The document discusses challenges with sizing components in total knee replacement. It notes that undersizing the femoral component in a posterior-referenced system can cause notching of the anterior cortex, while oversizing can cause patellofemoral overstuffing. For the tibial component, undersizing risks loosening due to lack of cortical coverage, while oversizing risks soft tissue irritation from overhang. Both under and oversizing the patellar component can cause pain; undersizing leaves bone uncovered while oversizing irritates surrounding tissues. Proper sizing of all components is important for reconstructing knee kinematics and avoiding post-operative pain.