1) Several clinical trials are underway to evaluate new trauma interventions such as viscoelastic-guided protocols, lyophilized plasma, tranexamic acid, fibrinogen concentrate, cryopreserved platelets, and cold-stored platelets.
2) Traditional clinical trials in trauma face challenges like patient heterogeneity and dichotomous outcomes like mortality, requiring very large sample sizes. Alternative outcomes being explored include longer term functional outcomes and biological surrogates.
3) Notable ongoing trials include iTACTIC evaluating lyophilized plasma, RePHILL and PATCH-Trauma evaluating tranexamic acid, FEISTY evaluating fibrinogen concentrate, CRYOSTAT-2 evaluating cryoprecipitate, and
Pre hospital reduced-dose fibrinolysis followed by pciVishwanath Hesarur
Extensive investigations of treatment strategies for patients with STEMIs have led to many improvements in care.
Yet optimal treatment strategies for patients aged ≥75 years with STEMIs are much less clear, and many knowledge gaps remain.
Age ≥75 years is an independent predictor of 30-day mortality in STEMI.
Although this higher mortality risk generally would dictate more aggressive treatments, recent data have shown, for example, that <1/2 of patients aged ≥80 years with STEMIs are treated with any reperfusion therapies at all.
Primary PCI with stenting immediately after coronary reperfusion salvage procedures jeopardizes myocardium, improves prognosis, and is the current standard of care for acute STEMI .
No-reflow is defined as an acute reduction in myocardial blood flow despite a patent epicardial coronary artery .
The pathophysiology of no-reflow involves microvascular obstruction secondary to distal embolization of clot, microvascular spasm, and thrombosis .
No-reflow occurs in ~10% of cases of primary PCI and is associated with patient characteristics such as advanced age and delayed presentation and coronary characteristics such as a completely occluded culprit artery and heavy thrombus burden .
Pre hospital reduced-dose fibrinolysis followed by pciVishwanath Hesarur
Extensive investigations of treatment strategies for patients with STEMIs have led to many improvements in care.
Yet optimal treatment strategies for patients aged ≥75 years with STEMIs are much less clear, and many knowledge gaps remain.
Age ≥75 years is an independent predictor of 30-day mortality in STEMI.
Although this higher mortality risk generally would dictate more aggressive treatments, recent data have shown, for example, that <1/2 of patients aged ≥80 years with STEMIs are treated with any reperfusion therapies at all.
Primary PCI with stenting immediately after coronary reperfusion salvage procedures jeopardizes myocardium, improves prognosis, and is the current standard of care for acute STEMI .
No-reflow is defined as an acute reduction in myocardial blood flow despite a patent epicardial coronary artery .
The pathophysiology of no-reflow involves microvascular obstruction secondary to distal embolization of clot, microvascular spasm, and thrombosis .
No-reflow occurs in ~10% of cases of primary PCI and is associated with patient characteristics such as advanced age and delayed presentation and coronary characteristics such as a completely occluded culprit artery and heavy thrombus burden .
Thrombus aspiration during percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is said to reduce PCI-induced distal occlusion.
In an attempt to enhance its effectiveness, thrombus aspiration is often coupled with glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, although conflicting results with this strategy have been reported.
GP IIb/IIIa antagonists inhibit the final common pathway that leads to platelet aggregation and leukocyte plugging, which are the main components of fresh thrombi.
Hello members...this powerpoint deals with A journal presentation, that aims at highlighting the "Efficacy & safety of Lacosamide in painful diabetic neuropathy patients".
This also elucidates a model of "Journal club presentation" for interested students.
Happy reading!!
:)
Cavernous sinus thrombosis represents a rare but devastating disease process that may be associated with significant long-term patient morbidity or mortality. The prompt recognition and management of this problem is critical.
Effect of hydrocortisone on development of shock amongDr fakhir Raza
effects of hydrocortisone on development of shock among patients with severe sepsis the HYPRESS Randomized Clinical Trial American Medical Association caring for the critically ill patients Surviving sepsis campaign, to determine weather hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock
Thrombus aspiration during percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is said to reduce PCI-induced distal occlusion.
In an attempt to enhance its effectiveness, thrombus aspiration is often coupled with glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, although conflicting results with this strategy have been reported.
GP IIb/IIIa antagonists inhibit the final common pathway that leads to platelet aggregation and leukocyte plugging, which are the main components of fresh thrombi.
Hello members...this powerpoint deals with A journal presentation, that aims at highlighting the "Efficacy & safety of Lacosamide in painful diabetic neuropathy patients".
This also elucidates a model of "Journal club presentation" for interested students.
Happy reading!!
:)
Cavernous sinus thrombosis represents a rare but devastating disease process that may be associated with significant long-term patient morbidity or mortality. The prompt recognition and management of this problem is critical.
Effect of hydrocortisone on development of shock amongDr fakhir Raza
effects of hydrocortisone on development of shock among patients with severe sepsis the HYPRESS Randomized Clinical Trial American Medical Association caring for the critically ill patients Surviving sepsis campaign, to determine weather hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock
Objectives:
•Learn about the current of SSI prevention in Canada
•Review the updated SSI-GSK
•Compare CPSI SSI-GSK to national and international literature
Cette présentation faite le 27 Avril 2017 à l'Hôpital Saint Joseph organisée par le Dr Vincent de Parades fait le point sur les nouvelles approches multidisciplinaires dans la prise en charge des cancers colorectaux en insistant sur la prise en charge de la maladie métastatique hépatique et de la carcinome péritonéale pour terminer sur les nouvelles approches par immunothérapie. Cette EPU a connu un large succès d'audience avec plus de 60 participants. Merci à toutes et tous.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
Trials on the horizon by Professor Michael Reade
1. Trauma trials on the horizon
Michael Reade
MBBS MPH DPhil DMedSc AFRACMA FCCM FANZCA FCICM
Anaesthetist & Intensive Care Physician
ADF Professor of Military Medicine & Surgery
Brigadier. Assistant Surgeon General – Australian Army
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
2. The problem with clinical trials in trauma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Heterogeneity of patients,
trauma mechanism and
physiological effect – none of
which can be well
characterised at time of
inclusion (combined with a
desire to enrol only those
with ‘preventable’ mortality
risk)
Landmark mortality is a
dichotomous outcome –
resulting in less study
power
Expecting a brief intervention to be ‘seen’ 28 days later is ambitious,
especially given the reduction in the third peak of the trimodal distribution of
death
Post-immediate
care
Some populations
are systematically
different; group
imbalances can
ruin trial
May interact with
intercurrent care
3. The problem with clinical trials in trauma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Needs:
- A very big mountain (effect size)
- Watching for a very long time (sample size)
- Other effects of the mountain e.g. a shadow (surrogate outcomes)
4. Alternatives to 28-day mortality
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• 24-hour mortality
• Long-term functional outcome
• Cause-specific mortality (e.g. death due to bleeding)
• Biological surrogates (e.g. inflammatory mediators)
• Health system efficiency outcomes (e.g. transfusion
requirement)
• Organ-support free days
• Length of stay
• Composites e.g. mortality OR transfusion >10 units
EQ-5D
5. Trials on the horizon
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• Viscoelastic-guided protocols
• Lyophilised plasma
• Tranexamic acid
• Fibrinogen concentrate & cryoprecipitate
• Cryopreserved platelets
• Cold-stored platelets
• Erythropoietin as an immunomodulator in trauma
8. Plasma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
First ever trial demonstration that
prehospital plasma reduces mortality
10. RePHILL
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
LyoPlas (Germany). Single donor. ABO-specific. Up to 15-month
shelf-life. In production since 2007 (1990-2006 had been a
pooled product)
11. RePHILL: progress
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
RePHILL trial investigators meeting. Study
of prehospital transfusion now halfway -
200th patient recruited Christmas Day!
@RePHILL_trial Emergency Care =
Research 24/7. @Magpas_Charity
@EastAngliAirAmb
29 Jan 2019
Jan 2019:
>200/490 patients
12. French Lyophilised Plasma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
FLyP reduced the requirement for massive transfusion
13. French Lyophilised Plasma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Will FLyP affect survival?
14. PATCH-Trauma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Screen
at scene of injury
Randomise
1g TXA
Bolus dose
placebo
Blood test
1g TXA placebo8 hr
infusion
STOP
Blood test
+24h
+ +
DVT
Ultrasound
Day 5-7
n = 579 n = 579
6 months
Telephone
interview
Pre-hospitalHospital
Blood test
73%
Recruitment Currently
860
Target
1184
Remaining
324
As of 1-Mar-2019
16. PATCH-Trauma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• 4 Western Pennsylvania Prehospital Systems
• Opt-out consent
• Within 2 hrs of injury, SBP<90mmHg, HR>110
• Excludes: cardiac arrest > 5 mins, penetrating TBI
• 1g bolus prehospital; bolus or infusion in hospital
• Primary outcome: 30 day mortality
• Coagulation / inflammation substudies
• 994 patients over 3 years
• Adult trauma patients requiring at least 1 unit of blood transfusion
and/or immediate operating room
• Excludes: MI, stroke, DVT/PE, seizure disorder
• Primary outcome: Differences in the proportion of activated
monocytes among the 3 treatment arms
• 2 dosing groups (2 g, 4 g) and placebo
• Completed 150 patient enrolment DEC 18
17. Fibrinogen in trauma
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Possible problems with fibrinogen concentrate:
• Unlike plasma, does not replace volume –
which presumably must be replaced with
crystalloid. This might be detrimental …
• Studies showing improved viscoelastic
results with fibrinogen administration may
misrepresent in vivo coagulopathy & not
reflect patient outcome benefit
18. FI in TIC
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Austria (Fries et al): FI in TIC
Inclusion Adult trauma patients with “significant signs of
internal bleeding” prehospital
Intervention Approx. 50mg/kg fibrinogen concentrate or
placebo
Blinding Double-blind
Outcome Primary outcome - FIBTEM MCF
Secondary outcomes -
transfusion requirement/blood loss,
thromboembolic complications,
morbidity and length of ICU and hospital stay
Progress 67 patients randomised; completed Dec 2015.
Not yet presented or published
19. FiiRST
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Canada (Callum et al) - FiiRST
Injured patient at risk of bleeding:
SBP <100mmHg at any time from injury until 30 min
post admission
AND RBC transfusion ordered
6g Fg Concentrate within 60 min vs. placebo
FgC prepared in blood bank
Feasibility (96% received in <1hr); FC concentration
achieved was higher than placebo
Completed recruitment 50 patients
20. FEISTY
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Fibrinogen Early In Severe Trauma study (FEISTY) pilot trial
• Queensland, Australia 40-hospital pilot trial
• Inclusion: major trauma, FIBTEM A5<10mm
• Fibrinogen concentrate vs. cryoprecipitate, with doses determined by FIBTEM A5
• Outcomes: feasibility, speed of administration, fibrinogen concentration
Endorsed by ANZICS CTG March 2016
Target 100 patients enrolment completed March 2018
Courtesy Dr James Winearls, Gold Coast University Hospital Australia
21. FEISTY
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Courtesy Dr James Winearls, Gold Coast University Hospital Australia
Secondary outcomes:
• No difference in PRBC transfused prehospital, at 24hr, or total
• Higher mortality in FC group (12 vs 3 patients); likely a spurious result
22. FEISTY
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
Courtesy Dr James Winearls, Gold Coast University Hospital Australia
FEISTY-II (Winearls et al.)
Inclusion Adults, ABC score>=2 OR “significant haemorrhage”,
activation of MTP, FIBTEM A5 <=10mm
Intervention 3-6g fibrinogen concentrate (as determined by the FIBTEM
A5) vs. 10-20U cryoprecipitate (as determined by the
FIBTEM A5)
Blinding Unblinded
Outcome Still under discussion.
? NON-INFERIORITY IN:
PRBC (units) in 1st 24hr
Functional outcome at 6 months
Progress Would require 2000 patients for 1U PRBC non-inferiority
In-principle provision of FC by CSL-Behring not yet agreed
Funded for lead-in phase by NBA and EMF
1. Avoids giving FC or cryoprecipitate to
patients who do not need it
2. Uses an outcome with economic
relevance
3. Avoids seeking differences in mortality
in a population likely to have a low
preventable death rate
4. Asks the most relevant question to
clinicians & blood policy-makers in
Australia (&?worldwide) i.e. is the
increasing use of FC, driven by the
increasing use of ROTEM/TEG,
something that at least is not inferior
(in both clinical outcomes and resource
utilisation) to standard care.
23. CRYOSTAT
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
UK (Curry, Stanworth, Brohi)
CRYOSTAT-1
Inclusion Adult trauma patients
Active bleeding with shock
Activation of MTP and/or
transfusion emergency (Group O)
RBC
<3hrs from injury
Intervention 2 pools of cryoprecipitate within
90min – vs. standard care
Blinding Unblinded
Outcome Feasibility
Progress Completed recruitment 43 patients.
85% received cryo. within 90
minutes. Cryo. concentration
achieved was higher in the cryo.
Group. Trend to reduced mortality
(10 vs 27%, p=0.14)
UK (Curry, Stanworth, Brohi)
E-Fit 1
Inclusion Adult trauma patients
Active bleeding with shock
Activation of MTP and/or
transfusion emergency (Group O)
RBC
Intervention 6g Fg Concentrate within 45min –
vs. placebo
Blinding Prepared study packs in ED.
Empty blinded bottles – use black
syringe
Outcome Feasibility
Progress Completed recruitment 48 patients
24. CRYOSTAT-2
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
UK (Curry, Davenport, Stanworth)
CRYOSTAT - 2
Inclusion Adult trauma patients
MTP activated
Has received at least one unit of a blood component
Intervention Early 3 pools (15U) cryoprecipitate (approx. 6g
fibrinogen) (within 90 min) vs. standard transfusion
therapy (i.e. MTP with no cryo.)
Blinding Not blinded
Outcome 28 day mortality
6 month functional outcome
90% power to detect 7% reduction in mortality from
baseline of 26%
Progress 1568 pts; commenced enrolment JUL17. 559
recruited to date (MAY 19)
25. CLIP
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• US Navy 1970s technology
• 2 year shelf life at -80°C
• Resuspended in plasma
• No requirement to remove
residual DMSO
26. CLIP
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• Hypothesis: cryopreserved platelets will be at least as effective, cost-effective and safe
as conventional liquid-stored platelets
• Blinded randomised phase III clinical non-inferiority trial in approximately 12 Australian
(and New Zealand?) hospitals.
• Eligibility: Adult cardiac surgical patients with a high risk of platelet transfusion by the
Adult Cardiac Surgery Platelet Transfusion (ACSePT) score.
• Primary Endpoint: Volume of post-surgical bleeding in the first 24 hours from the time
the patient arrives in the ICU
• Major Secondary Endpoints:
• BARC composite bleeding endpoint (≥2L bleeding in 24hr, ≥5U PRBC in 48hr, or reoperation due to
bleeding); requirement for blood products; volume of postoperative fluid resuscitation; adverse
effects, especially local or systemic infection, fever, venous thromboembolism, arterial occlusion, need
for surgical intervention, and ARDS.
30. EPO-TRAUMA
Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery
• Critically ill trauma patients requiring mechanical ventilation admitted to participating centres.
• Exclusions: history of DVT, PE or other thromboembolic event; chronic hypercoagulable disorder, including known malignancy;
• 40,000 Units EPO subcutaneously administered as soon as possible (maximum 24 hours) after the estimated time of traumatic injury
with a second dose on study day 8 vs. placebo
• Primary outcome: Combined mortality and severe disability (defined as a WHODAS 2.0 score ≥ 24) at six months
• 2403 patients
31. Joint Capabilities Group │ Joint Health Command │ Defence Professor of Military Medicine and Surgery