Uterine polyps are noncancerous growths that develop from an overgrowth of cells in the uterine lining. They vary in size and attach to the uterine wall by a stalk or broad base. The most common type is mucus polyps, which can arise from the body or cervix of the uterus. Uterine polyps may be asymptomatic but can sometimes cause irregular bleeding, heavy periods, or bleeding after menopause. Diagnosis involves physical examination, ultrasound, hysteroscopy, or biopsy. Treatment options include watchful waiting for small polyps, hormonal medication to reduce symptoms, or surgical removal by curettage, hysterotomy, or hysterectomy depending on the size and location of the poly
Bartholin’s Gland
Function :
The production of mucoid secretion that lubricates the
distal end of the vagina during intercourse.
The glands become active after menarche and are non
palpable.
Bartholinitis
Causative agent:
Gonococcus
Streptococcus
Staphylococcus
E. coli
End result :
Complete resolution
Recurrence
Abscess
Cyst formation
Clinical features :
Local pain discomfort.
Difficulty in walking / sitting.
Examination :
Tenderness
Induration of post half of vagina.
Secretion coming out from the duct when pressed.
Treatment
Local :
Systemic:
Ampicillin 500 mg TDS
Bartholin’s Abscess
End result of acute Bartholinitis.
Clinical features:
Severe local pain and discomfort.
Difficult / painful walking and sitting.
On examination:
Unilateral tender swelling.
Oedomatous red overlying skin.
Treatment:
Rest.
Sitz bath.
Systemic antibiotic Ampicillin 500 mg.
Drainage of abscess.
Bartholin’s cyst
The content is colourless glairy liquid.
C/f :
Small cyst : usually unnoticed.
Larger cyst : Local discomfort and dyspareunia.
Examination:
Unilateral swelling on post half of labia majora.
Projection on vulval cleft into S-shape.
Overlying skin is shiny and thin.
Cyst remains non tender and fluctuant.
Treatment:
Marsupilisation.
Explains the inflammatory process of endometrium,its causes and its two clinical variants as acute and chronic endometritis.
Describes the pathology of its two types with histologic perspective.
Bartholin’s Gland
Function :
The production of mucoid secretion that lubricates the
distal end of the vagina during intercourse.
The glands become active after menarche and are non
palpable.
Bartholinitis
Causative agent:
Gonococcus
Streptococcus
Staphylococcus
E. coli
End result :
Complete resolution
Recurrence
Abscess
Cyst formation
Clinical features :
Local pain discomfort.
Difficulty in walking / sitting.
Examination :
Tenderness
Induration of post half of vagina.
Secretion coming out from the duct when pressed.
Treatment
Local :
Systemic:
Ampicillin 500 mg TDS
Bartholin’s Abscess
End result of acute Bartholinitis.
Clinical features:
Severe local pain and discomfort.
Difficult / painful walking and sitting.
On examination:
Unilateral tender swelling.
Oedomatous red overlying skin.
Treatment:
Rest.
Sitz bath.
Systemic antibiotic Ampicillin 500 mg.
Drainage of abscess.
Bartholin’s cyst
The content is colourless glairy liquid.
C/f :
Small cyst : usually unnoticed.
Larger cyst : Local discomfort and dyspareunia.
Examination:
Unilateral swelling on post half of labia majora.
Projection on vulval cleft into S-shape.
Overlying skin is shiny and thin.
Cyst remains non tender and fluctuant.
Treatment:
Marsupilisation.
Explains the inflammatory process of endometrium,its causes and its two clinical variants as acute and chronic endometritis.
Describes the pathology of its two types with histologic perspective.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
Uterine polyp
1. UTERINE POLYPS
INTRODUCTION
Uterine polyps are growths attached to the inner wall of the uterus that extend into
the uterine cavity. Overgrowth of cells in the lining of the uterus (endometrium)
leads to the formation of uterine polyps, also known as endometrial polyps. These
polyps are usually noncancerous (benign), although some can be cancerous or can
eventually turn into cancer (precancerous polyps).
Uterine polyps range in size from a few millimeters — no larger than a sesame
seed — to several centimeters — golf-ball-size or larger. They attach to the uterine
wall by a large base or a thin stalk.
DIFFERENT TYPE OF POLYPS
Mucus
Fibroid
Placental
De Novo
SecondaryChanges Of Benign Polyp
Benign polyp is a clinical entity referring a tumor attached by a pedicle.
Mucus the commonest type of benign uterine polyp is mucus one. It may arise
from the bodyof the uterus or from the cervix.
Fibroid polyp may arise from the bodyof the uterus or from the cervix.
Placental polyp retained bit of placental tissue when adherent to the uterine wall
get Organized with the surrounding blood clots.
PATHOGENESIS
Body
The part of the thick endometrium project into the clarity ultimately attains a
pedicle.It seems to arise from the basal endometrium surrounded by the functional
zone. responsiveness to hormone. Multiple polyposis in endometrial hyperplasia
Due to hyperoestrogenism is excluded from such discrete polyp.
Nakedeye appearance - show a small polyp size of about 1-2 cm , look reddish
and feel soft
2. Polyp may at times be long enough to make the polyp protruded from the cervix.
Microscopically
The core contents stromal cells , glands, and large thick walled vascular channel
the surface is lined by endometrium may undergo squamous metaplasia
Rarely smooth muscle invade the polyp and is then called adenomyoma.
Cervical
The polyp arrived from the endocervix and rarely from the ectocervix . The
stimulus of Epithelial growth is probably due to hyperoestrogenism.
Nakedeye appearance showthe polyp of usually small size exceeding 1-2 cm ,
single and Red in colour .the pedicle may at times be long enough to reach the
vaginal interoitus
Microscopically
The stroma consists of fibrous connective tissue with numerous small blood
vessels and Cervical gland the lining epithelium is tall columnar like that of
endocervix. stroma dense and Fibrous and the term fibroadenomatous poly is used
CLINICAL FEATURES
There may not be any symptoms
Irregular menstrual bleeding — for example, having frequent, unpredictable
periods of variable length and heaviness
Bleeding between menstrual periods
Excessively heavy menstrual periods
Vaginal bleeding after menopause
Infertility
Contact bleeding if the polyp is situated at or outside the cervix
Excessive vaginal discharge which may be offensive
DIAGNOSIS
1-History collection
2-Physical examination per vaginal examination the uterus is bulky with the
patulous cervical canal.
3. 3-Sound test to differentiate a fibroid polyp from chronic inversion, sound test
is done if an uterine sound is fast all-round between the pedicle and dilating
cervical canal it is a polyp incomplete chronic inversion the sound cannot be
passed.
4-Transvaginalultrasound. A slender, wand-like device placed in vagina
emits sound waves and creates an image of uterus, including its interior.
See a polyp that's clearly present or may identify a uterine polyp as an area
of thickened endometrial tissue.
A related procedure, known as hysterosonography involves having salt
water (saline) injected into your uterus through a small tube threaded
through vagina and cervix. The saline expands uterine cavity, which gives a
clearer view of the inside of uterus during the ultrasound.
5-Hysterosalpingography to detect the filling defect in fibroid polyp.
6-Hysteroscopy
7-D&E examination under anaesthesia and exploration of the uterine cavity by
curette aur ovum aur ring forceps
8-Endometrial biopsy.
MANAGEMENT
Watchful waiting. Small polyps without symptoms might resolve on their
own. Treatment of small polyps is unnecessary unless at risk of uterine
cancer.
Medication. Certain hormonal medications, including progestins and
gonadotropin-releasing hormone agonists, may lessen symptoms of the polyp.
But taking such medications is usually a short-term solution at best —
symptoms typically recur once stop taking the medicine.
Mucous polyp
a) Endometrial polyp are usually removed by uterine curettage
b) In case of recurrence hysterectomy
4. Cervical polyps are removed by twisting of the pedicle the base of the pedicle
should be cauterized to prevent recurrence
Fibroid polyp
a) Removal politician by cutting the anterior wall of the uterus anterior
hysterotomy
b) Uterus to be removed hysterectomy is done with the fibroid polyp in situ.
Did fibroid line in the vagina remove by morcellement followed by
transfixation sutures on the pedicle