Vitamin D has widespread effects beyond bone health. It acts as a pleiotropic hormone that regulates over 200 genes and has important immunomodulatory properties. Maintaining optimal vitamin D levels may help reduce the risk of infections like tuberculosis and exacerbations of COPD, as well as cancers, cardiovascular disease, fractures and autoimmune disorders. More research is still needed but achieving a serum 25(OH)D level of at least 30 ng/mL through supplementation appears to provide the most benefits.
vitamin d is one of the fat soluble vitamin on which there is great emphasis in the present scenario. it is present in breast milk in very minute amount so it is recommended that it must be supplemented right after birth to prevent it deficiency which in children can result in rickets. if not diagnosed and treated in time it may result in number of bony deformities . in adults besides oesteomalacia it is associated with n umber of non communicable diseases.
Recent updates about Vitamin D (sunshine vitamin) & bone health. Co-testing of vitamin D(25-OH vitamin D) along with PTH is a scientific, holistic approach for diagnosis & monitoring of vitamin D deficiency.
Chemistry of Vitamin E, Biochemical role of Vitamin E, Recommended dietary Allowances, Dietary sources of Vitamin E, Deficiency symptoms of vitamin E, Hypervitaminosis of vitamin E, Toxicity of Vitamin E,
vitamin d is one of the fat soluble vitamin on which there is great emphasis in the present scenario. it is present in breast milk in very minute amount so it is recommended that it must be supplemented right after birth to prevent it deficiency which in children can result in rickets. if not diagnosed and treated in time it may result in number of bony deformities . in adults besides oesteomalacia it is associated with n umber of non communicable diseases.
Recent updates about Vitamin D (sunshine vitamin) & bone health. Co-testing of vitamin D(25-OH vitamin D) along with PTH is a scientific, holistic approach for diagnosis & monitoring of vitamin D deficiency.
Chemistry of Vitamin E, Biochemical role of Vitamin E, Recommended dietary Allowances, Dietary sources of Vitamin E, Deficiency symptoms of vitamin E, Hypervitaminosis of vitamin E, Toxicity of Vitamin E,
The global epidemic and the d lightful vitaminRISHIKESAN K V
Roughly 1 billion people globally having low vitamin D levels. Scientists believe that lack of vitamin D is not only linked with rickets and osteomalacia but it plays a major role in heart disease ,Diabetes and cancers
Need of Vitamin D3 supplement | Buy Vitamin D3 in EuropeRufus Greenbaum
Eat vitamin rich food; try as much as u can in contact with sun and start taking Vitamin D3 Supplement http://greenvits.eu/ . Many Researches proved that Vitamin D3 Supplement have numerous good effects on our health and it fight against various serious chronic illness like depression, cancer and many more.
Buying vitamin D in Europe is also important Decision as many over the counter supplements contains 180 % more vitamin d then stated in there level.
D is for Debacle - The Sun, Vitamin D, 25(OH)D and HealthIvor Cummins
The Story of Vitamin D, and the Debacle of Human Health Impact that has unfolded over the past 50 years, as we allowed the population necessary levels to collapse. For individuals, parents, families, mothers - don't miss this understanding - this is probably the most important single factor for your health and longevity.
Covid19 Immunoboosters : Role of Vitamin C Zinc and Vitamin DShivani Sachdev
Diet and nutrition invariably influence the immune system competence and determine the risk and severity of infections.
There are bi-directional relationships among diet, nutrition, infection, and immunity. The changes in one component have an impact on the others. Vitamin C may help shorten the duration and severity of colds caused by other viruses, but this is no guarantee that it will have the same effect on the coronavirus that causes COVID-19.
Nevertheless it is safe and inexpensive
The Upper Limit (UL) for supplemental vitamin C — the amount most people can consume daily without negative effects — is 2,000 mg .
Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Nutrients 2020 Apr William B Grant. Lower viral replication rates
Reduce concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lungs, leading to pneumonia. Increase concentrations of anti-inflammatory cytokines . Evidence supporting the role of vitamin D in reducing risk of COVID-19. Outbreak occurred in winter, a time when 25(OH)D3 concentrations are lowest
The number of cases in the Southern Hemisphere are low
Vitamin D deficiency has been found to contribute to acute respiratory distress syndrome
Case-fatality rates increase with age with chronic disease comorbidity, and also higher in dark skinned people and all of which are associated with lower 25(OH)D concentration
Vitamin-D and COVID-19: do deficient risk a poorer outcome? Fiona Mitchell Lancet 2020.
Biological diversity, or biodiversity, is the scientific term for the variety and variability of life on Earth. Biodiversity is the key indicator of the health of an ecosystem. Every living thing, including man, is involved in these complex networks of interdependent relationships, which are called ecosystems.
Like all healthy ecosystems, Richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states.Microbiota Biodiversity helps us : 1- Combat aggressions from other microorganisms, 2- Maintaining the wholeness of the intestinal mucosa. 3- Plays an important role in the immune system, 4- Performing a barrier effect.5- A healthy and balanced gut microbiota is key to ensuring proper digestive functioning. A gut out of balance means a body out of balance which means illness including Inflammation, Allergies, Infections, Nutrient deficiencies, Weight Gain, Asthma-allergies – Autoimmunity
• Arthritis, Metabolic Bone disease, Skin problems e.g. eczema, Rosacia, Mood disorders - Cognitive decline-Alzheimers and Cancer.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. Objectives of discussion
• Current status
– Dosage 60,000 units
– Indications Limited
– Need to expand perception
– Need to expand usage & market How?
• Suggestions
– Dosage
– Non standard Indications, Perception
– How to expand usage & market?
4. What?
• Producing more than one effect, the enabler
• Paracrine
– Chemical signals that diffuse into the area
and interact with receptors on nearby cells
– New insights due to the discovery of
1. Key activating and inactivating enzymes of
vitamin D.
2. Its intracellular receptor, VDR - present in nearly
every tissue and cell in the body
3. And hence adequate vitamin D status is essential
for optimal functioning of all tissues and cells
5. Why?
Dr. Robert P.
Henry
Creighton
University
Close
this gap
6. When?
• Serum 25(OH)D concentrations of 10 ng/ml
(25 nmol/l) considered the cut-off for defining
the lower limit of adequacy (in terms of
preventing rickets).
– But, serum concentration of > 30 ng/l (> 75
nmol / l) considered more appropriate to define
physiologically optimal concentrations,
associated with many other health benefits
– Epidemiological studies have revealed a dose-
dependent association between serum 25-OHD
levels and immunity, pulmonary function, etc.
7. Where?
• Serum total 25(OH)D is the:
– Functional indicator of vitamin D status
– Major storage form of vitamin D
• Serum total 25(OH)D2 is of no value unless
measured following vitamin D therapy;
• Serum total calcitriol does not measure
Risk assessment for vitamin
vitamin D status; D -- Hathcock et al. 85 (1): No toxicity
below 30,000
6-18, AJCN, 2007 iu/ day
Tolerable
upper level =
10,000 iu/
9. How?
Vitamin D deficiency Vitamin D insufficiency
Indexed mechanism Malabsorption Non-indexed mechanisms Genomic
of Ca & P signaling
Short latency Long latency Short latency Long latency
effects effects effects effects
Rickets, Osteoporosis The Falls • Cancer,
Osteomalacia amount • Immune
enough disorders,
for the • Infections
left side
However, current intake is based is not
on recommendations of 1997 for enough Hence, what is the more
the left side, totally overlooking for the useful endpoint?
the needs for the right side right
11. Vitamin D and homeostasis
1. Regulates more than 200 genes including
genes for cellular proliferation,
differentiation and apoptosis.
2. Regulates extracellular matrix homeostasis
in tissues, either indirectly or directly.
3. Potent immune modulator of the adaptive
immune system
4. Stimulates the innate immune response
upon infection.
12. Vitamin D and homeostasis
Regulation of immune function by 1,25(OH)2D. 1,25(OH)2D suppresses adaptive immunity (A) by inhibiting the maturation
of dendritic cells, reducing their capacity to present antigen to CD4 cells. 1,25(OH)2D further inhibits the proliferation and
differentiation of CD4 cells into Th1 and Th17 cells and promotes the production of Th2 and Treg cells. On the other hand
1,25(OH)2D promotes innate immunity (B) in that when the macrophage is activated by TLRs, VDR and CYP27B1 are
induced enabling the macrophage to produce 1,25(OH)2D, which then induces cathelicidin, a potent antimicrobial peptide.
13. Vitamin D and immunomodulation
• Immunomodulation is the therapeutic
approach in which interventions can be
achieved in auto regulating processes of
the defense system.
14. Vitamin D and immunomodulation
• All cells of the adaptive immune system (dendritic
cells, monocytes, T cells and B cells, NK cells)
express VDR either constitutively or after
appropriate immune stimulation and are sensitive
to calcitriol action.
• High level of vitamin D causes:
1. Potent inhibition of dendritic cell maturation +
2. Lower expression of major histocompatibility complex
(MHC) class II molecules,
3. Down-regulation of costimulatory molecules and
4. Lower production of proinflammatory cytokines such as
IL-2, IL-12, IFN-y and IL-23
18. Vitamin D and immunomodulation
• Dendritic cells (DCs) are immune cells that
function as antigen-presenting cells. They
act as messengers between the innate and
adaptive immunity.
• Vitamin D-induced inhibition of IL-12
release by dendritic cells has a profound
effect on T lymphocyte differentiation by
downregulating Th1 & upregulating Th2.
• As a result, the following are achieved:
19. Vitamin D and immunomodulation
1. Promotes differentiation
2. Antiproliferative - Potent antiproliferative effects on
T cells, principally T helper cells, and suppresses
B cell antibody production both directly and
indirectly
3. Immunosuppressive – one of the most important
modulatory actions is its effect on regulatory T
cells (Tregs) which prevent the activation of
peripheral autoreactive T cells.
4. Promotes infection control - can enhance the
phagocytic activity of macrophages and increase
the activity of natural killer cells.
20. Vitamin D and infection
• In cell types such as epithelial cells and WBCs, the
genes encoding for antimicrobial polypeptides such
as cathelicidin are driven by VDRE-containing
promoters
– As cathelicidin is also diffusely expressed in the surface
epithelia of human airways, in the submucosal glands,
and in secretory granules of macrophages and
neutrophils, vitamin D insufficiency may contribute to
chronic respiratory infections and airway colonization
– In monocytes, a local increase of the 1,25-(OH)2D-VDR
complex (via TLR-2) stimulates the production of
cathelicidin, resulting in an improved intracellular
eradication of MBT.
21. Vitamin D and Tuberculosis
• Higher sputum conversion and radiological
improvement (100%) compared to a placebo
group (76·7%) in TB patients administered
vitamin D or placebo following the 6th week of
standard TB treatment.
• Addition of calcitriol to primary human
macrophages infected with virulent M.
tuberculosis reduced the number of viable
bacilli.
22. Vitamin D and Tuberculosis
• The immune system is able to detect M.
tuberculosis via pathogen-associated
molecular patterns (PAMPs); VDR activation
and induction of cathelicidin.
• The cathelicidin gene encodes an anti-
microbial peptide, LL-37, and this gene, in
humans (but not in mice), contains a vitamin
D response element.
• Therefore binding of vitamin D leads to LL-
37-mediated killing of M. tuberculosis.
23. Vitamin D and Tuberculosis
• Cathelicidins and defensins
are small peptides with
amphipathic structures that
allow them to disrupt the
integrity of the pathogen cell
membrane, resulting in its
death.
• These proteins are expressed
by most immune cells or
those epithelial cells that are
in contact with the
environment.
• Deficiency in these peptides
results in increased
susceptibility to infection.
24. Vitamin D and HIV
• Use of certain ARTs, especially efavirenz, is
associated with alterations in cholecalciferol
levels.
• Studies have also shown that vitamin D
insufficiency/deficiency at baseline was
associated with increased risks of HIV
disease progression, anemia, and all-cause
mortality, as well as mother-to-child
transmission of HIV.
26. Vitamin D and COPD
• Although still defined using pulmonary criteria,
COPD is a chronic disease state that is not
confined to the lungs but is typically associated with
systemic inflammation and different comorbidities.
• The importance of such broader context has been
indirectly confirmed by the Toward a Revolution in
COPD Health (TORCH) study.
– In the 3-year follow-up of a large cohort of patients with
COPD, only one-third of deaths could be attributed to
respiratory failure, whereas the majority died from lung
cancer or cardiovascular events
Vitamin D beyond bones in COPD; Am J Respir Crit Care Med Vol 179. pp 630–636, 2009
27. Vitamin D and COPD
• A strong relationship exists between serum
levels of 25-OHD and pulmonary function, as
assessed by FEV1 and FVC.
• The observation that smoking African
Americans develop severe airflow
obstruction more rapidly than Caucasians is
in agreement with the idea that a presumed
lower vitamin D status in African Americans
correlates with an increased susceptibility to
COPD. bones in COPD; Am J Respir Crit Care Med Vol 179. pp 630–636, 2009
Vitamin D beyond
28. Vitamin D and COPD
• Appropriate antimicrobial therapy is considered the
mainstay for treating acute exacerbations of COPD.
• In case of colonization, repetitive and long-term
antibiotic therapy are still avoided as they
contribute to multiresistance of colonizing strains.
• A potent alternative approach would be the up-
regulation of the innate immune defense system,
especially with regard to native antimicrobial
polypeptides (AMP).
• the ability of vitamin D to enhance cathelicidin
expression, might reduce pathogen load and the
frequency of these exacerbations.
Vitamin D beyond bones in COPD; Am J Respir Crit Care Med Vol 179. pp 630–636, 2009
29. Vitamin D and COPD
• Muscle weakness is a prominent feature in rickets
and chronic renal failure,
• Skeletal muscle weakness common observation in
moderate to severe COPD and is an independent
predictor of respiratory failure and death.
• Main causes of COPD deterioration include a
combination of:
– Disuse because of respiratory limitation,
– Elevated oxidative stress,
– Systemic inflammation,
– Hypoxia, and
– Frequent steroid intake.
Vitamin D beyond bones in COPD; Am J Respir Crit Care Med Vol 179. pp 630–636, 2009
30. Vitamin D and COPD
• Whether sufficient vitamin D
supplementation will finally reduce
cardiovascular or lung cancer mortality in
patients with COPD is currently unknown,
but, given the potential beneficial effects of
other anti-inflammatory agents like statins in
the treatment of COPD, it is worthwhile to
further explore such hypothesis.
Vitamin D beyond bones in COPD; Am J Respir Crit Care Med Vol 179. pp 630–636, 2009
31. Vitamin D and fractures
• A +ve association between 25-OHD and
muscle strength or lower extremity function
in elderly people has been noted.
• A meta-analysis of 5 randomized clinical
trials revealed that vitamin D
supplementation reduces the risk of falls by
22% compared with placebo.
32. Vitamin D and cancer
• Studies in males have shown an increment
of 10 ng/ml in estimated 25-OH D was
associated with:
– a 17% reduction in total cancer incidence,
– a 28%reduction in total cancer mortality, and
– a 45% reduction in digestive cancer mortality
37. A rule of thumb
• To raise Serum 25-
(OH)D by 1 ng./ml.
[2.5 nmol / L] one
needs 100 additional
i.u. / day of vitamin D3
– Hence, to raise a
patient’s Vitamin D
level from 15 to 30
ng. / ml.; there will be
an additional
requirement of 1500
i.u./ day.
– Great inter-patient
variability in Cmax