This document discusses low back ache and sciatica. It notes that spinal pain is influenced by structural, biomechanical, biochemical, medical, and psychosocial factors. Treatment is often difficult. Chronic low back ache is defined as lasting over 3 months. It is a common cause of disability in adults under 45 years old and is the most expensive benign condition in industrialized countries. Sciatica involves leg pain localized to one or more nerve roots from L4-S2, with or without neurological deficits. Risk factors, clinical evaluation, diagnostic strategies, non-operative treatments, interventional procedures, surgery, and physical therapy approaches are described.