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Upper Gastro-Intestinal
Bleed
Oliver McLaren
GI Tract
Upper GI Tract
• Anatomically consists of:
» Mouth
» Pharynx
» Oesophagus
» Stomach
• Upper GI bleeding can include bleeding
from the duodenum up to the ligament of
Treitz, just before the junction between
the duodenum and the jejunum
Ligament of Treitz
Epidemiology
• Upper GI bleeding is a potentially life-
threatening and remains a common
cause of hospitalisation
• Incidence is 100 cases per 100,000
people per year
• Upper GI bleeds are 4 times more
common than Lower
• Overall mortality rate is 6-10 % overall
Upper GI Bleed Presentation
• Upper GI bleeding presents in 2 main
ways:
• Melaena = Black motions/stool
• Haematemesis = Vomiting blood
• Other symptoms:
• Anaemia
• Syncope
• Fatigue
Clinical Indicator Probability of
Upper GI Source
Haematemesis Almost certain
Melena Probable
Haematochezia Possible
Blood-streaked
stool
Rare
Melaena
• Melaena comes from the Greek melas
meaning black
• Has a characteristic smell of “altered
blood”
• Tar-like in presentation
• Colour is a result of iron oxidation as
blood moves through ileum and colon
Haematemesis
• Bloody vomitus
• Bright red/frank blood
• “Coffee-ground” vomitus
– Haem exposed to stomach acid for some time
– Oxidises
– Takes on dark colour
Causes of Upper GI bleeds
• Common causes:
• Mallory Weiss tear
• Oesophagitis
• Oesophageal varices
• Peptic Ulcers – gastric and duodenal ulcers
• Gastritis/gastric erosions
• Duodenitis
• Malignancy
• Drugs – NSAIDS, aspirin, steroids, thrombolytics,
anticoagulants
• Ideopathic
•Mallory-Weiss tear = Tear in mucosal layer at junction between oesophagus
and stomach
•Often as a result of prolonged + forceful vomiting
Oesophagitis Oesophageal varices
Duodenal ulcer seen via endoscopy
Gastric ulcer
PEPTIC ULCERS
•Severe Gastrits
•Erosive gastritis on
contrast radiograph
•Duodenitis
Causes of Upper GI Bleeds
• Rare causes:
• Bleeding disorders (eg Haemophilia)
• Portal hypertensive gastropathy
• Aortoenteric fistula
• Angiodysplasia
• Haemobilia
• Dieulafoy lesion
• Meckel’s diverticulum
• Peutz-Jegher syndrome
• Osler-Weber-Rendu syndrome
Portal hypertensive gastropathy
Aortoenteric fistula
Angiodysplasia
Dieulafoy lesion
Meckel’s diverticulum
Osler-Weber-Rendu
syndrome
Management
• In medical emergency:
» Protect airway
» IV line for fluids + cross match blood
» Monitor urine output
» Correct clotting abnormalities
» Monitor pulse, BP, CVP
» Inform surgeons of all severe bleeds
• Post-emergency:
» Locate + diagnose source of bleed , eg endoscopy
» Stop bleed, eg surgery, electrocautery, laser
therapy, adrenaline, banding, clipping

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Upper GI Bleeds

  • 3. Upper GI Tract • Anatomically consists of: » Mouth » Pharynx » Oesophagus » Stomach • Upper GI bleeding can include bleeding from the duodenum up to the ligament of Treitz, just before the junction between the duodenum and the jejunum
  • 5. Epidemiology • Upper GI bleeding is a potentially life- threatening and remains a common cause of hospitalisation • Incidence is 100 cases per 100,000 people per year • Upper GI bleeds are 4 times more common than Lower • Overall mortality rate is 6-10 % overall
  • 6. Upper GI Bleed Presentation • Upper GI bleeding presents in 2 main ways: • Melaena = Black motions/stool • Haematemesis = Vomiting blood • Other symptoms: • Anaemia • Syncope • Fatigue Clinical Indicator Probability of Upper GI Source Haematemesis Almost certain Melena Probable Haematochezia Possible Blood-streaked stool Rare
  • 7. Melaena • Melaena comes from the Greek melas meaning black • Has a characteristic smell of “altered blood” • Tar-like in presentation • Colour is a result of iron oxidation as blood moves through ileum and colon
  • 8. Haematemesis • Bloody vomitus • Bright red/frank blood • “Coffee-ground” vomitus – Haem exposed to stomach acid for some time – Oxidises – Takes on dark colour
  • 9. Causes of Upper GI bleeds • Common causes: • Mallory Weiss tear • Oesophagitis • Oesophageal varices • Peptic Ulcers – gastric and duodenal ulcers • Gastritis/gastric erosions • Duodenitis • Malignancy • Drugs – NSAIDS, aspirin, steroids, thrombolytics, anticoagulants • Ideopathic
  • 10. •Mallory-Weiss tear = Tear in mucosal layer at junction between oesophagus and stomach •Often as a result of prolonged + forceful vomiting
  • 12. Duodenal ulcer seen via endoscopy Gastric ulcer PEPTIC ULCERS
  • 13. •Severe Gastrits •Erosive gastritis on contrast radiograph •Duodenitis
  • 14. Causes of Upper GI Bleeds • Rare causes: • Bleeding disorders (eg Haemophilia) • Portal hypertensive gastropathy • Aortoenteric fistula • Angiodysplasia • Haemobilia • Dieulafoy lesion • Meckel’s diverticulum • Peutz-Jegher syndrome • Osler-Weber-Rendu syndrome
  • 15. Portal hypertensive gastropathy Aortoenteric fistula Angiodysplasia Dieulafoy lesion Meckel’s diverticulum Osler-Weber-Rendu syndrome
  • 16. Management • In medical emergency: » Protect airway » IV line for fluids + cross match blood » Monitor urine output » Correct clotting abnormalities » Monitor pulse, BP, CVP » Inform surgeons of all severe bleeds • Post-emergency: » Locate + diagnose source of bleed , eg endoscopy » Stop bleed, eg surgery, electrocautery, laser therapy, adrenaline, banding, clipping