This document discusses vitamin D deficiency in Australia. It notes that 75% of Brisbane residents are vitamin D deficient, and links low vitamin D levels to increased rates of osteoporosis and related diseases. While sun exposure is needed to produce vitamin D, Australia has high skin cancer rates due to sun exposure. The document examines the challenges of obtaining adequate vitamin D levels through diet and supplements while still practicing sun protection. It emphasizes the importance of monitoring vitamin D levels, especially in high risk groups.
This document discusses vitamin D deficiency in India. It provides the following key points:
1. More than 80% of adults in India do not get enough vitamin D, despite India's sunny climate, due to factors like skin pigmentation and low dietary intake.
2. The most common disorders caused by vitamin D deficiency in India are osteomalacia and rickets, which are bone diseases characterized by softening of the bones.
3. Good food sources of vitamin D include cod liver oil, fatty fish like salmon and tuna, and fortified foods like milk, cereal and orange juice. However, dietary intake of vitamin D is still low for most Indians.
Vitamin D plays an important role in maintaining bone and immune system health. The document discusses that vitamin D deficiency is common in Western countries due to limited sun exposure and may increase risk of conditions like diabetes. Maintaining adequate vitamin D levels through sun exposure, supplementation, or diet can help regulate blood sugar levels and support overall health.
Vitamin D deficiency is common worldwide and can cause many health issues. It is involved in calcium absorption and bone health. Deficiency leads to osteomalacia and rickets in children, and increases risk of fractures in adults. It may also play roles in cardiovascular disease, diabetes, cancer prevention, autoimmune disease, pregnancy complications, muscle weakness, and mortality. Treatment involves dietary sources of vitamin D, supplementation, and sunlight exposure.
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
Vitamin D deficiency is a widespread problem globally and in India. It can cause rickets in children and bone problems in adults. The document discusses the causes, presentation, diagnosis, and treatment of vitamin D deficiency. Key points include that it is caused by low dietary intake and sun exposure, symptoms range from bone pain to rickets, screening involves vitamin D and calcium levels as well as imaging, and treatment consists of high dose vitamin D supplements and calcium for several weeks.
Vitamin D deficiency is common, affecting approximately 66% of the global population. It is defined as a serum 25-hydroxyvitamin D level below 20 ng/mL. Symptoms include bone and muscle pain. At-risk groups include those with dark skin, obesity, or malabsorption issues. Screening is recommended for high-risk individuals. Treatment involves oral vitamin D supplements of 50,000 IU weekly or 6000 IU daily to raise levels above 30 ng/mL. Maintenance doses of 800-1000 IU daily are used thereafter to prevent recurrence.
Vitamin D deficiency is highly prevalent around the world, including in India where studies show 76-100% of populations are deficient or insufficient. Multiple factors contribute to low vitamin D levels, including limited sun exposure, skin pigmentation, traditional clothing, air pollution, and dietary habits. While sunlight exposure is important for vitamin D synthesis, too little or too much can be problematic. Maintaining optimal vitamin D levels of 30-50 ng/ml through balanced sun exposure and dietary sources is important for overall health.
Vitamin D is an essential nutrient that promotes calcium absorption in the intestines and maintains adequate serum calcium and phosphate concentrations to enable normal mineralization of bone. It exists in two main forms, D2 (ergocalciferol) and D3 (cholecalciferol), and is obtained through exposure to sunlight, dietary intake of oily fish, eggs, and vitamin D fortified foods. The liver converts vitamin D to calcidiol which is then converted by the kidneys to calcitriol, the biologically active form, which regulates calcium and phosphate levels. Deficiencies can lead to rickets in children and osteomalacia in adults, characterized by soft, deformed bones and muscle weakness.
This document discusses vitamin D deficiency in India. It provides the following key points:
1. More than 80% of adults in India do not get enough vitamin D, despite India's sunny climate, due to factors like skin pigmentation and low dietary intake.
2. The most common disorders caused by vitamin D deficiency in India are osteomalacia and rickets, which are bone diseases characterized by softening of the bones.
3. Good food sources of vitamin D include cod liver oil, fatty fish like salmon and tuna, and fortified foods like milk, cereal and orange juice. However, dietary intake of vitamin D is still low for most Indians.
Vitamin D plays an important role in maintaining bone and immune system health. The document discusses that vitamin D deficiency is common in Western countries due to limited sun exposure and may increase risk of conditions like diabetes. Maintaining adequate vitamin D levels through sun exposure, supplementation, or diet can help regulate blood sugar levels and support overall health.
Vitamin D deficiency is common worldwide and can cause many health issues. It is involved in calcium absorption and bone health. Deficiency leads to osteomalacia and rickets in children, and increases risk of fractures in adults. It may also play roles in cardiovascular disease, diabetes, cancer prevention, autoimmune disease, pregnancy complications, muscle weakness, and mortality. Treatment involves dietary sources of vitamin D, supplementation, and sunlight exposure.
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
Vitamin D deficiency is a widespread problem globally and in India. It can cause rickets in children and bone problems in adults. The document discusses the causes, presentation, diagnosis, and treatment of vitamin D deficiency. Key points include that it is caused by low dietary intake and sun exposure, symptoms range from bone pain to rickets, screening involves vitamin D and calcium levels as well as imaging, and treatment consists of high dose vitamin D supplements and calcium for several weeks.
Vitamin D deficiency is common, affecting approximately 66% of the global population. It is defined as a serum 25-hydroxyvitamin D level below 20 ng/mL. Symptoms include bone and muscle pain. At-risk groups include those with dark skin, obesity, or malabsorption issues. Screening is recommended for high-risk individuals. Treatment involves oral vitamin D supplements of 50,000 IU weekly or 6000 IU daily to raise levels above 30 ng/mL. Maintenance doses of 800-1000 IU daily are used thereafter to prevent recurrence.
Vitamin D deficiency is highly prevalent around the world, including in India where studies show 76-100% of populations are deficient or insufficient. Multiple factors contribute to low vitamin D levels, including limited sun exposure, skin pigmentation, traditional clothing, air pollution, and dietary habits. While sunlight exposure is important for vitamin D synthesis, too little or too much can be problematic. Maintaining optimal vitamin D levels of 30-50 ng/ml through balanced sun exposure and dietary sources is important for overall health.
Vitamin D is an essential nutrient that promotes calcium absorption in the intestines and maintains adequate serum calcium and phosphate concentrations to enable normal mineralization of bone. It exists in two main forms, D2 (ergocalciferol) and D3 (cholecalciferol), and is obtained through exposure to sunlight, dietary intake of oily fish, eggs, and vitamin D fortified foods. The liver converts vitamin D to calcidiol which is then converted by the kidneys to calcitriol, the biologically active form, which regulates calcium and phosphate levels. Deficiencies can lead to rickets in children and osteomalacia in adults, characterized by soft, deformed bones and muscle weakness.
What is vitamin D and why do you need it? What it does. Symptoms & Signs of Deficiency; Optimum blood levels. Latest research findings relating to vitamin D and health. What is the best supplement dose? Tolerable upper intakes. Toxicity.
Vitamin D has widespread effects beyond bone health. It acts as a pleiotropic hormone that regulates over 200 genes and has important immunomodulatory properties. Maintaining optimal vitamin D levels may help reduce the risk of infections like tuberculosis and exacerbations of COPD, as well as cancers, cardiovascular disease, fractures and autoimmune disorders. More research is still needed but achieving a serum 25(OH)D level of at least 30 ng/mL through supplementation appears to provide the most benefits.
Vitamin D is a fat-soluble vitamin that is obtained through sunlight exposure and dietary sources like fatty fish and fortified foods. It plays an important role in bone and immune health by aiding in calcium absorption and bone mineralization. Testing for vitamin D levels has increased in recent years due to research linking vitamin D deficiency to diseases like cancer, heart disease, diabetes and depression. While vitamin D shows promise for many health benefits, more research is still needed to fully understand its therapeutic potential.
Vitamin E is a fat-soluble antioxidant that protects cell membranes from damage. It is essential for neurological function and reproduction. A lack of vitamin E can cause neurological issues like difficulty coordinating movements and peripheral neuropathy. While vitamin E supplements are generally safe, more research is still needed on their long-term health effects for conditions like heart disease and cancer prevention. Vitamin E is especially important for premature infants to prevent complications like anemia and hemolysis.
Vitamin E was discovered in 1922 by Herbert Evans and Katherine Bishop. It acts as an antioxidant in the body and is important for immune and cell functions. Deficiency can cause anemia, poor balance, and muscle weakness. Symptoms of deficiency include shaky movements, aging spots on the skin, and sight problems. Deficiency is rare and mainly affects those over 55 years old in the U.S. Deficiency can be treated with a balanced diet, weekly injections, or supplements and resolved within a few weeks in children. Current research is exploring vitamin E's potential role in memory disorders and the elderly.
A brief review about the role of vitamin D in health and disease. Most of the content in these slides were taken from another author with some editing to custom it for the purpose of general physician workshop scientific material. Some figures were our own data in our hospital
Vitamin D may help prevent cancer according to recent research. Studies have found lower cancer rates in areas with higher sunlight exposure, which produces more vitamin D. Cancer researchers are studying vitamin D's effects, which include promoting cell differentiation, decreasing growth of cancer cells, and stimulating cell death. Vitamin D regulates genes related to cancer and suppresses tumors in mice. Randomized trials found up to a 60% reduced cancer risk with vitamin D supplementation. More research is still needed, but promising results suggest vitamin D could usher in a new era of cancer prevention.
A 28-year-old female presented with a 1 month history of intermittent fever, joint pains, puffiness of her face, hands and feet, and a malar rash. Examination found enlarged lymph nodes and spleen, with a faint pericardial friction rub. Tests found proteinuria, hematologic abnormalities, and autoantibodies consistent with systemic lupus erythematosus. SLE is an autoimmune disease caused by autoantibodies against self-antigens, which can affect multiple organ systems. Presentations, investigations, and treatments were discussed.
Vitamin D deficiency causes the bone disease rickets in children or osteomalacia in adults. It is characterized by skeletal abnormalities and soft, weak bones. Vitamin D is important for calcium absorption from the gut and deposition in bones. It is produced in the skin upon exposure to sunlight and undergoes conversions in the liver and kidney to become active. Deficiency can be caused by lack of vitamin D in diet, sunlight exposure, kidney/liver disorders, or genetic factors. Symptoms depend on age and severity but include bone deformities, fractures, and radiological changes like widened growth plates. Treatment involves daily high dose vitamin D and calcium supplements.
Vitamin D deficiency causes rickets in children and osteomalacia in adults. The document discusses vitamin D metabolism, forms, measurement, defining sufficiency, causes of deficiency including lack of sunlight and certain medical conditions or medications, clinical manifestations like bone pain and deformities, management including high dose oral supplementation or injections to correct deficiency followed by maintenance doses. Treatment aims to restore vitamin D levels to the sufficient range and ensure adequate calcium intake, with dosing recommendations provided for different age groups and medical conditions.
Vitamin D Update presented by Dustin Sulak D.O. at the Maine Osteopathic Association Midwinter Conference on February 8th, 2013. The presentation provided an overview and history of vitamin D, discussed vitamin D physiology including its activation in the body and role in the parathyroid hormone pathway. It reviewed past studies on vitamin D and various health outcomes such as heart disease, cancer, pain, and diabetes. Recent studies presented showed associations between vitamin D deficiency and increased risks of cesarean section, respiratory infections, and other conditions.
Vitamin D is a fat-soluble vitamin derived from cholesterol that functions as a steroid hormone. It is present in the skin in an inactive form, 7-dehydrocholesterol, and is converted to the active form calciferol when the skin is exposed to sunlight. The active form of vitamin D binds to vitamin D receptors in target cells and acts as a transcription factor that modulates gene expression involved in calcium absorption and bone health. Risk factors for vitamin D deficiency include inadequate sun exposure, skin pigmentation, obesity, and certain medical conditions or medications. Vitamin D deficiency can lead to rickets in children and osteomalacia in adults, and has also been associated with increased risk of diabetes, preecl
This document provides an overview and objectives of a malaria case management workshop. It discusses the epidemiology of malaria in Zimbabwe and covers classification, diagnosis, and treatment of both uncomplicated and severe malaria. The key points are:
1. Malaria is caused by a parasite transmitted by mosquitoes and remains highly endemic in parts of Africa. The workshop aims to equip participants to diagnose and manage both uncomplicated and severe malaria cases.
2. Zimbabwe has seen a 70% reduction in malaria prevalence since 2002. Districts are now classified as control or elimination areas depending on endemicity.
3. Treatment for uncomplicated malaria follows national guidelines to use Artemisinin-Based Combination Therapies
The document discusses vitamin D, including its synthesis from sun exposure, its role in various bodily processes, and its potential health benefits. Key points include:
- Vitamin D is synthesized in the skin upon exposure to sunlight and can also be obtained through food and supplements. It plays an important role in bone and immune health.
- Vitamin D receptors are found throughout the body and vitamin D has been shown to regulate gene expression, turning genes on and off. This may explain its wide-ranging effects.
- Studies suggest vitamin D may help reduce the risk of various cancers, heart disease, diabetes, respiratory infections, autoimmune diseases, and mental health conditions like depression. Optimal vitamin D levels are important
This document summarizes diabetes, which is an endocrine disorder characterized by high blood glucose levels due to issues with insulin production or action. There are two main types of diabetes: type 1 diabetes results from destruction of beta cells that produce insulin, leading to uncontrolled glucose production and hyperglycemia. Type 2 diabetes involves decreased sensitivity to insulin and less glucose uptake, also resulting in hyperglycemia. Risk factors, symptoms, complications, management, and treatment options are described for both type 1 and type 2 diabetes.
Vitamin D is a steroid that is present in animals, plants and yeast. It is insoluble in water but soluble in fat and organic solutions. Vitamin D is sensitive to oxygen, light and iodine. It is considered a prohormone because it is converted to the active form 1,25-dihydroxycholesterol. Vitamin D functions to regulate calcium and phosphorus metabolism by promoting their absorption in the intestines and mobilization from bones. It is necessary for bone development and growth. A deficiency of vitamin D can lead to rickets in children, causing bowed legs and bone fractures, and osteomalacia in adults characterized by poor bone mineralization. Toxicity can result from long-
This document provides an overview and update on osteoporosis. It reviews non-pharmacologic contributions to bone health like exercise, calcium, vitamin D, and smoking cessation. It discusses evaluating and treating secondary causes of osteoporosis. Treatment options reviewed include oral and intravenous bisphosphonates, denosumab, teriparatide, abaloparatide, and romosozumab. Guidelines for treatment thresholds based on fracture risk are presented. Adherence to bisphosphonates and drug holidays are also discussed.
Vitamin A deficiency is a major public health problem worldwide, especially in Africa and South Asia. It can cause blindness and increases the risk of death from infections in children. The first signs are night blindness and dryness of the conjunctiva. More severe deficiency can lead to Bitot's spots, corneal ulceration and keratomalacia which can cause scarring and permanent blindness. Increasing intake of foods rich in preformed vitamin A such as liver, eggs, dairy or carotenoid-rich fruits and vegetables can help prevent and treat vitamin A deficiency.
1) Vitamin D is produced in the skin from sunlight exposure and is also obtained in small amounts from dietary sources like fatty fish.
2) In the liver and kidneys, vitamin D is activated to its biological form which acts to regulate calcium and phosphate levels in the body by increasing their absorption in the intestines and mobilization from bones.
3) Vitamin D deficiency can lead to rickets in children and osteomalacia in adults, characterized by soft, weak bones due to poor mineralization.
1. The patient, a 78-year-old man, was admitted with acute confusion for 3 days. His family noted changes in his urine color and odor and he had a low-grade fever.
2. On examination, he appeared dehydrated, scored 6/10 on a cognitive assessment, and had an elevated temperature, respiration rate, and heart rate.
3. Blood tests showed elevated urea and low sodium levels. Additional tests found an elevated inflammatory marker and bacteria in his urine, suggesting a urinary tract infection as the cause of his delirium.
What is vitamin D and why do you need it? What it does. Symptoms & Signs of Deficiency; Optimum blood levels. Latest research findings relating to vitamin D and health. What is the best supplement dose? Tolerable upper intakes. Toxicity.
Vitamin D has widespread effects beyond bone health. It acts as a pleiotropic hormone that regulates over 200 genes and has important immunomodulatory properties. Maintaining optimal vitamin D levels may help reduce the risk of infections like tuberculosis and exacerbations of COPD, as well as cancers, cardiovascular disease, fractures and autoimmune disorders. More research is still needed but achieving a serum 25(OH)D level of at least 30 ng/mL through supplementation appears to provide the most benefits.
Vitamin D is a fat-soluble vitamin that is obtained through sunlight exposure and dietary sources like fatty fish and fortified foods. It plays an important role in bone and immune health by aiding in calcium absorption and bone mineralization. Testing for vitamin D levels has increased in recent years due to research linking vitamin D deficiency to diseases like cancer, heart disease, diabetes and depression. While vitamin D shows promise for many health benefits, more research is still needed to fully understand its therapeutic potential.
Vitamin E is a fat-soluble antioxidant that protects cell membranes from damage. It is essential for neurological function and reproduction. A lack of vitamin E can cause neurological issues like difficulty coordinating movements and peripheral neuropathy. While vitamin E supplements are generally safe, more research is still needed on their long-term health effects for conditions like heart disease and cancer prevention. Vitamin E is especially important for premature infants to prevent complications like anemia and hemolysis.
Vitamin E was discovered in 1922 by Herbert Evans and Katherine Bishop. It acts as an antioxidant in the body and is important for immune and cell functions. Deficiency can cause anemia, poor balance, and muscle weakness. Symptoms of deficiency include shaky movements, aging spots on the skin, and sight problems. Deficiency is rare and mainly affects those over 55 years old in the U.S. Deficiency can be treated with a balanced diet, weekly injections, or supplements and resolved within a few weeks in children. Current research is exploring vitamin E's potential role in memory disorders and the elderly.
A brief review about the role of vitamin D in health and disease. Most of the content in these slides were taken from another author with some editing to custom it for the purpose of general physician workshop scientific material. Some figures were our own data in our hospital
Vitamin D may help prevent cancer according to recent research. Studies have found lower cancer rates in areas with higher sunlight exposure, which produces more vitamin D. Cancer researchers are studying vitamin D's effects, which include promoting cell differentiation, decreasing growth of cancer cells, and stimulating cell death. Vitamin D regulates genes related to cancer and suppresses tumors in mice. Randomized trials found up to a 60% reduced cancer risk with vitamin D supplementation. More research is still needed, but promising results suggest vitamin D could usher in a new era of cancer prevention.
A 28-year-old female presented with a 1 month history of intermittent fever, joint pains, puffiness of her face, hands and feet, and a malar rash. Examination found enlarged lymph nodes and spleen, with a faint pericardial friction rub. Tests found proteinuria, hematologic abnormalities, and autoantibodies consistent with systemic lupus erythematosus. SLE is an autoimmune disease caused by autoantibodies against self-antigens, which can affect multiple organ systems. Presentations, investigations, and treatments were discussed.
Vitamin D deficiency causes the bone disease rickets in children or osteomalacia in adults. It is characterized by skeletal abnormalities and soft, weak bones. Vitamin D is important for calcium absorption from the gut and deposition in bones. It is produced in the skin upon exposure to sunlight and undergoes conversions in the liver and kidney to become active. Deficiency can be caused by lack of vitamin D in diet, sunlight exposure, kidney/liver disorders, or genetic factors. Symptoms depend on age and severity but include bone deformities, fractures, and radiological changes like widened growth plates. Treatment involves daily high dose vitamin D and calcium supplements.
Vitamin D deficiency causes rickets in children and osteomalacia in adults. The document discusses vitamin D metabolism, forms, measurement, defining sufficiency, causes of deficiency including lack of sunlight and certain medical conditions or medications, clinical manifestations like bone pain and deformities, management including high dose oral supplementation or injections to correct deficiency followed by maintenance doses. Treatment aims to restore vitamin D levels to the sufficient range and ensure adequate calcium intake, with dosing recommendations provided for different age groups and medical conditions.
Vitamin D Update presented by Dustin Sulak D.O. at the Maine Osteopathic Association Midwinter Conference on February 8th, 2013. The presentation provided an overview and history of vitamin D, discussed vitamin D physiology including its activation in the body and role in the parathyroid hormone pathway. It reviewed past studies on vitamin D and various health outcomes such as heart disease, cancer, pain, and diabetes. Recent studies presented showed associations between vitamin D deficiency and increased risks of cesarean section, respiratory infections, and other conditions.
Vitamin D is a fat-soluble vitamin derived from cholesterol that functions as a steroid hormone. It is present in the skin in an inactive form, 7-dehydrocholesterol, and is converted to the active form calciferol when the skin is exposed to sunlight. The active form of vitamin D binds to vitamin D receptors in target cells and acts as a transcription factor that modulates gene expression involved in calcium absorption and bone health. Risk factors for vitamin D deficiency include inadequate sun exposure, skin pigmentation, obesity, and certain medical conditions or medications. Vitamin D deficiency can lead to rickets in children and osteomalacia in adults, and has also been associated with increased risk of diabetes, preecl
This document provides an overview and objectives of a malaria case management workshop. It discusses the epidemiology of malaria in Zimbabwe and covers classification, diagnosis, and treatment of both uncomplicated and severe malaria. The key points are:
1. Malaria is caused by a parasite transmitted by mosquitoes and remains highly endemic in parts of Africa. The workshop aims to equip participants to diagnose and manage both uncomplicated and severe malaria cases.
2. Zimbabwe has seen a 70% reduction in malaria prevalence since 2002. Districts are now classified as control or elimination areas depending on endemicity.
3. Treatment for uncomplicated malaria follows national guidelines to use Artemisinin-Based Combination Therapies
The document discusses vitamin D, including its synthesis from sun exposure, its role in various bodily processes, and its potential health benefits. Key points include:
- Vitamin D is synthesized in the skin upon exposure to sunlight and can also be obtained through food and supplements. It plays an important role in bone and immune health.
- Vitamin D receptors are found throughout the body and vitamin D has been shown to regulate gene expression, turning genes on and off. This may explain its wide-ranging effects.
- Studies suggest vitamin D may help reduce the risk of various cancers, heart disease, diabetes, respiratory infections, autoimmune diseases, and mental health conditions like depression. Optimal vitamin D levels are important
This document summarizes diabetes, which is an endocrine disorder characterized by high blood glucose levels due to issues with insulin production or action. There are two main types of diabetes: type 1 diabetes results from destruction of beta cells that produce insulin, leading to uncontrolled glucose production and hyperglycemia. Type 2 diabetes involves decreased sensitivity to insulin and less glucose uptake, also resulting in hyperglycemia. Risk factors, symptoms, complications, management, and treatment options are described for both type 1 and type 2 diabetes.
Vitamin D is a steroid that is present in animals, plants and yeast. It is insoluble in water but soluble in fat and organic solutions. Vitamin D is sensitive to oxygen, light and iodine. It is considered a prohormone because it is converted to the active form 1,25-dihydroxycholesterol. Vitamin D functions to regulate calcium and phosphorus metabolism by promoting their absorption in the intestines and mobilization from bones. It is necessary for bone development and growth. A deficiency of vitamin D can lead to rickets in children, causing bowed legs and bone fractures, and osteomalacia in adults characterized by poor bone mineralization. Toxicity can result from long-
This document provides an overview and update on osteoporosis. It reviews non-pharmacologic contributions to bone health like exercise, calcium, vitamin D, and smoking cessation. It discusses evaluating and treating secondary causes of osteoporosis. Treatment options reviewed include oral and intravenous bisphosphonates, denosumab, teriparatide, abaloparatide, and romosozumab. Guidelines for treatment thresholds based on fracture risk are presented. Adherence to bisphosphonates and drug holidays are also discussed.
Vitamin A deficiency is a major public health problem worldwide, especially in Africa and South Asia. It can cause blindness and increases the risk of death from infections in children. The first signs are night blindness and dryness of the conjunctiva. More severe deficiency can lead to Bitot's spots, corneal ulceration and keratomalacia which can cause scarring and permanent blindness. Increasing intake of foods rich in preformed vitamin A such as liver, eggs, dairy or carotenoid-rich fruits and vegetables can help prevent and treat vitamin A deficiency.
1) Vitamin D is produced in the skin from sunlight exposure and is also obtained in small amounts from dietary sources like fatty fish.
2) In the liver and kidneys, vitamin D is activated to its biological form which acts to regulate calcium and phosphate levels in the body by increasing their absorption in the intestines and mobilization from bones.
3) Vitamin D deficiency can lead to rickets in children and osteomalacia in adults, characterized by soft, weak bones due to poor mineralization.
1. The patient, a 78-year-old man, was admitted with acute confusion for 3 days. His family noted changes in his urine color and odor and he had a low-grade fever.
2. On examination, he appeared dehydrated, scored 6/10 on a cognitive assessment, and had an elevated temperature, respiration rate, and heart rate.
3. Blood tests showed elevated urea and low sodium levels. Additional tests found an elevated inflammatory marker and bacteria in his urine, suggesting a urinary tract infection as the cause of his delirium.
Vitamin D is essential for strong bones and general good health. It is obtained mainly through sun exposure but can also come from supplements or food. The body undergoes multiple processes to activate vitamin D, including changing it in the liver and kidneys. Activated vitamin D then helps regulate calcium levels and cell communication throughout the body. While vitamin D is important, more research is still needed to fully understand its roles and health impacts.
Vitamin D is an essential vitamin that must be metabolized to become biologically active. It plays an important role in calcium homeostasis, bone and muscle health, immune function, and the regulation of cell growth. The best indicator of vitamin D status is the measurement of 25-hydroxyvitamin D in the blood, as it reflects vitamin D from dietary intake and sunlight exposure. Low vitamin D levels have been associated with increased risk of various chronic diseases. Vitamin D deficiency can lead to impaired bone mineralization and increased fracture risk.
you can find out all types of VEGF in this ppt and it is about physiological and path-physiological significance of VEGF and its possible targeting manoeuvering
The document summarizes recent research on vitamin D and its links to various chronic diseases. It finds that vitamin D is important for calcium absorption and other body functions, and recommends getting adequate vitamin D through sunlight exposure, dietary sources like fatty fish and fortified foods, and supplements if needed. Getting enough vitamin D may help reduce the risk of diseases like cancer, heart disease, and osteoporosis.
VEGF signaling plays an important role in angiogenesis and vasculogenesis. VEGF binds to VEGFR receptors and activates several key pathways involved in endothelial cell proliferation, survival, migration and permeability. This includes the Ras/MAPK, PI3K/Akt, eNOS and PKC pathways. VEGF signaling is tightly regulated during development and in response to hypoxia. Dysregulation of VEGF signaling can lead to various angiogenic diseases if there is either excess or deficiency of VEGF.
The document presents guidelines from the ADA and EASD on managing hyperglycemia in type 2 diabetes, recommending a patient-centered approach focusing on individualized glycemic targets and treatment options including lifestyle changes, oral medications, and insulin to reduce risks of complications while avoiding hypoglycemia. The pathogenesis of type 2 diabetes involves insulin resistance and defects in insulin secretion, incretin effect, and glucagon secretion leading to hyperglycemia.
Ueda 2016 5-pharmacological management of diabetes - lobna el toonyueda2015
Pharmacological management of diabetes involves approaches to treating type 2 diabetes, including glycemic control through oral antidiabetic drugs and insulin therapy. Insulin therapy is indicated for type 1 diabetes and can be used in type 2 diabetes when oral agents fail to control blood sugar levels. Basal insulin alone is often the initial insulin regimen but multiple daily injections or combined injectable regimens may be needed if blood sugar targets are not met. Insulin provides effective blood sugar control and is essential for treating diabetes in some patients.
The document discusses vitamin D, describing it as essential for health and important for numerous functions in the body. It outlines that vitamin D helps absorb calcium for strong bones and teeth, and supports immune function, mental health, and may lower risks of various diseases. It recommends getting vitamin D through moderate sun exposure or dietary supplements, and describes an optimal vitamin D blood level range.
The document discusses the history and development of thalidomide and its analogues. Thalidomide was originally introduced in the late 1950s as a sedative but was found to cause birth defects in thousands of children after being prescribed to pregnant women for morning sickness. This led to it being withdrawn in 1961. Researchers later discovered that thalidomide and its analogues have immunomodulatory and anti-inflammatory properties, leading to FDA approval to treat cancers and inflammatory diseases. New analogues like lenalidomide and pomalidomide were developed that are more potent with fewer side effects.
NEURODEGENERATION & NEUROPROTECTION-AN AYURVEDIC PERSPECTIVE.
WHAT AYURVEDA CAN OFFER BOTH IN PREVENTION & TREATMENT.FAMOUS PEOPLE SUFFERING FROM NEURODEGENERATION.MANDUKPARNI,SHANKHAPUSPI,POMGRENATE,ASWAGANDHA.BUDDHIBHRANSHA.NILANJAN DATTA.ROGNIDAN.PARKINSON,MULTIPLE SCLEROSIS,HUNTINGTONS CHOREA,ALZHEIMERS IN AYURVEDA TREATMENT.THANK YOU.ACKNOWLEDGEMENTS.DR.B.C.JANA.BHU.IPGAER AT SVSP,KOLKATA.BHU.
Vitamin D plays an important role in regulating calcium levels and bone health. It is also involved in insulin regulation and may protect against cancer, cardiovascular disease, and infections. Vitamin D deficiency can lead to rickets in children and osteomalacia in adults as well as increased risk of falls in older adults. Supplementation is recommended for those with inadequate sunlight exposure or dietary intake, with dosage depending on age.
This document summarizes the key components involved in vitamin D and calcium homeostasis, including the roles of vitamin D, parathyroid hormone (PTH), and calcitonin. It discusses how vitamin D is obtained from sunlight or diet and activated in the body. PTH and calcitonin work in opposition to regulate calcium levels - PTH increases calcium levels by acting on the kidneys and bone, while calcitonin decreases calcium levels by inhibiting bone resorption. PTH and vitamin D also interact, as vitamin D helps absorb calcium from the gut and PTH stimulates its production. Together this maintains appropriate calcium and phosphate levels in the blood and body.
D is for Debacle - The Sun, Vitamin D, 25(OH)D and HealthIvor Cummins
The Story of Vitamin D, and the Debacle of Human Health Impact that has unfolded over the past 50 years, as we allowed the population necessary levels to collapse. For individuals, parents, families, mothers - don't miss this understanding - this is probably the most important single factor for your health and longevity.
This document discusses vitamin D, beginning with an overview that while vitamin D is called a vitamin, it acts more like a hormone in the body. It describes how vitamin D is synthesized in the skin and transported to tissues where its active form binds to receptors. It then summarizes several roles and physiological functions of vitamin D related to calcium homeostasis, bone and muscle health, and potential extraskeletal effects. Finally, it provides details on vitamin D production, metabolism, and biological function, showing how vitamin D is converted to its active form in the body and its role in various health processes.
New treatment trends in alzheimer diseaseSarath Menon
This document summarizes new treatment trends in Alzheimer's disease. It discusses current treatments for mild-moderate Alzheimer's like donepezil, rivastigmine, and galantamine which are cholinesterase inhibitors. Memantine is used for more severe Alzheimer's as an NMDA receptor antagonist. Experimental therapies discussed include vaccines, secretase inhibitors, and stem cell therapy. Lifestyle factors like diet, exercise, and social support are also reviewed for prevention and management of Alzheimer's symptoms.
This document provides an overview of vitamin D, including its chemical nature, sources, importance, deficiency, and related diseases. It discusses vitamin D's role in bone health and calcium absorption. It also covers rickets and osteomalacia, bone diseases caused by vitamin D deficiency, and their symptoms, causes, prevalence worldwide, and treatment options. The document concludes by emphasizing the importance of obtaining sufficient vitamin D through sun exposure, diet, and supplements to prevent deficiency-related diseases.
AHS13 Anastasia Boulais — Is Sun Worshipping Increasing Your Risk of Melanoma? Ancestral Health Society
Those of us familiar with the evolutionary medicine model have come to question many of the conventional public health recommendations and, along with them, the complete sun avoidance. Dr Anastasia Boulais will describe the delicate balance between the benefits and risks of sun worshipping based on current evidence. The talk will focus on particular patterns of sun exposure which may increase the risk of formation of cutaneous melanoma. Other factors, such as diet, vitamin D status and even training patterns, contributing to that risk will be discussed. Anastasia will conclude with an overview of protective lifestyle factors.
1. Adequate sun exposure is essential for optimal health and vitamin D production, but most people do not get enough from their typical sun exposure or diet.
2. Getting regular moderate sun exposure of 10-15 minutes a few times per week or supplementing with 4000-10000IU of vitamin D per day can help ensure vitamin D levels are optimal for health benefits like reduced cancer and autoimmune disease risk.
3. While sun exposure has risks, adequate vitamin D provides more benefits than risks for most people, and targeting a blood level of 100-140 nmol/L appears to balance benefits and risks well.
- Adequate sun exposure is essential for optimal health and vitamin D levels, yet public health messages have overly focused on avoiding the sun.
- Most people in Western countries are vitamin D deficient due to inadequate sun exposure and population-wide calcium supplementation is unnecessary.
- Getting 10-15 minutes of sun exposure a few times per week without sunscreen can provide health benefits like reducing cancer and autoimmune disease risks while being safe and avoiding vitamin D deficiency.
Vitamin D Deficiency, by Dr. Mihir Adhikari Mihir Adhikari
Vitamin D deficiency can cause rickets in children and osteomalacia in adults. It is caused by lack of vitamin D from diet and sun exposure. The body synthesizes the inactive form cholecalciferol from cholesterol in skin upon sun exposure and the active form calcitriol is produced in the kidneys. Vitamin D plays a key role in calcium absorption and bone mineralization. Deficiency is highly prevalent in India due to low dietary intake and sun exposure. It is associated with many systemic disorders including musculoskeletal, autoimmune, cardiovascular and infectious diseases.
Vitamin D deficiency can cause rickets in children and osteomalacia in adults. It is caused by lack of vitamin D from diet and sun exposure. The body synthesizes the inactive form cholecalciferol from cholesterol in skin upon sun exposure and converts it to the active form calcitriol in the kidneys. Calcitriol regulates calcium and phosphate levels in blood and promotes their absorption in the gut. Deficiency leads to hypocalcemia and hypophosphatemia, impairing bone mineralization and causing softening and deformation of bones.
Vitamin D is important for human health and deficiency can lead to diseases like rickets. It is obtained through sun exposure, diet, and supplements. The document discusses vitamin D's roles in bone health, cancer prevention, cardiovascular, immune function, and other diseases. It provides recommendations for intake amounts and lists food sources of vitamin D like fatty fish, eggs, and fortified foods. Vitamin D deficiency is highly prevalent globally and putting populations at risk for various chronic conditions.
Vitamin D is formed in the skin upon exposure to sunlight and is important for calcium absorption and bone health. It can also be obtained through dietary sources. The document discusses vitamin D formation in the skin, dietary sources of vitamin D, risks of deficiency like rickets and osteomalacia, and recommendations for intake through diet and sunlight exposure.
This document provides an overview of vitamin K. It discusses the functions of vitamin K, which include its role in calcium binding proteins and the coagulation cascade. It notes the dietary sources of vitamin K, including green vegetables, and recommends dietary allowances ranging from 2 mcg in infants to 120 mcg in adult men. Vitamin K deficiency can cause bleeding disorders due to inadequate gamma-carboxylation of clotting factors.
Here I wrote in brief about 2 questions that were on my mind, will I ask my patients with photosensitive rash to wear sunscreen? Of course I will. But how will they get their vitamin D?
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Vitamins are organic nutrients needed in small amounts that facilitate important body processes. They are classified as either fat-soluble or water-soluble. Fat-soluble vitamins are absorbed into the lymph and stored in body fat, while water-soluble vitamins circulate freely and are not stored. The document defines several B vitamins and their roles, including thiamine (B1) which aids energy production, and niacin (B3) which helps metabolism and lowers cholesterol. Vitamin C aids immune function and wound healing as an antioxidant. Deficiencies of vitamins A, C, D, and B vitamins can cause diseases like scurvy or rickets.
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This document provides an overview of micronutrient deficiency disorders and their clinical signs. It discusses several key vitamins (A, D, K, C, thiamine, riboflavin, niacin) and deficiencies associated with each. For each vitamin, the document outlines functions, dietary sources, deficiency signs and symptoms, investigations for diagnosis, and treatment approaches. Common deficiency disorders covered include xerophthalmia, rickets, scurvy, beriberi, pellagra, and anemia. The summary focuses on clinical signs, diagnostic testing, and management strategies for different micronutrient deficiencies.
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This document discusses oxidation, antioxidants, and their roles in health and disease. It defines oxidation as the loss of electrons by atoms or molecules, which can result in free radical formation. Antioxidants are then introduced as substances that can neutralize reactive molecules and reduce oxidative damage. Examples of antioxidant nutrients are provided, along with their functions. Conditions related to oxidation, such as cancer and cardiovascular disease, are overviewed in relation to antioxidants and diet.
The document discusses establishing a new standard of care for nutrition intervention based on whole food concentrates rather than isolated vitamins and minerals. It outlines the limitations of current recommendations and the growing evidence from clinical studies showing whole food concentrates are more effective at the cellular level in supporting health, healing and reducing oxidative stress. Whole food concentrates have been shown to help conditions like cancer, heart disease, immune function and more in peer-reviewed research. The evidence suggests whole food concentrates should replace multivitamins as the recommended daily standard of care once healthcare professionals are properly educated on the data.
Vitamin D plays an important role in bone and mineral metabolism and is also involved in preventing many chronic diseases. It is synthesized in the skin upon exposure to sunlight and is also obtained through dietary sources. Most cells in the body have receptors for vitamin D. Deficiency is linked to increased risk of diseases such as cancer, cardiovascular disease, diabetes and multiple sclerosis. Adequate vitamin D levels can be maintained through sensible sun exposure, dietary sources like fatty fish, and supplementation.
1) The document discusses four fat-soluble vitamins: A, D, E, and K. It covers their common properties of being fat soluble and stored in the liver, as well as their individual roles and deficiency symptoms.
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Analyze the Molecular Genetics of a Solitary Causative Genetic Material behin...ijtsrd
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3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
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1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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1. What’s all the fuss
about vitamin D?
Dr Margaret Oziemski
Dermatologist
Brisbane
www.sunsafetyqld.com.au
2. Professor Michael Kimlin
AusSun Research Lab QUT
The Sunday Courier Mail 11/11/2009
75% of Brisbane residents are vitamin D deficient
3. Slip, Slop, Crack :
The Vitamin D crisis
The Age Dec 2007
Message to cover up has led to vitamin
D deficiencies between 30% - 70% of
the population
Osteoporosis Australia link low levels of
vitamin D to massive increase in
osteoporosis related diseases costing
$ 1.9 billion a year
4. The Challenge
Australia has the highest rate of skin
cancer in the world
Over 1000 lives lost each year
Skin cancer rates continuing to increase
Melanoma is the commonest life
threatening cancer in 15 – 25 year olds
Costs to health budget significant –
$ 264 million spent on nonmelanoma skin
cancer in 2000-01
5. Our Lifestyle
Sun worshipping continues
People underestimate the intensity of the sun
in the Sunshine State when timetabling
activities for leisure, school, sport or work
Sunburn frequently reported
6. Public education - Prevention
Slip, Slop, Slap
UV Index/ UV Alert
Protect in Five ways from skin cancer
7. What is Vitamin D?
Bulk of vitamin D is made in the skin
Small amount is obtained from food
Vitamin D is more of a hormone than a
vitamin
Most tissues posses vitamin D receptor
and can convert circulating vitamin D to
active
9. A Place for Vitamin D
Acne Eczema Immune system Nails Schizophrenia
Alzheimers Epidermolysis bullosa Infertility Neonatal tetany SCC of head and
AMI Epileptic drugs interfere Influenza neck
Anti-bacterial with metabolism prevention SLE
Asthma EPP Insulin resistance Systemic sclerosis
Autoimmune Statin induced
myalgia
Bones Fall prevention Keratoderma Obesity Tuberculosis
Bowel cancer Fatigue Kidneys Osteomalacia prevention and
Breast cancer/ Folliculitis Osteoporosis treatment
aromatase induced Ovarian cancer Transplant
arthralgia patients
Burns
Cathelicidin GIT - UC/Crohns Lichen sclerosus Parkinson’s UC/Crohns
Calciphylaxis Glucocorticosteroid Lymphomas - NHL Periodontitis Urticaria
Cardiomyopathy induced osteoporosis Lung cancer PCOD
Colorectal prevention Photoprotection
adenomas Pre-ecclampsia
Cystic fibrosis Pregnancy
Crohns Prostate
Psoriasis
Dementia Hair growth Macrophages Respiratory tract Vulvitis
Depression Headache Anti-melanoma infections
Diabetes type 1 Heart Morphea Rickets
and 2 HIV Muscles RhA
Hypertension MS
10. Molecular basis of the potential
of Vitamin D to prevent Cancer
1,25 (OH)2 D3 - Calcitriol - and functional VDR
required for normal control of cell cycle
Calcitriol has antiproliferative effects related to cell
cycle control involving p21, p27 and p53
Calcitriol influences genes affecting apoptosis
Calcitriol changes shape of cancer cells which
become more adhesive ?reduces metastases
Calcitriol targets BRCA1 - breast cancer susceptibility
protein involved in tumour suppression
Current Medical Research and Opinion vol 24, No 1, 2008, p 139-149
11. Vitamin D and Melanoma
1,25 (OH)2 vitD3 is antiproliferative in
melanoma cells
Clin Cancer Res 2000 Feb;6(2):498-504
VDR polymorphism associated with
occurrence and outcome of melanoma
Br J Dermatol 2002
12. Vitamin D and Melanoma
High vitamin D status associated with
improved survival for melanoma
Curr Opin Clin Nutr Metab Care 2007 Jan;10(1):6-11
Reduced serum 25 OH vitamin D levels in
stage IV melanoma
Anticancer Res 2009 Sep;29(9):3669-74
13. SMU Vit D and Melanoma
ANZCTR 2009
http://www.anzctr.org.au/trial_view.aspx?ID=83884
75 patients, 23 months
Randomised blind Vit D3 vs placebo
Vit D3 level >75 nmol/l
Primary, histologically resected stage Iib, Iic,
IIIa(N1a) and IIIb(N1a,N2a) cutaneous
melanoma
50,000IU D3 x10 on Day 1, then 50,000IU D3
once a month for the 23 months
14. Vitamin D Metabolism
D3, D2
Time of day
UVB Latitude Food
Season
Clothes
Sunscreen
Melanin
Age
7-dehydrocholesterol
Previtamin D3 Vit D
Skin Thermal
isomerisation
Liver
1,25 (OH)2 Vit D3 Tissues 25 OH Vit D3
Kidney
Chen et al Arch Biochem Biophys
2007(460);213-217
Calcitriol 1,25 (OH)2 Vit D3
15. Time of the Day
Reproduced with permission from Nutrition and Bone Health ed. Michael Holick and Bess Dawson-Hughes, 2004
16. Month of the Year
Reproduced with permission from Nutrition and Bone Health ed. Michael Holick and Bess Dawson-Hughes, 2004
18. Effect of Age
Reproduced with permission from Nutrition and Bone Health ed. Michael Holick and Bess Dawson-Hughes, 2004
19. Safe Sun concept
Most Australians need
sunprotection when the UV index is
3 or above.
It is safe to go outside without sun
protection in the early morning and
late afternoon when the UV Index
is below 3.
20. WHO Global Solar UV Index
Brisbane
Extreme
Very high
High
Moderate
Safe Sun
Low
21. Can we make vitamin D when the
UV is less than 3?”
“Recent results from our lab and others suggest
that not a lot of vitamin D is made when the UVB
wavelengths of even as low as 311 nm,
suggesting that not much if any D would be
made if the UV index is <3”.
Professor Rebecca Mason
Head, Physiology Bosch Institute Sydney
Email 4 June 2008
24. “few minutes of sunlight on either side of the
peak UV periods on most days of the week”
25. WHO Global
Solar UV Index
When UV is over
3
practice
sunprotection
“few minutes of sunlight on either side of the
peak UV periods on most days of the week”
26. Peak UV index in Melbourne in Low or
Moderate range for 6 months of year
Peak UV undex in Darwin in Extreme or Very
High range on average
27. Problems in Policy
The advice to sunprotect when the
UV index is over 3 includes the
time when vitamin D is made by
the action on UVB on the skin
28. You do not make vitamin D when the
UV index is less than 3
29. It is the same UVB which is
needed to make vitamin D that
causes damage to the skin
longterm if the skin is
overexposed
30. If we are not in the sun how
can we achieve adequate
Vitamin D levels?
31. Vitamin D
and the diet
Salmon 360 IU
Mackerel 345 IU
Sardines 270 IU
Milk Physical approx100 IU
Berri Australian Fresh
Tropical Fruit Juice 100 IU
Cereal 99 IU
Margarine* 40 IU
Cheese* 40 IU
Beef liver 30 IU
Egg yolk 25 IU
Note:
Cod liver oil 1 tbsp = 1360IU D3 but high vitamin A content can cause birth defects
32. Vit D3 Supplements
Ostevit D or Ostelin 1000 IU D3
Balckmores D3 1000 IU D3
Elevit 500 IU D3
Citracal with D 500 IU D3
Caltrate with D 200 IU D3
Bioceuticals drops 333.3 IU D3 per drop
34. Vitamin D status
Vitamin D sufficiency > 75 nmol/l
Sub-optimal levels 50 - 75 nmol/l
Vitamin D insufficiency 25 - 50 nmol/l
Vitamin D deficiency 15 - 25 nmol/l
Severe Vitamin D deficiency < 15 nmol/l
Joshi D, Center J and Eisman J.
Australian Prescriber 2010 Aug vol 33 No 4 p103-106
35. Sufficient Vitamin D
For Bone health Recommended Daily Intake
(RDI)
19 - 50 yo 200 IU/d
51 - 70 yo 400 IU/d
>70 yo 600 IU/d
For Better bones vitamin D blood level over
80 nmol/l recommended
36. Vitamin D levels for Other
Health Outcomes
50% of colon cancer incidence in Nth
America could be prevented by vit D level
of > 85 nmol/l
50% of breast cancer incidence in Nth
America could be prevented by vit D level
>130 nmol/l
Garland et al
Nutrition Reviews Aug 2007;65(8):S91-S95
37. Maintaining sufficient vitamin D
Replacement with 1000 - 5000 IU a day
vitamin D3 for 2 - 3 months and repeat
25 OH vitamin D level
Titrate dose of vitamin D3 supplement to
blood level at least over 80nmol/l
May require 1000 - 5000IU a day
maintenance
Monitor 25 OH vit D3, calcium and U&E
3 - 6 monthly once stable
38. Can you have too much
Vitamin D?
Vitamin D toxicity: due to raised blood calcium:
anorexia, nausea, headache, thirst, polyuria,
constipation, twitching, soft tissue calcification,
kidney stones, confusion, coma
Reported if vitamin D blood level > 350 nmol/l
Some side effects of supplements not related to
hypercalcemia: itch, headache, upset digestion,
cramps if Magnesium low
40. “At Risk” Groups of
Vitamin D Deficiency
Dark skinned
Religious/ Cultural covering
Elderly
Babies of vitamin D deficient
mothers
Housebound/ Institutionalised
41. Practice Audit
Period of 6 months March to August
2007, Brisbane private dermatology
practice
Patients during consultation questioned
about amount of time in the sun on day
to day basis
Sunprotective measures recorded
42. < 25 nmol/l < 50 nmol/l < 75 nmol/l
Number 9/310 61/310 170/310
(2.9%) (19.7%) (54.8%)
Sex F 8 47 120
M 1 14 50
Mean age 48.7 yrs 56.3 yrs 57.4 yrs
(32 - 87) (30 - 93) (22 - 93)
PH Melanoma,
4/9 34/61 101/170
NMSC, or both,
(44.4%) (55.7%) (59.4%)
DN, FH Mel
Immunosuppressed/ 8/61 12/170
Photosensitive 0/9
(13.1%) ( 7.1%)
Other 5/9 19/61 57/170
conditions (55.6%) ( 31.1%) (33.5%)
DN - Dysplastic naevi
NMSC - Non melanoma skin cancer
43. Additional “At risk” groups of
Vitamin D deficiency Reported
Past history of melanoma, non melanoma
skin cancer, dysplastic naevi, or family history
of melanoma
Photosensitive conditions or medications
Immunosuppressed conditions or medications
Working indoors
Check Vitamin D after Skin Cancer Diagnosis- Dr Margaret Oziemski
Medical Observer 3 April 2008
45. The vitamin D status of
Australian Dermatologists
Bruce et al, Clin & Exp Dermatol 34;2009: 621-638
Southern Australia winter 2006
47 dermatologists
6 had levels > 50nmol/l
15% had levels <20 nmol/l
46. QML Clinical Audit Aug 09
1/11/08-28/1/09 in Brisbane
15,000 vitamin D studies
35% vit D level> 75 nmol/l
41% level 50 - 75 nmol/l
24% level in deficient range <50 nmol/l
47. Our Obligation
If we advise sunprotection, we should
monitor for vitamin D sufficiency
If a patient is sunprotecting, we should
monitor for vitamin D sufficiency
If a patient is not in the sun, we should
monitor for vitamin D sufficiency
49. A B
43 yo indoor worker 47 yo indoor worker
Freckles, black hair Freckles, red hair
Solar lentigos, DSAP DSAP
Burned easily in Burned easily in
childhood childhood
2004 Level 1 2006 BCC left cheek
Melanoma on leg as as 45 yo
38 yo
51. A (23/3/07) B (26/4/07)
25 OH D 21 25 OH D 28
Bone Density - Bone Density -
mild osteopenia low normal
L4 T -1.0 L4 T -0.3
Supplemental D3 Supplemental D3
15,000IU/d 4000IU/d
25 OH D 138 25 OH D 148
52. Summary Points
It is important to maintain
adequate Vitamin D levels for a
whole host of
Health Outcomes
not only for Musculoskeletal health
53. It is possible to supplement
vitamin D and monitor with
blood levels rather than
recommend sun exposure to
achieve sufficiency
54. Vitamin D insufficiency is under
reported and its impact on our health
underestimated
More clinical trials are needed to look at
dosage, timing of supplementation and
health outcomes
55. SLIP
SLOP
SLAP
SLIDE ON SOME SHADES
SWALLOW A SUPPLEMENT
SEEK A SKIN CHECK