Active transport moves molecules or ions against their concentration gradient using energy. There are two types: primary active transport which directly uses ATP as an energy source, and secondary active transport which uses the concentration gradient of another substance like sodium. Primary active transport examples include the sodium-potassium pump and calcium pumps. Secondary active transport occurs by co-transport or counter-transport using the sodium gradient. Passive diffusion requires no energy and occurs down a gradient, while active transport is an uphill process requiring a carrier protein and energy. Vesicular transport involves endocytosis which brings substances into cells through pinocytosis or phagocytosis, and exocytosis which releases substances from cells.
The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle—is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate—derived from carbohydrates, fats, and proteins—into carbon dioxide.
The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle—is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate—derived from carbohydrates, fats, and proteins—into carbon dioxide.
The plasma membrane, which is also called the cell membrane, has many functions, but the most basic one is to define the borders of the cell and keep the cell functional.
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Lec # 5-movement of molecules accross the membranesoft worker
What molecules move across the cell membrane?
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Active Transport : Primary and secondary transport ppt.pptxLife sciences
This file is uploaded for your education purpose and This presentation name is Active transport. And it's types
Primary and secondary transport
Sodium glucose transporter
Potassium Pump
The control of respiration seems to be based on the following factors:
a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms.
b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The control of respiration seems to be based on the following factors:
a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms.
b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The Chemical Control of Respiration
As already pointed out the role of anoxemia is concerned with a direct depressing influence of oxygen lack on the respiratory cells of the medulla, and an opposing excitatory effect upon chemoreceptors in the carotid body whose stimulation results in reflex augmentation of respiration. The respiratory neurones of the medulla, however, are extremely sensitive to variations in the CO2 tension of the blood and somewhat less so to any other acids. In both cases the stimulatory effect concerns
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Brain is covered by meninges, CSF is fluid present in subarachnoid space
It has a protective function
Peripheral nervous system consists of cranial nerves and spinal nerves
There are 12 pairs of cranial and 31 pairs of spinal nerves Spinal cord is present in the vertebral canal of vertebral column, surrounded by the meninges and there is CSF present in subarachnoid space.
- It is almost cylindrical but in cervical and lower thoracic and lumbar regions it contains fusiform shaped enlargements called cervical enlargements and lumbar enlargements.
In the cervical segments there is more gray matter and also there is more gray matter in the lower thoracic and lumbar region. Cervical segments supply the upper limb i.e. it supplies more muscles, so more gray matter is present. Similarly the lumbar region supplies the lower limb so more gray matter is present in this region.
Just below the lumbar enlargements, spinal cord abruptly tapers, this tapering part is called conus medularis, and it gives attachment to a fibrous thread called filum terminale, which is attached to the back of coccvx.
In the spinal cord on the anterior surface there is anterior median fissure and on the posterior surface is posterior median sulcus. Fissure is much deeper than the sulcus.
Spinal nerves arise from the spinal cord and each spinal nerve has two roots.
1. Ventral (anterior root); which is motor and it contains both somatic and autonomic fibers.
2. Dorsal (Posterior root); is sensory and in the dorsal root there is dorsal root ganglia. It contains sensory neurons which give rise to cell fibers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
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Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
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• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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2. Define active transport and describe its general
mechanism.
Identify the types of active transport(primary and
secondary) and contrast the differences in between.
Give examples for the substances using active
transport as a method of transport
Compare and contrast passive diffusion, facilitated
diffusion and active transport
Brief the mechanism of vesicular transport(exocytosis
& endocytosis)
3. Active transport
When a cell membrane moves molecules or ions “uphill”
against a concentration gradient (or uphill against an
electrical or pressure gradient), the process is called
Active transport.
Types:
Primary active transport
Secondary active transport
4. Substances that use active transport mechanism
Sodium ions
Potassium ions
Calcium ions
Iron ions
Hydrogen ions
Chloride ions
Iodide ions
Urate ions
Several sugars and amino acids
5. Role of Carrier proteins
In active transport, the transport depends on carrier
Proteins that penetrate through the cell membrane
The carrier protein is capable of imparting energy to
the transported substance to move it against the
electrochemical gradient
6. Primary active transport
The energy for the process is derived directly from the
breakdown of adenosine triphosphate (ATP) or of some
other high energy phosphate compound.
Examples:
Na K pump
Primary active transport of Calcium
Primary active transport of Hydrogen ions
8. Carrier protein with 2 globular subunits:
Alpha and beta
Alpha subunit (100,000 mol. Wt.)
(larger)
1.Has 3 receptor sites for Na on inside
2.Has 2 receptor sites for K on outside
3.Inside portion has ATPase activity
Beta subunit ( 55,000 mol. Wt.)
(smaller)
Anchors the protein complex in the
lipid membrane.
Na-K pump…..General Characteristics
9. How the Na K pump works?
Binding of three sodium inside and two potassium
outside activates ATPase function, cleaves ATP , splitting
it to ADP and liberates high energy phosphate bond of energy.
The liberated energy then cause a chemical and conformational
change in protein carrier molecule, extruding the three sodium
out and two potassium to inside.
10. Reverse function of Na K Pump
If the electrochemical gradients for Na and K are
experimentally increased enough,,so that the energy stored in
Their gradients is greater than chemical energy of ATP
hydrolysis, ions will move down their conc gradient and ATP
will be formed from ADP and phosphate.
11. Significance of sodium potassium pump
For some cells such as electrically active nerve cells,
60 to 70% of the cell’s energy requirement may be
devoted to pumping sodium out of cell and K into the
cell
This pump performs a continual surveillance role in
maintaining normal cell volume
12. By the movement of sodium and potassium ions,
a net of one positive charge is moved from the
Interior of the cell to the exterior for each pump
cycle creating negativity on the inside.
It is said to be Electrogenic because it creates an
electrical potential across the cell membrane
Significance of sodium potassium pump
13. Primary active transport of Calcium ions
Calcium ions are normally maintained at extremely low
Concentration in the cytosol of virtually all cells in the
Body…about 10,000 times less than that in ECF.
This is achieved by two primary pumps:
One is in cell membrane, pumps calcium to outside
Other one pumps calcium into one of the vesicular
organelles such as SR of muscle, mitochondria of all
cells
The carrier protein acts as an ATPase enzyme
14. Primary active transport of Hydrogen ions:
At two places in the body, primary active transport
Of hydrogen ions is important:
1. In the gastric glands of the stomach
2. In the late distal tubules and cortical collecting ducts
of the kidneys
15. Energetics of Primary active transport
The energy required is proportional to the logarithm of
The degree that the substance is concentrated:
Energy(in calories per osmole) = 1400 log C1/C2
The energy required to concentrate a substance 100 folds
is twice as compared to concentrating a substance 10
times
16. Secondary Active Transport
The concentration gradient developed due to diffusion
of sodium is a storehouse of energy..This diffusion energy
of sodium can pull other substances along with sodium
through the cell membrane.
Types of Active transport:
Co transport
Counter transport
17. Co- Transport
The carrier serves as an attachment point for both the
Sodium ions and the substance to be transported.
Once attached, the energy gradient for sodium causes
both the sodium ions and other substance be transported
together to interior of cell
e.g. Co transport of glucose and amino acids along
with sodium
20. Counter transport
The type of active transport in which the sodium ions
move in one direction and other ions in the opposite
direction
Sodium - hydrogen counter transport
Sodium – calcium counter transport
24. • Occurs down a concn.
gradient
• No mediator or involves
a “channel” or “carrier”
• No additional energy
• Occurs against a concn.
gradient
• Involves a “carrier”
• Requires ENERGY
26. Ingestion by the cell -Endocytosis
Very large particles enter the cell by a specialized function
Of the cell membrane called endocytosis.
Pinocytosis
Phagocytosis
Pinocytosis means ingestion of minute particles that
form vesicles of extracellular fluid and particulate
constituents inside the cell cytoplasm
Phagosytosis means ingestion of large particles, such
as bacteria, whole cells or portions of degenerating
tissue
27. • Molecules attach to
cell-surface receptors
concentrated in clathrin-
coated pits
• Receptor binding
induces invagination
• Also ATP-dependent
and involves recruitment
of actin and myosin
Receptor-mingestediated
endocytosis:
Figure 2-11
Ingestion by the cell -Endocytosis
30. Define active transport and describe its general
mechanism.
Identify the types of active transport(primary and
secondary) and contrast the differences in between.
Give examples for the substances using active
transport as a method of transport
Compare and contrast passive diffusion, facilitated
diffusion and active transport
Brief the mechanism of vesicular transport(exocytosis
& Endocytosis)