CTG in simple methods in fetal assessment according to RCOG guidelines.
easy and concise
feel free to download
by OSAMA AKL
MRCOG instructor
contact me on WhatsApp 00201008067383
CTG in simple methods in fetal assessment according to RCOG guidelines.
easy and concise
feel free to download
by OSAMA AKL
MRCOG instructor
contact me on WhatsApp 00201008067383
Majority of fetal deaths occur in the antepartum period.
There is progressive decline in maternal deaths all over the world. Currently more interest is focused to evaluate the fetal health. The primary objective of antenatal assessment is to avoid fetal death.
Intra Partum Cardiotocography - dr vivek patkardrvivekpatkar
Cardiotocography ( CTG )
is a procedure of graphically ( graph) recording fetal heart activity and uterine contractions ( Toco ) – both recorded in the same time scale simultaneously and continuously through uterine quiscience and contractions
Antenatal assessment physical well being /introduction and methodsBabitha Mathew
The tests used to monitor fetal health include fetal movement counts, the nonstress test, biophysical profile, modified biophysical profile, contraction stress test, and Doppler ultrasound exam of the umbilical artery.
According to the International Federation of Gynaecology and Obstetrics (FIGO), prolonged pregnancy is defined as any pregnancy that exceeds 42wks (294 days) from the first day of the LMP in a woman with regular 28-day cycles.
Hello everyone
This presentation will give a insight into the recent advances in fetal therapy. Hope it might help you
Thanking you
Dr Ankit gupta
MD Pediatrics
Kims karad
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
1. ASSESSMENT OF FOETAL WELL BEING
ANTEPARTUM AND INTRAPARTUM
DR RAJEEV SOOD ASSOC. PROF. OBG
KAMLA NEHRU HOSPITAL
INDIRA GANDHI MEDICAL COLLEGE SHIMLA
2. INTRODUCTION ANTENATAL FETAL SURVEILLANCE IS
ASSESSMENT OF FETAL WELL BEING IN
ANTEPARTUM PERIOD TO ENSURE
DELIVERY OF HEALTHY NEONATE.
Two main objectives are:-
Early detection of fetuses at risk to
prevent perinatal mortality and
morbidity.
Find out normal fetuses and avoid
unwarranted interventions.
2
3. ANTEPARTUM FETAL ASSESSMENT METHODS:-
1a CLINICAL ASSESSMENT
Weight gain
Fundal height
Abdominal girth
Auscultation of fetal heart
1b fetal movement count by mother
2.ultrasound for fetal parameters
3.biochemical tests
4.NST
5.VAST
6.CST
3
4. 7.Nipple stimulation test
8.biophysical profile
9.doppler
10.fetal lung maturation test
11.placental grading
4
7. PREGNANCY RELATED Multiple pregnancy
Gestational hypertension
Preeclampsia
Decreased fetal movement
Abnormal placentation
Placental abruption
Amniotic fluid disorders
PROM
GDM
Previous unexplained still birth
ICP
Post term pregnancy
7
8. WHEN TO START?
Depends up on factors like:-
Past history of adverse outcome
Severity of maternal and fetal conditions
Generally Monitoring is recommended when
estimated fetal maturity is sufficient to expect a
reasonable chance of survival should intervention be
necessary.
8
9. CLINICAL ASSESSMENT
WEIGHT GAIN
9
Recommended Ranges of Weight Gain
During Singleton Gestations Stratified by Pre
pregnancy Body Mass Index
Category BMI Wt. in kgs
Low 19.8 12.5–18
Normal 19.8–26 11.5–12.5
High 26–29 7–11.5
Obese 29 7
10. Symphysio-fundal height
Measured from superior border of
pubis symphysis to fundus
From 24th wks of gestation corresponds
to period of gestation .
Difference of 2- 3 cms acceptable
below 10th percentile or difference of
>4cms suggests IUGR
positive predictive value of 60%
negative predictive value of 76.8%
10
11. Abdominal girth
Measured at lower border of umbilicus.
Increases by 2.5cm per week after 30wks.
95-100 cms at term.
Static or falling values alarming sign.
11
12. Fetal movement count
Cardiff” count 10” technique
Daily fetal movement count
Perception of three movement in 30 minutes.
12
13. Fetal movement count
Fetus spends 10% of its time making gross fetal
body movements
Periods of active fetal body movement last about
40 minutes
Longest period without fetal movements about
75 minutes.
Mother appreciate 70% to 80% of gross fetal
movements.
13
14. Fetal movement peak between 9:00 PM and
1:00 AM.
Time when maternal glucose levels are
falling.
Fetal activity does not increase after meals
or after maternal glucose administration.
14
15. Factors affecting maternal
perception of fetal movement
Fetal and placental factors :-
Placental location
The length and type of fetal movements
Amniotic fluid volume (AFV)
Maternal factors :-
Parity, obesity.
Psychological factors anxiety.
15
16. ULTRASOUND FOR FETAL
PARAMETERS HIGH RESOLUTION UTRASOUND
REVOLUTIONIZED PRENATAL DIAGNOSIS.
CAN BE:-
BASIC
TARGETED
BASIC:-(in early pregnancy)
Done at 10-14wks and includes :-
No. of fetuses
Fetal life
Placental localization
Internal os diameter
Cervical length
16
17. Gestational age
maternal pelvic masses
Any gross anomaly like anencephaly,limb
reduction defects.
Nuchal translucency(80% fetuses with 5%
false positive rates)
Only in high risk patients
17
18. CRL smaller than gestational age
chromalsomal anomalies
Absencence of nasal bone at 10-12wks
Down syndrome
NB+NT detection rate of 92% & false positive
rate of 3.5%
18
19. 2nd &3rd triemester
Serial measurements of BPD,AC,HC,FL.
HC/AC ratio exceeds 1 before 32wks.
1 bw 32to 34wks. After 34wk falls below 1.
In symmetric IUGR remains normal.
Ratio can identify 85% IUGR fetuses.
FL/AC remains 22 at all gestational ages from 21wks to term. >23.5
suggest IUGR.
AC remains single best parameter to detect IUGR with positive
predictive value of 50%.
Trans cerebellar diameter in mm corresponds to POG from 11wks –
32wks .
19
20. AMNIOTIC FLUID VOLUME
Single deepest pocket >2cm normal
Or
Amniotic fluid index 5-25cm.
20
21. Targetted ultrasound Done in high risk patients
In developed countries offered to all patients
Transverse section for fetal head
Shape and internal structures. BPD,HC Measured to
detect hydrocephalus,anencephaly
Transverse and longitudinal views of abdomen to
rule out anomalies of stomach, kidneys ,bladder,
ventral wall.
Transverse section of fetal thorax to four chambered
view of heart.
21
23. Identify three long bones in each limb
and any achondroplasia is looked for.
Saggittal ,coronal and transverse views taken to rule
out spinabifida.
cephalic index
Biparietal diameter/occipitofrontal diameter
23
26. Historically optimal timing between 18 and 22 weeks’
gestation.
moving into an era of early risk assessment .
fetal echocardiography late first and early second
trimesters
A limited number of reports describe the utility of
transvaginal imaging between 10 and 13 weeks.
26
27. Non stress test Freeman first described the NST in 1975.
Physiologic premise of the NST is that:-
Nonhypoxic fetus
stimulus
accelerate its heart rate
27
28. Method
FHR and uterine activity are monitored with
an external transducer
FHR is monitored for 20 minutes.
For 40 minutes in some cases to compensates
for sleep cycles then called EXTENDED NST.
In some cases when the fetus is not reactive,
acoustic stimulation by artificial larynx a
sound stimulus for 1 to 2 seconds.
28
29. INTERPRETATION Reactive NST presence of two accelerations of
15bpm over base line for 15sec in a 20-minute
time period with or without fetal movements.
Nonreactive NST absence of two accelerations
in a 40-minute period with or without acoustic
stimulation over a 40-minute period.
29
30. NST is not routinely started until 32-weeks
gestation.
Up to 50% of NSTs reactive from 24- to 28-
weeks gestation.
85% from 28 to 32 weeks of gestation
In up to 50% of NSTs variable decelerations
may be observed.
It last for <30 seconds and <2 during a 20-
minute period
NO fetal compromise
30
31. PREDICTIVE VALUE
With a reactive NST, the chance for fetal death
within 1 week is 1.9 per 1,000, giving a negative
predictive value of 99.8% after correction for
lethal anomalies.
Best senstivity and positive predictive value for
IUGR and Hypertensive disorders -70%
Reactive NST is reassuring.
Nonreactive NST is nonspecific and requires
further evaluation.
31
32. The false-positive rate is considerably higher,
ranging from 50% to more than 90% in various
studies.
In high-risk pregnancies, the false-negative rate
associated with a weekly NST may be
unacceptably high.
In these cases, increasing frequency of the NST to
twice weekly may be considered.
32
33. VIBROACOUSTIC STIMULATION
TEST
Used as an adjunct to NST
If NST non reactive even after 40min then:-
Continue CTG monitoring till 90min
OR
Perform BPP
OR
VAST
33
34. Auditory brainstem response functional at 26 to 28
weeks’ gestation.
VAST increase the incidence of reactive NSTs after 26
weeks’ gestation .
Reduce the testing time.
artificial larynx that generates sound 82 Db -100db
with a frequency of 80 Hz.
34
35. A stimulus for 3 seconds or less is applied
near the fetal head.
If the NST remains nonreactive
Stimulus is repeated at 1-minute
intervals up to three times. 35
36. VAST have shown a decreased incidence of
nonreactive NSTs from 13% to 14% down to 6% to 9%.
36
37. MANAGEMENT PROTOCOL OF NST
NST for 20 min Reactive
Repeate after 1wk Or earlier if situation demands
If non reactive Extend to 40min
Non reactive VAST Non reactive
BPP
37
38. BIOPHYSICAL PROFILE
Thorough evaluation of fetal well-being .
Potential to significantly reduce the false-positive rate
of the NST/CST.
The BPP was initially described by Manning and
colleagues .
Rationale:-Fetal biophysical activities controlled by
centers in the fetal brain sensitive to varying degrees
of hypoxia.
38
39. BPP SCORING( MANNING)
1. Movements Three or more gross body movements SCORE
in a 30-minute period.
Simultaneous trunk and limb 2
movements count as a single
Movement
Fewer than 3 gross body movements 0
in a 30-minute period
39
40. SCORE
2. TONE At least one movement of a limb from
a position of flexion to one of extension, 2
with a rapid return to flexion.
Fetal limb in extension with no return 0
to flexion with movement
3.Breathing At least 30 seconds of sustained
FBMs observed over a 30-minute period 2
Fewer than 30 seconds of sustained
FBMs observed over a 30-minute 0
40
41. SCORE
4.AFPAt least a single amniotic fluid pocket
measuring 2 cm in 2 perpendicular planes 2
No amniotic fluid pocket that 0
measures at least 2 cm
2 perpendicular planes
5. NST reactive 2
NST non reactive 0
41
42. Technique
Performance of an NST.
For gestations less than 32 weeks, the qualifying
criteria for accelerations are greater than 10 bpm,
lasting at least 10 seconds.
42
43. MANAGEMENT PROTOCOL OF BPP 10 Normal; low risk for chronic asphyxia Repeat testing
at weekly to twice-weekly intervals (IN HIGH RISK CASES)
8 Normal; low risk for chronic asphyxia Repeat testing
at weekly to twice-weekly intervals If oligohydroamnios
deliver.
6 Suspect chronic asphyxia If ≥36-37 wk gestation or <36
wk with positive testing for fetal pulmonary maturity, consider
delivery. Otherwise repeat with in 24hrs
if <36 wk and/or fetal pulmonary maturity testing negative,
repeat biophysical profile in 4 to 6 hr.
deliver if oligohydramnios is present
43
44. 4 Suspect chronic asphyxia If ≥36 wk gestation,
deliver.
if <32 wk gestation, repeat with in 24hrs. If repeat
score <6 deliver if >6 observe.
0-2 Strongly suspect chronic asphyxia Extend
testing time to 120 min.
if persistent score ≤4, deliver, regardless of
gestational age
44
45. NST and FBM Has highest senstivity
Fetal tone has highest specificity
45
46. MODIFIED BPP
Attempt to simplify and reduce the time.
Focusing on the components of the BPP most
predictive of perinatal outcome.
Two parameters:-
1. NST indicator of present fetal condition.
2. AFI /AFP a marker of long-term status.
46
47. Contraction Stress Test
CST/OCT first biophysical technique widely applied
for antepartum fetal surveillance.
Principle
uterine contractions
Reduction in blood flow to the intervillous space.
Inadequate placental respiratory reserve
Recurrent late decelerations in response to hypoxia.
47
48. TECHNIQUE
Fetal heart rate and uterine contraction baseline is
determined.
Blood pressure is recorded every 5 to 10 minutes to
detect maternal hypotension.
oxytocin started @.5-1 miu /min.
An adequate CST requires uterine contractions of
moderate intensity lasting about 40 to 45 seconds
with a frequency of three in 10 minutes.
48
49. INTERPRETATION
Negative: No late or significant variable
decelerations
Positive: Late decelerations with at least 50% of
contractions
Suspicious: Intermittent late or variable
decelerations
Hyperstimulation: Decelerations with
contractions longer than 90 seconds’ duration or
2-minute frequency
Unsatisfactory: Fewer than three contractions per
10 minutes or an uninterpretable tracing
49
50. PREDICTIVE VALUE OF CST
A negative CST good fetal outcome.
incidence of perinatal death within 1 week of a
negative CST (i.e., the false-negative rate) to be
less than 1 per 1000.
50
51. MANAGEMENT PROTOCOL OF CST
Positive CST is usually repeated in 24 hours .
This is of historical importance .
Not used now.
53. Nipple stimulation test
Alternative method of performing CST
ACOG Recommends stimulation through light
clothing for two minutes at a time with rest
interval of five minutes.
Adequate uterine contractions obtained with in
four minutes of stimulation.
53
54. DOPPLER VELOCIMETRY
Noninvasive technique to assess blood flow by
characterizing downstream impedance
Three fetal and one maternal vascular circuits :-
Umbilical artery,
Middle cerebral artery
Ductus venosus
Uterine artery
54
56. UTERINE ARTERY
INDICATIONS
(1) history of Preeclampsia
(2) previous child with IUGR
(3) unexplained high maternal
serum alpha-fetoprotein level
(4) high human chorionic gonadotropin
level.
(5) thrombophilias
56
57. The indices used to
quantify uterine artery
systolic (S) to diastolic (D) velocity ratio (S/D)
pulsatility index (PI)
resistive index (RI)
early diastolic notching.
Abnormalities in these indices are defined as PI or RI
above a chosen value and/or percentile
the presence of unilateral or bilateral diastolic notches
57
58. How to calculate indices S/D ratio
systolic peak velocity/diastolic peak velocity
Resistance index (RI)
systolic- end diastolic peak velocity/systolic peak
velocity
Pulsatility index (PI)
systolic-end diastolic peak velocity/time averaged
maximum −velocity
58
59. Uterine Doppler screening is commonly performed
around 20 weeks.
increased uterine artery impedance to flow at 20–
24 weeks follow-up at 26–28 weeks.
Cut-off values at 23 weeks' gestation are:-
a mean PI above 1.5–1.61.
mean RI above 0.57–0.58.
Bilateral notches are found in about 25–30% of
pregnancies at 12 weeks.
10–15% at 20 weeks .
5% at 24 weeks.
60. sensitivity is up to 85% when performed between
22 and 23 weeks’ gestation.
high risk patients given low-dose aspirin because
of bilateral uterine artery notching at 12 to 14 weeks
have an 80% reduction of placental disease
60
61. An early diastolic notch in the uterine arteries at
12 to 14 weeks suggest delayed trophoblast
invasion.
Persistence “notching” beyond 24 weeks
confirmatory evidence.
61
63. sensitivities and specificities of uterine artery Doppler
in low-risk populations varied from 34% to 76% and
83% to 93%, respectively.
63
64. For both preeclampsia and IUGR uterine
artery Doppler more accurate in the second
than the first trimester.
Increased PI with notching in the second
trimester best predictor of preeclampsia.
64
68. FACTS SHEET RI had the best discriminatory
ability when compared with the S/D ratio (P<.05),
the PI (P<.001).
S/D ratio, however, remains the most popular
index.
S/D ratio less than or equal to 3.0.
Resistance index less than or equal
to 0.6 is considered normal after 27 completed
weeks of pregnancy.
Benefits of this technique before 28 weeks of
gestation are uncertain.
68
69. Diagnostic feature of umbilical artery Doppler
waveform is the end diastolic flow.
Absent or reverse end diastolic flow ominous
finding.
frequency of absent end diastolic flow is
approximately 2% in high-risk pregnancies .
0.3% in a general obstetric population.
In pregnancies complicated with FGR, fetal
surveillance should consist of weekly umbilical
Doppler.
.
69
70. BPP or NST should be used either as a backup
test or simultaneously with the umbilical
artery Doppler.
Umbilical Doppler index is high or increasing
weekly umbilical Doppler ultrasound
+
Twice wkly NST/ BPP
70
71. MANAGEMENT WITH ABSENT END DIASTOLIC FLOW
Guided by the gestational age.
>34 completed weeks Delivery
Bw 28 to 34 completed conservative
Daily umbilical artery Doppler, NST, and BPP (or modified
BPP)+ Ductus venosus
Reverse flow at any gestational age beyond 28 weeks
Delivery
71
72. MIDDLE CEREBRAL ARTERY
Two major applications
Monitoring of IUGR fetuses
Evaluate peak systolic flow in fetuses at risk for
anaemia.
72
74. Contrast to fetuses with normal growth
Resistance of the MCA is usually higher than in
the umbilical artery.
MCA Doppler useful to monitor the third-
trimester growth restricted Fetus.
Redistribution may occur in the presence of
normal umbilical Doppler.
RI and PI on MCA Doppler in IUGR fetuses
74
75. TECHNIQUE
Measured at internal third of the vessel
50 to 100 waveforms in at least 3 sets examined.
Impedance to flow decreases and maximum blood
velocity increases with advancing gestation.
75
76. MCA-PSV new development.
better parameter in the prediction of perinatal
mortality than PI/RI.
MCA PI in IUGR fetuses can normalize in later stages.
MCA-PSV becomes abnormal, remains as such.
Ratio of MCA PI to Umbilical PI >1.5
in normal fetal circulatory condition.
76
79. Anemic fetus increased cardiac output
Associated with lower blood viscosity.
So increased blood velocities
Peak velocity in the fetal MCA
value of greater than 1.5(MoMs) for the corresponding
GA
79
81. MCA-PSV for the prediction of severe,
moderate, and mild anemia at a
sensitivity of 100% showed false-positive
rates of 6%, 37%, and 70%, respectively
Measurements can be obtained reliably
as early as 18 weeks’ gestation.
Repeated every 1 to 2 weeks depending
on the trend.
Values after 35wks higher rate of false-
positive results
81
82. Ductus Venosus
Connects the intra-abdominal portion of the umbilical
vein with the inferior vena cava at its inlet to the right
atrium.
Shunt plays a critical role in the delivery of well-
oxygenated blood to the left side of fetal heart.
Sample siteInlet, where the highest velocities are
recorded
waveform of the ductus venosus triphasic.
82
84. Blood flow in the ductus venosus is usually
forward in physiological conditions.
In the 11–14 weeks, a negative a-wave may be
recorded in about 3% of normal fetuses.
Absolute blood flow velocities increase,
whereas the pulsatility decreases with
advancing gestation.
This reflecs decreasing cardiac afterload and
maturation of diastolic ventricular function.
84
85. IUGR <32 progressive increase in ductus venosus
pulsatility paralleled by decrease of short time
variation of the fetal heart rate pattern.
Parameters normal in late-onset growth restriction.
Primary value in early-onset FGR.
Perinatal mortality increases to 38.8% when venous
Doppler indices become abnormal.
85
86. Management goals & protocol Prevention of stillbirth
Delivery based on an accurate assessment of fetal versus
neonatal risks.
Abnormal venous Doppler indices, mandate higher
testing frequency, up to daily testing.
Reversal of DV a wave increases the risk for an abnormal
biophysical profile score within 1 to 8 days.
Reversal of DV a wave only becomes an independent risk
factor for neonatal morbidity and mortality after 27
weeks’ gestation.
86
87. Tests for fetal lungs maturity
1. L/S ratio(>2)
2.Shake or bubble test
3.foam stability index
4.phosphatidyl glycerol
5.amniotic fluid optical density.
6.lamellar body count (>30000/micl
7.amniotic fluid turbidity test
8. Nile blue sulphatase test
87
88.
89. GOAL
The timely identification and rescue of the fetus at
risk of neonatal and long term morbidity from
intrapartum hypoxic insult
92. TECHNICAL CONSIDERATIONS
Basis for FHR monitoring is beat to beat recording
For practical purposes ,this is possible only when
direct fetal electrocardiograms are recorded with a
scalp electrode.
93. Internal FHR monitoring-
Spiral electrode attatched to the fetal scalp with a
connection to FHR monitor.
The fetal membranes must be ruptured, and the cervix
must be at least partially dilated before the electrode
may be placed on the fetal scalp.
94. Intermittent auscultation
In uncomplicated pregnancies .
Doppler better than stethoscope.
Every 15 - 30 minutes in active phase of first stage and every 5
minutes in second stage
Listen in the absence of active pushing and toward the end of the
contraction and at least for 30seconds after each contraction
CONTINUOUS EFM
No benefit in low risk
Continuous EFM -when risk factors for present
Every 15 minutes in first stage and every 5 minutes during the
second stage.
95. Fetal Assessment : IA & EFM
Surveillence
Acceptable methods
Low-Risk
Pregnancies
High-Risk
Pregnancies
Intermittent Auscultation* Yes Yes (a)
Continuous Electronic Fetal
Monitoring (EFM)
Yes Yes (b)
Evaluation Intervals
First-stage Labour 30 min 15 min (a,b)
Second –stage labour 15 min 5 min (a,c)
•a- before, during and especially after a contraction for 60 sec
•b- includes evaluation in every 15 min
• c- evaluation in every 5 min
97. Risk factors during labour-
Prolonged rupture of membranes (> 24 hours)
Meconium-stained or blood-stained liquor
Fetal bradycardia
Fetal tachycardia
Maternal pyrexia > 38 ˚C
Chorioamnionitis
Vaginal bleeding in labour
• Prolonged second stage of labour .
98. Other indications
Any use of oxytocin whether for induction or for
augmentation of labour
Before and for at least 20 minutes after administration
of prostaglandin
Epidural analgesia (immediately after inserting an
epidural block)
100. External fetal monitoring
BASELINE
The mean FHR rounded to increments of 5 bpm during a 10-
minute segment, excluding:
—Periodic or episodic changes
—Periods of marked FHR variability
—Segments of baseline that differ by more than 25 bpm
The baseline must be for a minimum of 2 minutes in any
10-minute segment
Normal : 110–160 bpm
Tachycardia: > 160 bpm
Bradycardia: <110 bpm
101. FETAL HEART RATE MONITORING
Baseline Variability
Fluctuations in the baseline FHR that are irregular in
amplitude and frequency
Visually quantitated as the amplitude of peak-to-
trough in bpm.
Absent—amplitude range undetectable
Minimal—0 to5 bpm
Moderate (normal) — 6 to 25 bpm
Marked—> 25 bpm
102. Short term variability – small changes in fetal beat to
beat intervals under physiological conditions
Long term variability- certain periodicity in the
direction and size of these changes causes oscillations
of fetal heart rate around mean level
106. ACCELERATION
A visually apparent abrupt increase in the FHR
<32 weeks: >10 BPM above baseline for >10 sec
>32 weeks: >15 BPM above baseline for > 15 sec
Prolonged acceleration lasts >2 min but <10 min in
duration.
If an acceleration lasts 10 min or longer, it is a baseline
change
107. Early Deceleration
Symmetrical gradual decrease and return of the FHR
associated with a uterine contraction
The nadir of the deceleration occurs at the same time
as the peak of the contraction.
In most cases the onset, nadir, and recovery of the
deceleration are coincident with the beginning, peak,
and ending of the contraction, respectively
108. Caused by fetal head compression
by uterine cervix
Usually seen between 4 and 6 cm of
dilation
109. Late Deceleration
Symmetrical gradual decrease and return of the FHR
associated with a uterine contraction
The deceleration is delayed in timing, with the nadir of
the deceleration occurring after the peak of the
contraction.
In most cases, the onset, nadir, and recovery of the
deceleration occur after the beginning, peak, and
ending of the contraction, respectively
111. Variable Deceleration
Visually apparent abrupt decrease in FHR
The decrease in FHR is ≥ 15 bpm , lasting ≥ 15 sec, and
<2 minutes in duration.
When variable decelerations are associated with
uterine contractions, their onset, depth, and duration
commonly vary with successive uterine contractions.
112. TYPES
Typical
Atypical
Slow return to baseline
Prolonged secondary rise in baseline
Loss of variability during deceleration
Continuation at lower baseline
113. Classification of the severity of
variable deceleration
MILD-
Deceleration of a duration of <30sec , regardless of
depth
Deceleration not below 80bpm , regardless of
duration
MODERATE- Deceleration with a level <80bpm
SEVERE- Deceleration to a level <70bpm for >60sec
114. Prolonged Deceleration
Decrease from baseline that is 15 bpm or more, lasting
≥ 2 min but <10 min
If lasts 10 minutes or longer, it is a baseline change
Causes-prolonged cord compression,prolonged
uterine hyperstimulation,severe degree of
abruptio,eclamptic seizure,following conduction
anaesthesia
115. SINUSOIDAL PATTERN
Visually apparent, smooth, sine wave-like undulating
pattern in FHR baseline with a cycle frequency of 3–5
per minute which persists for 20 min or more.
Indicates
severe fetal anemia as occurs in
Rh isoimmunization
Feto maternal hemorrhage
Twin twin transfusion syndrome
severe hypoxia
117. Three-Tiered Fetal Heart Rate
Interpretation System
Category I- NORMAL acid base status
• Baseline rate: 110–160 bpm
• Moderate Baseline FHR variability
• No Late or variable decelerations
• Early decelerations:
• Accelerations: +
Category II-INDETERMINATE not categorized as Category I or III.
Category III-ABNORMAL acid base status-Intervention
• Absent baseline FHR variability and any of the following:
—Recurrent late decelerations
—Recurrent variable decelerations
—Bradycardia
• Sinusoidal pattern
118.
119. RCOG CLASSIFICATION
BASELINE VARIABILITY DECELERATIO
N
ACCELERATIO
N
REASSURING 110-160 ≥ 5 bpm None present
NON
REASSURING
100-109
161-180
< 5 for ≥40 min
but <90 min
Early decel;
typical variable;
single prolonged
≤ 3min
ABNORMAL <100
>180
sinusoidal ≥ 10
min
< 5 for ≥90 min Late decel;
atypical variable;
single prolonged >
3min
120. Ancillary tests that can aid in the management of
Category II or Category III FHR tracings-
Four techniques are available to stimulate the fetus:
1)fetal scalp sampling,
2) Allis clamp scalp stimulation,
3) vibroacoustic stimulation, and
4) digital scalp stimulation
121. Standard interventions for NRFS -
Supplemental oxygen
Discontinuation of any labor stimulating agent
Changing maternal position
Resolution of maternal hypotension-hydration.
P/V to determine umbilical cord prolapse, rapid
cervical dilation, or descent of the fetal head,ARM
Assessment of uterine contraction .
Tocolytics-in tachysystole with associated FHR
changes.
When the FHR tracing includes recurrent variable
decelerations -Amnioinfusion
122.
123. MANAGMENT
Suspicious CTG-
If inadequate quality-check contact and connections
If hypercontractility-discontinue oxytocin, consider
tocolytics
Maternal tachycardia,pyrexia,dehydration, hypotension
Supine? Epidural? sedation? drugs?
i/v crystalloid bolus; 10 L/min O2
If persistent → do ancillary tests
Pathological CTG
FBS if feasible
If not feasible-expedite delivery (within 30 min)
124. Effects of Medications on FHR
Patterns
Narcotics-
decreased variability and accelerations
Corticosteroids-
Decreased variability (with beta-methasone but not dexamethasone)
Magnesium sulfate-
A significant decrease in short-term variability, clinically insignificant
decrease in FHR inhibits the increase in accelerations with advancing
gestational age
Epidural analgesia-
decreased variability and accelerations
Terbutaline-
Increase in baseline FHR
125. FETAL SCALP PH
In women with "abnormal“ fetal heart rate tracings .
Cervix needs to be 4-5cm dilated and Vx at -1 st or
below
pH <7.20 –fetal acidosis: deliver
pH 7.20-7.25 – borderline, repeat in 30 min or deliver if
rapid fall
pH > 7.25 – reassuring, repeat if FH abnormality
persists
Greater utility of scalp pH is in its high negative
predictive value (97–99%).
128. FETAL PULSE OXIMETRY
Acidosis: O2 sat. <30% for >2min
Approved by FDA for use in fetuses with NRFS in May
2000
The ACOG currently recommends against its use until
further studies are available to confirm its efficacy and
safety
Insufficient evidence for its use as an adjunct or
independent of electronic fetal surveillance.
129. FETAL SCALP LACTATE TESTING
Higher sensitivity and specificity than scalp pH
> 4.8 mmol/L : acidosis
Clinical trial that compared the use of scalp pH to
scalp lactate level did not demonstrate a difference in
the rate of acidemia at birth, Apgar scores, or neonatal
intensive care unit admissions
Not recommended for routine use
130. ST WAVEFORM ANALYSIS
Method: STAN S31 fetal heart monitor(USFDA)
Scalp electrodes
The electrical fetal cardiac signal – P wave, QRS
complex, and T wave – is amplified and fed into a
cardiotachometer for heart rate calculation
131. Restrict fetal ST waveform analysis to those with non
reassuring fetal status on EFM
The use of ST waveform analysis for the intrapartum
assessment of the compromised fetus is not recommended
for routine use at this time.