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ANTIBIOTICS and CLASSIFICATION
PART – 1
ZAG
Substance produced by a
microorganism or a similar product
produced wholly (synthetic) or
partially (semi-synthetic) by
chemical synthesis and in low
concentrations inhibits the growth
of or kills microorganisms
Classification of Antibiotics
 Antibiotics are classified into different categories, on
the basis of ;
 Mechanism of Action
 Spectrum / Target specificity
 Effects of their activity
 Route of administration
 Chemical structure
Classification : Spectrum Basis
 On the basis of target specificity, antibiotics are divided
into two;
 Broad Spectrum
 broad spectrum antibiotics affect a wide range of bacteria,
including both Gram positive and negative (Large Number of
families).
 E.g. Ampicillin, Amoxicillin
 Narrow spectrum
 Narrow spectrum antibiotics act against a limited group of
bacteria, either gram positive or gram negative. for example
 Sodium Fusidate only acts against staphylococcal bacteria.
Classification : Effects of Specificity
 On the basis of Effects of specificity, antibiotics are divided
into two;
 Bacteriostatics
 A drug that prevents bacterial growth and reproduction
but does not necessarily kill them. Examples are;
 Sulfonamide, tetracycline, chloramphenicol, trimethoprim,
macrolides, Lincosamide
 Bactericidal
 An agent that kills bacteria.
 Aminoglycosides, Penicillin, Cephalosporin
Classification : Chemical structure
 Following are some major classes of antibiotics ;
 Beta Lactams
 Macrolides
 Aminoglycosides
 Quinolones and Flouroquinolones
 Sulphonamides
 Glcopeptides
 Lincosamides
 Streptogramins
 Trimethoprim
 Steroid Antibiotics
Classification : Mechanism of Action
Categorically divided as;
 Inhibitor of cell wall synthesis/ Peptidoglycan Inhibitors
 Beta-lactum; Penicillin
 Bacitracin
 Inhibitor of Protein Synthesis
 Streptomycin
 Aminoglycosides
 Inhibitor of Nucleic acid synthesis
 Quinolones
 Ciprofloxacin
 Inhibitor of Essential Metabolite synthesis
 Inhibitor of Folic acid synthesis
 Sulfonamide
 Trimethoprim
 Inhibitor of cytoplasmic membrane
 Polymyxin; Colistin
For further knowledge about Antibiotics check Part
- II

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Antibiotics and their classification, Part - 1

  • 2. Substance produced by a microorganism or a similar product produced wholly (synthetic) or partially (semi-synthetic) by chemical synthesis and in low concentrations inhibits the growth of or kills microorganisms
  • 3. Classification of Antibiotics  Antibiotics are classified into different categories, on the basis of ;  Mechanism of Action  Spectrum / Target specificity  Effects of their activity  Route of administration  Chemical structure
  • 4. Classification : Spectrum Basis  On the basis of target specificity, antibiotics are divided into two;  Broad Spectrum  broad spectrum antibiotics affect a wide range of bacteria, including both Gram positive and negative (Large Number of families).  E.g. Ampicillin, Amoxicillin  Narrow spectrum  Narrow spectrum antibiotics act against a limited group of bacteria, either gram positive or gram negative. for example  Sodium Fusidate only acts against staphylococcal bacteria.
  • 5. Classification : Effects of Specificity  On the basis of Effects of specificity, antibiotics are divided into two;  Bacteriostatics  A drug that prevents bacterial growth and reproduction but does not necessarily kill them. Examples are;  Sulfonamide, tetracycline, chloramphenicol, trimethoprim, macrolides, Lincosamide  Bactericidal  An agent that kills bacteria.  Aminoglycosides, Penicillin, Cephalosporin
  • 6. Classification : Chemical structure  Following are some major classes of antibiotics ;  Beta Lactams  Macrolides  Aminoglycosides  Quinolones and Flouroquinolones  Sulphonamides  Glcopeptides  Lincosamides  Streptogramins  Trimethoprim  Steroid Antibiotics
  • 7. Classification : Mechanism of Action Categorically divided as;  Inhibitor of cell wall synthesis/ Peptidoglycan Inhibitors  Beta-lactum; Penicillin  Bacitracin  Inhibitor of Protein Synthesis  Streptomycin  Aminoglycosides  Inhibitor of Nucleic acid synthesis  Quinolones  Ciprofloxacin  Inhibitor of Essential Metabolite synthesis  Inhibitor of Folic acid synthesis  Sulfonamide  Trimethoprim  Inhibitor of cytoplasmic membrane  Polymyxin; Colistin
  • 8.
  • 9. For further knowledge about Antibiotics check Part - II