This document discusses the biomechanics of the normal and replaced knee. It covers the axes of motion of the lower limb, tibiofemoral motion including flexion, extension, rotation, and stability mechanisms like muscles, ligaments, and menisci. It then discusses the goals and designs of total knee replacements, including whether to retain or sacrifice the cruciate ligaments, the use of cam and spine mechanisms to substitute for the PCL, and considerations for femoral and tibial implant design. Recent research topics discussed include the adductor moment, rotatory knee arthritis, and the shape of the tibial plateau.