This document presents a consensus statement on the early reperfusion and pharmaco-invasive approach for patients presenting with ST elevation myocardial infarction (STEMI) in India. It finds that treatment delays exist in India based on registries. The consensus recommends administering early fibrinolysis within 120 minutes of first medical contact for eligible STEMI patients, followed by angiography and PCI if needed within 3-24 hours. This pharmaco-invasive approach can compensate for delays in accessing primary PCI and improves outcomes when total ischemic time is under 4 hours. The statement provides guidance on fibrinolytic agents and timing of PCI to optimize reperfusion for STEMI care in India.