- Cervical cancer is a major cause of cancer deaths worldwide, with over 500,000 new cases and 260,000 deaths estimated annually. Most deaths occur in developing countries where screening and prevention programs are lacking.
- Early detection through screening programs can make cervical cancer highly curable, but the majority of cases in developing nations are diagnosed at late stages when survival rates are low. Vaccination and screening can help prevent a large percentage of cervical cancer cases.
- Risk factors for cervical cancer include human papillomavirus infection and lack of access to healthcare. While HPV infection is necessary, most infections clear without causing cancer. Other factors like multiple pregnancies, smoking, and HIV infection can increase the risk.
Endometrial Cancer is a malignancy that arises from the lining of the uterus, endometrium.
It is the most common gynaelogical cancer in developing countries, while in developed countries it is the second most common cancer, behind cervical cancer.
• In year 2012 a total of 320,000 new cases were recorded.
• Globally, it is the sixth most common cancer in women, fourteenth most common overall.
• In Peninsular Malaysia, it is the seventh most common cancer in women, according to Malaysian cancer Registry 2006.
• It is rare among women younger than 40 years.
• Peak incidence occurring at age 60-69.
• Majority are of Chinese ethnicity (47.5%), followed by Malays (41.6%) and Indian (10.9%).
In gynecologic cancers, fertility preservation strategies include fertility-sparing surgical approaches and assisted reproductive technologies (ART). Fertility preservation can be considered in women with early stage I epithelial ovarian cancer and most borderline tumors, stages I–III
Endometrial Cancer is a malignancy that arises from the lining of the uterus, endometrium.
It is the most common gynaelogical cancer in developing countries, while in developed countries it is the second most common cancer, behind cervical cancer.
• In year 2012 a total of 320,000 new cases were recorded.
• Globally, it is the sixth most common cancer in women, fourteenth most common overall.
• In Peninsular Malaysia, it is the seventh most common cancer in women, according to Malaysian cancer Registry 2006.
• It is rare among women younger than 40 years.
• Peak incidence occurring at age 60-69.
• Majority are of Chinese ethnicity (47.5%), followed by Malays (41.6%) and Indian (10.9%).
In gynecologic cancers, fertility preservation strategies include fertility-sparing surgical approaches and assisted reproductive technologies (ART). Fertility preservation can be considered in women with early stage I epithelial ovarian cancer and most borderline tumors, stages I–III
Join Dr. Kara Long Roche, Associate Director of the Gynecologic Oncology Fellowship Program at Memorial Sloan Kettering Cancer Center, as she breaks down new advancements in ovarian cancer research and treatment.
All in the Family: Hereditary Risk for Gynecologic Cancerbkling
Knowing and understanding your inherited genetics is important for ovarian and uterine cancer patients. Dr. Melissa Frey, gynecologic oncologist at Weill Cornell Medicine, discusses how genetic factors affect women with ovarian and uterine cancer and influence treatment decisions, with a particular focus on BRCA1 & 2 and Lynch Syndrome.
This webinar was being put on in partnership with FORCE.
Join Dr. Kara Long Roche, Associate Director of the Gynecologic Oncology Fellowship Program at Memorial Sloan Kettering Cancer Center, as she breaks down new advancements in ovarian cancer research and treatment.
All in the Family: Hereditary Risk for Gynecologic Cancerbkling
Knowing and understanding your inherited genetics is important for ovarian and uterine cancer patients. Dr. Melissa Frey, gynecologic oncologist at Weill Cornell Medicine, discusses how genetic factors affect women with ovarian and uterine cancer and influence treatment decisions, with a particular focus on BRCA1 & 2 and Lynch Syndrome.
This webinar was being put on in partnership with FORCE.
excelente exposicion de cancer cervical, funciona tanto para la materia de oncologia, como la de ginecologia, muy pero muy pocas observaciones, se presenta completo el tema.
VIA is an attractive alternative to cytology-based cervix uteri screening in low-resource settings. Cryotherapy is the treatment option for test-positive individuals. Hereby a “Screen and Treat” approach can be integrated into existing reproductive health services in low-resource countries.
Current controversies in cervical cancer management (2014)Jyotirup Goswami
Overview of the current controversies in the management of cervical cancer, including screening, prevention, staging, chemoradiation,teletherapy techniques, brachytherapy techniques
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
V. Kesic - Cervical cancer - State of the art
1. Vesna Kesić Institute of Obstetrics and Gynecology Clinical Center of Serbia EASO Masterclass in Clinical Oncology 27-29. October, 2011, Amman, Jordan Cervical Cancer - State of Art -
2. It has been estimated that approximately 500 000 women develop cervical cancer every year, and 260 000 women die of the disease. WHO, 2009
3.
4. Life-time risk (%) for cervical cancer USA 0,83 Scandinavia 1,01 India 2,22 South Amerika 5,31 5.8 West Asia 7.4 East Asia 7.4 Australia/N. Zeal. 7.7 North America 9.0 North Europe 10.0 West Europe 10.7 South Europe 12.1 North Africa 14.5 East Europe 18.7 South East Asia 26.2 South Cent. Asia 28.0 Central Africa 28.6 South America 29.3 West Africa 30.6 Central. America 38.2 South Africa 42.7 East Africa
5. Incidence of Cervical Cancer per 100,000 Females in Arab World < 4.0 4.0 – 7.9 8.0 – 11.9 12.0 – 15.9 ≥ 16.0 Algeria Map produced by Prof. Inas Elattar Pakistan Pakistan Morocco Afghanistan Palestine Bahrain Iran Iraq Sudan Somalia Libya Egypt Saudi Arabia Oman Yemen UAE Jordan Qatar Kuwait Syria Lebanon Djibouti
6. Two key reasons : 1. The vast majority of women still know little about cervical cancer or what they should do to prevent it. 2. Many countries have ineffective prevention programmes or no prevention programmes at all.
7. As the consequence, a high proportion of cervical cancer is diagnosed when already advanced and metastatic, leading to low probability of cure and high mortality rates . 85% Cervical Cancer: Groote Schuur Hospital, 1984 – 2000 (n = 3098)
16. HPV infe c tion Low-grade changes High-grade lesions Cancer 300 milion s 30 milion s 10 milion s 0. 5 milion s HPV E6, E7 Cellular changes Many years 8-15 HPV infe ction Parkin DM, Bray F, Ferlay J, Pisani P. CA Cancer J Clin. 2005;55:74–108 World Health Organization. Geneva, Switzerland: World Health Organization; 1999:1–22. Number of cases 0.15% ! Estimated World Burden of HPV-related Disease and Diagnoses
18. Natural history of cervical cancer and prevention Precancerous lesion Invasive disease Normal Cervix Persistent infection with HR types HPV Clearance Progression Initial HPV infection
33. Most patients with early stage cervical cancer are treated by either radical surgery or radical radiotherapy. Both treatment modalities have proven to be equally effective . Landoni et al : Lancet 1997 350 535- 540
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38. Modern approach to the surgical management of cervical cancer Conservative Radical for early disease for advanced disease Tailored
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42. x The diagnosis of stage Ia cervical cancer should be based on conization !
43. If distant spread is very unlikely, simple but complete excision of the lesion suffices. If it is likely that the cancer has spread, than an extended operation should be performed.
44. Depth of invasion LVSI Risk of node metastases 0-3 - < 1 / 1000 0-3 + 2 / 100 3-5 - 2/ 100 3-5 + 5 / 100 Stage Ia cervical cancer
53. T y p e II I T ype II Types of hysterectomy- Piver 40% Magrina, 1995 0.8% Urinary dysfunction 7% 1.1% Thromboembolism 0.3% 0.5% Deaths 1% 0.3% Digestive fistulas 4.8% 0.3% Urinary fistulas Type III Type II Complication
62. Adjuvant therapy in early cervical cancer For adjuvant irradiation - High risk, negative nodes - Positive nodes (1-3) - Poorly differentiated or undiferentiated tumor (G3) - LVSI (lympho-vascular space invasion) - Primary tumor > 3cm (tumor-cervix volume > 3cm ) - Endocervical invasion (barrel shaped ) - Inadequate surgery - Insufficient HP report For adjuvant chemo-irradiation - Positive resection margins - Involvement of parametria - Residual tumor
63. Postoperative pelvic radiation in patients with nodal metastases has been the standard approach. It increases local control, but not the overall survival , due to inability of adjuvant pelvic irradiation to influence distant metastases
67. The survival of patients that had bulky nodes removed has been significantly improved compared to those who had not the nodes resected (31% vs 6%) Hacker et al. Int. J Gynecol Cancer, 1995;5: 250-256 1. KiKim et al. Gynecol Oncol, 1998; 69: 243-7
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69. Extended-field radiotherapy is the standard part of treatment achieving the long-term survival of 30-40% for stage Ib patients with positive PALN. Consistent benefit of concurrent chemo-radiation with Cis-platin based chemotrerapy incorporated in extended-field irradiation.
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71. Neo-adjuvant chemotherapy followed by radical surgery has emerged as a possible alternative to conventional chemo-radiation, which may improve a survival in patients with stage Ib2 disease Benedetti -Panici P.J Clin Oncol, 2002; 20: 179-188 Tierney J. Eur J Cancer, 2003; 39: 2470-2486 14%
80. The incidence of cervical cancer in one country is an indicator of how much the whole society takes care about its women.
Editor's Notes
Prevention is not a new invention. It took a long way, 4000 years way, from old Egypt to Zur Hausen who identified HPV virus and got Nobel Prize, to realize
This is when precancer develops and which will eventually progress to CC
In two words…
This means that there must be something to modify the course of HPV - Immune response