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Imrt For Anal Cancer

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fondas vakalis
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The document discusses using intensity-modulated radiation therapy (IMRT) for the treatment of anal cancer. Dosimetric studies and small clinical trials show that IMRT reduces radiation dosing and toxicity to normal tissues compared to conventional radiation therapy, without decreasing treatment effectiveness or local cancer control. Larger clinical trials are still needed to further evaluate IMRT for anal cancer and detect possible small variations in outcomes. The Radiation Therapy Oncology Group is currently conducting a phase II trial to further evaluate dose-painted IMRT for anal cancer.

Health & Medicine
1 of 20
IMRT for the Treatment of Anal Cancer Kristen O’Donnell, MS3 December 12, 2007
Anal Cancer: Just the Facts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Jemal et al., 2007; Hansen and Roach, 2007)
Anal Cancer: Just the Facts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Up-to-date; cancerbackup.org)
Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Hansen and Roach, 2007)
Current Standard is Definitive Chemoradiotherapy for Anal Cancer ,[object Object],[object Object],[object Object],[object Object],(UKCCCR, 1996; Bartelink et al., 1997)
Current Standard is Definitive Chemoradiotherapy for Anal Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(EORCT, Bartelink et al., 1997)
Current Standard is Definitive Chemoradiotherapy for Anal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rates of Locoregional Recurrence with Definitive Chemoradiotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Patterns of Locoregional Recurrence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IMRT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IMRT in anal cancer ,[object Object],[object Object],[object Object],[object Object]
IMRT Dosimetry studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Chen et al. 2005)
IMRT Dosimetry studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IMRT Dosimetry studies ,[object Object],[object Object],[object Object],[object Object],[object Object],24.8 ± 2.4 15.9 ± 1.3 15.9 ± 2.3 28.8 ± 3.2 18.9 ± 8.2 19.4 ±16.1 13.5 ±5.9 Mean dose with IMRT (Gy) 50 50 45 50 50 36 36 Dose Constraint (Gy) Sacrum Pelvis Femoral Necks Bladder Small Bowel Genitalia Perineum
Clinical use of IMRT for anal cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Milano et al., 2005; Bartelink et al., 1997)
Clinical use of IMRT for anal cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],(Milano et al., 2005)
Multicenter experience with IMRT for anal cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Multicenter experience with IMRT for anal cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object]
Future Studies using IMRT for Anal Cancer ,[object Object],[object Object],[object Object],[object Object]

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