This document discusses several blood pressure and heart disorders. It defines key terms like pulse, blood pressure, and how blood pressure is measured. It then summarizes various disorders including hypotension (low blood pressure), hypertension (high blood pressure), coronary artery disease, congenital heart defects, congestive heart failure, heart fibrillation, thrombus vs. embolus, thrombocytopenia, and hemophilia. Causes and characteristics of each condition are provided.
The short circuit that causes a heart attack.Jia Maheshwari
What happens when you get a heart attack? It could be either a disease of the valves or akin to a short circuit, where there are spikes or less elasticity, calcification or thickening of walls etc. Knowing about heart abnormalities can help you take care of your heart better.
The short circuit that causes a heart attack.Jia Maheshwari
What happens when you get a heart attack? It could be either a disease of the valves or akin to a short circuit, where there are spikes or less elasticity, calcification or thickening of walls etc. Knowing about heart abnormalities can help you take care of your heart better.
Atherosclerosis is an intima-based lesion organized into a fibrous cap and an atheromatous (gruel-like) core and composed of SMCs, ECM, inflammatory cells, lipids, and necrotic debris.
Atherogenesis is driven by an interplay of inflammation and injury to vessel wall cells.
Atherosclerotic plaques accrue slowly over decades but may acutely cause symptoms due to rupture, thrombosis, hemorrhage, or embolization.
Risk factor recognition and reduction can reduce the incidence and severity of atherosclerosis-related disease.
Endothelial function can be improved after successful periodontal treatment
Normal Heart
Fist size muscular pump
Pumps 6000 lit of blood daily
Perfuses
tissues with nutrients and
Facilitates
removal of waste products.
Heart diseases
Have severe physiologic consequences
Are leading cause of morbidity and mortality in developed nations
750,000 deaths/ year (In US
Atherosclerosis is an intima-based lesion organized into a fibrous cap and an atheromatous (gruel-like) core and composed of SMCs, ECM, inflammatory cells, lipids, and necrotic debris.
Atherogenesis is driven by an interplay of inflammation and injury to vessel wall cells.
Atherosclerotic plaques accrue slowly over decades but may acutely cause symptoms due to rupture, thrombosis, hemorrhage, or embolization.
Risk factor recognition and reduction can reduce the incidence and severity of atherosclerosis-related disease.
Endothelial function can be improved after successful periodontal treatment
Normal Heart
Fist size muscular pump
Pumps 6000 lit of blood daily
Perfuses
tissues with nutrients and
Facilitates
removal of waste products.
Heart diseases
Have severe physiologic consequences
Are leading cause of morbidity and mortality in developed nations
750,000 deaths/ year (In US
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. (1) Pulse
• Pressure wave that travels through arteries
– Result of contraction and relaxation of artery
– Pulse Rate should = Heart Rate
• Could vary if blood vessel filled with fatty deposits or
damaged interior walls
3. (2) Blood Pressure
• Pressure blood exerts against vessel walls
• Keeps blood circulating
• Ventricles Contract:
– Blood forced into arteries
– Arteries expand as blood travels through
– Blood moves high low pressure
• Blood continues to move into areas without blood
• Eventually moves back to heart (when heart empties
out)
4. (3) Measuring Blood Pressure
•
Systolic Pressure
– Pressure in arteries
– Peak of ventricular contraction
•
Diastolic Pressure
– Pressure in ventricles
– Relaxed ventricles
•
Measuring Blood Pressure
1. Cuff is inflated/tightened until cuff pressure is greater than systolic
pressure
2. Blood flow in arm ceases
3. No pulse (heard + felt)
4. Pressure in cuff is reduced listen for pulse sounds
5. Systolic Blood Pressure = first soft tapping sounds
6. Diastolic Blood Pressure = no more tapping sounds, constant flow
7. Expressed: “Systolic over Diastolic”
5.
6. (4) Hypotension
• Low blood pressure
• Systolic = 100 and under
• Causes:
– Increase in fitness
– Change in body position and circulation of
blood pressure (sitting standing)
– Poor nutrition (decreased viscosity)
– Blood loss
7. (5) Hypertension
• High blood pressure
• Systolic = 140 and over
• Causes:
– Damaged arterial walls
– Fatty deposits
– Increased viscosity of blood
– Increased stress
8. (6) Coronary Artery Disease
• Blood vessels fill with fat + calcium
deposits
• Constricts inner volume of blood vessels
• Severely increases pressure within blood
vessels
• Can build up + not allow blood flow
9.
10. (7) Congenital Heart Defect
• Common in infants
• Causes:
– Maternal infection
– Drugs
• Defects:
– Valves do not open/close properly
– Septum separating right + left side may not be
complete
– Missing chambers/arteries
11.
12. (8) Congestive Heart Failure
• Weaking of heart + blood vessels:
– Common in older + unhealthy individuals
• Pumping efficiency decreased:
– Decrease in blood flow
– Decrease in muscle contraction
• Vessels most likely clogged with fat + calcium:
– Leads to straining of heart muscle
– Damage to vessels scar tissue in repair
13. (9) Heart Fibrillation
• Rapid uncoordinated
shuddering/pulsing of heart muscle
– Does not allow for proper pumping of blood
– Major cause of heart attack + death in
adults
• Tachycardia = rapid heart rate
• Brachycardia = slowed heart rate
14.
15. (10) Thrombus vs. Embolus
• Thrombus Clot in wall of blood vessel
• Embolus Free Floating Thrombus
• Causes:
– Rough blood vessel tissue from burns,
ruptures, fat.
– Slow blood flow (low levels of activity)
• Aspirin: Common over the counter
anticoagulant.
16.
17.
18. (11) Thrombocytopenia
(Hemostatic Disorder)
• Low platelet count & Slow Clotting
Rate
• Typical of bone marrow cancer and/or
radiation patients.
• Caused by damaged liver Cannot
make clotting factors.
