By Dr. Vishal Pawar, MD pharmacology
considering the complex nature of this topic, i am hereby providing a comprehensive review of prostaglandins and its various effects in the body, which after a through go through should be enough for simplifying the understanding of prostaglandins
antitussive drugs, uses, lists, sideffect and many morefcapital
June 15 2016 Antitussives are drugs that suppress coughing, possibly by reducing the activity of the cough center in the brain. Antitussive agents are used to relieve dry cough.
By Dr. Vishal Pawar, MD pharmacology
considering the complex nature of this topic, i am hereby providing a comprehensive review of prostaglandins and its various effects in the body, which after a through go through should be enough for simplifying the understanding of prostaglandins
antitussive drugs, uses, lists, sideffect and many morefcapital
June 15 2016 Antitussives are drugs that suppress coughing, possibly by reducing the activity of the cough center in the brain. Antitussive agents are used to relieve dry cough.
Antiemetic pharmacology and classification are fundamental aspects of understanding how drugs are used to manage nausea and vomiting, common symptoms in various medical conditions. Antiemetics encompass a diverse group of medications that play a crucial role in providing relief to patients. These drugs are classified into several categories based on their mechanisms of action and target receptors. One important class of antiemetics is serotonin antagonists, which work by blocking serotonin receptors in the gastrointestinal tract and the central nervous system. Dopamine antagonists, on the other hand, target dopamine receptors and are particularly effective in preventing chemotherapy-induced nausea and vomiting. Antihistamines, often used for motion sickness, act on histamine receptors, while corticosteroids have broad anti-inflammatory effects and are employed in various situations where nausea and vomiting are problematic. NK1 receptor antagonists are newer additions to the antiemetic arsenal and specifically target substance P receptors. Lastly, cannabinoids, derived from cannabis, have gained attention for their potential antiemetic properties. Understanding the pharmacological mechanisms and classifications of these antiemetic drugs is essential for healthcare professionals to select the most appropriate treatment for their patients, tailored to the underlying cause and individual needs.
This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
Paracetamol iv as a single analgesic is very safe analgesic, but only for mild and moderate pain.
It can be combined with many analgesic or adjuvan drugs to provide strong analgesic for postoperative pain.
So, it can be the basic regiment for Multimodal Analgesia.
Because of its safety it can be the choice for high risk surgical patient
Lecture slides for undergraduates medical (MBBS) Students. Source material for this presentation is Essentials of Pharmacology, KD Tripathi, Katzung and Goodman and Gillman. It deals with Local anaesthetics with their mechanism of action, pharmacokinetics , adverse effects and therapeutic uses.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
Antiemetic pharmacology and classification are fundamental aspects of understanding how drugs are used to manage nausea and vomiting, common symptoms in various medical conditions. Antiemetics encompass a diverse group of medications that play a crucial role in providing relief to patients. These drugs are classified into several categories based on their mechanisms of action and target receptors. One important class of antiemetics is serotonin antagonists, which work by blocking serotonin receptors in the gastrointestinal tract and the central nervous system. Dopamine antagonists, on the other hand, target dopamine receptors and are particularly effective in preventing chemotherapy-induced nausea and vomiting. Antihistamines, often used for motion sickness, act on histamine receptors, while corticosteroids have broad anti-inflammatory effects and are employed in various situations where nausea and vomiting are problematic. NK1 receptor antagonists are newer additions to the antiemetic arsenal and specifically target substance P receptors. Lastly, cannabinoids, derived from cannabis, have gained attention for their potential antiemetic properties. Understanding the pharmacological mechanisms and classifications of these antiemetic drugs is essential for healthcare professionals to select the most appropriate treatment for their patients, tailored to the underlying cause and individual needs.
This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
Paracetamol iv as a single analgesic is very safe analgesic, but only for mild and moderate pain.
It can be combined with many analgesic or adjuvan drugs to provide strong analgesic for postoperative pain.
So, it can be the basic regiment for Multimodal Analgesia.
Because of its safety it can be the choice for high risk surgical patient
Lecture slides for undergraduates medical (MBBS) Students. Source material for this presentation is Essentials of Pharmacology, KD Tripathi, Katzung and Goodman and Gillman. It deals with Local anaesthetics with their mechanism of action, pharmacokinetics , adverse effects and therapeutic uses.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
It will provide you a complete journey through the routes of drug administration, with all the basics covered I hope this presentation will make your fundamentals crystal clear.
Drug delivery systems has undergone major modification in the recent past . With the advent of nanomedicines and liposomes , drug delivery systems has taken a huge leap towards targeted, carrier mediated and sustained release drug delivery.
Dr. Eliana Paladino - How the GFI#213/VFD Affected the Pattern of Submissions...John Blue
How the GFI#213/VFD Affected the Pattern of Submissions at the UMN-VDL - Dr. Eliana Paladino, from the 2017 Allen D. Leman Swine Conference, September 16-19, 2017, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2017-leman-swine-conference-material
This PowerPoint Presentation is fully academic. Pictures and Photos added here are randomly selected from the net so as to understand the subject in a better way. This will be helpful for the learner and learned learners and teachers
Currently efficacy of therapy of patients with
MDR ТВ does not exceed 48.7% worldwide and in Russian
Federation. One of the reason is a frequent development of
adverse drug reactions during the use of combination of
antituberculosis drugs. Since 2013 after registration of
tioureidoiminomethylpyridinium perchlorate (Pecrhlozon®) in
Russian Federation, opportunities appeared for further study
of its efficacy and safety in treatment of tuberculosis with
multiple drug resistance (MDR). In the present study we
applied monitoring of adverse drug reactions during complex
therapy by Perchlozon in combination with five other drugs
with the use of international 5-grade scale. We used Common
Terminology Criteria for Adverse Events (version 3.0). In the
study only mild (grade 1) and moderate (grade 2) adverse drug
reactions were observed except single case when severe (grade
3) adverse drug reaction happened. Mild adverse reactions that
during receiving Perchlozon therapy in complex with other
drugs for MDR-TB did not require its cessation.
Grape Seed Extract : A potential Cancer suppressing agent sudharani028
Natural Polyphenol "Resveratrol" present predominantly in the grape seed plays an very important role in the treatment of devastating disorder Cancer (diseases involving abnormal and uncontrolled growth of cell with the potential to spread to other parts of the body)
2016 05-24 Kick-off The Danish Biomarker Network, Copenhagen, Alain van GoolAlain van Gool
Keynote lecture given at the kick-off of The Danish Biomarker Network in Copenhagen for a great audience of enthousiastic patients, biotech/pharma developers and ICT experts.
2016 04-21 Association of Dutch Producers of Children and Diet Nutrition (VNF...Alain van Gool
Keynote lecture at the 55-year lustrum conference of the Association of Dutch Producers of Children and Diet Nutrition (VNFKD) to reflect on the use of (specialized) nutrition in personalized healthcare.
APRIL 2018, VOL. 22 NO. 2 CLINICAL JOURNAL OF ONCOLOGY NURSING.docxfestockton
APRIL 2018, VOL. 22 NO. 2 CLINICAL JOURNAL OF ONCOLOGY NURSING 175CJON.ONS.ORG
C
Nephrotoxicity
Evidence in patients receiving cisplatin therapy
Elizabeth A. Duffy, DNP, RN, CPNP, Wendy Fitzgerald, RN, MSN, PPCNP-BC, CPON®, Kelley Boyle, MSN, RN, PCNS-BC, and Radha Rohatgi, PharmD, BCOP
CISPLATIN IS A PLATINUM COMPOUND THAT HAS BEEN USED as a chemotherapeutic
agent for many different cancers, including ovarian, testicular, lung, cervical,
and bladder cancers (Ruggiero, Rizzo, Trombatore, Maurizi, & Riccardi, 2016;
Santoso, Lucci, Coleman, Shafer, & Hannigan, 2003). The primary dose-
limiting toxicity of cisplatin is nephrotoxicity, a well-known side effect
(Jones, Spunt, Green, & Springate, 2008; Miller, Tadagavadi, Ramesh, &
Reeves, 2010). Nephrotoxicity involves glomerular or tubular dysfunction
of the kidneys after exposure to medications, other treatments, or toxins
(Skinner, 2011). Nephrotoxicity associated with cisplatin is related to accu-
mulation of metabolites in the renal proximal tubule cells of the kidneys,
where about 90% of cisplatin undergoes urinary excretion (Ruggiero et al.,
2016). Accumulation of these metabolites causes direct inflammation; the
production of reactive oxygen species, which leads to oxidative cell damage;
and cell death (Miller et al., 2010; Ruggiero et al., 2016). Many methods are
available to measure kidney function and define nephrotoxicity or acute
kidney injury (see Table 1).
Most patients receiving cisplatin experience acute impairment of glo-
merular and tubular function in varying degrees. Toxicity is dependent on
individual cisplatin pharmacokinetics and is usually more severe with high
total cisplatin doses and when other potential nephrotoxic medications are
given concurrently (Skinner, 2011; Womer, Pritchard, & Barratt, 1985). In one
study, children aged 10 years or older at treatment had a lower glomerular
filtration rate 10 years after therapy compared to children aged younger than
10 years at treatment (Skinner et al., 2009).
Nephrotoxicity can be reversible, but for some individuals, it can result
in permanent kidney injury, chronic progressive renal failure, or renal tubule
function impairment (Skinner et al., 2009). Chronic and severe reductions
of renal function have several sequelae. The immediate impact may be dose
reduction or cessation of potentially lifesaving nephrotoxic chemotherapy,
thereby increasing the risk of relapse or progression of the cancer. In the
event of a disease relapse or progression, changes to renal function may limit
enrollment in phase 1 or 2 clinical trials because of inclusion parameters
related to baseline renal function.
Hydration and diuretics have been used in conjunction with cisplatin
administration for decades to improve the excretion of cisplatin and reduce
the incidence of nephrotoxicity. One method of promoting this excretion is
through osmotic diuresis with mannitol (Morgan et al., 2014). However, the
amount ...
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
newer drug delivery systems
1. Newer drug delivery systems
Dr. Manjeeta Gupta
Department of Pharmacology
MIMER Medical College
Friday, July 8, 2016 1
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
2. Newer drug delivery systems
ACKNOWLEDGEMENTS
- Principal
- Members Staff Research Society
- Faculty members & PG students
(Pharmacology)
- Scientists & researches whose work was a source of
inspiration & information for this presentation
Friday, July 8, 2016 2
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
3. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
3
New drug or New
delivery??
4. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
4
5. Friday, July 8, 2016 5
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Oral drug delivery
systems
6. Osmotic drug delivery
system
Friday, July 8, 2016 6
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Nifedipine
Chlorpheniramine
(Salt)
Before After
7. Hydrodynamic drug delivery
system
Friday, July 8, 2016 7
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Valrelease tablet-Diazepam
Liquid formulation
↓
Collapsible drug
container
↓
Absorbent layer
↓ (Water)
Hydrodynamic pressure
↓
Release of drug
8. Friday, July 8, 2016 8
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Gastroretentive drug delivery
system
Absorptive
window
Acyclovir
Bisphosphonates
Captopril
Furosemide
Metformin
Gabapentin
Levodopa
Baclofenac
Ciprofloxacin
9. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
9
10. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
10
Undertrial -
Hepatitis B,
Norwalk virus for
diarhoea,
Rabies,
Corona virus for
gastroenteritis
11. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
11
Transdermal drug delivery system
13. Diclofenac Pain relief (Pain in terminal
stages of malignancies and
other pains)
Fentanyl, buprenorphine
(Opioids)
Lidocaine Herpes Zoster (Pain relief)
Scopolamine Motion sickness
Nicotine patch Smoking cessation
Clonidine (Catapres) Hypertension
Nitroglycerine Angina
Friday, July 8, 2016 13
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
14. Vitamin B12 Anaemia (Avoiding multiple
injections / Daily oral treatment)
Methylphenidate
(Daytrana)
ADHD (2006)
Rivastigmine (Exelon) Alzheimer disease (2007)
5-hydroxytryptophan
(2014) Depressive disorder
Selegiline (2006)
(Emsam)
Friday, July 8, 2016 14
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
15. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
15
Pellet Implant
Estradiol &
Testosterone
Implants
16. Friday, July 8, 2016 16
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Use of ultrasonic waves (1-3 MHz) for enhancement of migration
of drug molecule through skin
Hydrocortisone in arthritis
Sonophoresis
17. Intranasal drug delivery system
Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
17
Vortical flow principle
Rotational motion +
Particles also move in
directions opposite to
each other
Forceful, deeper,
wider penetration
Better bioavailability
18. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
18
Mucosal
automizatio
n device
Nitroglycerine
Progesterone
Estradiol
Testosterone
Naloxone
Oxytocin
Desmopressin
Dihydro-ergotamine
Calcitonin
20. Intraperitoneal Nebulizer
Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
20
Ropivacaine ---- Pain control after
laparoscopic cholecystectomy
A double-blind,
randomized, placebo-controlled
trial
http://bja.oxfordjournals.org,
September 11, 2014
21. Friday, July 8, 2016
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
21
Microneedle drug
delivery system
22. Friday, July 8, 2016 22
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Influenza vaccine
Hepatitis B vaccine
Lidocaine
Parathormone
Desmopressin
Vitamin B
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Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
-Bare metal stent coated with drug-polymer matrix
-Local, controlled delivery
- Prevents re-stenosis
Sirolimus - eluting coronary stent – (CYPHER)
Paclitaxel - eluting coronary stent – (TAXUS )
Drug Eluting Stents
24. Sutures
Sutures impregnated with antimicrobial agent
• Polyglactin 910 (absorbable suture material coated
with antiseptic agent Triclosan)
• Monofilament sutures: Monocryl & PDS (for both
gram positive & gram negative organisms)
• Under clinical trial
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Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
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MIMER Medical College Talegaon
Dabhade
25
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MIMER Medical College Talegaon
Dabhade
27
Lacrisert
-Treatment of dry eye keratitis
- Drug : Hydro-propyl cellulose
Retisert
-Treatment of chronic
infectious uveitis
- Drug : Fluocinolone acetonide
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MIMER Medical College Talegaon
Dabhade
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Drug : Gancyclovir
Drug : Latanoprost
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MIMER Medical College Talegaon
Dabhade
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MIMER Medical College Talegaon
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Insulin Pen Insulin jet
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MIMER Medical College Talegaon
Dabhade
32
Insulin pump
33. Inhaled Insulin
• Approved (Jan.2006)
• Short-actinginsulin
• Tocontrolpost-prandialhyperglycemia
Friday, July 8, 2016 33
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
34. Oral Insulin: a long awaited dream.. !!
Phase 2 & 3 clinical trials
IN-105 (Biocon India)
NN-1952 (Novo nordisk)
ORMD-0801(Oramed)
Pharmfilm (MonoSol, Midatech) - transbuccal
Oral-lyn (Generex) - buccal spray
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Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
35. Patient- Controlled Analgesia
Programmable device
For pain relief
Terminal stages of
malignancies
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Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
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MIMER Medical College Talegaon
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MIMER Medical College Talegaon
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Doxorubicin (Doxil)
– Kaposi’s sarcoma
Amphotericin B –
Serious Systemic
fungal infections
Paclitaxel (Abraxane)
– Metastatic breast
Ca (2005),
Non small cell lung
Ca (2012)
Advanced pancreatic
Ca (2013)
39. Friday, July 8, 2016 39
Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
Medical application of nanotechnology
Nano-sized (1-100 nanometers) particles
Diagnosis, prevention & treatment of diseases
To gain complete understanding of complex patho-
physiology of disease
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MIMER Medical College Talegaon
Dabhade
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Gold nanoparticles
-Generation of free radicals
- Killing of cancer cells
41. Carbon nanotubules
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MIMER Medical College Talegaon
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Enhanced solubility
Efficient tumour
targeting/drug delivery
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MIMER Medical College Talegaon
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Nano-Erythrosomes
Carry proteins, enzymes & macromolecules
Liver tumours, parasitic & enzymatic diseases
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MIMER Medical College Talegaon
Dabhade
43
Genetic transfer system
Under Phase 3 trial
for Adenovirus &
HIV
44. Imagine…….
• An injectable microfilm goes into the body
• Releases a drug layer by layer
• Over a period of ………. long time
• Long ? How much long ??
• 1 week? 1 month? 6 months ??? STILL LONGER…
• More than a year
• Give anti-TB drug only once, and Will it be done?
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Department of Pharmacology
MIMER Medical College Talegaon
Dabhade
45. Future will be unimaginably different ??
• Biodegradable nanoscale film - Targeted Controlled delivery
• Pain medications - Release the drug for more than 14 months
• Professor Paula Hammond
• Koch Institute for Integrative Cancer Research at –
• Massachusetts Institute of Technology – Cambridge- USA
• http://pub.mims.com/India/topic/medical-tribune-in/new-te
. accessed 26 Sept 2014
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MIMER Medical College Talegaon
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Editor's Notes
In the GI tract laminate absorbs fluid & gets swollen, which generates hydrodynamic pressure
Edible vaccine significantly reduces burden of diseases like hepatitis and diarrhea in country like India where administration of vaccines major problem.
Edible vaccines prepared from molecular farming by using genetic engineering techniques.
Selected gene introduced in plant and this transgenic plant encodes required protein.
Ease of administration.
Eliminate the concern about transmission of human and animal pathogens by vaccines.
Reduce the need for trained medical personnel to administer the vaccine.
Remove the need for needles and syringes.
Convenience and safety in storing and transporting vaccines .
Delivery of multiple antigens.
Possible production of vaccines with low costs.
Adjuvant for immune response is not necessary.
Excellent safety and economic feasibility of oral administration compared to injection.
E.g. Hepatitis B, Norwalk virus for diarrhoea, Rabies, Corona virus for gastroenteritis, cholera, HIV virus, Typhoid, Polio
Small pellets like rice grains are inserted under the skin usually in the lower abdominal wall or near upper gluteal region with a small incision made under LA and the closed with a skin tape. They release the drug at a constant rate and therefore avoid fluctuations in women with low levels of hormones. Painless, almost needleless. Helpful in migraine & menstrual headaches.
Vortical flow
Needleless, painless, rapid delivery of drug with almost 100% bioavailability. Eg. Naloxone (opiod antagonist) for respiratory distress & midazolam (short acting BZD) for seizures in children.
Sirolimus is a macrolide & immunosupressant.
Paclitaxel is a mitotic inhibitor & used in Ca chemothearpy.
PDS- polydioxanone system
Lacrisert - Acts as an artificial tear gland (A substitute for artificial tears)
Placed in the conjunctival sac and softens within 1 hour and completely dissolves within 14 to 18 h
Stabilizes and thickens the pre-corneal tear film and prolongs the tear film break-up time
NDA – New Drug Application
Subcutaneous, both deliver drugs but jet delivers it to a larger surface area, therefore more bioavailability
Controlled, compliant
Use polymer based & nanotechnology.
A liposome is a synthetic spherical vesicle with a membrane composed of a phospholipid & cholesterol bilayer consisting of hydrophilic and hydrophobic layers used as a vector for carrying lipid soluble, water soluble & also DNA to the target tissues.
The design, characterization, production of structures, devices by controlling shape and size to nanometric scale (10-9 meters)
Allotropes of carbon with cylindrical nanostructure. Members of fullerene structural family.
Enhanced solubility & allows efficient tumour targeting / drug delivery.
Have same structure (skeleton) as RBCs & therefore the name.