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TRANSPORT IN HUMANS
Anatomy & Physiology of Heart
Anatomy & Physiology of Heart
How does human heart work?
How do the heart valve’s work?
• The valves respond to pressure changes
during a cardiac cycle.
• Tricuspid
• Bicuspid
• Semi-lunar
• Systole
• Diastole
Heartbeats
Heartbeat
• 3 main stages
Atrial systole
Ventricular systole
Diastole
Ekg
Normal EKG
Abnormal EKG
Tachycardia (heart rate of over 100 beats)
Abnormal EKG
Ventricular fibrillation-
interference with rhythmic
contractions of ventricles, lead to
cardiac arrest
Abnormal EKG
Heart block – failure of
stimulation to ventricles
following contraction of atrial.
Another ways of measuring heartbeat
• The pulse..
• During systole, heart pumps blood into the
arteries.
• Produces a pressure in the blood vessels that
is felt as a pulse in the blood vessels close to
the skin.
THE HEART
Human Heart
• 4 chambers:
- 2 atria (thin-walled)
- 2 ventricles (thick- walled)
• Veins: deoxygenated blood except pulmonary vein
• Arteries: Oxygenated blood except pulmonary artery
• Valves: They stop blood flowing backwards.
• Coronary arteries: They supply the heart muscle with
food and oxygen.
Human heart
Valves of the heart
CONTROL OF THE HEART BEAT
• At rest: normal heart rate, 50-100 beats per
minutes.
• During exercise: 200 beats/min
• The heart beat is initiated by the pacemaker, a
small group of specialized muscles cells at the
top of the right atrium.
Control of the heart beat
• Blood pressure ↑ ↓ heart rate
• Blood pressure ↓
↑ heart rate
• ↓ O₂ concentration
• ↑ CO₂ concentration
• Hormone adrenaline
THE CIRCULATION
CIRCULATION
BLOOD VESSELS
Blood vessels
Function Structure of wall Width of lumen
ARTERIES Carry blood away from
the heart
Thick and strong,
containing muscles and
elastic tissue.
Relatively narrow, it
varies with heart beat, as
it can stretch and recoil.
CAPILLARIES supply all cells with their
requirements and take
away waste products.
Very thin, only one cell
thick.
Very narrow, just one cell
can pass through.
VEINS Return blood to the heart Quite thin, containing
less muscle and elastic
tissue.
Wide, contains valves
Arteries, veins: hystology
CORONARY HEART DISEASES
ATHEROMA and THROMBOSIS
Possible causes of coronary heart
diseases
• SMOKING
• FATTY DIET
• STRESS
• LACK OF EXERCISE
• OBESITY
• GENES
COMPOSITION OF BLOOD
• RED CELLS
• WHITE CELLS
• PLATELETS
floating in a liquid called
PLASMA
COMPOSITION OF BLOOD
COMPOSITION OF BLOOD
RED BLOOD CELLS
• Biconcave discs
• No nuclei
• Spongy cytoplasm enclosed in an elastic cell
membrane
• Red pigment called haemoglobin
• Are made by the red bone marrow of certain
bones in the skeleton: ribs, vertebrae and
breastbone
Red blood cells: hystology
Red bone marrow
HAEMOGLOBIN
Haemoglobin (Hb)
• Hb + O₂ oxyhaemoglobin (OHb)
In places where the O₂ concentration is low, OHb breaks down
and releases its O₂. Where??
• Oxygenated blood : contains mainly OHb.
• Deoxygenated blood : with little OHb.
Oxyhaemoglobin
Red blood cells
After 4 months
Hb Iron
Bilirubin Stored in the liver
Bile
WHITE CELLS
• Different types
• Larger than red cells
• They have nuclei
• They are made in the same bone marrow that
red cells
• The two more numerous types are:
- Phagocytes
- Lymphocytes
White blood cells
White blood cells
White blood cells: Phagocytes
• They collect at the site of an infection,
engulfing (ingesting) and digesting harmful
bacteria. They prevent the spread of infection
through the body.
Phagocytes
White blood cells: Lymphocytes
Production of antibodies (proteins)
PLATELETS
They help to clot the blood
PLASMA
• Ions: sodium, potassium, calcium, chloride,
hydrogen carbonate.
• Proteins: fibrinogen (clotting), albumin and
globulins (antibodies).
• Food substances: aa, glucose and fats.
• Hormones
• Urea
Functions of the blood
• Homeostatic functions
• Transport
• Defence against infections
- Clotting
- White cells
Functions of blood: Transport
Substance From To
Oxygen Lungs Whole body
Carbon dioxide Whole body lungs
Urea liver kidneys
Hormones glands Target organs
Digested food intestine Whole body
Heat (opening and closing of
blood vessels)
Abdomen and muscle Whole body
Blood functions: DEFENCE AGAINST
INFECTIONS
• WHITE CELLS:
- Phagocytes: - at the sites of a wound
- in the blood capillaries
- in lymph nodes
ingest harmful bacteria and stop them entering the
general circulation
- Lymphocytes: Production of antibodies
• CLOTTING
CLOTTING
• When tissue is damaged and blood vessels cut
• Platelets clump together and block the smaller capillaries.
• Fibrinogen fibrin (network of fibres across
the wound)
• Red cells become trapped in this network and form a blood
clot.
↓ entry of harmful bacteria
prevents
further loss of blood
Clotting
Blood clotting
Materials are exchanged between blood and
tissues at the capillaries: tissue fluid is formed
• TISSUE FLUID:
- is formed when blood plasma is squeezed out of
the capillaries.
- contains no blood cells or plasma proteins.
- is returned to the blood.
TISSUE FLUID
LYMPHATIC SYSTEM
Lymphatic system
• Thin-walled vessels called lymphatics.
• They empty their contents into the blood system.
• The fluid is called lymph.
• Most of the lymph flow results from the vessels being
compressed when the body muscles contract in movements
such as walking or breathing.
• There are valves, which force the fluid in one direction:
towards the heart.
• Lymph nodes: storage of lymphocytes. There are also
phagocytes.
• Lymphatic organs: Spleen and thymus
Lymphatic organs: spleen and thymus
SPLEEN: functions
• Remove worn-out red cells, bacteria and cell
fragments from the blood.
• Produce lymphocytes and antibodies.
THYMUS: functions
• Particularly important lymphoid organ in the newborn:
- controls the development of the spleen and the
lymph nodes.
- produces lymphocytes (immunity)
• After puberty , important immunological organ, although it
becomes smaller.
- storage of white cells
- production of a large population of lymphocytes T.
Thankyou
NAME RITESH
CLASS 10-C
ROLL NO. 1020

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Ritesh

  • 4. How does human heart work?
  • 5. How do the heart valve’s work? • The valves respond to pressure changes during a cardiac cycle. • Tricuspid • Bicuspid • Semi-lunar • Systole • Diastole
  • 7. Heartbeat • 3 main stages Atrial systole Ventricular systole Diastole
  • 8. Ekg
  • 10. Abnormal EKG Tachycardia (heart rate of over 100 beats)
  • 11. Abnormal EKG Ventricular fibrillation- interference with rhythmic contractions of ventricles, lead to cardiac arrest
  • 12. Abnormal EKG Heart block – failure of stimulation to ventricles following contraction of atrial.
  • 13. Another ways of measuring heartbeat • The pulse.. • During systole, heart pumps blood into the arteries. • Produces a pressure in the blood vessels that is felt as a pulse in the blood vessels close to the skin.
  • 15. Human Heart • 4 chambers: - 2 atria (thin-walled) - 2 ventricles (thick- walled) • Veins: deoxygenated blood except pulmonary vein • Arteries: Oxygenated blood except pulmonary artery • Valves: They stop blood flowing backwards. • Coronary arteries: They supply the heart muscle with food and oxygen.
  • 17. Valves of the heart
  • 18. CONTROL OF THE HEART BEAT • At rest: normal heart rate, 50-100 beats per minutes. • During exercise: 200 beats/min • The heart beat is initiated by the pacemaker, a small group of specialized muscles cells at the top of the right atrium.
  • 19. Control of the heart beat • Blood pressure ↑ ↓ heart rate • Blood pressure ↓ ↑ heart rate • ↓ O₂ concentration • ↑ CO₂ concentration • Hormone adrenaline
  • 23. Blood vessels Function Structure of wall Width of lumen ARTERIES Carry blood away from the heart Thick and strong, containing muscles and elastic tissue. Relatively narrow, it varies with heart beat, as it can stretch and recoil. CAPILLARIES supply all cells with their requirements and take away waste products. Very thin, only one cell thick. Very narrow, just one cell can pass through. VEINS Return blood to the heart Quite thin, containing less muscle and elastic tissue. Wide, contains valves
  • 27. Possible causes of coronary heart diseases • SMOKING • FATTY DIET • STRESS • LACK OF EXERCISE • OBESITY • GENES
  • 28. COMPOSITION OF BLOOD • RED CELLS • WHITE CELLS • PLATELETS floating in a liquid called PLASMA
  • 31. RED BLOOD CELLS • Biconcave discs • No nuclei • Spongy cytoplasm enclosed in an elastic cell membrane • Red pigment called haemoglobin • Are made by the red bone marrow of certain bones in the skeleton: ribs, vertebrae and breastbone
  • 32. Red blood cells: hystology
  • 35. Haemoglobin (Hb) • Hb + O₂ oxyhaemoglobin (OHb) In places where the O₂ concentration is low, OHb breaks down and releases its O₂. Where?? • Oxygenated blood : contains mainly OHb. • Deoxygenated blood : with little OHb.
  • 37. Red blood cells After 4 months Hb Iron Bilirubin Stored in the liver Bile
  • 38. WHITE CELLS • Different types • Larger than red cells • They have nuclei • They are made in the same bone marrow that red cells • The two more numerous types are: - Phagocytes - Lymphocytes
  • 41. White blood cells: Phagocytes • They collect at the site of an infection, engulfing (ingesting) and digesting harmful bacteria. They prevent the spread of infection through the body.
  • 43. White blood cells: Lymphocytes Production of antibodies (proteins)
  • 44. PLATELETS They help to clot the blood
  • 45. PLASMA • Ions: sodium, potassium, calcium, chloride, hydrogen carbonate. • Proteins: fibrinogen (clotting), albumin and globulins (antibodies). • Food substances: aa, glucose and fats. • Hormones • Urea
  • 46.
  • 47. Functions of the blood • Homeostatic functions • Transport • Defence against infections - Clotting - White cells
  • 48. Functions of blood: Transport Substance From To Oxygen Lungs Whole body Carbon dioxide Whole body lungs Urea liver kidneys Hormones glands Target organs Digested food intestine Whole body Heat (opening and closing of blood vessels) Abdomen and muscle Whole body
  • 49. Blood functions: DEFENCE AGAINST INFECTIONS • WHITE CELLS: - Phagocytes: - at the sites of a wound - in the blood capillaries - in lymph nodes ingest harmful bacteria and stop them entering the general circulation - Lymphocytes: Production of antibodies • CLOTTING
  • 50. CLOTTING • When tissue is damaged and blood vessels cut • Platelets clump together and block the smaller capillaries. • Fibrinogen fibrin (network of fibres across the wound) • Red cells become trapped in this network and form a blood clot. ↓ entry of harmful bacteria prevents further loss of blood
  • 53. Materials are exchanged between blood and tissues at the capillaries: tissue fluid is formed • TISSUE FLUID: - is formed when blood plasma is squeezed out of the capillaries. - contains no blood cells or plasma proteins. - is returned to the blood.
  • 56. Lymphatic system • Thin-walled vessels called lymphatics. • They empty their contents into the blood system. • The fluid is called lymph. • Most of the lymph flow results from the vessels being compressed when the body muscles contract in movements such as walking or breathing. • There are valves, which force the fluid in one direction: towards the heart. • Lymph nodes: storage of lymphocytes. There are also phagocytes. • Lymphatic organs: Spleen and thymus
  • 58. SPLEEN: functions • Remove worn-out red cells, bacteria and cell fragments from the blood. • Produce lymphocytes and antibodies.
  • 59. THYMUS: functions • Particularly important lymphoid organ in the newborn: - controls the development of the spleen and the lymph nodes. - produces lymphocytes (immunity) • After puberty , important immunological organ, although it becomes smaller. - storage of white cells - production of a large population of lymphocytes T.