The document discusses the application of pharmacoinformatics and summarizes various drug information resources. It describes the history and purpose of drug information centers and services. Three main types of drug literature are discussed - tertiary, secondary, and primary literature. Examples are provided for each type of literature along with their descriptions and advantages/disadvantages. Common tertiary resources include textbooks, PDR, and Drug Facts and Comparisons. Index Medicus and IOWA Drug Information System are examples of secondary indexing and abstracting services. Primary literature refers to original research studies published in journals like JAMA and American Journal of Health System Pharmacy. Other references discussed include CD-ROM databases like DRUGDEX and POISONDEX as well