Neonatal sepsis is a serious infection that can affect newborns, especially those born prematurely or with low birth weight. The immaturity of a newborn's immune system makes them highly susceptible to infection. Symptoms of neonatal sepsis are non-specific and can include poor feeding, temperature instability, and respiratory distress. Diagnosis relies on clinical signs and abnormal laboratory test results, as there is no single diagnostic marker. Treatment involves administering broad-spectrum antibiotics early while infection is considered, with supportive care and management of any complications.