AIDS was first reported in 1981 and has since killed over 25 million people worldwide. It is caused by the HIV virus, which was likely transmitted to humans from chimpanzees in Central Africa. HIV targets and destroys CD4+ T cells of the immune system, ultimately weakening the body's ability to fight infections and disease. While drug cocktails can suppress HIV and prolong life, there is currently no cure as the virus is highly mutable and exhibits frequent antigenic variations. Researchers are exploring immunotherapy and stem cell gene therapy approaches to achieve a permanent cure for AIDS.