Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Acute Poststreptococcal Glomerulonephritis (APSGN) <ul><li>MBBS.weebly.com </li></ul>Mbbs.weebly.com
Acute  Glomerulonephritis <ul><li>Acute Nephritic Syndrome </li></ul><ul><ul><li>gross hematuria (sudden onset) </li></ul>...
Causes of Acute  Glomerulonephritis <ul><li>Numerous infectious  organisms , include fungi, bacteria, rickettsia, virus, e...
<ul><li>one of the most common glomerular causes of  gross hematuria  in children, surpassed only by IgA nephropathy. </li...
<ul><li>APSGN follows infection of the throat or skin by certain “ nephritogenic ” strains of group A β-hemolytic streptoc...
PATHOLOGY <ul><li>The kidneys appear symmetrically enlarged.  </li></ul><ul><li>All glomeruli appear enlarged and relative...
Diagrams depicting the ultrastructural features of a normal glomerular capillary loop  (A)  , and the ultrastructural feat...
<ul><li>Neutrophils infitration </li></ul>LM of a glomerulus with APSGN demonstrating marked influx of neutrophils (arrows...
IF micrograph of a glomerular segment from a patient with APSGN showing coarsely granular capillary wall staining for IgG(...
EM of a portion of a glomerular capillary from a patient with APSGN showing subepithelial dense deposits and a neutrophil ...
Immune  complexes,  antigens Activation of Compliments Recruitment of leukocytes GBM damage, Blood ingredients leakage  He...
<ul><li>Although morphologic studies and a depression in the serum complement (C3) level strongly suggest that   APSGN is ...
<ul><li>Age :   APSGN is most common in children aged  5-12 yr  (5-15yr)and uncommon before the age of 3 yr.  </li></ul><u...
Typical manifestations (1) <ul><li>This syndrome can present with an entire spectrum of severity from asymptomatic   micro...
<ul><li>Hematuria :  Gross hematuria (30-50%), microscopic hematuria are more common. </li></ul><ul><li>Edema  (90%): typi...
<ul><li>Proteinuria  </li></ul><ul><ul><li>Many patients have significant proteinuria, but <5% of symptomatic patients dev...
<ul><li>Clinical course </li></ul><ul><ul><li>Spontaneous improvement typically begins within 1 wk with resolution of edem...
Complications in severe cases <ul><li>Circulatory hypervolemia / Congestive heart failure   Jugular venous distention, the...
<ul><li>Asympatimatic type   </li></ul><ul><ul><li>With urine changes, but no edema or hypertension . </li></ul></ul><ul><...
<ul><li>Urinalysis </li></ul><ul><ul><li>Hematuria  is nearly always present in APSGN. Other findings on microscopy are th...
<ul><li>GFR and Blood chemistory </li></ul><ul><ul><li>The  BUN  concentration is elevated in 75% of patients, and serum  ...
<ul><li>evidences of streptococcal infection   </li></ul><ul><ul><li>Throat or skin  cultures .  </li></ul></ul><ul><ul><l...
DIAGNOSIS   <ul><li>Acute Nephritic Syndrome </li></ul><ul><ul><li>gross hematuria  (sudden onset) </li></ul></ul><ul><ul>...
Renal biopsy   <ul><li>acute renal failure </li></ul><ul><li>nephrotic syndrome </li></ul><ul><li>absence of evidence of s...
<ul><li>IgA nephropathy </li></ul><ul><li>Rapid progressive glomerulonephritis (RPGN), include Goodpature syndrome </li></...
Clinical  manifestations APSGN IgAN Goodpature Syndrome  RPGN   Age and sex All ages,  2 : 1 male 10–35 yr, 2 : 1 male 15–...
<ul><li>Treatment of APSGN is largely that of supportive care.  </li></ul><ul><li>Usually, patients undergo a spontaneous ...
<ul><li>Bed rest </li></ul><ul><ul><li>Bed rest is indicated as long as there are clinical manifestation of active disease...
Treatments (3) <ul><li>Diet </li></ul><ul><ul><li>Protein, sodium and water intake should be restricted in patients with a...
Treatment of complications (1) <ul><li>Hypertension </li></ul><ul><ul><li>Salt and water restriction </li></ul></ul><ul><u...
<ul><li>Acute renal failure </li></ul><ul><ul><li>Management of hypertension, hypervolemia, electrolytes disorder and meta...
Treatment of complications (3) <ul><li>Indications for dialysis </li></ul><ul><ul><li>Volume overload with evidence of hyp...
Prognosis <ul><li>Complete recovery occurs in more than 95% of children with APSGN. </li></ul><ul><li>Mortality in the acu...
Mbbs.weebly.com
Upcoming SlideShare
Loading in …5
×

19 Acute Glomerulonephritis

29,482 views

Published on

Published in: Health & Medicine
  • GIVE HER A BIGGER PACKAGE THIS VALENTINE'S DAY ♥♥♥ https://bit.ly/30G1ZO1
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Fact: Penis Enlargement CAN Work. Here's How. ◆◆◆ https://bit.ly/30G1ZO1
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Get Your Ex Back Today Relationship expert Justin Sinclair shows you how with 3 easy steps. ◆◆◆ http://ow.ly/mOLD301xGxr
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • How I Cured My Yeast Infection, Ex Sufferer reveals secret system, For Lasting Candida Freedom ♣♣♣ https://tinyurl.com/y4uu6uch
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • DOWNLOAD FULL BOOKS, INTO AVAILABLE FORMAT ......................................................................................................................... ......................................................................................................................... 1.DOWNLOAD FULL. PDF EBOOK here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... 1.DOWNLOAD FULL. EPUB Ebook here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... 1.DOWNLOAD FULL. doc Ebook here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... 1.DOWNLOAD FULL. PDF EBOOK here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... 1.DOWNLOAD FULL. EPUB Ebook here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... 1.DOWNLOAD FULL. doc Ebook here { https://tinyurl.com/y3nhqquc } ......................................................................................................................... ......................................................................................................................... ......................................................................................................................... .............. Browse by Genre Available eBooks ......................................................................................................................... Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, Cookbooks, Crime, Ebooks, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult,
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here

19 Acute Glomerulonephritis

  1. 1. Acute Poststreptococcal Glomerulonephritis (APSGN) <ul><li>MBBS.weebly.com </li></ul>Mbbs.weebly.com
  2. 2. Acute Glomerulonephritis <ul><li>Acute Nephritic Syndrome </li></ul><ul><ul><li>gross hematuria (sudden onset) </li></ul></ul><ul><ul><li>Edema </li></ul></ul><ul><ul><li>Hypertension </li></ul></ul><ul><ul><li>renal insufficiency (oliguria) </li></ul></ul>
  3. 3. Causes of Acute Glomerulonephritis <ul><li>Numerous infectious organisms , include fungi, bacteria, rickettsia, virus, especially influenza, and parasites could induce PAGN. </li></ul><ul><li>However, APSGN accounts for 80 to 90% of such cases and is used as the prototype for this group of disorder. </li></ul><ul><li>APSGN is a classic example of the acute nephritic syndrome </li></ul><ul><li>Non-infectious </li></ul><ul><li>Infectious </li></ul>
  4. 4. <ul><li>one of the most common glomerular causes of gross hematuria in children, surpassed only by IgA nephropathy. </li></ul>Acute post-steptococcal glomerulonephritis ( APSGN )
  5. 5. <ul><li>APSGN follows infection of the throat or skin by certain “ nephritogenic ” strains of group A β-hemolytic streptococci </li></ul><ul><ul><li>Throat ( serotype 12 ) , cold weather months. </li></ul></ul><ul><ul><li>skin ( serotype 49 ) , warm weather months. </li></ul></ul><ul><li>APSGN is most commonly sporadic, although epidemics of nephritis have been described. </li></ul>Etiology and epidemiology
  6. 6. PATHOLOGY <ul><li>The kidneys appear symmetrically enlarged. </li></ul><ul><li>All glomeruli appear enlarged and relatively bloodless and show diffuse mesangial cell proliferation with an increase in mesangial matrix. </li></ul><ul><li>Polymorphonuclear leukocytes are common in glomeruli during the early stage of the disease. </li></ul><ul><li>Crescents and interstitial inflammation may be seen in severe cases. </li></ul><ul><li>IF reveals lumpy-bumpy deposits of immunoglobulin and complement on the glomerular basement membrane (GBM) and in the mesangium. </li></ul><ul><li>EM: electron-dense deposits, or “ humps, ” are observed on the epithelial side of the GBM </li></ul>
  7. 7. Diagrams depicting the ultrastructural features of a normal glomerular capillary loop (A) , and the ultrastructural features of APSGN ( B ), Note the subepithelial hump like dense deposits and endocapillary hypercellularity.
  8. 8. <ul><li>Neutrophils infitration </li></ul>LM of a glomerulus with APSGN demonstrating marked influx of neutrophils (arrows). (Masson trichrome, ×700.)
  9. 9. IF micrograph of a glomerular segment from a patient with APSGN showing coarsely granular capillary wall staining for IgG(left) and C3(right). IgG and C3 deposition
  10. 10. EM of a portion of a glomerular capillary from a patient with APSGN showing subepithelial dense deposits and a neutrophil (N) marginated against the basement membrane with no intervening endothelial cytoplasm.
  11. 11. Immune complexes, antigens Activation of Compliments Recruitment of leukocytes GBM damage, Blood ingredients leakage Hematuria Proteinuria RBC Casts Proliferation of MC and EC Blockage of renal capillaries and decreased GFR Edema hypertention heart failure encephalopathy renal failure Oliguria, sodium and water retention, hypervolemia Inflammation mediates, Cytokines, proliferative F. Infection of streptocacci PATHOGENESIS
  12. 12. <ul><li>Although morphologic studies and a depression in the serum complement (C3) level strongly suggest that APSGN is mediated by immune complexes , the precise mechanisms by which nephritogenic streptococci induce complex formation remain to be determined. </li></ul><ul><li>The finding of circulating immune complexes in APSGN is not uniform </li></ul><ul><li>Complement activation is primarily through the alternative rather than the classic (immune complex – activated) pathway. </li></ul>PATHOGENESIS Questions still unsolved
  13. 13. <ul><li>Age : APSGN is most common in children aged 5-12 yr (5-15yr)and uncommon before the age of 3 yr. </li></ul><ul><li>Sex : more common in boys than in girls, male : female ratio is 2 : 1 . </li></ul><ul><li>Antecedent infection : pharyngitis 1-2 wk , pyoderma 2-3wk (3–6 wk). </li></ul>General manifestations
  14. 14. Typical manifestations (1) <ul><li>This syndrome can present with an entire spectrum of severity from asymptomatic microscopic hematuria to oliguric acute renal failure . </li></ul><ul><li>Classically, the syndrome of APSGN presents abruptly with hematuria, proteinuria, hypertension, edema, and azotemia . </li></ul><ul><li>Nonspecific symptoms include malaise, lethargy, abdominal or flank pain, and fever. </li></ul>
  15. 15. <ul><li>Hematuria : Gross hematuria (30-50%), microscopic hematuria are more common. </li></ul><ul><li>Edema (90%): typically presents in the face and upper extremities. Ascites and anasarca may occur in children. </li></ul><ul><li>Hypertension (75% ): usually mild to moderate, and most evident at the onset of nephritis and typically subsides promptly after diuresis. </li></ul><ul><li>Oliguria and anuria : transient oliguria. Anuria is infrequent and, if persistent, may indicate the development of crescentic glomerulonephritis. </li></ul>Typical manifestations (2)
  16. 16. <ul><li>Proteinuria </li></ul><ul><ul><li>Many patients have significant proteinuria, but <5% of symptomatic patients develop frank nephrotic syndrome. </li></ul></ul><ul><ul><li>urinary protein excretion usually normalize by 4-6 wk after onset. </li></ul></ul><ul><ul><li>The long-term persistence of proteinuria may be an indication of persistence of proliferative glomerulonephritis. </li></ul></ul>Typical manifestations (3)
  17. 17. <ul><li>Clinical course </li></ul><ul><ul><li>Spontaneous improvement typically begins within 1 wk with resolution of edema in 5-10 days and hypertension in 2-3 wk, but urinalysis may be abnormal ( persistent microscopic hematuria ) for several years. </li></ul></ul>Typical manifestations (4)
  18. 18. Complications in severe cases <ul><li>Circulatory hypervolemia / Congestive heart failure Jugular venous distention, the presence of an S3 gallop, dyspnea, and signs of pulmonary congestion. </li></ul><ul><li>Encephalopathy presenting as confusion, headache, somnolence, or even convulsion. </li></ul><ul><li>Acute renal failure Usually mild, a form of rapidly progressive glomerulonephritis is unusual(<1%). Oliguria, electrolytes disorder, and acidosis. </li></ul>
  19. 19. <ul><li>Asympatimatic type </li></ul><ul><ul><li>With urine changes, but no edema or hypertension . </li></ul></ul><ul><li>Extrarenal manifestation type </li></ul><ul><ul><li>With edema and/or hypertension, but mild or none urine abnormalities. </li></ul></ul><ul><li>Nephrotic type </li></ul><ul><ul><li>with nephrotic range of proteinuria, hypoalbuminemia, hypercholesteremia </li></ul></ul>Atypical manifestations
  20. 20. <ul><li>Urinalysis </li></ul><ul><ul><li>Hematuria is nearly always present in APSGN. Other findings on microscopy are those of leukocytes , red blood cell casts, and granular casts . Macroscopic hematuria typically has a rusty or tea-color. </li></ul></ul><ul><ul><li>Proteinuria is nearly always present but typically in the sub-nephrotic range. Nephrotic-range proteinuria occurs in <5% of patients. </li></ul></ul><ul><ul><li>The urine contains large amounts of fibrin degradation products , and fibrinopeptides . </li></ul></ul>Laboratory Findings (1)
  21. 21. <ul><li>GFR and Blood chemistory </li></ul><ul><ul><li>The BUN concentration is elevated in 75% of patients, and serum creatinine level is increased in one half of the patients, but profound decrease in GFR is uncommon in children. </li></ul></ul><ul><ul><li>Hyperkalemia, hypocalcaemia, hyponatremia, and metabolic acidosis are seen only in severe patients. </li></ul></ul><ul><ul><li>A mild normochromic anemia may be present from hemodilution and low-grade hemolysis. </li></ul></ul>Laboratory Findings (2)
  22. 22. <ul><li>evidences of streptococcal infection </li></ul><ul><ul><li>Throat or skin cultures . </li></ul></ul><ul><ul><li>Antistreptolysin O ( ASO ) titer. Pharyngitis (80%), skin infections (<50%). </li></ul></ul><ul><ul><li>Anti-deoxyribonuclease (DNase) B level. Pharyngitis (98%), skin infections (80%). IT’s the best single antibody titer to document cutaneous streptococcal infection . </li></ul></ul><ul><li>Activation of complements </li></ul><ul><ul><li>Serum C3 level, decrease (90%), return to normal within 4-8 wk (6-12wk). </li></ul></ul><ul><ul><li>Serum C4 levels are typically normal. </li></ul></ul>Laboratory Findings (3)
  23. 23. DIAGNOSIS <ul><li>Acute Nephritic Syndrome </li></ul><ul><ul><li>gross hematuria (sudden onset) </li></ul></ul><ul><ul><li>Edema </li></ul></ul><ul><ul><li>Hypertension </li></ul></ul><ul><ul><li>renal insufficiency (oliguria) </li></ul></ul><ul><li>evidences of streptococcal infection </li></ul><ul><ul><li>Antecedent infection: pharyngitis, pyoderma . </li></ul></ul><ul><ul><li>ASO </li></ul></ul><ul><ul><li>Anti-deoxyribonuclease B level </li></ul></ul><ul><li>Activation of complements </li></ul><ul><ul><li>C3 level </li></ul></ul>
  24. 24. Renal biopsy <ul><li>acute renal failure </li></ul><ul><li>nephrotic syndrome </li></ul><ul><li>absence of evidence of streptococcal infection </li></ul><ul><li>normal complement levels. </li></ul><ul><li>when hematuria and proteinuria, diminished renal function, and/or a low C3 level persist more than 2 mo after onset. </li></ul>
  25. 25. <ul><li>IgA nephropathy </li></ul><ul><li>Rapid progressive glomerulonephritis (RPGN), include Goodpature syndrome </li></ul><ul><li>Idiopathic nephrotic syndrome (nephritic type) </li></ul><ul><li>Exacerbation of chronic glomerulonephritis </li></ul><ul><li>Secondary glomerulonephritis : HS , SLE , HBV, ect. </li></ul>Differential Diagnosis
  26. 26. Clinical manifestations APSGN IgAN Goodpature Syndrome RPGN   Age and sex All ages, 2 : 1 male 10–35 yr, 2 : 1 male 15–30 yr, 6 : 1 male Adults, 2 : 1 male   nephritic syndrome 90% 50% 90% 90%   Asymptomatic hematuria Occasionally 50% Rare Rare   NS 10–20% Rare Rare 10–20%   Hypertension 70% 30–50% Rare 25%   ARF 50% (transient) Very rare 50% 60%   Other Latent period of 1–3 wk Follows viral syndromes P. Hemorrhage IDA None Laboratory findings ↑ ASO titers (70%) ,↓C3 ↑ Serum IgA (50%) anti-GBM Ab Positive ANCA in some   Renal pathology LM, IF Diffuse proliferation Granular IgG, C3 Focal proliferation Diffuse mesangial IgA deposits Focal ➙ diffuse Proliferation with crescents Linear IgG, C3 Crescentic GN No immune deposits Prognosis 95% resolve spontaneously 5% RPGN Slow progression in 25–50% 75% stabilize or improve if treated early 75% stabilize or improve if treated early
  27. 27. <ul><li>Treatment of APSGN is largely that of supportive care. </li></ul><ul><li>Usually, patients undergo a spontaneous diuresis within 7 to 10 days after the onset of their illness. </li></ul><ul><li>Management is directed at treating the acute effects of renal insufficiency and hypertension </li></ul>Treatments (1)
  28. 28. <ul><li>Bed rest </li></ul><ul><ul><li>Bed rest is indicated as long as there are clinical manifestation of active disease, such as edema, hypertension, or gross hematuria. </li></ul></ul><ul><ul><li>The acute phase generally resolves within 2-3 wk. </li></ul></ul><ul><ul><li>Children could go back school after ESR returns to normal. </li></ul></ul><ul><ul><li>But, exhausting and competive activites are prohibited until the Addis count returns to normal. </li></ul></ul>Treatments (2)
  29. 29. Treatments (3) <ul><li>Diet </li></ul><ul><ul><li>Protein, sodium and water intake should be restricted in patients with acute renal failure. </li></ul></ul><ul><ul><li>Sodium and water restriction is also needed in treating hypertension. </li></ul></ul><ul><li>Antibiotics </li></ul><ul><ul><li>A 10-day course of systemic antibiotic therapy with penicillin is recommended to limit the spread of the nephritogenic organisms. </li></ul></ul><ul><ul><li>Antibiotic therapy does not affect the natural history of glomerulonephritis. </li></ul></ul>
  30. 30. Treatment of complications (1) <ul><li>Hypertension </li></ul><ul><ul><li>Salt and water restriction </li></ul></ul><ul><ul><li>Diuresis usually with intravenous Lasix, </li></ul></ul><ul><ul><li>pharmacotherapy with calcium channel antagonists, vasodilators, or ACEI. </li></ul></ul><ul><li>Hypertensive encephalopathy or congestive heart failure </li></ul><ul><ul><li>Sodium Nitroprusside is the first choice. </li></ul></ul>
  31. 31. <ul><li>Acute renal failure </li></ul><ul><ul><li>Management of hypertension, hypervolemia, electrolytes disorder and metabolic acidosis. </li></ul></ul><ul><ul><li>Some patients with substantial volume expansion and marked pulmonary congestion do not respond to diuretics. In those individuals, dialytic support is appropriate </li></ul></ul>Treatment of complications (2)
  32. 32. Treatment of complications (3) <ul><li>Indications for dialysis </li></ul><ul><ul><li>Volume overload with evidence of hypertension and/or pulmonary edema refractory to diuretic therapy </li></ul></ul><ul><ul><li>Persistent hyperkalemia </li></ul></ul><ul><ul><li>Severe metabolic acidosis unresponsive to medical management </li></ul></ul><ul><ul><li>Neurologic symptoms (altered mental status, seizures) </li></ul></ul><ul><ul><li>Blood urea nitrogen greater than 100–150 mg/dL </li></ul></ul><ul><ul><li>Calcium/phosphorus imbalance, with hypocalcemic tetany . </li></ul></ul>
  33. 33. Prognosis <ul><li>Complete recovery occurs in more than 95% of children with APSGN. </li></ul><ul><li>Mortality in the acute stage can be avoided by appropriate management of acute renal failure, cardiac failure, and hypertension. </li></ul><ul><li>Infrequently, the acute phase may be severe and lead to glomerular hyalinization and chronic kidney disease. </li></ul><ul><li>Recurrences are extremely rare. </li></ul>
  34. 34. Mbbs.weebly.com

×