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‫افغانستان‬ ‫اسالمی‬ ‫جمهوری‬
‫عامه‬ ‫صحت‬ ‫وزارت‬
‫بلخی‬ ‫سینای‬ ‫علی‬ ‫ابو‬ ‫آموزشی‬ ‫وی‬ ‫حوزه‬ ‫شفاخانه‬
‫عصبی‬ ‫و‬ ‫روانی‬ ‫سرویس‬
‫کننده‬ ‫ترتیب‬:‫فردین‬ ‫احمد‬ ‫داکتر‬
‫عالمی‬ ‫آرتین‬
‫نظر‬ ‫تحت‬:‫داکتر‬ ‫الحاج‬ ‫ورپوه‬ ُ‫رنح‬
‫عالمی‬ ‫نادر‬ ‫محمد‬
Cyclothymia or Cyclothymic Disorder
19.7.99
Cyclothymia
Cyclothymic Disorder
1. The Mood Spectrum and Mood Swing.
2. Understanding Cyclothemia / Cyclothemic Disorder
3. Diagnosis and it’s Features
4. Etiology and prevelance
5. Differential Diagnosis of Cyclothymia & Treatment.
6. Clinical Course & Prognosis
7. Reference
Here’s what we’ll Cover :
The term mood describes a dominant and
sustained emotional state.
Mood
Mood :
Intensity : Not much intense or immediate
Cause : unclear or less specific
Duration : Hours of Days
+ & - mood. ( Multiple Emotions )
Expressions : not distinct
a mood episode refers to any period of
time when a patient feels abnormally
happy or sad.
Mood episodes are the building blocks that
mood disorders are constructed.
Mood Episode
The Mood Spectrum
cyclothymia
thymia A condition of the mind.(Greek thumos, state of mind)
dysthymia (Greek dus-, bad or difficult)
cyclothymia (Greek kuklos, circle)
Mood Swings
A mood swing is an extreme or
rapid change in mood.
+ Outcomes.
- Outcomes.
Changes in a person’s :
• energy level
• sleep patterns
• self-esteem
• Concentration
• drug or alcohol use can be signs of an oncoming
mood disorder.
The Mood Spectrum
Understanding Cyclothymia
patients have had repeated mood
swings, but none that are severe or
long enough to be called major
depressive episodes or manic
episodes.
cyclothymia
(Greek kuklos, circle)
Understanding Cyclothymia
patients have had repeated mood
swings, but none that are severe or
long enough to be called major
depressive episodes or manic
episodes.
cyclothymia
(Greek kuklos, circle)
- 2 Year *
+ Episodes of Hypomanic symptoms .
+ Episodes of Major Depressive symptoms.
During this Timeline :
Half of this time ; Episodes should be
Present.
Not + 2 months ; Symptom Free.
Not meet the Criteria for
Depressive ; Manic ; Hypomanic episode.
Not Better Explained by :
Schizo-spectrum ;
Delusional Disorder
Psychotic Disorder.
Not Due to Substance Use or
Another medical condition
Causes Impairment in Daily Life.
Cyclothymic Disorder ( Dx Criteria )
Elevated
Mood /
Depressive
Symptoms
Not Better
Explained by :
Schizo-spectrum
Delusional Disorder
Psychotic Disorder.
Not meet the
Criteria for
Depressive ; Manic
; Hypomanic
episode.
Have been
Present ½ the
time ; + 2m
Symptom Free.
Not Due to
Substance Use or
Another medical
condition
Causes
Impairment in
Daily Life.
The depressive symptoms of cyclothymic disorder include:
•Feeling hopeless or sad +
•Losing interest in favorite activities +
•Becoming easily tearful
•Irritability & Restlessness
•Changes in weight
•Feeling guilty and worthless
•Having sleep problems
•Feeling fatigued
•Problems with concentration
•Having thoughts of suicide or death
The hypomanic symptoms of cyclothymic disorder include:
•Experiencing a sense of euphoria or happiness +
•Feeling extremely optimistic
•Having an inflated self-esteem ( grandiosity )
•Talkativeness
•Making poor decision and Partaking in risky behaviors
•Having racing thoughts and easily distracted
•Excessive physical actions
•Feeing irritable or agitated +
•Not needing as much sleep as normal ( 3 hours )
Maj.Dep.Episode
+5 Symptoms / 2wks ( +2c )
+ Depressed Mood
+ Loss of Interest or Pleasure
Guilt or Shame
Low Self-Esteem
Anergia / Fatigue
Abnormal Sleep
Abnormal Appetite
Psychomotor Retardation or Agitation
Hypomanic Episode
4 Days ; ( 2c+ 4s)
+ Elated Mood
+ Irritability
Distractibility
Irresponsibility
Impulsivity
Reckless Risk Taking
Hyperactivity
Over-Talkativeness
OPD patients
in NPHs.
3-5%
Affects 1% of World Wide
Population *
10 – 20 %
+ Borderline
Personality
Disorder
M : F
2 : 3
50 – 75% in
15 -25y Age.
Etiology of Cyclothymic Disorder :
family history of
major depression,
bipolar disorder,
suicide, or alcohol or
drug dependence.
Idiopathic
Genetic factors
( bipolar disorder )
~ 15% to 50% risk that
people with cyclothymia
will be Dx
Bipolar Disorder
comorbidities
Triggers and Life events.
the most common comorbidities with cyclothymia are :
In children and adolescents :
• anxiety disorders – GAD ; PD ; OCD.
• impulse control issues
• eating disorders – Anorexia & Bulimia Nervosa ; Pica
• ADHD.
• In adults, cyclothymia also tends to be comorbid with impulse control
issues.
( gambling and compulsive sexuality in men)
( compulsive buying and binge eating in women)
Clinical Course
• Onset : Gradual. Early Adolescents
• Mood Swings – Mild ( Hours ; Days ; Weeks , Months )
• Mood Elation Episodes maybe more enjoyable due to
• Increased Productivity ; Activity ; Sociability.
• Reason of Visit to Doctor : Depressive Symptoms.
• May Remain undiagnosed.
- Life Impact -
These swings in mood often negatively impact a person's work and
social life.
Consequences often include instability with an uneven work and
schooling history, impulsive and frequent changes of residence,
repeated romantic or marital breakups, and an episodic abuse of
alcohol and drugs.
Differensial Daignose
Other Mood Disorders
Drug Abuse
• Cocaine
• Amphetamine
• Steroids
Personality Disorder
• Borderline
• Anti-social
• Histrionic
• ADHD ( in children & teens ) :Stimulants in ADHD + ; while worsens in –
Cyclothymic disorder.
•
- Bipolar Mood Disorder ; With Rapid Cycling ; Ultra Rapid Cycling.
Recurrent Depressive Disorder ; Drug or Alcohol Misuse ;
Treatment
Goals
Mood Stabilizer
mood stabilizer" does not describe a mechanism, but rather an effect.
 Anti-convulsant Mood Stabilizers
 Valproate
 Lamotrigine
 Carbamazepine
• Topiramate / Gabapentin ( not FDA App.)
• Anti Psychotics : Atypical.
• Olanzapine ; Quetiapine ; aripiprazole …
• Omega 3 fatty acids vs placebo !
• Lithium Carbonate
Slow Onset of Anti Manic effects ( 1 – 3w)
Avoid in the Acute Phase due to :
Unpredictable Response
Side Effects
Lab Tests.
Treatment
Crisis : Sedating Antipsychotics :
Chlorpromazine 50mg nocte
Risperidone 1mg nocte
Olanzapine 2.5mg nocte
Combination Therapy
monotherapy ; not sufficient.
Atypical AP + lithium or
Valproate + Benzodiazepine
Bases of an Effective Treatment
Psycho-Social
Support.
The Right Drugs.
Life Style Changes.
Avoid Triggers.
Strict – and
Adequate Sleep
Proper Exercise
RESEARCH RESOURCES
● Kaplan & Sadock's ; 2015.
● DSM – V Made Easy ; 2017.
● ICT 10 https://icd.who.int/browse10/2019/en#/F30-F39
● WebMD ;
● American Psychiatric Association Official Website
● Oxford Medical Handbook of Psychiatry 3rd Edition
Thank You

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Cyclothemic Disorder

  • 1.
  • 2. ‫افغانستان‬ ‫اسالمی‬ ‫جمهوری‬ ‫عامه‬ ‫صحت‬ ‫وزارت‬ ‫بلخی‬ ‫سینای‬ ‫علی‬ ‫ابو‬ ‫آموزشی‬ ‫وی‬ ‫حوزه‬ ‫شفاخانه‬ ‫عصبی‬ ‫و‬ ‫روانی‬ ‫سرویس‬ ‫کننده‬ ‫ترتیب‬:‫فردین‬ ‫احمد‬ ‫داکتر‬ ‫عالمی‬ ‫آرتین‬ ‫نظر‬ ‫تحت‬:‫داکتر‬ ‫الحاج‬ ‫ورپوه‬ ُ‫رنح‬ ‫عالمی‬ ‫نادر‬ ‫محمد‬ Cyclothymia or Cyclothymic Disorder 19.7.99
  • 4. 1. The Mood Spectrum and Mood Swing. 2. Understanding Cyclothemia / Cyclothemic Disorder 3. Diagnosis and it’s Features 4. Etiology and prevelance 5. Differential Diagnosis of Cyclothymia & Treatment. 6. Clinical Course & Prognosis 7. Reference Here’s what we’ll Cover :
  • 5. The term mood describes a dominant and sustained emotional state. Mood Mood : Intensity : Not much intense or immediate Cause : unclear or less specific Duration : Hours of Days + & - mood. ( Multiple Emotions ) Expressions : not distinct
  • 6. a mood episode refers to any period of time when a patient feels abnormally happy or sad. Mood episodes are the building blocks that mood disorders are constructed. Mood Episode
  • 7. The Mood Spectrum cyclothymia thymia A condition of the mind.(Greek thumos, state of mind) dysthymia (Greek dus-, bad or difficult) cyclothymia (Greek kuklos, circle)
  • 8. Mood Swings A mood swing is an extreme or rapid change in mood. + Outcomes. - Outcomes. Changes in a person’s : • energy level • sleep patterns • self-esteem • Concentration • drug or alcohol use can be signs of an oncoming mood disorder.
  • 10. Understanding Cyclothymia patients have had repeated mood swings, but none that are severe or long enough to be called major depressive episodes or manic episodes. cyclothymia (Greek kuklos, circle)
  • 11. Understanding Cyclothymia patients have had repeated mood swings, but none that are severe or long enough to be called major depressive episodes or manic episodes. cyclothymia (Greek kuklos, circle)
  • 12. - 2 Year * + Episodes of Hypomanic symptoms . + Episodes of Major Depressive symptoms.
  • 13. During this Timeline : Half of this time ; Episodes should be Present. Not + 2 months ; Symptom Free.
  • 14. Not meet the Criteria for Depressive ; Manic ; Hypomanic episode.
  • 15. Not Better Explained by : Schizo-spectrum ; Delusional Disorder Psychotic Disorder.
  • 16. Not Due to Substance Use or Another medical condition
  • 17. Causes Impairment in Daily Life.
  • 18. Cyclothymic Disorder ( Dx Criteria ) Elevated Mood / Depressive Symptoms Not Better Explained by : Schizo-spectrum Delusional Disorder Psychotic Disorder. Not meet the Criteria for Depressive ; Manic ; Hypomanic episode. Have been Present ½ the time ; + 2m Symptom Free. Not Due to Substance Use or Another medical condition Causes Impairment in Daily Life.
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  • 21. The depressive symptoms of cyclothymic disorder include: •Feeling hopeless or sad + •Losing interest in favorite activities + •Becoming easily tearful •Irritability & Restlessness •Changes in weight •Feeling guilty and worthless •Having sleep problems •Feeling fatigued •Problems with concentration •Having thoughts of suicide or death
  • 22. The hypomanic symptoms of cyclothymic disorder include: •Experiencing a sense of euphoria or happiness + •Feeling extremely optimistic •Having an inflated self-esteem ( grandiosity ) •Talkativeness •Making poor decision and Partaking in risky behaviors •Having racing thoughts and easily distracted •Excessive physical actions •Feeing irritable or agitated + •Not needing as much sleep as normal ( 3 hours )
  • 23. Maj.Dep.Episode +5 Symptoms / 2wks ( +2c ) + Depressed Mood + Loss of Interest or Pleasure Guilt or Shame Low Self-Esteem Anergia / Fatigue Abnormal Sleep Abnormal Appetite Psychomotor Retardation or Agitation Hypomanic Episode 4 Days ; ( 2c+ 4s) + Elated Mood + Irritability Distractibility Irresponsibility Impulsivity Reckless Risk Taking Hyperactivity Over-Talkativeness
  • 24. OPD patients in NPHs. 3-5% Affects 1% of World Wide Population * 10 – 20 % + Borderline Personality Disorder M : F 2 : 3 50 – 75% in 15 -25y Age.
  • 25. Etiology of Cyclothymic Disorder : family history of major depression, bipolar disorder, suicide, or alcohol or drug dependence. Idiopathic Genetic factors ( bipolar disorder ) ~ 15% to 50% risk that people with cyclothymia will be Dx Bipolar Disorder comorbidities Triggers and Life events.
  • 26. the most common comorbidities with cyclothymia are : In children and adolescents : • anxiety disorders – GAD ; PD ; OCD. • impulse control issues • eating disorders – Anorexia & Bulimia Nervosa ; Pica • ADHD. • In adults, cyclothymia also tends to be comorbid with impulse control issues. ( gambling and compulsive sexuality in men) ( compulsive buying and binge eating in women)
  • 27. Clinical Course • Onset : Gradual. Early Adolescents • Mood Swings – Mild ( Hours ; Days ; Weeks , Months ) • Mood Elation Episodes maybe more enjoyable due to • Increased Productivity ; Activity ; Sociability. • Reason of Visit to Doctor : Depressive Symptoms. • May Remain undiagnosed.
  • 28. - Life Impact - These swings in mood often negatively impact a person's work and social life. Consequences often include instability with an uneven work and schooling history, impulsive and frequent changes of residence, repeated romantic or marital breakups, and an episodic abuse of alcohol and drugs.
  • 29. Differensial Daignose Other Mood Disorders Drug Abuse • Cocaine • Amphetamine • Steroids Personality Disorder • Borderline • Anti-social • Histrionic • ADHD ( in children & teens ) :Stimulants in ADHD + ; while worsens in – Cyclothymic disorder. • - Bipolar Mood Disorder ; With Rapid Cycling ; Ultra Rapid Cycling. Recurrent Depressive Disorder ; Drug or Alcohol Misuse ;
  • 31. Mood Stabilizer mood stabilizer" does not describe a mechanism, but rather an effect.  Anti-convulsant Mood Stabilizers  Valproate  Lamotrigine  Carbamazepine • Topiramate / Gabapentin ( not FDA App.) • Anti Psychotics : Atypical. • Olanzapine ; Quetiapine ; aripiprazole … • Omega 3 fatty acids vs placebo ! • Lithium Carbonate Slow Onset of Anti Manic effects ( 1 – 3w) Avoid in the Acute Phase due to : Unpredictable Response Side Effects Lab Tests.
  • 32. Treatment Crisis : Sedating Antipsychotics : Chlorpromazine 50mg nocte Risperidone 1mg nocte Olanzapine 2.5mg nocte Combination Therapy monotherapy ; not sufficient. Atypical AP + lithium or Valproate + Benzodiazepine
  • 33. Bases of an Effective Treatment Psycho-Social Support. The Right Drugs. Life Style Changes. Avoid Triggers. Strict – and Adequate Sleep Proper Exercise
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  • 35. RESEARCH RESOURCES ● Kaplan & Sadock's ; 2015. ● DSM – V Made Easy ; 2017. ● ICT 10 https://icd.who.int/browse10/2019/en#/F30-F39 ● WebMD ; ● American Psychiatric Association Official Website ● Oxford Medical Handbook of Psychiatry 3rd Edition

Editor's Notes

  1. خلق و عاطفه و احساس
  2. نوسان خلقی مفرط ؛ یا بی نهایت الگو خواب ارزش و شخصیت شخص ؛ نزد خودش
  3. Bereavement : داغداری یا محرومیت
  4. Periods of elevated mood and depressive symptoms for at least half the time during the last two years for adults and one year for children and teenagers.
  5. Periods of stable moods last only two months at most.
  6. Symptoms do not meet the criteria for bipolar disorder, major depression, or another mental disorder.
  7. موصوف جنبه Symptoms are not caused by substance use or a medical condition.
  8. اختلال و سختی قابل توجه Symptoms create significant problems in one or more areas of life.
  9. احساس اندوه تقلیل یا از دست دادن اشتیاق در امور اشکبار شدن کج خلق یا زود رنج
  10. خوشبینی مفرط اعتماد به نفس یا بزرگ اندیشی پر حرفی تحریک پذیر
  11. مشخصه های اساسی اختلال یا آشفتگی پر نوسان و طولانی مدت یا دراز مدت
  12. مشخصه های اساسی اختلال یا آشفتگی پر نوسان و طولانی مدت یا دراز مدت