Depression and SSRI's

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This file accompanies a Youtube clip covering the role of serotonin and SSRI's in the development and treatment of depression.

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  • Genes: Even more likely if both parents suffered from it (but not cause and affect, there are other social, psychological causes)Thus serotonin has a calming affectNonadrenalin found in the amygdala, and mediates attention, stress response, etc
  • Genes: Even more likely if both parents suffered from it (but not cause and affect, there are other social, psychological causes)Thus serotonin has a calming affectNonadrenalin found in the amygdala, and mediates attention, stress response, etc
  • Genes: Even more likely if both parents suffered from it (but not cause and affect, there are other social, psychological causes)Thus serotonin has a calming affectNonadrenalin found in the amygdala, and mediates attention, stress response, etc
  • Depression and SSRI's

    1. 1. Depression - Symptoms• Thoughts of suicide or death• Anhedonia (the loss of ability to experience pleasure, or the inability to gain pleasure from normally pleasurable activities.• Difficulty concentrating• Reduced energy or feeling fatigued• Altered sleep patterns – insomnia (difficulty going/ staying asleep), hypersomnia (feeling tired after excessive sleep – 12hrs + per day)• Prolonged sadness for the majority of the day for at least 2 weeks.• Dramatic change in weight (either loss or gain)• Change in appetite – either loss or increase• Inappropriate guilt or self-blame• Agitated for retarded psychological/ physical activity
    2. 2. Application of Biopsychosocial framework to understanding a Mood disorder: Depression1: Biological triggers• Genes – more likely to develop depression if a/ both parents suffered from mood disorder• Low levels of Serotonin• Which is a neurotransmitter that has an inhibitory (calming effect) on Central.N.S• Serotonin deficiencies – linked to – anorexia, bulimia, social anxiety & mood disorders, OCD, Schizophrenia, sl eep disorders• Low levels of Noradrenalin aka norepinephrine also linked to symptoms of depression
    3. 3. SSRI’s: (Selective Serotonin re-uptake inhibitors)• Typically mimic the effect of serotonin• Which after 2-6 weeks start to take effect• Short-term side effects: anxiety, insomnia, weight gain• SSRI’s block the reabsorption of serotonin at the pre- synaptic neuron, thus increasing serotonin activity at post-synaptic neuron

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