Bipolar Presentation

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Current Topic
Presentation
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Evan Homison

2. Disease State: Bipolar Disorder
Overview
• Also known as Manic Depression
• Illness marked by extreme changes in mood, thought, energy and
behavior
• It has symptoms of Mania: The "Highs" of Bipolar Disorder and
Depression (Hypomania): The "Lows" of the disorder
• Changes in mood, or "mood swings" are intense and can last for hours,
days, weeks or even months
• These mood swings can affect sleep, energy, activity, judgment,
behavior and the ability to think clearly
• Episodes of mood swings may occur rarely or multiple times a year
• lifelong condition, you can manage your mood swings and other
symptoms by following a treatment plan.

3. Symptoms/Types
• There are several types of bipolar and related disorders
• Bipolar I disorder. You've had at least one manic episode that may be preceded or followed
by hypomanic or major depressive episodes.
• Bipolar II disorder. You've had at least one major depressive episode and at least one
hypomanic episode, but you've never had a manic episode.
• Cyclothymic disorder. You've had at least two years — or one year in children and teenagers
— of many periods of hypomania symptoms and periods of depressive symptoms
• ***Bipolar II disorder is not a milder form of bipolar I disorder, but a separate diagnosis.
• Manic Symptoms: Abnormally Upbeat, Increased Activity, Racing Thoughts, Euphoria, Poor
decision-making
• Hypomanic Symptoms: Loss of interest, Depression, Fatigue, Feelings of worthlessness or
Guilt, Decreased ability to think or concentrate, or indecisiveness. Thinking about, planning
or attempting suicide

4. Brand Name: Zyprexa
Generic Name: Olanzapine

5. Management through medication
• Brand names: Zyprexa®
Typically taken by: Tablet: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg
Injection (immediate release): 10 mg (extended release): 150 mg, 210 mg, 300 mg, 405 mg
• Generic name: olanzapine (oh LANZ a peen)
• Class of Drug: Atypical antipsychotics (block receptors in the brain's dopamine pathways) (SGA)
• Second Generation: Doesn’t cause as many involuntary movements like a first generation would (Parkinson's)
• Rebalances dopamine and serotonin to improve thinking, mood, and behavior
• Too much dopamine it can make you see or hear things that are not there (hallucinations), or think things that
others do not (delusions).
• Help to decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated
• The exact mechanism of action of olanzapine is not known.
• Binds to alpha-1, dopamine, histamine H-1, muscarinic, and serotonin type 2 (5-HT2) receptors.

6. Most Reported Symptoms
The most common side effects of
Zyprexa include:
▪ weight gain (more common in
teenagers)
▪ increased appetite
▪ headaches
▪ dizziness
▪ drowsiness
▪ feeling tired or restless
▪ problems with speech or memory
▪ tremors or shaking
▪ numbness or tingly feeling,
▪ personality changes,
▪ dry mouth,
▪ increased salivation,
▪ stomach pain,
▪ constipation, and
▪ pain in your arms or legs

7. Other Side Effects
• Uncontrolled muscle movements in your
face (chewing, lip-smacking, frowning,
tongue movement, blinking or eye
movement),
• Trouble speaking or swallowing
• Swelling in the hands or feet
• Confusion
• Unusual thoughts or behavior
• Hallucinations
• Thoughts about hurting yourself,
• Sudden weakness or ill feeling,
• Fever
• Swollen gums
• Painful mouth sores

8. Special Considerations
• For any mental disorder, Psychological intervention is recommended
• Zyprexa may impair your thinking or reactions
• Avoid Alcohol
• Causes issues with driving or anything that requires you to be alert
• You may gain weight or have high cholesterol and triglycerides
• Olanzapine can cause high blood sugar (hyperglycemia) (Diabetes patients
need checked regularly)
• Avoid getting up too fast from a sitting or lying position, or you may feel
dizzy
• Avoid becoming overheated or dehydrated
• Increase risk of death in older adults with dementia-related psychosis and is
not approved for this use.
• Your blood may need to be tested often. Visit your doctor regularly.

9. References
“Bipolar Disorder.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 16
Feb. 2021, www.mayoclinic.org.
“Olanzapine (Zyprexa).” NAMI, https://www.nami.org/About-Mental-
Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Olanzapine-(Zyprexa).
“Zyprexa, Zyprexa Zydis (Olanzapine): Uses, Dosage, Side Effects, Interactions, Warning.”
RxList, RxList, 12 Oct. 2021, https://www.rxlist.com/zyprexa-drug.htm.