2. Main purpose ventilator is to decrease work of breathing
What is work of breathing ?
Respiratory muscles account for 1% - 3% of total oxygen consumption
In patients with acute hypoxemic respiratory failure and shock who are
undergoing cardiopulmonary resuscitation the respiratory muscles account
for approximately 20% of total oxygen consumption
This result in increased work of breathing
11. Inspiratory Flow Pattern
Inspiration
Expiration
Time (sec)
Flow
(L/min)
Beginning of inspiration
exhalation valve closes
Peak inspiratory flow rate
PIFR
Beginning of expiration
exhalation valve opens
Total cycle time
TCT
Insp. time
TI
Expiratory Time
TE
27. Components of
Inflation Pressure
Begin Expiration
P
aw
(cm
H
2
O)
Time (sec)
Begin Inspiration
PIP
Pplateau
(Palveolar)
Transairway Pressure (PTA)
} Exhalation Valve Opens
Expiration
Inspiratory Pause
28. Begin Inspiration
Begin Expiration
P
aw
(cm
H
2
O)
Time (sec)
Distending
(Alveolar)
Pressure Expiration
Inflation Hold
(seconds)
Begin Expiration
P
aw
(cm
H
2
O)
Time (sec)
Begin Inspiration
PIP
Pplateau
(Palveolar
Transairway Pressure (PTA)
} Exhalation Valve Opens
Expiration
PIP
29. PIP vs Pplat
Normal High Raw
High Flow Low Compliance
Time (sec)
Paw
(cm
H
2
O)
PIP
PPlat
PIP
PIP PIP
PPlat
PPlat
PPlat
40. PATIENT -VENTILATOR ASYNCHRONY
Synchronous ventilation occurs when the ventilator responds
appropriately to a patients inspiratory effort and delivers the amount
of flow and requested by the patient
Asynchrony occurs when the patient inspiratory efforts and flow
demands are not accomaated by the ventilator
Asynchrony may also accompanied by Tachypnea, chest wall
retractions and chest-abdominal paradox
43. TRIGGER ASYNCHRONY
Trigger asynchrony occurs when the ventilator sensitivity settings is not
appropriate for the patient, with this type of asynchrony ventilator does not
sense the patients inspiratory effort and fails to deliver the gas flow
Trigger that is too insensitive requires the patient to make a strong,
spontaneous effort to achieve gas flow from the ventilator
In a patient with spontaneous breathing effort, If pressure triggering is being
used, a change to flow triggering may help because flow triggering generally
reduces inspiratory WOB.
45. Ineffective Efforts
Ineffective effort is defined as a patient’s effort being unable to trigger the
ventilator breath.
the ventilator is unable to detect the patient’s neural effort despite the presence of
an inspiratory effort
From a clinical point of view, ineffective effort can be detected by analyzing the
breathing frequency shown on the ventilator monitoring system that is lower than
the breathing frequency monitored by observing the patient’s chest/abdomen
movements.
46.
47. Cause of Asynchrony
1. Low trigger sensitivity
2. Weak respiratory drive or weak effort secondary to heavy sedation, excessive
respiratory support, or diaphragm dysfunction
3. Presence of high threshold load such as intrinsic PEEP
4. Delayed cycling, especially in PSV mode or obstructive condition or during
NIV in presence of intentional leak in a ventilator unable to compensate for
them
48. Solution of Asynchrony
Adjust trigger sensitivity,
reduce sedation or use drugs with no effect on the respiratory drive,
increase PEEP to counter intrinsic PEEP,
shorten inspiratory time,
49. Delayed triggering
• Triggering delay is a time lag between the onset of the patient’s effort and the
onset of ventilator pressurization. This is a typical asynchrony between the
respiratory drive and the inspiratory trigger
• A time lag of > 100ms between the onset of patient effort and the onset of flow
delivered by the ventilator
51. Cause of Asynchrony
o low trigger sensitivity
o Low respiratory drive
o Presence of a partially obstructed ETT or HME
Solution of Asynchrony
Adjust trigger sensitivity,
Decrease inspiratory time and increase expiratory time
Reduction of minute ventilation by lowering assist (decrease set pressure, set VTe)
increase PEEP to counter intrinsic PEEP,
replace HME or ETT, change NIV interface
52. Auto triggering
Auto-triggering is a mechanical breath that is not triggered by the patient’s
inspiratory effort beyond the mandatory breaths
It is an asynchrony between the respiratory drive and the
inspiratory trigger.
53. Auto-triggering caused by leak
in the circuit. Note that there is
no drop of the airway pressure
in the pressure/time waveform
(Upper waveform) at the
beginning of the inspiratory
phase which means that the
breaths are not patient trigger
54. Cause of Asynchrony
High trigger sensitivity
Leaks
Random noise in the circuit (eg, cardiac oscillations,condensed water in the
ventilator circuit, copious tracheobronchial secretions)
Solution of Asynchrony
Adjust trigger sensitivity
Check for leaks in circuit
Remove condensed water from the trap
Auscultate and check for secretions
Inflate ETT cuff
55. Double triggering
Double-triggering, also called double-cycling or breathstacking, consists
of 2 breaths that may or may not be separated by a very short
expiratory time.
Occurrence of 2 consecutive breaths with an interval of less than half of
the mean inspiratory time (TI).
56. Red arrow show double-
triggering in the
pressure/time waveform.
White arrow show double-
triggering in the flow/time
waveform
57. Cause of Asynchrony
Respiratory drive is high
Delivered ventilatory support is insufficient (eg, tidal volume [VT] or V
̇ E too
low)
Neural TI is longer than the TI set on the ventilator
Solution of Asynchrony
Increase inspiratory time
Modes that allow variation in tidal volume, such as PCV
Decrease the cycling threshold percentage (PSV)
Patient factor-Correct underlying fever, anxiety
58. Reverse triggering
Reverse-triggering is a type of asynchrony that happens when a
patient’s effort occurs after the initiation of a ventilator breath (ie, a
breath not triggered by the patient).
Cause of Asynchrony
Occurs mainly in patients who are deeply sedated
Over assistance
Prolonged NMB
60. Solution of Asynchrony
No single effective treatment strategy.
Reducing RR to increase patient triggered breaths.
Reducing sedation and awakening the patient
Neuromuscular Paralysis
61. Flow asynchrony
Flow asynchrony occurs when the patient’s flow demand is not met by the
ventilator. The type of mode being used often determines how much flow is
available
During volume control ventilation, if flow is constant, the set flow may not match
patient demand. This is a fairly common problem . An initial flow of 80 L/min is
typically suggested. In this situation the best way to determine if adequate flow is
being provided is to evaluate the pressure–time scalar. When the pressure curve
appearance changes from breath to breath, the patient is actively breathing. A
concave appearance on the inspiratory pressure curve during volume control
ventilation indicates active inspiration
62. During pressure-targeted ventilation, such as PC-CMV and PSV, the
ventilator rapidly provides a high flow to achieve and maintain the
set pressure. As long as the set pressure is adequate, flow to the
patient will be adequate
63. Breath a is a control breath
with no patient effort. Breath
b is a patient-triggered breath
with adequate flow. The
dotted line mimics a passive
breath as in a. Breath c is a
patient-triggered breath with
inadequate flow to meet
patient demand (solidline).
65. Insufficient flow
Determining factor Therapeutic strategy
Ventilator :
• In VCV, the flow setting is
too low
• In PCV and PSV the
applied pressure is too low,
long rise time
• In VCV, increase inspiratory
flow
• PCV or PSV increase
pressure support
66. Excessive ventilator
demand, increased
neural drive
Reduce neural drive and
metabolic demand.
control fever, pain,
metabolic acidosis and
anxiety.
Patient factors :
67.
68. Excess flow
Determining factor Therapeutic strategy
In VCV, the flow setting is
too high
In VCV, decrease inspiratory
flow
In PCV and PSV, the applied
pressure is too high, rise time
is too short
In PCV and PSV, decrease
applied pressure, increase
rise time
70. Cycle asynchrony
Cycle asynchrony, also called termination asynchrony, usually occurs when the
patient starts to exhale before the ventilator has completed inspiration.
Cycle asynchrony often occurs when TI is too long. Increasing the flow in volume
control ventilation to shorten TI, - decreasing the set TI time in volume control or
pressure control may help.
Cycle asynchrony can occur with both mechanical (mandatory) and spontaneous
breaths. During spontaneous ventilation with PSV, cycle asynchrony commonly
occurs when the patient actively tries to exhale before the expiratory flow
termination
72. Premature cycling
Determining factor Therapeutic strategy
Inspiratory time is too short relative
to patient inspiratory time
Low level of assist
In VCV, decrease inspiratory flow
or increase tidal volume or add end
inspiratory pause
In PCV, increase inspiratory time.
.
73. Example of premature cycling.
White arrows show an
inspiratory effort that continues
after the inspiratory phase
ended in the pressure/ time
waveform.
Red arrows show a sudden
change in the expiratory flow
caused by the inspiratory effort
of the patient
75. Determining factor Therapeutic strategy
Inspiratory time > patient
inspiratory time
Excessive tidal volume , long I
time
In VCV, decrease in Vt(will dec I
time)
In PCV, decrease inspiratory
time.
Bronchodilator, steroid therapy,
aspiration of secretions.