Aromatic compounds contain benzene-like, 6-membered carbon rings with 3 double bonds. They are unusually stable and undergo electrophilic substitution reactions. Many drugs contain aromatic compounds, such as aspirin, codeine, and ibuprofen, which are used for pain relief and medicine.

1. Aromatic Compounds John Robert C. James Daniel Thomas A. Berberabe Mark Angelo N. Siguenza Charles Jervis T. Sy GROUP 4 BSP2A Aromatic Compounds

2. WHAT ARE AROMATIC COMPOUNDS ??? Class of compounds that contain benzene-like, 6 membered rings with 3 double bonds

3. Estrone Ibuprofen

4. BENZENE Should not be used as an laboratory solvent because it causes depressed white blood cell count or Leukopenia on prolonged exposure

5. History 1800 – the formula for benzene ring is C6H6 Relatively unreactive towards most reagents that attack alkenes It reacts with bromine in the presence of Iron to give the SUBSTITION product C6H6 + Br2  C6H5Br

6. AUGUST KEKULE Proposed in 1865 that benzene contains a ring of carbon atoms

7. Properties of Aromatic Compounds with aroma will burn with a smokey yellow flame due to incomplete carbon combustion hydrophobic or water hating non-polar dissolves organic substance but insoluble with water can interact with other aromatic compounds by Intermolecular bonding by Van der Waals forces of attraction

8. Properties of Aromatic Compounds unusually stable type of reaction : electrophilic substitution less dense than water

9. Many drugs contain aromatic compounds. Codeine, for example, is a powerful analgesic or pain reliver.

10. Application of Aromatic Compounds in Medicine ASPIRIN Acetyl-Salicylic Acid

11. CODEINE