisplatin The anticancer drug, cisplatin was clinically approved in 1978. Ref: B. Rosenberg, L. Vancamp, J. E. Trosko and V. H. Mansour, Nature, 1969, 222, 385–386. Head cancer Lung cancer Ovarian cancer esophageal cancers Neck cancer Carboplatin
- 7. Why not Cisplatin drug..? peripheral neuropathy hair loss myelotoxicity Resistance of tumors to platinum and treatment failure 1 2 Non-cancer cell toxicity
- 10. Arene ruthenium complexes Polypyridyl ruthenium complexes Nanomaterial ruthenium complexes Ruthenium(II) complexes as anticancer agents 1 21 3
- 11. Cellular uptake of Ruthenium(II) complexes
- 12. Localization in Nucleus Ref: H. Huang, P. Zhang, B. Yu, Y. Chen, J. Wang, L. Ji and H. Chao, J. Med. Chem., 2014, 57, 8971–8983.
- 13. Localization in Mitochondria Ref: V. Pierroz, T. Joshi, A. Leonidova, C. Mari, J. Schur, I. Ott, L. Spiccia, S. Ferrari and G. Gasser, J. Am. Chem. Soc., 2012, 134, 20376–20387.
- 14. DNA as a target Ref: M. R. Gill, S. N. Harun, S. Halder, R. A. Boghozian, K. Ramadan, H. Ahmad and K. A. Vallis, Sci. Rep., 2016, 6, 31973; M. R. Gill, J. Garcia-Lara, S. J. Foster, C. Smythe, G. Battaglia and J. A. Thomas, Nat. Chem., 2009, 1, 662–667.
- 15. Protein as a target
- 17. Ruthenium(II) Selenium nanoparticles Ref T. Liu, L. Zeng, W. Jiang, Y. Fu, W. Zheng and T. Chen, Nanomedicine, 2015, 11, 947–958. D. Sun, Y. Liu, Q. Yu, X. Qin, L. Yang, Y. Zhou, L. Chen and J. Liu, B
- 18. Ruthenium(II) Gold nanomaterials Ref: P. Zhang, J. Wang, H. Huang, K. Qiu, J. Huang, L. Ji and H. Chao, J. Mater. Chem. B, 2017, 5, 671–678.
- 20. Ruthenium(II) Carbon nanotubes Ref: N. Wang, Y. Feng, L. Zeng, Z. Zhao and T. Chen, ACS Appl. Mater. Interfaces, 2015, 7, 14933–14945.
- 21. 1 2 3 References