This document discusses aromatic compounds and benzene reactions. It covers criteria for aromaticity including Hückel's rule. Electrophilic aromatic substitution reactions on benzene such as halogenation, nitration, sulfonation, Friedel-Crafts acylation and alkylation are explained. The mechanisms and products of these reactions are described. Methods to modify substituents on benzene rings through oxidation, reduction and coupling reactions are also summarized.
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Aromatic amines:
Methods of Preparation, reaction, Basicity of Aromatic Amines, Effect of Substituents on Acidity of Aromatic amines, Aryl diazonium salt and Uses of Aromatic Amines.
Lipstick is a cosmetic product containing pigments, oils, waxes, and
emollientsthat apply colour,texture, and protection to the lips.
• Lipsticks provide moist appearance to the lips.
• Lipstick is used change the shape of the lips, so it looks more beautiful lip
color.
• lipstick dosage forms are stems, but there are also other dosage forms such
as ointments, liquid, pencil, transparent, and others.
• Lip color is one of the most popular decorative cosmetics by women
ranging from teenagers, adults, to the elderly.
Aromatic amines:
Methods of Preparation, reaction, Basicity of Aromatic Amines, Effect of Substituents on Acidity of Aromatic amines, Aryl diazonium salt and Uses of Aromatic Amines.
Introduction to benzene, orbital picture, resonance in benzene, Huckel‟s rule
Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel- Craft‟s alkylation- reactivity, limitations, Friedel-Craft‟s acylation.
Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
Aromatic amines topic includes basicity of the aromatic amine. It also includes the comparison of the basicity. It is designed according to new PCI syllabus of B. Pharmacy.
Benzene is a colorless and highly flammable liquid with a sweet smell, and is partially responsible for the aroma around petrol (gasoline) stations.
It is used primarily as a precursor to the manufacture of chemicals with more complex structure, such as ethylbenzene and cumene, of which billions of kilograms are produced annually.
Although a major industrial chemical, benzene finds limited use in consumer items because of its toxicity
Introduction to benzene, orbital picture, resonance in benzene, Huckel‟s rule
Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel- Craft‟s alkylation- reactivity, limitations, Friedel-Craft‟s acylation.
Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
Aromatic amines topic includes basicity of the aromatic amine. It also includes the comparison of the basicity. It is designed according to new PCI syllabus of B. Pharmacy.
Benzene is a colorless and highly flammable liquid with a sweet smell, and is partially responsible for the aroma around petrol (gasoline) stations.
It is used primarily as a precursor to the manufacture of chemicals with more complex structure, such as ethylbenzene and cumene, of which billions of kilograms are produced annually.
Although a major industrial chemical, benzene finds limited use in consumer items because of its toxicity
1. Introduction
2. History of benzene
3. Nomenclature
4. Orbital structure
5. Kekule structure
6. Resonance structure
7. Resonance energy and stability 8. Structural evidence
9. Synthetic evidence
10. Analytical evidence
11. Aromaticity and huckle rule
12. Method of preparation of benzene
13. Electrophilic substitution of benzene
14. Classification of substituent 15. Directive effect : Ortho and para director, meta director
16. Reaction of monosubstituted benzene
17. Effect of Substituents on reactivity and orientation of monosubstituted benzene towards electrophilic substitution 18. Structure and uses of BHC,DDT, Saccharine and chloramine
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Benzene has 6π electrons delocalized in 6p orbitals that overlap above and below the plane of the ring. Because benzene’s six pie electrons satisfy Huckel’s rule, benzene is especially stable. Reaction that keep the aromatic ring intact are therefore favoured
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
General Chemistry of AROMATIC COMPOUNDS
CONTENTS:
-Aromatic compounds and aromaticity.
- Characteristic properties of aromatic compound.
- Nomenclature of derivatives of benzene.
- Benzene.
- Kekule’s structure of Benzene.
X-ray study of the structure of Benzene.
Molecular orbital description of benzene.
- Hückel 4n+2 Rule.
- Resonance of Benzene.
- Preparations of Benzene.
- Reactions of aromatic compound.
- Orientation in electrophilic substitution reactions.
Similar to Ch14MR aromaticity-benzene reactions.ppt (20)
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
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What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
3. Benzene is unusually stable because of electron
delocalization
Compounds with unusually large resonance energies,
like benzene, are called aromatic compounds
4. Criteria for Aromaticity
1. A compound must have an uninterrupted cyclic cloud
of p electrons above and below the plane of the
molecule
2. The p cloud must contain an odd number of pairs
of p electrons
5. Hückel’s Rule
For a planar, cyclic compound to be aromatic, its
uninterrupted p cloud must contain (4n + 2) p electrons,
where n is any whole number
6. Monocyclic hydrocarbons with alternating single and
double bonds are called annulenes
Cyclobutadiene and cyclooctatetraene are not aromatic
because they have an even number of p electron pairs
Furthermore, cyclooctatetraene is nonplanar
7. Cyclopentadiene does not have an uninterrupted ring of
p orbital-bearing atoms
not
aromatic
not
aromatic
aromatic
Cyclopentadienyl cation has an even number of p
electron pairs
Cyclopentadienyl anion has an uninterrupted ring of p
orbital-bearing atoms and an odd number p electron pairs
8. The resonance hybrid shows that all the carbons in the
cyclopentadienyl anion are equivalent
Each carbon has exactly one-fifth of the negative charge
associated with the anion
18. A compound is antiaromatic if it is a planar, cyclic
compound with an uninterrupted ring of p orbital-bearing
atoms, and the p cloud must contain an even number of
pairs of p electrons
Antiaromaticity
Antiaromatic compounds are highly unstable
19. A Molecular Orbital Description of
Aromaticity and Antiaromaticity
Aromatic compounds are stable because they have filled
bonding p molecular orbitals
22. When a benzene ring is a substituent, it is called a
phenyl group
A benzene ring with a methylene group is called a benzyl
group
23. With the exception of toluene, benzene rings with an alkyl
substituent are named as alkyl-substituted benzenes or
as phenyl-substituted alkanes
Aryl group (Ar) is the general term for either a phenyl
group or a substituted phenyl group
26. Benzene is a nucleophile that reacts with an electrophile
An electrophilic substitution yields an aromatic product
which is significantly more stable than the addition
reaction
28. There are five common electrophilic aromatic substitution
reactions
1. Halogenation
2. Nitration
3. Sulfonation
4.Friedel-Crafts acylation
5.Friedel-Crafts alkylation
46. However, a 100% of the 2-methyl-2-phenylbutane
product can be obtained if a bulky alkyl halide is used
47.
48. It is not possible to obtain a good yield of an
alkylbenzene containing a straight-chain group via
Friedel–Crafts alkylation due to carbocation
rearrangement
Acylium ions, however, do not rearrange