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RIGHT ILIAC FOSSA LUMP, WITH SPECIAL REFERENCE TO RIGHT COLONIC CANCER
This document discusses potential causes of masses in the right iliac fossa, including appendicular abscess, appendicular mass, ileocecal tuberculosis, and carcinoma of the caecum. It provides characteristics of some common right iliac fossa masses like appendicular masses being tender, soft to firm, and having ill-defined borders, while ileocecal tuberculosis masses are firm to hard and highly placed. The document also reviews colon carcinoma risks such as aging, hereditary factors, and diet high in animal fat or low in fiber, as well as the pathogenesis involving mutations in microsatellite sequences regulating cell growth.
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RIGHT ILIAC FOSSA LUMP, WITH SPECIAL REFERENCE TO RIGHT COLONIC CANCER
- 1. RIGHT ILLIAC FOSSALUMP Sandipan Bhattacharya 10.03.2017 Malda Medical College
- 3. RIGHT ILLIAC FOSSA(STRUCTURES) •APPENDIX WITH MESOAPPENDIX • CAECUM • TERMINAL ILEUM • RETROPERITONEAL TISSUE • ILIAC NODES • ILIAC ARTERIES
- 4. RIGHT ILIAC FOSSAMASS ABDOMINAL WALL INTRAPERITONEAL RETROPERITONEAL MISCELLANEOUS Haematoma Appendicular abscess Iliopsoas abscess Loose bodies Abscess Carcinoma of colon Undescended testis Ovarian mass/ tubo- ovarian mass Incisional Hernia (post appendectomy) Appendicular mass Retroperitoneal lymph nodes Uterine mass Tumours a. benign (lipoma, fibroma, neurofibroma, fibromatosis) b. malignant (desmoids tumour, soft tissue sarcoma) Ileocecal tuberculosis Aneurysm Ameboma Psoas abscess Diverticulitis Crohn’s disease
- 6. MASS CHARACTERISTICS APPENDICULAR MASSILEO -CAECAL TB CARCINOMA CAECUM TENDER SOFT TO FIRM ILL DEFINED BORDERS IRREGULAR AND FIXED NON TENDER FIRM TO HARD HIGHLY PLACED DOUGHY ABDOMEN NON TENDER HARD FIXED ASCITIS HEPATOMEGALY
- 7. COLON CARCINOMA • INCIDENCE -Mostcommon malignancy of GI tract -Third most common cancer in the world -95% colorectal carcinomas are adenocarcinoma
- 8. COLON CARCINOMA • RISKFACTORS 1.AGEING- incidence increases after 50 years 2. HEREDITARY- 80% sporadic, 20% with known family history. 3.DIETARY FACTORS AND ENVIRONMENTAL FACTORS: - i)Diet rich in animal fat- directly toxic to colonic mucosa inducing early malignant changes. ii) low dietary fibres iii)alcohol iv)obesity and sedentary lifestyle
- 9. COLON CARCINOMA 4. INFLAMMATORYBOWEL DISEASE- Chronic inflammation leading to malignant changes. 5. OTHERS: - i) Cigarette smoking - >35 years age ii) Ureterosigmoidostomy iii) Pelvic irradiation
- 10.
- 12. MUTATION IN MICROSATELITESEQUENCE IN CODING AND PROMOTOR REGIONS OF GENES REGULATING CELL GROWTH BAX TGF-B INHIBITS COLONIC EPITHELIAL CELL PROLIFERATION SURVIVAL OF GENETICALLY ABNORMAL CLONES