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Vitamins
• Organic molecules with a wide variety of functions
Essential, supplied in the diet
• Cofactors for enzymatic reactions
•
• Two distinct types: Fat soluble (A, D, E, K)
What are vitamins?
• Water soluble (B – complex, C)
Vitamins are organic molecules that are essential for normal
health and growth. They are required in trace amounts and must
be obtained from the diet because they are not synthesized in the
body. Before vitamins were discovered, it was known that lime
juice prevented the disease scurvy in sailors and that cod liver oil
could prevent rickets. In 1912, scientists found that, in addition to
carbohydrates, fats, and proteins, certain other factors called
vitamins must be obtained from the diet.
Why are they good for us?
Greater need due to
worse environment
Improved immunity
Prevent illnesses
Slower aging
Soluble in aqueous
solutions
Used as cofactors by
many enzymes
Not stored in the body
Water-
soluble
vitamins
K
Are A, D, E, and K.
A
Soluble in lipids, but not in
aqueous solutions
Important in vision, bone
formation, antioxidants, and
blood clotting
D
E
Stored in the body
Fat-Soluble Vitamins
Fat-Soluble Vitamins
Thiamine (Vitamin B1)
Was the first B vitamin identified
Is part of the coenzyme thiamine pyrophosphate(TPP)
TPP coenzyme is required by enzymes in the decarboxylation of
-keto carboxylic acids.
Deficiency results in beriberi (fatigue, weight loss, and nerve
degeneration).
Influences saccharide metabolism
Reduces fatigue
Is destroyed by severe washings
of rice and vegetables
Severe deficiency leads to beri-
beri
Sources: yeasts, cereals,rice,
liver, legumes
Thiamine
Riboflavin (Vitamin B2)
0
55%
Made of the sugar alcohol ribitol and flavin
Part of the coenzymes flavin
N
N
HH3C
H3C N N O
CH2 CH CH
OH OH
adenine dinucleotide (FAD) and flavin mononucleotide (FMN).
30%
Needed for good vision and healthy skin
O.
D-Ribitol
CH CH2 OH
OH
Saccharide and lipid metabolism
Curing of skin diseases
Support of sight function
Light sensitive
Sources: cerals, eggs, vegetables, dairy products, yeast, liver
Niacin (Vitamin B3)
• Is part of the coenzyme
nicotinamide adenine
dinucleotide (NAD+)
involved in oxidation-
reduction reactions.
• Deficiency can result in
dermatitis, muscle
fatigue, and loss of
appetite.
• Is found in meats, rice,
and whole grains.
Pantothenic Acid (Vitamin B5)
• Is part of coenzyme A needed for energy production as well as
glucose and cholesterol synthesis.
• Deficiency can result in fatigue, retarded growth and anemia.
• Part of coenzymeA
• Reduces stress, prevents tiredness
•
•
Necessary for formation of glycogen, fatty acids, steroid hormones
Sources: whole grains, and vegetables ,eggs,liver, heart, yeast
O
C N CH2 CH2 C OH
H
CH3 OH O
HO CH2 C CH
CH3
Pyridoxine (Vitamin B6)
• Pyridoxine and pyridoxal are two forms of vitamin B6,
which are converted to the coenzyme pyridoxal
phosphate (PLP).
• PLP is required in the transamination of amino acids and
decarboxylation of carboxylic acids.
• Deficiency of pyridoxine may lead to dermatitis, fatigue,
and anemia.
Pyridoxine
• Amino acids and protein
metabolism
• Cure of anemia
• Erythropoiesis
• Antibody formation
• Sources: meat, fish,
liver, vegetables, cerals,
yolk, legumes
Cobalamin (Vitamin B12)
• Consists of four pyrrole
rings with a Co2+.
• Is a coenzyme for
enzymes that transfer
methyl groups and
produce red blood cells.
• Deficiency can lead to
pernicious anemia and
nerve damage.
Cyanocobalamin
• Formation of red
blood cells
• Maintenance of
neuronal tissue
• Cure of neuro
diseases, anemia
• Sources: dairy
products, meat,
poultry, sea
products
Ascorbic Acid (Vitamin C)
• Is required in collagen
synthesis.
• Deficiency can lead to
weakened connective
tissue, slow-healing
wounds, and anemia.
• Is found in Indian
gooseberries,
blueberries, citrus fruits,
tomatoes, broccoli, red
and green vegetables.
O
CH2OH
CHOH
OHHO
O
Vitamin C
• Hormone, collagen
synthesis
• Infection resistance, cure
of cuts
• Hypervitaminosis:
addiction, diarrhea
• Hypovitaminosis: scurvy
• Source: fruits,vegetables
Vitamin A
• Vitamin A is obtained from meats and
beta-carotenes in plants.
• Beta-carotenes are converted by liver
enzymes to vitamin A(retinol).
H3C CH3
CH3
CH3
CH3 CH3
H3C CH3
H3C
CH3 CH3
CH2OH
H3C CH3
CH3
Beta-carotene
CH3
Retinol (vitaminA)
2222
Vitamin A and Provitamin A
Retinol
• Cancer cure and prevention
• Skin, eyes, genital glands
• Provitamin changes to A vitaminin
liver
• Sources: liver, egg yolks, dairy
products
• Provitamin A sources: carrots,
pepper, spinach, yellow fruits
Vitamin D
Vitamin D (D3):
• Is synthesized in skin
exposed to sunlight.
• Regulates the
absorption of
phosphorus and calcium
during bone growth.
• Deficiency can result in
weakened bones.
• Sources include cod
liver oil, egg yolk, and
enriched milk.
Vitamin D
• Calciferols
• the "sunshine vitamin" (UV rays)
• regulation of calcium metabolism
• sources: yeasts, fish, yolks, dairy products
Vitamin E
O
• Is an antioxidant in cells.
• May prevent the oxidation of
unsaturated fatty acids.
• Is found in vegetable oils, whole grains,
and vegetables.
CH3
HO
H3C
CH3
CH3
CH3
CH3 CH3 CH3
Vitamin E
Tocoferols
• Antioxidant (lipid protection)
• improves immunity
• Cures muscle, heart and skin diseases,
burns
• Sources: green vegetables, vegetable oil,
corn, eggs, bread, dairy products, peas,
beans
Vitamin K
• Vitamin K1 in plants has a saturated side
chain.
• Vitamin K2 in animals has a long
unsaturated side chain.
• Vitamin K2 is needed for the synthesis of
zymogens for blood clotting.
3
CH3
O
O CH3
CH3
n
CH3
Vitamin K2 (menaquinone)
CH3
CH3
O
O CH3 CH3
Vitamin K1 (phylloquinone)
Vitamin K
• Blood clotting
• Higher need by newborns, people with
liver diseases, or fat malabsorbtion
• Sources: green fruits and vegetables,
tomatoes, soy, beef liver, yolks, wheat,
butter, cheese
Recommended Values:
Daily values [mg]:
1-3
30 - 200
25 - 200
30 - 100
20 - 500
10 - 15
5 - 8
300 - 5000
2 - 12 g
10
400 - 2000
Vitamin:
A (retinol)
B1 (thiamine)
B2 (riboflavin)
B3 (niacin, niacinamid)
B5 (Pantothenic acid)
B6 (pyridoxine)
B12 (Cynocobalamine)
H (Biotin)
C (Ascorbic acid)
D (cholecalciferol)
E (tokoferol)
K 80
Thank You!

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Vitamins

  • 2. • Organic molecules with a wide variety of functions Essential, supplied in the diet • Cofactors for enzymatic reactions • • Two distinct types: Fat soluble (A, D, E, K) What are vitamins? • Water soluble (B – complex, C) Vitamins are organic molecules that are essential for normal health and growth. They are required in trace amounts and must be obtained from the diet because they are not synthesized in the body. Before vitamins were discovered, it was known that lime juice prevented the disease scurvy in sailors and that cod liver oil could prevent rickets. In 1912, scientists found that, in addition to carbohydrates, fats, and proteins, certain other factors called vitamins must be obtained from the diet.
  • 3. Why are they good for us? Greater need due to worse environment Improved immunity Prevent illnesses Slower aging
  • 4.
  • 5. Soluble in aqueous solutions Used as cofactors by many enzymes Not stored in the body Water- soluble vitamins
  • 6.
  • 7. K Are A, D, E, and K. A Soluble in lipids, but not in aqueous solutions Important in vision, bone formation, antioxidants, and blood clotting D E Stored in the body Fat-Soluble Vitamins
  • 9. Thiamine (Vitamin B1) Was the first B vitamin identified Is part of the coenzyme thiamine pyrophosphate(TPP) TPP coenzyme is required by enzymes in the decarboxylation of -keto carboxylic acids. Deficiency results in beriberi (fatigue, weight loss, and nerve degeneration).
  • 10. Influences saccharide metabolism Reduces fatigue Is destroyed by severe washings of rice and vegetables Severe deficiency leads to beri- beri Sources: yeasts, cereals,rice, liver, legumes Thiamine
  • 11. Riboflavin (Vitamin B2) 0 55% Made of the sugar alcohol ribitol and flavin Part of the coenzymes flavin N N HH3C H3C N N O CH2 CH CH OH OH adenine dinucleotide (FAD) and flavin mononucleotide (FMN). 30% Needed for good vision and healthy skin O. D-Ribitol CH CH2 OH OH
  • 12. Saccharide and lipid metabolism Curing of skin diseases Support of sight function Light sensitive Sources: cerals, eggs, vegetables, dairy products, yeast, liver
  • 13. Niacin (Vitamin B3) • Is part of the coenzyme nicotinamide adenine dinucleotide (NAD+) involved in oxidation- reduction reactions. • Deficiency can result in dermatitis, muscle fatigue, and loss of appetite. • Is found in meats, rice, and whole grains.
  • 14. Pantothenic Acid (Vitamin B5) • Is part of coenzyme A needed for energy production as well as glucose and cholesterol synthesis. • Deficiency can result in fatigue, retarded growth and anemia. • Part of coenzymeA • Reduces stress, prevents tiredness • • Necessary for formation of glycogen, fatty acids, steroid hormones Sources: whole grains, and vegetables ,eggs,liver, heart, yeast O C N CH2 CH2 C OH H CH3 OH O HO CH2 C CH CH3
  • 15. Pyridoxine (Vitamin B6) • Pyridoxine and pyridoxal are two forms of vitamin B6, which are converted to the coenzyme pyridoxal phosphate (PLP). • PLP is required in the transamination of amino acids and decarboxylation of carboxylic acids. • Deficiency of pyridoxine may lead to dermatitis, fatigue, and anemia.
  • 16. Pyridoxine • Amino acids and protein metabolism • Cure of anemia • Erythropoiesis • Antibody formation • Sources: meat, fish, liver, vegetables, cerals, yolk, legumes
  • 17. Cobalamin (Vitamin B12) • Consists of four pyrrole rings with a Co2+. • Is a coenzyme for enzymes that transfer methyl groups and produce red blood cells. • Deficiency can lead to pernicious anemia and nerve damage.
  • 18. Cyanocobalamin • Formation of red blood cells • Maintenance of neuronal tissue • Cure of neuro diseases, anemia • Sources: dairy products, meat, poultry, sea products
  • 19. Ascorbic Acid (Vitamin C) • Is required in collagen synthesis. • Deficiency can lead to weakened connective tissue, slow-healing wounds, and anemia. • Is found in Indian gooseberries, blueberries, citrus fruits, tomatoes, broccoli, red and green vegetables. O CH2OH CHOH OHHO O
  • 20. Vitamin C • Hormone, collagen synthesis • Infection resistance, cure of cuts • Hypervitaminosis: addiction, diarrhea • Hypovitaminosis: scurvy • Source: fruits,vegetables
  • 21. Vitamin A • Vitamin A is obtained from meats and beta-carotenes in plants. • Beta-carotenes are converted by liver enzymes to vitamin A(retinol). H3C CH3 CH3 CH3 CH3 CH3 H3C CH3 H3C CH3 CH3 CH2OH H3C CH3 CH3 Beta-carotene CH3 Retinol (vitaminA)
  • 22. 2222 Vitamin A and Provitamin A Retinol • Cancer cure and prevention • Skin, eyes, genital glands • Provitamin changes to A vitaminin liver • Sources: liver, egg yolks, dairy products • Provitamin A sources: carrots, pepper, spinach, yellow fruits
  • 23.
  • 24. Vitamin D Vitamin D (D3): • Is synthesized in skin exposed to sunlight. • Regulates the absorption of phosphorus and calcium during bone growth. • Deficiency can result in weakened bones. • Sources include cod liver oil, egg yolk, and enriched milk.
  • 25. Vitamin D • Calciferols • the "sunshine vitamin" (UV rays) • regulation of calcium metabolism • sources: yeasts, fish, yolks, dairy products
  • 26. Vitamin E O • Is an antioxidant in cells. • May prevent the oxidation of unsaturated fatty acids. • Is found in vegetable oils, whole grains, and vegetables. CH3 HO H3C CH3 CH3 CH3 CH3 CH3 CH3
  • 27. Vitamin E Tocoferols • Antioxidant (lipid protection) • improves immunity • Cures muscle, heart and skin diseases, burns • Sources: green vegetables, vegetable oil, corn, eggs, bread, dairy products, peas, beans
  • 28. Vitamin K • Vitamin K1 in plants has a saturated side chain. • Vitamin K2 in animals has a long unsaturated side chain. • Vitamin K2 is needed for the synthesis of zymogens for blood clotting. 3 CH3 O O CH3 CH3 n CH3 Vitamin K2 (menaquinone) CH3 CH3 O O CH3 CH3 Vitamin K1 (phylloquinone)
  • 29. Vitamin K • Blood clotting • Higher need by newborns, people with liver diseases, or fat malabsorbtion • Sources: green fruits and vegetables, tomatoes, soy, beef liver, yolks, wheat, butter, cheese
  • 30. Recommended Values: Daily values [mg]: 1-3 30 - 200 25 - 200 30 - 100 20 - 500 10 - 15 5 - 8 300 - 5000 2 - 12 g 10 400 - 2000 Vitamin: A (retinol) B1 (thiamine) B2 (riboflavin) B3 (niacin, niacinamid) B5 (Pantothenic acid) B6 (pyridoxine) B12 (Cynocobalamine) H (Biotin) C (Ascorbic acid) D (cholecalciferol) E (tokoferol) K 80