BALKAN MCO 2011 - E. Vrdoljak - Locoregional therapy in LABC
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The document discusses evidence from randomized controlled trials on the use of postmastectomy radiotherapy (PMRT) for breast cancer patients. The key trials found that PMRT reduces locoregional recurrence rates from 30% to 10% and breast cancer mortality by 5% at 15 years. PMRT improved disease-free and overall survival rates particularly in patients with 4 or more positive lymph nodes. Modern radiotherapy techniques can help reduce risks of complications from PMRT.
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BALKAN MCO 2011 - E. Vrdoljak - Locoregional therapy in LABC
- 3. Effects of RT on breast cancer mortality and all cause mortality after breast conserving / mastectomy and axillary clearance EBCTCG. Lancet 2005.
- 17. PMRT 1-3 L N+ with 8 or more nodes dissected- DBCG 82 b and 82 c trial Overgaard et al. Radioth Oncol 2007. RT No RT p value LRR 4% 27% <0.001 Overall survival 57% 48% 0.03
- 19. . Pierce L J JCO 2005 . British Columbia Trial - OS
- 31. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomised trials Lancet 2005;366:2087-2106
- 32. Trials of post-mastectomy RT Effect on LR and breast cancer mortality in N- pts Mastect + AC Mastect + AC Mastect + AC + RT Mastect + AC + RT
- 33. Trials of post-mastectomy RT Effect on LR and breast cancer mortality in N+ pts Mastect + AC + RT Mastect + AC Mastect + AC + RT Mastect + AC
- 35. Incidence of 2nd cancers and mortality from causes other than breast cancer
- 36. Breast cancer and overall mortality after RM/RT Mastect + AC Mastect + AC + RT Mastect + AC Mastect + AC + RT
- 37. Main findings II RT can increase mortality for heart disease and lung cancer and incidence of contr a lateral breast cance r which reduce its net beneficial effect on 15-y breast cancer mortality. Nevertheless, RT produced reductions not only in 15-y breast cancer mortality but also in 15-y overall mortality.
- 43. 4D CT: sorting process Full respiratory cycle End-inspiration CT Image Sorting Program End-expiration 4 sec
- 44. Opto-electronic system IR flash IR flash Processing unit Motion analyzer Bunker Control room
- 45. Breath adapted radiotherapy D eep inspiration breath hold Free breathing Irradiated heart volume 8% Irradiated heart volume 1% AN Pedersen, Copenhagen