Thalidomide & its derivatives by Dr. Harmanjit Singh, Department of Pharmacology, GMC, Patiala

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Govt Medical College & Hospital, Sector-32

Health & Medicine Business

Thalidomide & its analogues: Importance in Pharmacology Dr. Harmanjit Singh Department of Pharmacology, GMC, Patiala

History ,[object Object],[object Object],[object Object],[object Object]

Thalidomide – the sleeping pill Hailed as a "wonder drug" that provided a "safe, sound sleep". However the drug was also found to cure morning sickness in pregnant women Was available as OTC drug

Chemistry of thalidomide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]

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The Thalidomide Disaster ,[object Object],[object Object],[object Object],[object Object]

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Symptom Pattern ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MECHANISM OF TERATOGENICITY ,[object Object],[object Object],[object Object],[object Object]

Thalidomide Today ,[object Object],[object Object],[object Object],[object Object],[object Object]

Thalidomide analogues ,[object Object],[object Object],[object Object],[object Object]

IMiDs – NOVEL THALIDOMIDE ANALOGUES AS ANTICANCER AGENTS ,[object Object],[object Object],[object Object],[object Object]

IMiDs as Immunomodulators ,[object Object],[object Object],[object Object],[object Object],[object Object]

IMiDs as Pro-apoptotic agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Adverse effects of Thalidomide & its analogues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Uses of Thalidomide & its analogues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ENL ( Erythema Nodosum Leprosum ) ,[object Object],[object Object],[object Object],[object Object],[object Object]

6 weeks 200 mg 1 week 200 mg ,[object Object],[object Object],[object Object],[object Object],Before

Multiple Myeloma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Demonstrated Mechanisms of Action of Thalidomide/IMiDs in MM

Other Potential Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Precautions and Concerns ,[object Object],[object Object],[object Object],[object Object],[object Object]

S.T.EP.S ,[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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