This document summarizes different types of aerosol delivery systems including metered dose inhalers, dry powder inhalers, and nebulizers. It provides details on popular brand names, pharmacology, dosing, and contraindications of common medications delivered via these systems. The key types of aerosol delivery devices covered are metered dose inhalers, dry powder inhalers, and nebulizers. Specific drugs discussed include beclometasone, ipratropium bromide, salbutamol, fluticasone propionate, and acetylcysteine.

1. Presentation on
1
AEROSOL
PRESENTED BY
Md. Hamidul Kowsar
Dept. of Pharmacy
State University of Bangladesh

2. The three principle types of devices widely used
are :-
 Metered Dose Inhalers(MDI)
 Dry Powder Inhalers (DPI)
 Nebulizers
AEROSOL DELIVERY SYSTEM

3. METERED-DOSE INHALER (MDI)
BECLOMETASONE
Brand Name Company Name
ASCON-250 HFA The Acme Laboratories Ltd.
AZBEC Eskayef Bangladesh Ltd.
BECLOCORT-HFA Aristopharma Ltd.
BECLOMIN-HFA 100 Square Pharmaceuticals Ltd.
DECOMIT-100HFA Beximco Pharmaceuticals Ltd
STERADIN-HFA 250 INH ACI Ltd.

4. Pharmacology action :-
•Beclometasone controls the rate of protein synthesis, depresses the
migration of polymorphonuclear leukocytes, fibroblasts, reverses
capillary permeability and lysosomal stabilisation at the cellular level to
prevent or control inflammation.
Dose :-
Adult: Initially, 600-800 mcg daily. Maintenance: 400 mcg
daily in 2-4 divided doses.
Child: 50 or 100 mcg bid-qid or 100 or 200 mcg bid.
Function :-
Beta-2 agonist ; Antiasthmatic
Contraindication :-
Hypersensitivity

5. METERED-DOSE INHALER (MDI)
IPRATROPIUM + SALBUTAMOL
Brand Name Company Name
IPRASOL Beximco
Pharmaceuticals Ltd.
SALPIUM ACME Laboratories Ltd.
SULPREX Square Pharmaceuticals
Ltd.
SULPREX Square Pharmaceuticals
Ltd.

6. Pharmacology action :-
−Ipratropium bromide has anticholinergic (parasympatholytic)
properties. In preclinical studies, it appears to inhibit vagally
mediated reflexes by antagonising the action of acetylcholine, the
transmitter agent released from the vagus nerve.
−The bronchodilation following inhalation of ipratropium bromide
is primarily local and site specific to the lung and not systemic in
nature.
Dose :-
Initially, 3 ml every 6 hr. Max: 3 ml every 4 hr.
Chronic obstructive pulmonary disease
Function :-
Contraindication :-
Tachyarrhythmia

7. Metered-Dose Inhaler (MDI)
FLUTICASONE + SALMETEROL
Brand Name Company Name
AROFLO-125 HFA Aristopharma Ltd.
AROTIDE 25/125 INHALER Eskayef Bangladesh Ltd
AXINAT-F Inhaler 125 The Acme Laboratories Ltd.
BEXITROL F HFA60 Beximco
SEROXYN 25/125 ACI Ltd.

8. Pharmacology action :-
−Salmeterol, a long acting -agonist which acts locally in
the lung to mediate bronchodilation. Fluticasone, a
corticosteroid with mainly glucocorticoid activity, reduce
symptoms and exacerbations of asthma.
Dose :-
Salmeterol 50 mcg and fluticasone propionate
100/250/500 mcg/dose of inhalation powder:
Function :-
Asthma; Chronic obstructive pulmonary disease (COPD)
Contraindication :-
Hypersensitivity

9. METERED-DOSE INHALER (MDI)
SALBUTAMOL
Brand name Company name
AZMASOL Beximco Pharmaceuticals Ltd.
AZMASOL HFA Beximco Pharmaceuticals Ltd.
SALMOLIN ACME Laboratories Ltd.
SALMOLIN-200 Cosmic Chemical Industries Ltd .
SALOMAX 100 Eskayef Bangladesh Ltd

10. −After inhalation, salbutamol reaches the lungs directly and acts
within 3-5 minutes with a peak at 15-20 minutes. Overall duration
of action of salbutamol is 4-6 hours.
Pharmacology action :-
Dose :-
−Each inhalation contains 100 microgram salbutamol
in HFA (hydrofluoroalkane) propellant
Function
−Bronchodilator. Relieve bronchospasm in bronchial asthama,
chronic bronchitis, emphysema and other airway resistance
diseases.
Contraindication :- Hypersensitivity

11. Dry Powder Inhaler (DPI)
SALBUTAMOL
Brand name Company name
SALMOLIN-200 Cosmic Chemical Industries
Ltd .
SULTOLIN Square Pharmaceuticals
Ltd.

12. −After inhalation, salbutamol reaches the lungs directly and
acts within 3-5 minutes with a peak at 15-20 minutes. Overall
duration of action of salbutamol is 4-6 hours.
Pharmacology action :-
Dose
:-−Each inhalation contains 100 microgram salbutamol in HFA
(hydrofluoroalkane) propellant
Function :-
−bronchodilator. relieve bronchospasm in bronchial asthama,
chronic bronchitis, emphysema and other airway resistance
diseases.
Contraindication :-Hypersensitivity

13. NEBULIZERS
Generic name Brand name Company name
Acetylcysteine Mucomist® Beximco Pharmaceuticals Ltd.
SALBUTAMOL VENTOLIN GlaxoSmithKline Bangladesh
Ltd.

14. −Decreases thickness of mucous secretions in lung; protects
the liver by maintaining or restoring glutathione levels or by
acting as an alternate substrate for conjugation with, and thus
detoxification of, the acetaminophen reactive metabolite.
Pharmacology action :-
Acetylcysteine 200 mgc
Dose :-
Each inhalation contains 100 microgram
salbutamol in HFA (hydrofluoroalkane) propellant
Function :-
Contraindication :-
Acetylcysteine -- Chronic bronchopulmonary disease
SALBUTAMOL-Bronchospasm; Exercise-Induced Bronchospasm
Acetylcysteine - Hypersensitivity
SALBUTAMOL- Dyspepsia

15. Nasal Spray
Fluticasone
Brand Name Company Name
Flixonase GlaxoSmithKline
Bangladesh Limited
Flonaspray Square Pharmaceuticals Ltd.
Flutica Aristopharma Ltd.
Fluticon The Acme Laboratories Ltd
Fluvate Spry Opsonin Pharma Limited
Fluvent ACI

16. Pharmacology action :-
−Fluticasone utilises a fluorocarbothioate ester linkage at the C17
position. It has potent vasoconstrictive and anti-inflammatory
activity, but weak HPA inhibitory effect when applied topically.
Dose :-
Adult : As powder or aerosol: 100-250 mcg ,
up to 500-1000 mcg
Child : As powder or aerosol: >4 yr: Initially,
50-100 mcg bid. May increase to 200 mcg,
Function :- Asthma prophylaxis
Contraindication :- Nosebleeds may occur

17. Thanks to all
Any Question ?